KR101675831B1 - Cosmetics Composition for Improving them Using Eyebrows Growth-stimulating Properties of Capsaicin - Google Patents

Abstract

The present invention provides a composition for improving eyebrows by mixing capsaicin, which is high in Compound Scoville Heat Units (SHU), with a solvent or an excipient of cosmetics, using the property that the hot component promotes hair growth.
The pungent composition of the present invention has a significant effect on the length of the eyebrows, the thickness of the eyebrows and the number of the eyebrows when applying the eyebrows, thereby improving the eyebrows and making both eyebrows darker. This is because capsaicin promotes blood circulation, increases skin temperature, and continuously promotes hair growth. This is because the eyebrows can be supplemented with relatively light eyebrows by capsaicin application.

Description

TECHNICAL FIELD The present invention relates to a cosmetic composition for improving eyebrows using a hair growth promoting property of a capsaicin component,

The present invention relates to a method for improving hair growth by mixing capsaicin, which is high in Compound Scoville Heat Units (SHU), with solvent or cosmetic excipients, using capsaicin component promoting hair growth, Thereby providing a cosmetic composition.

The pungent composition of the present invention has a significant effect on the length of the eyebrows, the thickness of the eyebrows and the number of the eyebrows when applied to the eyebrows or the both eyebrows, so that the eyebrows and both eyebrows can be dramatically improved. This is because capsaicin promotes blood circulation, increases skin temperature, and continuously promotes hair growth. This is because the eyebrows can be supplemented with relatively light eyebrows by capsaicin application.

Capsaicin (Capsaicin, (N- (4- hydroxy-3-methoxybenzyl) -8-methyl-6- nonenamide), MF; C 18 H 27 NO 3 MW;. 305) is spicy units (SHU; Scoville Heat Units) is 15,000,000. It is a kind of alkaloid. It is a spicy flavor ingredient of red pepper. It is most abundant in red pepper seeds and also in the skin. It also promotes appetite and stimulates metabolism to burn away fat, thus preventing fat accumulation in the body. It is a colorless, volatile compound extracted from red pepper. It is used as medicine and fragrance. It is most abundant in red pepper seeds. Capsaicin-producing plants produce capsaicin for the purpose of protecting themselves against fungi and herbivores.

The content of capsaicin in red pepper varies from each pepper to 0.1 to 1.0%. Capsaicin is known to have various physiological activities, and it is a physiologically active substance which causes temporary pain when it is ingested but is beneficial to health. Capsaicin acts on the adrenal gland to increase the secretion of catecholamines, thereby promoting energy metabolism, thereby exhibiting antioxidative effects, inhibiting the oxidation of LDL (low density lipoprotein), and inhibiting the physiological activities such as anticancer, antiinflammatory, . Capsaicin is a vanilloid family that binds to a receptor called the vanilloid receptor (transient receptor potential vanilloid 1, TRPV1 or VR1), which is present in the body, to sense pain and heat, ≪ / RTI > On the other hand, in the related art related to the medical use of capsaicin, there is a paper that low temperature capsaicin is applied to skin to raise skin temperature and promote blood circulation (Ahluwalia & Flower, 1993; Nielsen et al ., 2013; Khambam et al ., 2011). This principle is also used as a treatment for arthritis.

In addition, Okazima (2004) of Kumamoto Graduate School of Medicine and Research Department took capsicin 6 mg (2 g of red pepper) and 75 mg of isoflavone (about 200 g of tofu) each day to men who had lost hair or eyebrows due to stress. And hair on the part of eyebrows were confirmed, hair growth effect was confirmed. This proved the hair growth effect of capsaicin in people who could not see any effect in dermatological treatment. However, there is no prior art relating to improving the eyebrow using capsaicin or thickening both eyebrows.

Eyebrows may be born from birth or may occur during the growth process. Women can easily correct or improve their eyebrows by scratching their eyebrows or by drawing them with a black fan. However, in the case of men, it is common to have eyebrows without any other means.

The present invention provides a cosmetic composition for improving eyebrows by mixing capsaicin having a high compound unit (Compound Scoville Heat Units (SHU)) with an excipient of a solvent or cosmetic using the property that the pungent component of capsaicin promotes hair growth. Capsaicin can be used as cosmetics for skin, lotions, creams, packs and ointments to relieve the burning effect even at low concentrations.

It can be seen that the present invention is effective for improving eyebrows hair growth effect that continuously promotes hair growth of capsaicin. In particular, it is effective for a woman who is a subject to provide cosmetics in accordance with the opinion of the experimenter that the eyebrows become thicker and 'the impression becomes clearer and' it will be happy because it looks younger '.

Fig. 1 shows the eyebrow length measurement result.
Fig. 2 shows the results of eyebrow thickness measurement.
Fig. 3 shows the results of counting eyebrows.
4 is a change in eyebrow absorbance after capsaicin treatment. *: p < 0.05
Figure 5 is a photograph of eyebrows before and after the experiment in the studio.
6 is a method for measuring the pixel value of eyebrows. (a) the original image, (b) the choice of the measurement method after applying the black and white effect, (c) the selected measurement principle, (d) the measurement range of 300% magnification, Measurement of pixel values.

The amount of eyebrows increased by 21.0% in eyebrows, 36.3% in eyebrows, and 46.3% in eyebrows in the control group compared to the control group, indicating that capsaicin is a very effective substance for eyebrow hair growth. It was also thought that capsaicin applied more than diet. The application of capsaicin to eyebrows promoted circulation of blood, increased temperature, and stimulated the growth of eyebrows continuously. In addition, changes in secretion of cytokines such as IGF-1 are also expected. However, in the experiment, the eyebrows were partially shortened due to the shortening of the growth period, and unlike the hair, the eyebrows parted into the dormant period during the experiment.

The spicy ingredient of the present invention may be a reagent grade capsaicin product (Aldrich). After removing the cocks from the cheongyang red pepper purchased on the day of experiment, we weighed 30 g including pulp and seed, cut into 2 cm pieces, and extracted with 150 mL of 95% ethanol (alcohol) for 24 hours at room temperature to prepare a Cheongyang pepper extract .

<Research Method>

(1) Subject and period

This experiment was conducted by the IRB of Konkuk University under IRB No. 7001355-201405-HR-019, which was deliberated on the ethical and scientific validity of human subjects and human body studies. Experimental subjects were one of 20 to 50-year-old eyebrows residing in Seoul who had taken a relatively light body healthy adult and had been taking blood pressure medication or other blood vessel-related medication 6 months before the experiment or planned to take it during the experiment 15 persons were selected and finalized. I have explained the details of the experiment contents including the precautions and the experimental method in detail and have received the consent to participate in the experiment. The experiment was performed for 2 months from June 9, 2014 to August 8, 2014, with the relatively light side of the eyebrows of the subjects and the dark side as the control group.

(2) Experimental material

Cheongyang red pepper used in this experiment is fresh Cheongyang red pepper sold in E-Mart (Domestic). Reagent grade capsaicin is available from Sigma-Aldrich.

(3) Preparation of Cheongyang pepper extract and measurement of average capsaicin concentration

After removing the nectar from the cheongyang red pepper purchased on the day of testing, we weighed 30 g including flesh and seeds and cut into 2 cm pieces and then extracted with 150 mL of 95% ethanol (alcohol) for 24 hours at room temperature to produce Cheongyang pepper extract. The capsaicin concentration of the extract was measured by HPLC and the mobile phase composition was modified. YL 9100 HPLC system (Young Lin Instrument, Korea) column was Capcell PakC18 MG 100 250x4.6 mm, Ea, 5 Phenomenex, USA) and measured at UV 280 nm wavelength. The mobile phase was acetonitrile: water (6: 4, v / v) at a flow rate of 0.8 mL / min and 20 samples were injected. Capsaicin standard solution was prepared by diluting capsaicin 95% (Sigma-Aldrich, USA) with ethanol to 10, 20, 50, and 100 ppm. Capsaicin standard solution and Cheongyang pepper extract were filtered with 0.45 membrane filter, Analysis conditions. HPLC grade (Sigma-Aldrich, USA) was used for the acetonitrile and water used in the experiment.

(4) How to store capsaicin solution

The samples were stored in a 95% alcoholic solution, refrigerated, adjusted to a capsaicin concentration of 7-8 ppm in a diluted alcohol solution with an ethanol concentration of 20%, and then applied in a refrigerator.

(5) Capsaicin solution dilution and application method

The subjects were asked to apply a 20% ethanol solution containing 8 to 9 ppm of capsaicin to the cotton swabs after washing. The eyebrows were covered with a light brow and then applied twice on a light brow. The sensitivity of the capsaicin extract After 1 to 2 minutes of burning sensation, a preliminary experiment was carried out. In case of burning sensation, it was applied every morning and evening, once every 5 minutes for 5 minutes, and every 2 days for 5 to 10 minutes.

The data collected in this study were expressed as means ± standard error (mean ± SE) using SPSS for Window Version 18.0 program and the changes before and after the experiment were confirmed by the significance test using the corresponding sample t-test. Changes in the number of pixels of the eyebrows were measured using photoshop CS2 program and confirmed by significance test using the Wilcoxon signed rank test among nonparametric methods.

(6) eyebrow measurement

In this experiment, the degree of darkness, length, thickness, number and degree of eyebrows were measured once and before each experiment, and the degree and length of eyebrows were measured using a program after photographing, And eyebrow density was measured by an experiment using methylene blue.

&Lt; Example 1 > Hair growth confirmation

People with eyebrows were selected as subjects. In order to confirm eyebrow hair growth effect by capsaicin application, the control eyebrows were selected to be relatively thicker than the eyebrows, and the lightly browned side was selected as the experimental group. As shown in Table 1, the experimental group and the control group showed statistically significant difference only in the length, and the eyebrows were significantly longer in the control group than the control group. There was no significant difference in eyebrow density, which was indirectly observed by eyebrow thickness, number, and absorbance, but the control group was in a better condition.

Confirm eyebrow homogeneity before and after experiment division Cont. (N = 15) Exp. (N = 15) p Mean ± SE Mean ± SE Thickness (mm) 0.0597 ± 0.0018 0.0579 ± 0.0017 0.254 Length (mm) 0.56 + 0.02 0.53 + 0.02 0.028 Eyebrow count 12.58 + - 0.43 12.38 + - 0.39 0.673 Density (OD _{660 nm} ) 0.051 ± 0.006 0.069 0.013 0.276

&Lt; Example 2 > Eyebrow length

According to the result of the preliminary experiment, the number of application of capsaicin solution to each eye in the eyebrow application test for 2 months was made to follow the experimental method. For eyebrow length before and after the experiment, photographs taken at the studio for measuring eyebrow length were measured using the ruler function of Photoshop (Fig. 1). The results are shown in Table 2. The eyebrow length before the experiment was 0.56 ± 0.02 mm in the control group and 0.53 ± 0.02 mm in the experimental group, which was significantly shorter in the experimental group. After the experiment, the control group did not show a significant increase of 0.54 ± 0.02 mm (5.4%), but the experimental group showed a significant increase of 0.67 ± 0.02 mm (26.4%). There was no significant difference in the control group before and after the experiment, suggesting that capsaicin application to the eyebrows of the experimental group almost did not affect the eyebrows of the control group.

Comparison of eyebrow length before and after experiment (Unit: mm) division Before After p Mean ± SE Mean ± SE Control 0.56 + 0.02 0.59 + 0.02 0.057 Experimental Section 0.53 + 0.02 0.67 ± 0.02 0.000 p 0.028 0.000

&Lt; Experimental Example 3 > Eyebrow thickness

The thickness and the number of eyebrows were measured using a pen at the center of the pupil's central vertical area and the center of the eyebrow thickness at the meeting of the reference horizontal line, and then the area was measured using a contact type hair diagnosis machine (Multi-cam 1000, The lens was photographed with an area of 3.6 mm x 2.8 mm with a 100 magnification lens and measured using the function of the device.

After 2 months capsaicin solution was applied, eyebrow thickness was measured. The thickness of the eyebrows was measured by measuring the thickness of the eyebrows as shown in Figure 3-5 using the function of the hairdresser on a 3.6 mm x 2.8 mm photograph taken with a hair diagnostic machine. The results are shown in Table 3. The eyebrow thickness before and after the experiment was not changed from 0.0597 ± 0.0018 mm to 0.0597 ± 0.0013 mm in the control group, but increased significantly from 0.0579 ± 0.0017 mm to 0.0789 ± 0.0019 mm in the experimental group by 36.3%. The mean eyebrow thicknesses of the control group and the experimental group were 59.7 μm and 57.9 μm, respectively, and the average eyebrow thickness of the experimental group was 78.9 μm.

Comparison of eyebrow thickness before and after experiment (Unit: mm) division Before After p Mean ± SE Mean ± SE Control 0.0597 ± 0.0018 0.0597 ± 0.0013 0.973 Experimental Section 0.0579 ± 0.0017 0.0789 ± 0.0019 0.000 p 0.254 0.000

&Lt; Example 4 > Counting eyebrows

The number of eyebrows was 3.6 mm x 2.8 mm photographed with a hair diagnostic machine and the number of hairs was measured based on hair roots as shown in Fig. The results are shown in Table 4. The number of eyebrows before and after the experiment showed a significant increase of 13.7% from 12.58 ± 0.43 to 14.30 ± 0.49 in the control group, and a significant increase of 60.0% in the experimental group from 20.38 ± 0.39 to 20.60 ± 0.82. The increase in the eyebrow count after the experiment in the control group was carried out from June 9 to August 8, and as the experiment was completed in the summer, the blood circulation was improved to the hot air temperature in the control group, I thought it looked. However, the number of eyebrows in the experimental group was 46.3% higher than that of the control group. The number of hair follicles per unit area in the scalp is 1,100 / cm ^{2 in} the neonate, 515 / cm ^{2 in the} 20th to 30th neonates, and 400-500 / cm ² in the 70s and older However, Therefore, eyebrows were about 120 / cm ² before experiment and about 206 / cm ² after experiment, so 23% and 40% of adult hair were 515 / cm ² , respectively.

Number of eyebrows before and after the experiment (Unit: number of eyebrow) division Before After p Mean ± SE Mean ± SE Control 12.58 + - 0.43 14.30 0.49 0.001 Experimental Section 12.38 + - 0.39 20.60 ± 0.82 0.000 p 0.673 0.000

&Lt; Example 5 > Eyebrow density measurement

After using the studio and the contact type hair styling device, eyebrows of the area indicated by using the pen were sampled with three rabbits using a razor, and eyebrow density was measured. Eyebrows were cut to 5 mm and then stained with 2% methylene blue reagent for 1 hour. The eyebrows were washed with distilled water, ethanol and glacial acetic acid 50: 49: 1 desorb solution and eluted for 10 minutes. After elution, the eluate from which eyebrows were removed was measured for absorbance at 660 nm using a UV-Vis spectrophotometer.

Comparison of eyebrow damage before and after experimental group (absorbance 660 nm) division Before After p Mean ± SE Mean ± SE Control 0.051 ± 0.006 0.043 ± 0.008 0.383 Experimental Section 0.069 0.013 0.038 ± 0.005 0.049 p 0.276 0.646

The photographs were taken in the studio using Nikon D3, lens 24-70 before and 2 months after the experiment. Photographs were analyzed using Photoshop (Adobe, photoshop CS2). The degree of eyebrows was evaluated by selecting the eyebrows using the color range function of photoshop and then selecting the color of the eyebrows as white and the other colors as black. The length of the eyebrow is determined by taking the eyebrows on the fixed ruler when the subject is photographed, selecting the eyebrows based on the middle of the eyes, then dividing the eyebrows using the tape, and then photographing the pictures using the ruler function of Photoshop The length was compared with the length. The number of eyelashes used for measuring the length was 5, and the average value was used as the length of the eyebrows. The experiment using methylene blue was conducted to indirectly determine the eyebrow density change due to capsaicin application. The measurement results are shown in Table 5 and FIG. 3. As a result of measuring the absorbance of the eluted methylene blue, the control group was decreased by 15.7% from 0.051 ± 0.006 to 0.043 ± 0.008, but there was no significant difference. The experimental group showed a significant decrease of 44.9% from 0.069 ± 0.013 to 0.038 ± 0.005. Here, the decrease in absorbance of 15.7% absorbance was not significant in the control group, but it was thought that the result of stimulation of blood circulation by the increase of temperature was the result of ending the experiment in summer, as the number of eyebrows was 13.7% However, the absorbance of the experimental group was 29.2% lower than that of the control group.

&Lt; Example 6 > Changes in eyebrow darkness

The changes in the eyebrows of the eyebrows before and after the experiment by application of capsaicin were photographed in the studio, and some of them were shown in Fig. In FIG. 5, the portion with the downward arrow is the eyebrow of the experimental group. The control group is the one without the arrow. Overall, the eyebrows of the experimental group tended to thicken, and when viewed with the naked eye, it was easy to see that the edge of the eyebrows mainly thickened. In the Photoshop CS2 program, the magic want tool can represent the amount of color in a plane. However, this program could not quantify the intensity of the entire eyebrow on the curved surface, not on the plane. In order to solve this problem, a method of quantitatively obtaining a change in the degree of eyebrow darkness by cutting out a part of the eyebrow as flat as possible was considered. The reproducibility of the eyebrows was measured by measuring the eyebrows' pixel values, which can be used to quantify the amount of all eyebrows in the eyebrows. 6, the degree of darkness of the eyebrows was measured using Photoshop CS2 program. The measurement method is as follows. First, we applied the black-and-white effect to the original photograph (Fig. 6-a) using the image-adjustments-desaturate function. After that, the experimental group was selected as the part where the change was clear, and the control group was selected as the rectangular marquee tool (5 mm in the vertical direction and 5 mm in the fixed size, 60 × 60 px). 6-c), and enlarged to 300% by using a zoom tool (FIG. 6-d). Then, when the eyebrow hair is clicked with the magic want tool (tolerance 32) and the selected range coincides with the eyebrow shape (Fig. 6-e) and the pixel values of the window- ) The pixel value is defined as the eyebrow pixel value. The values thus determined are summarized in Table 6 of the experimental group and in Table 7 of the control group. As shown in Table 6, the eyebrows of the 15 experimental groups showed 48.12% of the eyebrows darker than the pre-experiment, and they were significantly darker than those before the experiment. Meanwhile, in the control group of Table 7, 19.05% of the eyebrows were thickened with the average change rate after the experiment, showing a significant difference. After the experiment, eyebrows were darkened significantly in both groups, but the experimental group showed 29.7% more darkness than the control group. Thus, eyebrow hair growth by capsaicin application on the relatively light brow side was 26.4% increase in eyebrow length, 36.3% increase in thickness, 46.3% increase in number of eyebrows, 44.9% decrease in absorbance, And 29.7%, respectively, which showed significant difference.

Comparison of pixel values in the experimental group (Wilcoxon signed rank test) division Before experiment
(Pixel) After the experiment
(Pixel) Rate of change
(%) Change rate average (%) p experimenter 1 2101 2328 10.80






48.12






0.001 experimenter 2 1268 2215 74.68 experimenter 3 2291 2495 8.90 experimenter 4 1265 1970 55.73 experimenter 5 1296 2260 74.38 experimenter 6 682 1088 59.53 experimenter 7 975 1456 49.33 experimenter 8 642 1072 66.98 experimenter 9 1775 2236 25.97 experimenter 10 1678 1766 5.24 experimenter 11 1245 1260 1.20 experimenter 12 676 707 4.59 experimenter 13 1239 1420 14.61 experimenter 14 487 798 63.86 experimenter 15 186 569 205.91

Comparison of pixel values in the control group (Wilcoxon signed rank test) division I'm
(Pixel) after
(Pixel) Rate of change (%) Change rate average (%) p experimenter 1 2666 2799 4.99






19.05






0.001 experimenter 2 2161 2485 14.99 experimenter 3 1999 2010 0.55 experimenter 4 1469 1499 2.04 experimenter 5 2127 2547 19.75 experimenter 6 1541 1790 16.16 experimenter 7 862 1298 50.58 experimenter 8 2039 2284 12.02 experimenter 9 1769 2005 13.34 experimenter 10 1550 1571 1.35 experimenter 11 1598 1998 25.03 experimenter 12 1245 1263 1.45 experimenter 13 559 610 9.12 experimenter 14 364 433 18.96 experimenter 15 452 883 95.35

The eyebrows are always exposed to the outside because the bones on the eyes grow in a bow shape along the ridge. Therefore, it is likely to be influenced by the temperature of four seasons. These seasonal changes and eyebrows, which are accompanied by eyebrows in various factors, may also appear in adults. The application of capsaicin to eyebrows promoted circulation of blood, increased temperature, and stimulated the growth of eyebrows continuously. In addition, changes in secretion of cytokines such as IGF-1 are also expected. However, in the experiment, the eyebrows were partially shortened due to the shortening of the growth period, and unlike the hair, the eyebrows parted into the dormant period during the experiment. Most of the eyebrows have eyebrows with different concentrations of the tail part of the eyebrows. When capsaicin is applied, the eyebrows can be clearly seen at this part. This is thought to be caused by the increase of blood circulation by capsaicin. As a result, it was found that relatively lighter eyebrows were sufficiently complemented by capsaicin application.

From the above results, it was confirmed that the hot component was effective for eyebrow hair growth. In order to alleviate the suffering of the subject, it was decided to apply to the experiment such as Example 6 (change of the darkness of the eyebrow) by making a blend ratio such as cosmetics in order to alleviate the suffering of the subject.

&Lt; Application Example 1 > Manufacture of capsaicin cosmetics

Capsaicin cosmetic composition was prepared by adding 1 to 1,000 ppm of pure capsaicin to a general compounding ratio of skin, lotion, cream, pack and ointment agent as in the following application example.

&Lt; Application Example 2 > Capsaicin skin

Capsaicin skins were made by adding 5 to 10 ppm of pure capsaicin to the general compounding ratio of skins.

&Lt; Application example 2-1 >

5 ppm capsaicin, 0.05w% EDTA · 2Na, 2.2w% betaine, 1w% glycerin, 3w% butylene glycol, 3w% ethanol, 0.15w% methylparaben, 0.5w% polyoxyethylene hydrogenated castor oil, 0.3% by weight of phenoxyethanol, 0.05% by weight of sodium hyaluronate, 0.05% by weight of citric acid, 0.01% by weight of sodium citrate and the balance of purified water.

&Lt; Application example 2-2 >

10 ppm capsaicin, 0.05w% EDTA · 2Na, 0.05w% dipotassium glycyrrhizate, 1.8w% betaine, 1.2w% glycerin, 2.9w% butylene glycol, 4.5w% ethanol, 0.15w% 0.05% by weight of sodium hyaluronate, 0.05% by weight of citric acid, 0.01% by weight of sodium citrate, and the balance of purified water.

&Lt; Application Example 3 > Capsaicin lotion

Capsaicin skins were made by adding 10 to 50 ppm of pure capsaicin to the general compounding ratio of lotion.

<Application example 3-1>

Capsaicin 10 ppm, 1.2w% of L-ascorbic acid-2-phosphate magnesium salt, 1w% of water soluble collagen, 0.1w% of citric acid, 0.05w% of citric acid and 3.2wt% of 1,3- The total was set at 100.

&Lt; Application example 3-2 &

, Capecycin 50 ppm, chitoserol 2.2w%, polyglyceryl 2-oleate 1.5w%, ceramide 0.9w%, cetearate -4 1.2w%, cholesterol 1.5w%, dicetyl phosphate 0.4w%, glycerin 5.0w% 10 wt% of sunflower oil, 0.2 wt% of carboxyvinyl polymer, 0.3 wt% of xanthan gum, a small amount of preservative, a small amount of perfume, and purified water of the rest were mixed to give a total of 100.

&Lt; Application example 4 > Capsaicin cream

Capsaicin skins were prepared by adding 10 to 50 ppm of pure capsaicin to the general compounding ratio of the cream.

<Application example 4-1>

10 wt% of capsaicin, 2 wt% of polyethylene glycol monostearate, 5 wt% of monostearic acid glycerin, 4 wt% of cetyl alcohol, 5 wt% of tri-2-ethylhexanoic acid glyceryl, 4.5 wt% of sodium hyaluronate, , 4.0w% of mineral oil, an antiseptic proper amount, a pigment suitable amount, a perfume proper amount and the remaining purified water.

<Application Example 4-2>

Capsaicin 30 ppm, liquid paraffin 3.5, capric glyceride 4.5, stearic acid 1.5, cetyl alcohol 2.0, wax 1.0, vaseline 2.0, glyceryl monostearate 1.0, polysorbate 60 1.5, sorbitan sesquioleate 0.5, sodium hyaluronate (1% aqueous solution) 5.00, glycerin 5.0, butylene glycol 5.0, triethanolamine 0.2, mineral oil 4.0, antiseptic proper amount, pigment suitable amount, perfume proper amount, remaining purified water.

&Lt; Application example 4-3 > Massage Cream

, 50 wt% of capsaicin, 4 wt% of vaseline, 0.5 wt% of triethanolamine, 24 wt% of liquid paraffin, 2.2 wt% of beeswax, 0.1 wt% of tocopheryl acetate, 2.5 wt% of polysorbate 60, 2.1% w / w of tanshequaolate, an appropriate amount of preservative, a suitable amount of coloring matter, a proper amount of perfume, and a purified water of the remaining amount.

&Lt; Application Example 5 > Capsaicin pack

Capsaicin skins were made by adding 500-1000 ppm of pure capsaicin to the usual compounding ratio of the pack.

<Application Example 5-1>

Capsaicin 500 ppm, polyvinyl alcohol 15 ppm, L-ascorbic acid-2-phosphate magnesium salt 1.5w% lauroyl hydroxyproline 1w%, water soluble collagen 2.5w%, 1,3-butylene glycol 3.3w% 4.5 w% of ethanol, an appropriate amount of preservative, a suitable amount of pigment, a proper amount of perfume, and a purified water of the remainder.

<Application Example 5-2>

A mixture of 1,000 ppm of capsaicin, 3 wt% of ethanol, 0.02 wt% of EDTA-2Na, 5 wt% of propylene glycol, 4.5 wt% of glycerin, 1 wt% of carbopol, 0.1 wt% of polyoxide, antiseptic proper amount, Purified water was added and the total was 100.

&Lt; Application Example 6 > Ointment

A typical compounding ratio of ointment agent to pure capsaicin 1000ppm 28 ppm of white vaseline, 25 ppm of stearyl alcohol, 15w% of ethyl (or methyl) p-oxybenzoate, 14w of propylene glycol, 15w% of sodium lauryl sulfate, 3.5 wt% of oxybenzoate, an appropriate amount of preservative, a suitable amount of coloring matter, a proper amount of perfume, and a purified water of the remaining amount were mixed to give a total of 100 parts.

<Test Example>

The amount of darkness of the eyebrows was quantitatively measured using photoshop CS2 program in order to quantitatively measure changes in eyebrow darkness before and after the experiment, that is, the method of measuring the degree of change in darkness of eyebrows in Example 6, . The average change rate (%) was calculated and the results are shown in Table 8 below.

Skins, lotions, creams, packs and ointments

The mean change rate (%) of the pixel values of the experimental group and the control group (control) division Average change rate of pixel value (%) skin Lotion cream pack Ointment Remarks Experimental group Subject 1 65.12 51.92 61.34 40.09 39.69 Subject 2 59.23 49.46 55.93 48.26 65.12 Subject 3 45.62 60.16 48.61 45.82 63.23 Subject 4 71.01 25.89 70.11 39.23 41.54 Subject 5 19.91 38.47 10.13 20.89 20.35 Control Subject 1 34.24 25.16 30.03 15.12 20.10 Subject 2 15.25 15.90 24.21 21.56 10.56 Subject 3 5.92 5.96 15.39 10.81 28.43 Subject 4 23.54 31.5 6.27 29.15 15.85 Subject 5 39.72 16.09 30.84 18.32 25.46

From the above results, the average change rate (%) of the pixel value in the cosmetic containing capsaicin was high, so that the effect of capsaicin hair growth was confirmed.

The present invention can be used for improving eyebrows by utilizing the property of promoting hair growth of capsaicin. Therefore, relatively light brow can be supplemented by application of capsaicin, which is industrially applicable.

Claims (5)

delete delete delete 10 wt% of a cosmetic composition for eyebrow improvement, 0.05 wt% of EDTA · 2Na, 2.2 wt% of betaine, 1.0 wt% of glycerin, 3.0 wt% of butylene glycol, 3.0 wt% of ethanol, 0.15 wt% of methylparaben, 0.5% by weight of a generic castor oil, 0.3% by weight of phenoxyethanol, 0.05% by weight of sodium hyaluronate, 0.05% by weight of citric acid, 0.01% by weight of sodium citrate and the balance purified water,
The cosmetic composition for eyebrow improvement is prepared by adjusting the capsaicin concentration to 5 to 10 ppm by adjusting the pepper extract obtained by extracting red pepper with water or ethanol for 24 hours at room temperature for 24 hours. delete

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