KR101858217B1 - Healthy food with promoting hair growth - Google Patents
Healthy food with promoting hair growth Download PDFInfo
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- KR101858217B1 KR101858217B1 KR1020170140184A KR20170140184A KR101858217B1 KR 101858217 B1 KR101858217 B1 KR 101858217B1 KR 1020170140184 A KR1020170140184 A KR 1020170140184A KR 20170140184 A KR20170140184 A KR 20170140184A KR 101858217 B1 KR101858217 B1 KR 101858217B1
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Images
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
Description
본 발명은 적양파와 호박을 주원료하여 발모 촉진 효과를 가질 수 있도록 하는 건강식품에 관한 것이다.The present invention relates to a health food which is able to have an effect of promoting hair growth by mainly raw onion and amber.
탈모는 정상적으로 모발이 존재해야 할 부위에 모발이 없는 상태를 말하며, 일반적으로 두피의 성모가 빠지는 것을 의미한다. 탈모의 원인은 스트레스, 자극적인 식사, 흡연, 심리적인 불안감 등이 있고, 유전적인 원인이나 체내 호르몬의 변화로도 기인한다.Hair loss refers to a state in which there is no hair on the area where hair normally should be present, and generally means that the hair of the scalp is missing. The causes of hair loss include stress, irritating eating, smoking, and psychological anxiety, and are also caused by genetic causes and hormonal changes in the body.
이러한 탈모는 성인 70%가 질환으로 인식하고 있으며, 이로 인해 사회생활에 직간접적 손해를 느낀다는 조사 결과 있다. 아울러 성인의 약 23%가 탈모를 경험하고, 주로 20 ~ 30대에 시작해서 전체 인구의 약 10 ~ 15% 정도가 환자군 및 잠재적 환자군으로 분류되고 있다.This hair loss is recognized by 70% of adults as a disease, resulting in direct or indirect damage to the social life is a survey. In addition, about 23% of adults experience hair loss, mainly in their 20s and 30s, and about 10 to 15% of the total population are classified as patients and potential patients.
기존 탈모의 치료를 위해서 상품화된 약품으로는 특허문헌 1에서와 같이 미녹시딜 성분의 제품과 피나스테라이드 성분의 제품이 있다. 미녹시딜은 원래 고혈압 치료제로 개발 중 부작용으로 발모 효과가 발견되어 탈모치료제로 개발된 것으로 두피에 도포하는 형태이며, 발모 메카니즘은 일산화질소(Nitric oxide) 작용기에 의한 혈관 확장을 통해 모낭으로 혈류량 증대 및 이를 통한 모발성장을 촉진하는 작용기전이다. 그러나 눈의 통증, 도포부위 발진, 홍반 등의 부작용이 초래될 수 있으며, 미성년자는 사용이 불가하고 여성은 3% 농도 이상의 제품은 사용할 수 없는 등, 사용상의 제한이 크고 심각한 알러지 반응을 유발할 수 있어 사용상 주의가 필요하다. 아울러, 기본적으로 화학제품이기 때문에 다양한 부작용이 초래될 가능성이 있다.As commercialized drugs for the treatment of existing hair loss, there are products of minoxidil and pinasteride as in Patent Document 1. Minoxidil was originally developed as a therapeutic agent for hypertension and was found to be effective as a hair loss treatment due to side effects. It was applied to the scalp and the hair growth mechanism was a method of increasing the blood flow to the hair follicle through vasodilation by the nitric oxide Is a mechanism of action that promotes hair growth. However, it may cause side effects such as pain in the eyes, rash of the application site, erythema and erythema, and it is impossible to use it for minors and women can not use products with a concentration of 3% or more. Use caution. In addition, since it is basically a chemical product, various side effects may occur.
또한 피나스테라이드 성분의 제품 역시 양성 전립선 비대증 치료제로 개발 중 부작용으로 모발성장이 발견되어 탈모치료제로 개발된 것으로, 경구투여하는 제품이다. 발모 메카니즘은 제2형 5-알파-리덕타제(5-alphareductase)효소 작용을 차단시켜 남성호르몬에 작용하여 탈모를 억제한다. 본격적으로 호르몬에 작용하므로심각한 부작용이 초래될 수도 있다. 즉, 남성호르몬에 직접 작용하므로 남성 전용으로, 여성은 사용과 접촉조차 금지된다. 여성이 이 성분에 노출시 가임 여성의 경우 불임을 초래할 수도 있다. 또한 사용한 남성의 경우 발기부전을 초래할 수 있고 성기능 감퇴가 우려된다. 따라서 3개월 이상 연속 사용이 어려우며, 효과는 일시적으로 중단시 다시 탈모가 진행될 수 있다.In addition, the product of the finasteride component of the benign prostatic hyperplasia treatment as a side effect during the development of hair growth was discovered and developed as a remedy for hair loss, orally administered products. The hair growth mechanism blocks the action of type 2 5-alphaareductase enzymes and acts on the male hormone to inhibit hair loss. Because it acts on hormones in earnest, serious side effects may occur. In other words, because it works directly on male hormones, men are forbidden to use and even contact with women. Women exposed to this ingredient may cause infertility in women who are still young. In addition, men who have used can cause erectile dysfunction, and there is concern about sexual dysfunction. Therefore, it is difficult to use continuously for more than 3 months.
따라서 보다 안전하고 친환경적이며 효과가 우수한 발모 촉진제의 개발이 절실히 요구되어 왔다. 아울러, 성별에 구분 없이 사용가능하고 부작용 및 인체독성이 없는 제품의 개발이 요구되어 왔다. Therefore, it has been urgently required to develop a hair growth promoting agent which is more safe, environmentally friendly and effective. In addition, there has been a demand for the development of products that can be used regardless of gender and have no side effects or toxicity to humans.
본 발명은 상기와 같은 문제점을 해결하기 위한 것으로, 적양파와 호박을 주원료로 한 건강식품을 제공함으로써 발모 촉진 효과를 가질 수 있도록 함을 과제로 한다.Disclosure of Invention Technical Problem [8] Accordingly, the present invention has been made to solve the above-mentioned problems, and it is an object of the present invention to provide a health food containing mainly onion and amber as a main ingredient.
아울러, 본 발명은 상기와 같은 주원료에 검은콩, 검은깨, 솔잎과 같은 천연물을 배합하여 발모 촉진 효과를 더욱 향상시킬 수 있도록 함을 다른 과제로 한다.Another object of the present invention is to further enhance the hair growth promoting effect by blending natural materials such as black beans, black sesame seeds and pine needles with the above-mentioned main ingredients.
또한, 본 발명은 상기와 같은 주원료 또는, 주원료와 천연물의 배합물을 적양파 식초와 혼합 및 발효시킴에 따라 발모 촉진 효과를 더욱 향상시킬 수 있도록 함을 또 다른 과제로 한다.It is another object of the present invention to further enhance the hair growth promoting effect by mixing and fermenting the above-mentioned raw materials or the blend of the raw materials and the natural products with the red onion vinegar.
본 발명은 건강식품에 있어서, 적양파 50 ~ 70 중량% 및 늙은 호박 30 ~ 50 중량%로 이루어지는 것을 특징으로 하는, 발모 촉진 효과를 가지는 건강식품을 과제의 해결 수단으로 한다.The present invention relates to a health food having a hair growth promoting effect, which is characterized by comprising 50 to 70% by weight of red onion and 30 to 50% by weight of an old amber in health food.
그리고 상기 적양파 50 ~ 70 중량% 및 늙은 호박 30 ~ 50 중량%로 이루어지는 혼합물 100 중량부에 대하여, 검은콩 20 ~ 30 중량부, 검은깨 20 ~ 30 중량부 및 솔잎 10 ~ 20 중량부를 더 혼합할 수도 있다.20 to 30 parts by weight of black beans, 20 to 30 parts by weight of black sesame and 10 to 20 parts by weight of pine needles are further mixed with 100 parts by weight of the mixture consisting of 50 to 70% by weight of red onion and 30 to 50% by weight of old pumpkin, You may.
또한, 상기 적양파 50 ~ 70 중량% 및 늙은 호박 30 ~ 50 중량%로 이루어지는 혼합물 100 중량부에 대하여, 적양파 식초 20 ~ 25 중량부를 더 혼합 및 발효할 수도 있다.Further, 20 to 25 parts by weight of red onion vinegar may be further mixed and fermented to 100 parts by weight of the mixture of 50 to 70% by weight of the red onion and 30 to 50% by weight of the old amber.
본 발명은 적양파와 늙은 호박의 혼합 또는, 적양파, 늙은 호박, 검은콩, 검은깨 및 솔잎의 혼합 또는, 이에 대한 적양파 식초의 적용에 따른 혈액 순환 촉진 효능을 바탕으로 혈액의 원활한 순환을 통해, 두피에 공급되어야할 영양과 수분이 효율적으로 두피에 공급되도록 하고 이로 인해 두피, 모근 및 모발 등에 영양을 충분히 공급하여 발모를 촉진시킬 수 있도록 하는 효과가 있다.The present invention relates to a method for improving the circulation of blood on the basis of a mixture of red onion and old amber or a mixture of red onion, old amber, black bean, black sesame and pine leaves, or on the blood circulation promoting effect of the application of red onion vinegar The nutrient and moisture to be supplied to the scalp are efficiently supplied to the scalp through the hair, and thereby the nutrition can be sufficiently supplied to the scalp, hair roots and hair, thereby promoting hair growth.
도 1은 발모 촉진 효과에 대한 육안적 관찰 결과를 나타낸 실물사진
도 2는 발모 촉진 효과에 대한 조직학적 분석 결과를 나타낸 40배율 광학현미경 사진
도 3은 피부 조직 ALP(alkaline phosphatase) 활성 측정결과를 나타낸 그래프
도 4는 피부 조직 γ-GT(γ-glutamyl transpeptidase) 활성 측정결과를 나타낸 그래프Fig. 1 is a photograph showing a result of gross observation on the effect of promoting hair growth
FIG. 2 is a photograph of a 40-magnification optical microscope photograph showing the results of histological analysis of the hair growth promoting effect
FIG. 3 is a graph showing the results of measurement of skin tissue ALP (alkaline phosphatase) activity
FIG. 4 is a graph showing the results of measuring the activity of γ-GT (γ-glutamyl transpeptidase)
상기의 효과를 달성하기 위한 본 발명은 발모 촉진 효과를 가지는 건강식품에 관한 것으로서, 본 발명의 기술적 구성을 이해하는데 필요한 부분만이 설명되며 그 이외 부분의 설명은 본 발명의 요지를 흩트리지 않도록 생략될 것이라는 것을 유의하여야 한다.The present invention for achieving the above effect is related to a health food having hair growth promoting effect, and only a part necessary for understanding the technical structure of the present invention will be explained, and the description of other parts is omitted so as not to disturb the gist of the present invention. .
이하, 본 발명에 따른 발모 촉진 효과를 가지는 건강식품을 상세히 설명하면 다음과 같다.Hereinafter, the health food having the hair growth promoting effect according to the present invention will be described in detail.
본 발명에 따른 발모 촉진 효과를 가지는 건강식품은, 적양파 50 ~ 70 중량% 및 늙은 호박 30 ~ 50 중량%로 이루어진다.The health food having hair growth promoting effect according to the present invention comprises 50 to 70% by weight of red onion and 30 to 50% by weight of old amber.
일반적으로 양파는 매운맛이 약한 감미종과 매운맛이 강한 신미종으로 크게 나뉘고, 다시 비늘줄기의 색깔에 따라 황색·적색·백색계로 나뉜다. 감미종은 생식하는 데 많이 이용되고, 신미종은 조리에 주로 이용된다. 또한 양파는 동의보감에서 이르길 "오장의 기에 모두 이롭게 한다" 라고 기록하고 있고, 오래전부터 전통민간요법으로 사용되고 있는 식물로서 알려져 있는 바와 같이 인체에 유익한 화학 성분인 퀘르세틴(quercetin) 함량이 생양파의 경우에는 16 ~ 42 mg/100g 정도 함유되어 있고, 이러한 퀘르세틴(quercetin) 성분은 비특허문헌 1, 2에 게재된 바와 같이 혈액 속의 불필요한 지방과 콜레스테롤을 용해시키는 작용을 하므로 동맥경화와 고지혈증을 예방하고, 혈압을 내리고, 혈당을 저하시키는 작용을 하는 것으로 알려져 있다.Generally speaking, onions are divided into weak sweet spicy and pungent strong, and again divided into yellow, red, and white based on the color of the stem of the scales. Sweet ginseng is widely used for reproduction, and the new breed is mainly used for cooking. Onion also records that "it is beneficial to all of the days of the five o'clock" in Donguibogam, and quercetin, a chemical ingredient beneficial to the human body, is known to have been used as a traditional folk remedy for a long time. 16 to 42 mg / 100 g. Such a quercetin component dissolves unnecessary fats and cholesterol in the blood as disclosed in Non-Patent Documents 1 and 2. Therefore, it prevents arteriosclerosis and hyperlipemia, To lower blood sugar, and to lower blood sugar is known.
한편, 본 발명에서 사용되는 적양파는 비특허문헌 3에 게재된 바와 같이 일반 양파에 비해 퀘르세틴(quercetin) 함량이 풍부하며, 혈액 속의 불필요한 지방과 콜레스테롤을 용해시키는 등의 혈행 개선 효과를 나타낸다. 즉, 적양파는 상기와 같은 효과를 바탕으로 발모 촉진효과를 부여하기 위해 첨가되는 것으로, 적양파의 함량 50 중량% 미만일 경우 발모 촉진 효과가 미비해질 우려가 있고, 70 중량%를 초과할 경우 사용량 대비 효과의 증가 효율이 미비하여 비경제적일 우려가 있다.On the other hand, as disclosed in Non-Patent Document 3, the red onion used in the present invention is rich in quercetin as compared with general onion, and exhibits blood circulation improving effect such as dissolving unnecessary fat and cholesterol in the blood. That is, the red onion is added to give the hair growth promoting effect on the basis of the above effect. When the content of the red onion is less than 50% by weight, the hair growth promoting effect may be insufficient. There is a possibility that the increase efficiency of the contrast effect is insufficient, which is uneconomical.
일반적으로 호박은 박과에 속하는 1년생 덩굴식물로서 열대 아메리카가 원산지이며, 크게 동양계 호박과 서양계 호박 및 페포호박으로 나눌 수 있다. 호박은 성숙함에 따라 당질과 비타민 A 등의 영양성분이 증가하여 식품적 가치가 높으며, 황색을 나타내는 천연색소 등이 존재하는데 이런 천연색소는 여러가지 가공식품의 첨가물로 이용되고 있다. 이중에서도 특히 베타카로틴(β-carotene)은 비타민 A의 좋은 급원이며, 다양한 약리효과를 가지는 것으로 보고되고 있다. In general, amber is a year - old vine plant belonging to the genus Bacillus, and originates from the tropical Americas, and can be roughly divided into oriental amber, western amber, and puffer amber. Pumpkin has high nutritional value such as carbohydrate and vitamin A due to its maturity and it has a high value of food. There are natural pigments that show yellow color. These natural pigments are used as additives of various processed foods. In particular, beta-carotene is a good source of vitamin A and has been reported to have various pharmacological effects.
한편, 본 발명에서 사용되는 늙은 호박은 늙어서 겉이 굳고 씨가 잘 여문 호박으로 정의되며 동양계 겨울호박으로 봄에 심어 가을에 수확한다. 특히 상기 늙은 호박은 비특허문헌 4에 게재된 바와 같이 베타카로틴(β-carotene)과 같은 항산화 성분이 많기 때문에 체내 산소 공급과 혈액 순환에 도움을 준다고 알려져 있다. 즉, 늙은 호박은 상기와 같은 효과를 바탕으로 발모 촉진효과를 부여하기 위해 첨가되는 것으로, 늙은 호박의 함량 30 중량% 미만일 경우 발모 촉진 효과가 미비해질 우려가 있고, 50 중량%를 초과할 경우 사용량 대비 효과의 증가 효율이 미비하여 비경제적일 우려가 있다.On the other hand, the old pumpkin used in the present invention is defined as an old pumpkin, which is hard on the outside and seeds well, and is harvested in autumn in an oriental winter pumpkin planted in spring. In particular, the old pumpkin has been known to contribute to oxygen supply and blood circulation in the body since it contains many antioxidant components such as beta-carotene as disclosed in Non-Patent Document 4. That is, the old pumpkin is added to give the hair growth promoting effect on the basis of the above effect. When the content of the old pumpkin is less than 30% by weight, the effect of stimulating the hair growth may be insufficient. When it exceeds 50% There is a possibility that the increase efficiency of the contrast effect is insufficient, which is uneconomical.
즉, 본 발명은 적양파와 늙은 호박이 가지는 혈액 순환 촉진 및 이를 바탕으로 한 혈액의 원활한 순환을 통해, 두피에 공급되어야할 영양과 수분이 효율적으로 두피에 공급되도록 하고 이로 인해 두피, 모근 및 모발 등에 영양을 충분히 공급하여 발모를 촉진시키는 것이다.That is, the present invention promotes circulation of blood of red onion and old pumpkin and smooth circulation of blood based on the nutrition and moisture to be supplied to the scalp, so that the scalp, scalp and hair And nutrition is sufficiently supplied to promote hair growth.
한편, 본 발명은 상기 적양파 50 ~ 70 중량% 및 호박 30 ~ 50 중량%로 이루어지는 혼합물 100 중량부에 대하여, 검은콩 20 ~ 30 중량부, 검은깨 20 ~ 30 중량부 및 솔잎 10 ~ 20 중량부를 더 혼합할 수도 있다.On the other hand, 20 to 30 parts by weight of black beans, 20 to 30 parts by weight of black beans and 10 to 20 parts by weight of pine needles are added to 100 parts by weight of the mixture consisting of 50 to 70% by weight of red onion and 30 to 50% You can mix more parts.
상기 검은콩은 비특허문헌 5에 게재된 바와 같이 혈액의 항산화능을 증가시키고 혈중 중성 지질을 감소하는 효과를 가져 혈액을 맑게 하고 혈액 순환에 도움을 준다고 알려져 있다.The black bean has been known to increase the antioxidant capacity of blood and reduce neutral lipid in blood as described in Non-Patent Document 5, thereby clearing blood and helping blood circulation.
상기 검은깨는 비특허문헌 6에 게재된 바와 같이 항산화 활성물질을 포함함에 따라 혈액에 대한 항산화활성을 증가시킬 수 있고 이 역시 혈액 순환에 도움을 준다고 알려져 있다.As disclosed in Non-Patent Document 6, the black sesame can increase antioxidant activity against blood as it contains an antioxidant active substance, which is also known to help blood circulation.
상기 솔잎은 비특허문헌 7에 게재된 바와 같이 혈액 중 콜레스테롤을 감소시켜 혈액 성상을 개선하고 혈액 순환에 도움을 준다고 알려져 있다.As described in Non-Patent Document 7, the pine needle has been known to reduce cholesterol in the blood, thereby improving blood characteristics and helping blood circulation.
즉, 상기 검은콩, 검은깨 및 솔잎과 같은 천연물은 모두 혈액의 원활한 순환을 돕는 것으로, 이러한 천연물의 첨가로 인해 발모를 촉진 효능을 더욱 향상시킬 수 있으며, 상기 각 천연물의 함량이 상기 범위를 벗어날 경우 발모 촉진 효능의 향상 효율이 미비하거나 또는 비경제적일 우려가 있다.That is, the natural products such as black beans, black sesame seeds, and pine needles all contribute to smooth circulation of blood. The addition of such natural products can further enhance the hair growth promoting effect, and the content of each natural product There is a possibility that the efficiency of enhancing the hair growth promoting effect is insufficient or uneconomical.
또한, 본 발명은 적양파 식초 20 ~ 25 중량부를 더 혼합하고 발효함으로써 발모 촉진 효과를 더욱 향상시킬 수도 있다.In addition, the present invention may further enhance the hair growth promoting effect by further mixing and fermenting 20 to 25 parts by weight of red onion vinegar.
상기 적양파 식초는 적양파를 이용하여 제조되는 식초로써 특허문헌 2에 게재된 바와 같이 퀘르세틴 성분이 함유되어 있어 혈압 및 콜레스테롤 저하 등의 효과를 증진시킨다고 알려져 있다. 즉 본 발명에서 사용되는 적양파 식초는 적양파, 호박 및 천연물 등이 가지는 유효성분 및 효능을 더욱 활성화시키기 위해 첨가되는 것으로, 상기 적양파 식초의 함량이 20 중량부 미만일 경우 이러한 활성화 효율이 미비해질 우려가 있고, 25 중량부를 초과할 경우 사용량 대비 효과의 증가 효율이 미비하여 비경제적일 우려가 있다.The red onion vinegar is a vinegar prepared by using red onion, and it is known that the vinegar contains quercetin as disclosed in Patent Document 2, thereby enhancing effects such as blood pressure and cholesterol lowering. That is, the red onion vinegar used in the present invention is added in order to further activate the active ingredients and potency of red onion, zucchini, and natural products. When the content of the red onion vinegar is less than 20 parts by weight, If the amount is more than 25 parts by weight, there is a possibility that the efficiency of increase in the effect of the use amount is insufficient, which is uneconomical.
한편, 상기 적양파 식초는 이미 공지된 다양한 방법으로 제조될 수 있으나 일 예로 밀기울 50 ~ 70 중량% 및 적양파 분말 30 ~ 50 중량%로 이루어지는 혼합물과, 물 60 ~ 80 중량% 및 주정 20 ~ 40 중량%로 이루어진 혼합물을 상호 혼합하고 3 ~ 6개월간 숙성시켜 중초를 만들고, 세미, 적양파 분말, 흑설탕을 1 : 1 : 1 중량비로 혼합하여 약 6 ~ 12 개월 숙성시킨 식초원료를 제조한 후, 상기 식초원료에 중초를 섞어 약 6 ~ 12개월 숙성시켜 적양파 식초를 제조한다. 여기서 상기 적양파의 제조 방법, 함량, 조건은 상기 범위에 한정되는 것은 아니고 이미 공지된 다양한 적양파 식초의 사용이 가능하다.On the other hand, the red onion vinegar may be prepared by various known methods, for example, a mixture comprising 50 to 70% by weight of bran and 30 to 50% by weight of red onion powder, 60 to 80% by weight of water and 20 to 40% The mixture was mixed for 3 to 6 months, and the mixture was aged for 3 ~ 6 months. Then, the mixture was mixed with semi-, red onion powder and brown sugar at a weight ratio of 1: 1: 1 to prepare a vinegar raw material aged for about 6 to 12 months, The vinegar raw material is mixed with the herb and aged for about 6 to 12 months to produce red onion vinegar. Here, the production method, content and condition of the red onion are not limited to the above-mentioned range, but various known onion vinegar can be used.
아울러, 상기 적양파 식초를 적용하는 방법은 적양파와 늙은 호박의 혼합물 또는, 적양파, 늙은 호박, 검은콩, 검은깨 및 솔잎의 혼합물에 적양파 식초를 섞어 3 ~ 10일 동안 발효시켜 적용할 수도 있고, 또는 각각의 원료에 상기 적양파 식초를 먼저 적용하여 발효시킨 후 상기 공정을 추가적으로 진행할 수도 있다.In addition, the method of applying the red onion vinegar may include applying a mixture of red onion and old amber on a mixture of red onion, old amber, black bean, black sesame and pine needles, followed by fermentation for 3 to 10 days Alternatively, the above-mentioned process can be further performed after fermentation by applying the above-mentioned onion vinegar to each raw material.
한편, 상기 각 물질은 모두 세척, 절단, 건조 및 분쇄 등의 공지된 공정을 거칠 수 있으며, 분쇄에 의한 분말화 공정에서 그 입자크기는 특정 크기에 한정하지 않고 제품의 종류나 사용연령, 사용환경 등에 따라 가변적으로 적용할 수 있다. 아울러, 건강 식품의 형태 역시 과립, 환, 액상 등 다양하게 적용할 수 있다.On the other hand, all of the above materials can be subjected to known processes such as washing, cutting, drying and pulverization. In the pulverization process by pulverization, the particle size is not limited to a specific size, And the like. In addition, the form of health food can be applied to various forms such as granule, ring, and liquid.
이하, 본 발명의 실시 예를 들면서 상세히 설명하는 바, 본 발명이 다음의 실시예에 의해서만 반드시 한정되는 것은 아니다. Hereinafter, the present invention will be described in detail with reference to examples thereof, but the present invention is not necessarily limited to the following examples.
1. 건강 식품의 제조1. Manufacture of health food
(실시예 1)(Example 1)
적양파 분말 70 중량% 및 늙은 호박 분말 30 중량%를 혼합한 혼합물 100 중량부에 대하여, 적양파 식초 20 중량부를 혼합하고 발효, 건조 및 분말화하여 건강식품을 제조하였다.20 parts by weight of red onion vinegar was mixed with 100 parts by weight of a mixture of 70% by weight of red onion powder and 30% by weight of old pumpkin powder, and fermented, dried and pulverized to prepare a health food.
(실시예 2)(Example 2)
적양파 분말 50 중량% 및 늙은 호박 분말 50 중량%를 혼합한 혼합물 100 중량부에 대하여, 적양파 식초 25 중량부를 혼합하고 발효, 건조 및 분말화하여 건강식품을 제조하였다.25 parts by weight of red onion vinegar was mixed with 100 parts by weight of a mixture of 50% by weight of red onion powder and 50% by weight of old amber powder, followed by fermentation, drying and pulverization.
(실시예 3)(Example 3)
적양파 분말 70 중량% 및 늙은 호박 분말 30 중량%를 혼합한 혼합물 100 중량부에 대하여, 검은콩 분말 20 중량부, 검은깨 분말 20 중량부 및 솔잎 분말 10 중량부를 혼합한 후, 적양파 식초 20 중량부를 더 혼합하고 발효, 건조 및 분말화하여 건강식품을 제조하였다.20 parts by weight of black soybean powder, 20 parts by weight of black sesame powder and 10 parts by weight of pine needle powder were mixed with 100 parts by weight of a mixture of 70% by weight of red onion powder and 30% by weight of old pumpkin powder, Were further mixed and fermented, dried and pulverized to prepare a health food.
(실시예 4)(Example 4)
적양파 분말 50 중량% 및 늙은 호박 분말 50 중량%를 혼합한 혼합물 100 중량부에 대하여, 검은콩 분말 30 중량부, 검은깨 분말 30 중량부 및 솔잎 분말 20 중량부를 혼합한 후, 적양파 식초 25 중량부를 더 혼합하고 발효, 건조 및 분말화하여 건강식품을 제조하였다.30 parts by weight of black soybean powder, 30 parts by weight of black sesame powder and 20 parts by weight of pine needle powder were mixed with 100 parts by weight of a mixture of 50% by weight of red onion powder and 50% by weight of old pumpkin powder, Were further mixed and fermented, dried and pulverized to prepare a health food.
2. 건강식품의 평가 항목 및 방법2. Evaluation Items and Methods of Health Food
(1) 탈모 방지 효과 평가(1) Evaluation of preventing hair loss
- 실험동물 처치- Treatment of experimental animals
마우스(Mouse)를 1주간 적응 시킨 다음 마우스의 등을 동물용 이발기를 이용하여 털을 제거하고, 피부 속에 남아 있는 미세한 털을 제거하기 위하여 제모제를 피부에 도포하여 완전히 털을 제거하였다. 시료도포는 제모 당일로부터 매일 1회 일정한 시간에 경구투여하였다.The mouse was adapted for 1 week, and then hair was removed from the back of the mouse using an animal hair clipper. To remove fine hair remaining in the skin, a depilator was applied to the skin to remove hair completely. Sample application was orally administered once a day at a constant time from the day of hair removal.
- 마우스의 육안적 관찰- Gross observation of mouse
육안적 관찰방법은 실험 시작일로부터 일주일마다 사진 촬영을 하였다. 실험군과 대조군의 발모 효과는 사진 상으로 제모 부위에 털이 어느 정도 자랐는지 육안으로 평가하였다.Gross observations were taken every week from the start of the experiment. The hair growth effect of the experimental group and the control group was visually evaluated on the basis of the degree of hair growth on the hair removal area.
- 마우스 조직학적 분석(hematoxyline & eosin, toluidin blue)- Mouse histological analysis (hematoxyline & eosin, toluidine blue)
실험 4주째 경피 적출한 피부조직들은 10% 중성 포르말린에 48시간동안 고정한 다음 흐르는 물에 수세하였다. 피부조직을 적출해서 티슈 캡슐(tissue capsule)에 넣어 70% 알코올, 80% 알코올, 95% 알코올, 100% 알코올로 각각 1시간 처리하여 탈수하였고, 자일렌(xylene)을 3회에 각각 1시간씩 담가둔 후 파라핀으로 치환하였다. 피부조직은 파라핀에 포매한 후 포매 된 조직은 4㎛ 두께로 절편을 만들어 헤마톡실린-에오진(Hematoxylin-Eosin) 염색을 하여 현미경상에서 조직학적 변화를 관찰하였다.At 4 weeks of the experiment, the dermal tissues were fixed in 10% neutral formalin for 48 hours and then rinsed in flowing water. The skin tissue was removed and dehydrated by treating with 70% alcohol, 80% alcohol, 95% alcohol and 100% alcohol for 1 hour each in a tissue capsule. The xylene was added to the tissue capsule three times for 1 hour each After soaking, it was replaced with paraffin. The skin tissue was embedded in paraffin, and the embedded tissue was cut into a 4-μm-thick section and stained with hematoxylin-Eosin to observe the histological changes on the microscope.
(2) 피부조직의 효소활성도 측정(2) Measurement of enzymatic activity of skin tissue
- ALP(alkaline phosphatase)- ALP (alkaline phosphatase)
피부조직을 적출하여 빙냉하에서 미세 절편으로 만들고, 그 중 일정량을 청량한 후, 4배량의 0.1M 인산완충용액(pH 7.4)을 가하여 마쇄기를 이용하여 20%(w/v)균질액을 만들었다. 이 균질액을 12,000 rpm에서 4℃, 30 분간 원심 분리하여 그 상층액에서 PMF(post-mitochondrial fraction)을 분리하고, ρ-니트로페놀(ρ-nitrophenol)에 알칼리(alkali)를 가하여 비색 정량하는 Bessey-Lowry-Brock 방법에 의하였다. 활성도 단위는 단백질 1 mg 당 Bessey-Lowry unit로 하였고, 단백질의 정량은 Lowry 등의 방법에 준하여 보빈 알부민(bovin albumin)을 표준품으로 하여 측정하였다.The skin tissue was excised and made into micro slices under ice-cooling. After a certain amount of the slices were cooled, a homogenate of 20% (w / v) was prepared using a 4-fold amount of 0.1 M phosphate buffer solution (pH 7.4) This homogenate was centrifuged at 12,000 rpm at 4 ° C for 30 minutes to separate the post-mitochondrial fraction (PMF) from the supernatant and to colorimetry by applying alkali to the ρ-nitrophenol. -Lowry-Brock method. The activity was determined as Bessey-Lowry unit per mg of protein. Protein quantification was performed using bovine albumin as a standard according to the method of Lowry et al.
- γ-GT(γ-Glutamyl transpeptidase)- γ-GT (γ-Glutamyl transpeptidase)
γ-GT를 기질로 하여 생성된 5-아미노살리실산(5-aminosalicylic Acid)를 다시 -ρ-자일레놀(-ρ-xylenol)와 소듐 페리오데이트(Sodium Metaperiodate)로 반응시켜 생성된 케노이드(Kenoid) 색소를 635 nm에서 측정하는 키트(kit) 시약에 의해 측정하였다.(5-aminosalicylic Acid), which is produced using γ-GT as a substrate, is reacted with -ρ-xylenol and sodium metaperiodate to form a kenoid ) The dye was measured by a kit reagent measuring at 635 nm.
3. 건강식품의 평가 결과3. Evaluation results of health food
(1) 실험동물 (1) Experimental animals
5주령 C57BL/6 마우스 수컷을 ㈜샘타코코리아에서 구입하여 실험에 사용하였다. 각 실험에 쓰이는 동물은 난괴법에 의하여 3군으로 나눠 분리시키고 사육기간 동안에 일반식이를 정해진 양에 따라 배식시켰으며 물은 자유로이 섭취시켰다. 주 5일 동안 일정한 시간에 경구 투여하여 발모 촉진 효과를 확인하였다.Five-week-old C57BL / 6 male males were purchased from Samtaco Korea and used in the experiment. The animals used for each experiment were divided into three groups according to the nanking method, and the regular diet was distributed according to the predetermined amount during the breeding period and the water was freely consumed. The effect of stimulating the hair growth was confirmed by oral administration for a period of 5 days per week.
(2) 처리방법(2) Processing method
4주 동안 샘플들을 털이 제거된 마우스에 경구 투여한 후 마지막 샘플 처리가 끝난 직후 18시간 절식시킨 후 에테르로 마취하여 희생시켜 등 피부를 벗겨 조직학적 관찰 실험을 위해 포르말린으로 고정시켰고, 고정시키고 남은 피부 조직은 피부 조직 효소 활성 측정을 위해 -70℃에 보관하였다.For 4 weeks, samples were orally administered to hairless mice, and immediately after the last sample treatment, they were fasted for 18 hours, sacrificed by anesthesia with ether, and the skin was removed and fixed with formalin for histological observation. Tissues were stored at -70 ° C for skin tissue enzymatic activity.
(3) 육안적 관찰(3) Gross observation
비교예 1 - 일반식이, 물Comparative Example 1 - General diet, water
비교예 2 - 일반식이, 판시딜(동국제약, 탈모치료제 100 mg/kg)Comparative Example 2 - General Diet, Pancidil (Dongkuk Pharmaceutical, Hair loss treatment agent 100 mg / kg)
실시예 1 - 일반식이, 실시예 1에 따른 혼합물(100 mg/kg)Example 1 - General Diet, Mixture According to Example 1 (100 mg / kg)
도 1에 도시된 바와 같이, 털을 제거하고 1주경과 후에는 모든 군에서 털이 자라나지 않음을 확인하였고, 2주후에도 모든 군에서 큰 차이가 나지 않았다. 3주경과 후 비교예 1에서는 털이 자라지 않았지만 비교예 2와 실시예 1에서는 피부가 검게 변하고 털이 자라남을 확인할 수 있었다. 4주경과 후 비교예 1에서는 털이 자람을 확인 할 수 없었고, 비교예 2와 실시예 1은 털이 자라고, 자라지 않은 부분은 피부가 검게 변함을 확인하였다. 해부 직전에 진행한 사진촬영에서는 비교예 1은 피부가 검게 변하는 부분이 있었고 일부분 털이 자랐다. 비교예 2와 실시예 1은 제모 전과 같은 상태로 털이 검고 길게 자라 제모한 등 피부가 보이지 않을 정도로 자랐다. 실시예 1이 비교예 2와 유사한 수준으로 털이 자란 것은 실시예 1이 발모 촉진에 효과적임을 알 수 있다.As shown in FIG. 1, hair was removed, and hairiness did not grow in all the groups after one week and there was no significant difference in all groups after two weeks. In Comparative Example 1 and Comparative Example 2, hair was not grown in Comparative Example 1 and after 3 weeks. In Comparative Example 2 and Example 1, skin was changed to black and hair was grown. In Comparative Example 1 after 4 weeks, no hair growth was observed. In Comparative Example 2 and Example 1, hair was grown. In the portion not growing, the skin was darkened. In the photographing just before the dissection, in Comparative Example 1, there was a portion where the skin turned black and a part of hair was grown. Comparative Example 2 and Example 1 were the same as before hair removal, and the hair was grown so long that it was dark and hairless and the skin was not visible. It can be seen that Example 1 is effective for promoting hair growth when hair grows at a level similar to that of Comparative Example 2.
(4) 조직학적 분석(4) Histological analysis
비교예 1 - 일반식이, 물Comparative Example 1 - General diet, water
비교예 2 - 일반식이, 판시딜(동국제약, 탈모치료제 100 mg/kg)Comparative Example 2 - General Diet, Pancidil (Dongkuk Pharmaceutical, Hair loss treatment agent 100 mg / kg)
실시예 2 - 일반식이, 실시예 2에 따른 혼합물(100 mg/kg)Example 2 - General Diet, Mixture According to Example 2 (100 mg / kg)
등 조직의 털 굵기와 길이를 비교하기 위해 광학현미경으로 관찰한 결과, 도 2에 도시된 바와 같이, 비교예 1은 피부에 털과 털의 사이 간격이 넓고 길이도 길게 자라지 못하였다. 비교예 2는 털과 털 간격이 좁고 길이도 길게 자랐다. 실시예 2도 비교예 2와 같은 수준으로 털과 털 사이가 좁고 비교예 1에 비해 털의 길이가 길고 굵기도 굵게 털이 자랐다. 이러한 결과로 보아 실시예 2가 발모 촉진 및 모발 굵기 증진에 효과적임을 알 수 있다.As a result of observation with an optical microscope in order to compare the hair thickness and length of the back tissue, as shown in FIG. 2, in Comparative Example 1, the interval between hair and hair was not wide and the hair did not grow long. In Comparative Example 2, the distance between fur and hairs was narrow and the length was long. Example 2 also had the same level of hair and hair as that of Comparative Example 2, and the length of hair was longer than that of Comparative Example 1, and the hair was thicker in thickness. From these results, it can be seen that Example 2 is effective for promoting hair growth and increasing hair thickness.
(5) 피부 조직 ALP(alkaline phosphatase) 활성 측정(5) Measurement of ALP (alkaline phosphatase) activity of skin tissue
비교예 1 - 일반식이, 물Comparative Example 1 - General diet, water
비교예 2 - 일반식이, 판시딜(동국제약, 탈모치료제 100 mg/kg)Comparative Example 2 - General Diet, Pancidil (Dongkuk Pharmaceutical, Hair loss treatment agent 100 mg / kg)
실시예 3 - 일반식이, 실시예 3에 따른 혼합물(100 mg/kg)Example 3 - General Diet, Mixture According to Example 3 (100 mg / kg)
ALP(alkaline phosphatase)가 발모 기전에 관여하는 메커니즘은 명확하게 규명되어있지 않지만 혈관 신생 과정에 관여한다는 보고와 모발이 성장기로 될 때 효소활성이 증가한다고 알려져 있어 발모 지표로 이용되고 있다. 이러한 ALP활성을 측정한 결과 도 3에 도시된 바와 같이, 비교예 1은 511.53%, 비교예 2는 987.32%, 실시예 3은 832.64%로 측정되었다. 즉, 실시예 3이 비교예 1에 비해 ALP효소 활성이 증가한 것으로 보아 발모 촉진 효과가 있음을 알 수 있다.The mechanism of ALP (alkaline phosphatase) involvement in the hair growth mechanism has not been clearly elucidated, but it has been reported that it participates in the angiogenesis process and the enzyme activity is increased when the hair grows. As shown in FIG. 3, the ALP activity was measured as 511.53% for Comparative Example 1, 987.32% for Comparative Example 2, and 832.64% for Example 3. That is, it can be seen that the activity of ALP enzyme is increased in Example 3 compared to Comparative Example 1, and that the hair growth promoting effect is exhibited.
(6) 피부 조직 γ-GT(γ-glutamyl transpeptidase) 활성 측정(6) Measurement of γ-GT (γ-glutamyl transpeptidase) activity of skin tissue
비교예 1 - 일반식이, 물Comparative Example 1 - General diet, water
비교예 2 - 일반식이, 판시딜(동국제약, 탈모치료제 100 mg/kg)Comparative Example 2 - General Diet, Pancidil (Dongkuk Pharmaceutical, Hair loss treatment agent 100 mg / kg)
실시예 4 - 일반식이, 실시예 4에 따른 혼합물(100 mg/kg)Example 4 - General Diet, Mixture According to Example 4 (100 mg / kg)
γ-GT(γ-glutamyl transpeptidase)는 발모와 관련된 생화학적 효소로 세포막을 통한 아미노산과 펩티드의 배출, 흡수에 관여하며, 모발이 성장기로 될 때 효소활성이 증가한다고 알려져 있어 또 다른 발모 지표로 이용되고 있다. 이러한 γ-GT 효소 활성을 측정한 결과 도 4에 도시된 바와 같이 비교예 1은 44.66%, 비교예 2는 80.04%, 실시예 4는 66.84%로 측정되었다. 즉, 실시예 4가 비교예 1에 비해 γ-GT 효소 활성이 증가한 것으로 보아 발모 촉진 효과가 있음을 알 수 있다.γ-GT (γ-glutamyl transpeptidase) is a biochemical enzyme involved in hair growth. It is involved in the release and absorption of amino acids and peptides through the cell membrane. It is known that when the hair grows, the enzyme activity increases and is used as another hair growth index . As shown in FIG. 4, the γ-GT enzyme activity was measured as 44.66% in Comparative Example 1, 80.04% in Comparative Example 2, and 66.84% in Example 4. In other words, the activity of γ-GT enzyme was increased in Example 4 compared to Comparative Example 1, indicating that the hair growth promoting effect was exhibited.
상술한 바와 같이, 본 발명에 따른 발모 촉진 효과를 가지는 건강식품을 상기의 바람직한 실시 예를 통해 설명하고, 그 우수성을 확인하였지만 해당 기술분야의 당업자라면 하기의 특허청구범위에 기재된 본 발명의 사상 및 영역으로부터 벗어나지 않는 범위 내에서 본 발명을 다양하게 수정 및 변경시킬 수 있음을 이해할 수 있을 것이다.As described above, the health food having the hair growth promoting effect according to the present invention has been described through the above-described preferred embodiments, and its superiority has been confirmed. However, those skilled in the art will appreciate that the present invention, It will be understood that the invention can be variously modified and changed without departing from its scope.
Claims (3)
적양파 50 ~ 70 중량% 및 늙은 호박 30 ~ 50 중량%로 이루어지는 혼합물 100 중량부에 대하여, 검은콩 20 ~ 30 중량부, 검은깨 20 ~ 30 중량부, 솔잎 10 ~ 20 중량부 및 적양파 식초 20 ~ 25 중량부를 혼합 및 3 ~ 10일 동안 발효하여 이루어지되,
상기 적양파 식초는 밀기울 50 ~ 70 중량% 및 적양파 분말 30 ~ 50 중량%로 이루어지는 혼합물과, 물 60 ~ 80 중량% 및 주정 20 ~ 40 중량%로 이루어진 혼합물을 상호 혼합하고 3 ~ 6개월간 숙성시켜 중초를 만들고, 별도로 세미, 적양파 분말, 흑설탕을 1 : 1 : 1 중량비로 혼합하여 6 ~ 12 개월 숙성시킨 식초원료를 제조한 후, 상기 식초원료에 중초를 섞어 6 ~ 12개월 숙성시켜 제조되는 것을 특징으로 하는, 발모 촉진 효과를 가지는 건강식품.In health food,
20 to 30 parts by weight of black beans, 20 to 30 parts by weight of black beans, 10 to 20 parts by weight of pine needles and 10 to 20 parts by weight of red onion vinegar are added to 100 parts by weight of a mixture consisting of 50 to 70% by weight of red onion and 30 to 50% And 20 to 25 parts by weight of the mixture, and fermenting the mixture for 3 to 10 days,
The red onion vinegar is prepared by mixing the mixture of bran 50-70 wt.% And red onion powder 30-50 wt.% With 60-80 wt.% Water and 20-40 wt.% Alcohol mixture and aging for 3-6 months Then, the mixture was mixed with a mixture of semi, red onion powder and brown sugar in a weight ratio of 1: 1: 1 to prepare a vinegar raw material aged for 6 to 12 months. The vinegar raw material was aged for 6 to 12 months Wherein the health food has a hair growth promoting effect.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200046505A (en) | 2018-10-24 | 2020-05-07 | (주)한지 | Method of fermentation of red onions using effective microorganisms |
| KR102237076B1 (en) | 2019-10-31 | 2021-04-07 | (주)한지 | A composition for preventing hair loss or improving hair growth comprising Red Allium cepa fermented concentrate, Cucurbita moschata extract, and Angelica gigas Nakai extract |
| WO2021091080A1 (en) * | 2019-11-08 | 2021-05-14 | 구스타 주식회사 | Composition for preventing or treating hair loss, or promoting hair growth or hair thickening, comprising complex extract of beet, red onion and purple-fleshed sweet potato as active ingredient |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200046505A (en) | 2018-10-24 | 2020-05-07 | (주)한지 | Method of fermentation of red onions using effective microorganisms |
| KR102160239B1 (en) * | 2018-10-24 | 2020-09-25 | (주)한지 | Method of fermentation of red onions using effective microorganisms |
| KR102237076B1 (en) | 2019-10-31 | 2021-04-07 | (주)한지 | A composition for preventing hair loss or improving hair growth comprising Red Allium cepa fermented concentrate, Cucurbita moschata extract, and Angelica gigas Nakai extract |
| WO2021091080A1 (en) * | 2019-11-08 | 2021-05-14 | 구스타 주식회사 | Composition for preventing or treating hair loss, or promoting hair growth or hair thickening, comprising complex extract of beet, red onion and purple-fleshed sweet potato as active ingredient |
| KR20210056473A (en) * | 2019-11-08 | 2021-05-20 | 구스타 주식회사 | Composition for Preventing or Treating Hair Loss or Stimulating Hair Sprouting or Hair Growth Comprising Complex Extracts of Beet, Red Onion, and Purple Sweet Potato as an Active Ingredient |
| KR102327237B1 (en) * | 2019-11-08 | 2021-11-17 | 구스타 주식회사 | Composition for Preventing or Treating Hair Loss or Stimulating Hair Sprouting or Hair Growth Comprising Complex Extracts of Beet, Red Onion, and Purple Sweet Potato as an Active Ingredient |
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