KR101633639B1

KR101633639B1 - Nano gel emulsion having similar structure with cell membrane using self-assembled gel characteristics and osmetic composition using the same

Info

Publication number: KR101633639B1
Application number: KR1020150083310A
Authority: KR
Inventors: 정관영
Original assignee: 정관영
Priority date: 2015-06-12
Filing date: 2015-06-12
Publication date: 2016-06-27

Abstract

The present invention relates to a nanogel-type emulsion of a cell membrane-like structure using a self-assembled gel, and a cosmetic composition using the nanogel-type emulsion.
The nanogel-type emulsion of the present invention is a polyglyceryl emulsifier having a self-associating gel property, a polymer emulsifier capable of hydration coating, and a polymer emulsifier capable of imparting an electrostatic repulsion force so as to complement the stability of a multilayer nanoemulsion composed of a phospholipid, The active ingredient can be concentrated and stabilized to a size of 50 to 300 nm while having a structure similar to the cell membrane through combination with the lipid constituting the skin to form a transparent gel It is useful as a cosmetic composition for imparting a high moisturizing effect by having an unusual feeling of changing from an appearance of an appearance, a moisture gel to oil upon application, a promotion of transepidermal absorption of active ingredients, and a strong barrier to skin .

Description

TECHNICAL FIELD [0001] The present invention relates to a nano gel type emulsion having a cell membrane-like structure using a self-assembled gel, and a cosmetic composition using the nano gel type emulsion.

The present invention relates to a nano gel type emulsion having a cell membrane-like structure using a self-assembled gel and a cosmetic composition using the same. More particularly, the present invention relates to a nano- By combining a polyglyceryl type emulsifier having an associative gel property with a polymer emulsifier capable of hydration coating and an anionic emulsifier giving an electrostatic repulsive force, a stable viscosity can be formed without using an increasing agent, and a maximum viscosity of 40 wt% While stabilizing the oil-soluble and water-soluble active ingredients, promoting the transepidermal absorption of the stabilized active ingredients, forming a strong barrier to the skin, giving a high moisturizing effect, and giving a unique appearance and instant To provide a skin-healing effect No it relates to a cosmetic composition using the same emulsion and gel-type.

Cosmetics are mainly prepared in the form of an emulsion because they are required to be mixed with various substances which do not dissolve each other such as water-soluble ingredients, oil-soluble ingredients, active ingredients and the like in order to moisturize and protect skin and maintain skin health.

The emulsion-related technology has developed various emulsifying techniques to improve not only the formulation and stabilization but also the efficacy corresponding to the purpose of each product and the feeling of use felt by the user.

Therefore, in the cosmetics industry in recent years, stabilization of the active ingredient, penetration of the stabilized ingredient into the skin, as well as a unique appearance and immediate skin improvement effect are important factors for the success and failure of the product.

Accordingly, development of a variety of emulsifiers excellent in physical nano technology and skin-affinity using a high-pressure emulsifier has led to development of a product technology that can give special advantages over conventional products.

Conventional nanotechnology has been mainly developed to increase the two effects of stabilization of the active ingredient and penetration of the skin. It has been developed mainly in emulsion and liposome, and has a size of several tens to several hundreds of nm, Stability under the gravitational field conditions is excellent, skin contact area of the active ingredient is maximized, and skin penetration is promoted, so that it is widely applied to functional cosmetics.

Therefore, the nano emulsion has physico-chemical properties different from those of conventional emulsions such as stability, rheological properties, uniformity, and high interface area, thereby maximizing the absorption power to the skin. Therefore, it is important to select emulsifier rather than other process conditions in the production of nano emulsion.

Thus, L'Oreal offers an emulsifier (Korean Patent No. 345097) selected from behenyl alcohol ether, stearyl alcohol ether, behenic acid ester, or stearic acid ester as an emulsifier, while presenting a nano emulsion having a number average size of oil sphere of less than 100 nm (Korean Patent No. 369260) composed of mono-, di- and triesters of ethoxylated lauryl alcohol and citric acid and mixtures thereof, esters of phosphoric acid with C ₉ to C ₁₅ alcohols, phosphoric acid and stearyl alcohol And / or esters of isostearyl alcohol, esters of phosphoric acid and cetyl alcohol and oxyethylenated derivatives thereof, esters of phosphoric acid and tridecyl alcohol and oxyethylenated derivatives thereof, and mixtures thereof (Korean Patent No. 345098 Decaglycerol monostearate, distearate, tristearate, and pentastearate And emulsifiers selected from the group consisting of diglycerol monostearate (Korean Patent No. 358548) and sorbitan monostearate, sorbitan monopalmitate and sorbitan 20 EO tristearate No. 369258). Nano emulsions are produced through a combination of various emulsifiers.

On the other hand, in terms of biocompatibility and effective penetration of the active ingredient into the skin, using the particle wall of the nanoparticles as a component similar to the lipid constituting the intercellular lipid or the cell membrane results not only in skin safety, Phospholipids, ceramides, cholesterol and derivatives thereof have been developed and used.

However, it is practically impossible to manufacture a cosmetic having a nano-size and a viscosity, because it is difficult to obtain a desired nano-size by mixing these intercellular lipid or cell membrane analogues with a common water-in-oil or water-in-oil type emulsifier.

Generally, after particles are nano-sized with a high-pressure emulsifier, they are gradually added to a thickening agent such as Carbomer, Microcrystalline cellulose, Xanthan gum and Sodium polyacrylate Thereby producing a cosmetic having a viscosity.

However, in such a case, the particle size again becomes larger than a few micro (micro), and since the polymer holds the continuous phase of water as a strong ionic bond, the unique appearance of transparent to translucent and the feeling of phase transition felt during application, Is lowered. In addition, it is necessary to add a thickener to a manufacturing tank after treatment with a high-pressure emulsifier, and to disperse the thickening agent, so that it is not economical in the manufacturing process and it is necessary to improve the application to cosmetics in general.

In addition, the nano formulation using the high-pressure emulsifier has excellent self-stability, but when applied to cosmetics having various viscosities, it is impossible to realize advantages of nano-form due to loss of nano- Has been pointed out.

Accordingly, the present inventors have made efforts to improve the problems of the nano formulation using the high-pressure emulsifier. As a result, the present inventors have found that an emulsifier having a self-associating gel property capable of compensating the stability of a multi-layer nano emulsion composed of a phospholipid and a polymer emulsifier capable of hydration coating By using a combination of anionic emulsifiers that impart an electrostatic repulsive force to achieve stabilization, a stable viscosity can be formed without using a thickening agent, and more than 40% of oil can be almost transparently nanoized At the same time, when a high content of water-soluble active ingredient is stabilized and applied to skin care cosmetics having various viscosities, it is possible to stably form particles having a size of several tens to several hundreds of nanometers by simple agitation while stabilizing active ingredients and improving skin penetration efficiency And a protective film is formed on the skin to give a high moisturizing effect, thereby completing the present invention.

It is an object of the present invention to provide a nanogel type emulsion of a cell membrane-like structure using a self-assembled gel property and a method for producing the emulsion.

Another object of the present invention is to provide a cosmetic composition wherein the nanogel type emulsion is stabilized in a viscous water gel.

To achieve the above object, the present invention relates to an oil composition comprising (a) 1 to 10% by weight of a polyglyceryl type emulsifier, 0.1 to 4% by weight of a higher alcohol, 0.1 to 4% by weight of a fatty acid, 0.01 to 5% To 40% by weight of a lipid concentrate;

(b) 0.1 to 3% by weight of a phospholipid, 0.05 to 1% by weight of an anionic emulsifier, 0.01 to 0.5% by weight of a polymeric emulsifier, 5.0 to 15% by weight of a solvent having two or more hydroxyl groups, 0.01 to 5% An aqueous gelation part comprising; And

(c) an ethanol portion containing 1 to 10% by weight of ethanol and 0.001 to 0.005% by weight of an aroma.

In the above-mentioned nano gel type emulsion of the present invention, the polyglyceryl type emulsifier (a) constituting the lipid concentration portion (a) is composed of two or more glyceryl groups and 12 to 18 hydrocarbon chains Wherein at least two glyceryl groups are self-assembled by hydrogen bonding in a cooling process at a temperature of 50 DEG C or less after high-temperature emulsification using a high-pressure emulsifier, Properties.

The nanogel type emulsion of the present invention may contain up to 40% by weight of the oil component. The oil component (a) contains 8 to 35% by weight of at least two members selected from the group consisting of a nonpolar oil, a polar oil and a silicone oil. Specifically, (a) the oil component is squalane, hydrogenated polydecene, At least one nonpolar oil selected from the group consisting of hydrogenated polyisobutene and mineral oil; Caprylic / caprylic triglyceride, neopentylene glycol diheptanoate, dicapryl carbonate, glyceryl trioctanoate, octyldodecyl myristate, cetylhexylhexanoate, isostearylisostearate, isopropyl At least one polar oil selected from the group consisting of palmitate, isopropyl myristate and octyl palmitate; Or at least one silicone oil selected from the group consisting of dimethicone, cyclomethicone, and cetyl dimethicone. In the examples of the present invention, a nanogel type emulsion containing three kinds of oil components selected from the group consisting of nonpolar oil, polar oil and silicone oil is described.

In addition, the oil soluble active ingredient of the lipid concentrate (a) is selected from the group consisting of tocopherol and its derivatives, coenzyme Q10, vitamin C lipophilic derivatives, retinol and its derivatives, oleanolic acid, at least one selected from the group consisting of ursolic acid, diacetyl boldine, idebenone and lipophilic licorice extract.

In the nano-gel type emulsion of the present invention, the anionic emulsifier constituting the water-gelatinous portion (b) is selected from the group consisting of sodium stearoyl-L-glutamate, potassium cetyl phosphate, dipotassium cetyl phosphate, diaicetyl phosphate, And disodium cetyl phosphate are used.

The polymer emulsifier constituting the water-gelled portion (b) is preferably selected from the group consisting of Inulin lauryl carbamate, Polyquarternium-51, Polyglutamic acid, At least one selected from the group consisting of polyvinyl alcohol, polyvinyl alcohol, and polyvinyl alcohol.

The water-soluble active ingredient contained in the water-gelatinous portion (b) is adenosine, arbutin, vitamin C and its hydrophilic derivatives, various hydrophilic vitamins and derivatives thereof such as vitamin B3, vitamin B5 and vitamin H, acetylglucosamine, , At least one selected from the group consisting of fermented products obtained by fermentation of yeast and lactic acid bacteria, various plant extracts, various peptide components obtained through cell culture, or a mixture of two or more thereof use.

The nanogel-type emulsion is characterized in that the nanoparticles of 50 to 300 nm are viscous, and preferably the emulsion is dispersed at a viscosity of 2000 to 120,000 cps.

(1) a polyglyceryl emulsifier in an amount of 1 to 10 wt%, a higher alcohol in an amount of 0.1 to 4 wt%, a fatty acid in an amount of 0.1 to 4 wt%, an oil soluble active ingredient in an amount of 0.01 to 5 wt% % And 3 to 40% by weight of an oil component at 70 to 85 캜 to prepare a lipid concentrate;

(2) 0.1 to 3% by weight of a phospholipid, 0.05 to 1% by weight of an anionic emulsifier, 0.01 to 0.5% by weight of a polymeric emulsifier, 5.0 to 15% by weight of a solvent having two or more hydroxyl groups, 0.01 to 5% At 70 to 85 占 폚 to prepare an aqueous gelatinized portion;

(3) dissolving 1 to 10% by weight of ethanol and 0.001 to 0.005% by weight of an ethanol at room temperature to prepare an ethanol portion;

(4) The water-gelatinized portion of the step (2) is added to the lipid thickening part of the step (1) and stirred at 2,000 to 3,000 rpm. The ethanol part of the step (3) is then stirred at 2,000 to 3,000 rpm, To form an oil-in-water gel emulsion;

(5) The underwater type gel emulsion of step (4) is introduced into a high-pressure emulsifier at 50 to 80 ° C and treated at a pressure of 500 to 1,500 bar to form a high-density gel at the interface between the particles having a size of 50 to 300 nm step; And

(6) cooling the high-density gel to 30 to 40 占 폚 to stabilize the emulsion.

Further, the present invention provides a cosmetic composition in which the above-mentioned nanogel type emulsion is dispersed and stabilized in a viscous water gel as a base composition.

Specifically, the nano-gel type emulsion is applied from a low-viscosity skin, a mask sheet to a high-viscosity cream. Examples of the emulsion include a skin, lotion, essence, cream, eye cream, ampoule, body lotion, body cream, And can be applied to a product selected from the group consisting of

At this time, the cosmetic composition of the present invention transitions from a water gel to an oil film upon application of a skin to form a protective film on the skin to impart a high moisturizing effect.

According to the present invention, nano-gel type emulsion using the high-pressure type emulsifier of the present invention is a nanotechnology that has been popular in skin care cosmetics in recent years. It is mainly composed of a polyglyceryl type emulsifier having self- The active ingredient is concentrated and stabilized to a size of 50 to 300 nm to have a transparent gel-like appearance, a unique feeling of changing from a water-gel to oil upon application, and a transdermal absorption of the active ingredient (Transepidermal absorption of drugs) to promote the formation of a strong skin to give high moisturizing.

In addition, the nano gel type emulsion of the present invention can be used in combination with a polyglyceryl type emulsifier having the self-associating gel property, a polymer emulsifying agent capable of hydration coating and an anionic emulsifying agent giving electrostatic repulsion, Viscosity, and it is possible to nanoize almost transparently while containing up to 40% by weight of oil.

Further, since the nano-gel type emulsion of the present invention can be easily stabilized in a water gel having a nano size and various viscosities, it can be applied to a low viscosity skin, a mask sheet to a high viscosity cream, .

FIG. 1 is a schematic view showing the structure of a nanogel-type emulsion of a cell membrane-like structure using the self-assembled gel of the present invention and the formation of a viscosity according to temperature,
2 is a photograph of a nano gel emulsion prepared in Example 3 of the present invention by a frozen electron micrograph,
FIG. 3 is a graph showing the results of dispersing the nanogel emulsion (A) prepared in Example 3 of the present invention and the nanogel emulsion in water gels at 10% by weight, 20% by weight, 30% by weight, 40% by weight and 50% (B), (C), (D), (E), and (F)
4 is a particle size result measured by a particle size analyzer for (A), (B), (C), (D), (E)
Figure 5 FIG. 7 is a photograph showing the transformation of the nano gel emulsion prepared in Example 3 of the present invention when applied to skin,
6 is a result of measurement of skin moisturizing effect of the nano gel emulsion prepared in Example 3 of the present invention,
7 is a photograph (B) of the nano gel emulsion composition (A) prepared in Example 9 of the present invention and 20% by weight of the nano gel emulsion composition dispersed in 80% by weight of water gel, (D) when 20 wt% of the nanogel emulsion composition (C) and the nano gel emulsion composition are dispersed in 80 wt% of water gel,
8 is a particle size result measured by a particle size analyzer for (A), (B), (C) and (D)
9 is a cross- The results of measurement of the amount of percutaneous absorption of the active substance contained in the cosmetic composition in which the nanogel type emulsion prepared in Examples 8, 9, 10 and 11 are dispersed and stabilized in a water gel.

Hereinafter, the present invention will be described in detail.

The present invention relates to a composition comprising (a) 1 to 10% by weight of a polyglyceryl type emulsifier, 0.1 to 4% by weight of a higher alcohol, 0.1 to 4% by weight of a fatty acid, 0.01 to 5% by weight of an oil active ingredient and 3 to 40% Lipid concentrate;

(b) 0.1 to 3 wt% of a phospholipid, 0.05 to 1 wt% of an anionic emulsifier, 0.01 to 0.5 wt% of a polymer emulsifier, 5 to 15 wt% of a solvent having two or more hydroxyl groups, 0.01 to 5 wt% An aqueous gelation part comprising; And

The characteristics of the composition of each constituent of the above-mentioned Nanoprene type emulsion are described

(a) a lipid concentration unit

The polyglyceryl type emulsifier in the lipid thickening part (a) stabilizes the particles by forming a gel structure on the oil phase at the molecular phase in the form of powder, and forms a hydrogen bond in a cooling process after high temperature emulsification using a homomixer and a high pressure type emulsifier. And exhibit self-assembled properties by a plurality of glyceryl groups having strong bonding force. FIG. 1 is a schematic view showing formation of a nanogel-type emulsion of a cell membrane-like structure using the self-assembled gel of the present invention, wherein two or more glyceryl groups, which are hydrophilic groups of a polyglyceryl emulsifier, It realizes self-assembling characteristics between particles and particles by hydrogen bonding in a cooling process at 50 캜, more preferably at 50 캜 or lower after emulsification.

FIG. 2 is a photograph of the nanogel emulsion prepared in Example 3 of the present invention by a frozen electron micrograph. As a result, the surface of the nanogel emulsion can be observed stably at a size of 50 to 300 nm. From the above results, it has been found that a polyglyceryl type emulsifier having self-associating properties capable of stabilizing oils up to 40% in size of 50 to 300 nm due to the formation of an intergranular gel network by self- Depending on the characteristics, a stable viscosity can be formed without using an aging agent commonly used in the industry, and a feeling of feeling of phase transition from water gel to oil upon application to the skin can be provided.

The polyglyceryl-type emulsifier is an emulsifier that combines two or more glyceryl groups with one or more fatty acids. The hydrophilic group is usually referred to as polyglyceryl, and glyceryl groups are 2 to 10, It is preferable to use at least one kind of emulsifier selected from the group of substances having a hydrocarbon chain length of 12 to 18.

The content of the polyglyceryl-type emulsifier is determined depending on the content of the oil-soluble components including the oil component constituting the lipid-enriched portion, preferably 1 to 10% by weight. If the content is less than 1% by weight, the gel can not be formed at the oil interface, and thus nano-sized particles are poor in stability. On the other hand, if the content is more than 10% by weight, the viscosity becomes too high, There is a problem that it is difficult to form nanoparticles by processing.

The higher alcohol constituting the lipid thickening part (a) strengthens the particle interface and strengthens the gel property of the polyglyceryl type emulsifier. In addition, the higher alcohols include alcohols such as stearyl alcohol, palmityl alcohol, At least one member selected from the group consisting of allyl alcohol, cetearyl alcohol and behenyl alcohol is used.

The content of the higher alcohol is preferably from 0.1 to 4% by weight, and if it is less than 0.1% by weight, the effect on the solidity of the grain boundary is too small. If the content is more than 4% by weight, Or there is a problem of generating severe turbidity. Another fatty acid, which is a component for assisting the gel property of the polyglyceryl type emulsifier, is at least one selected from the group consisting of myristic acid, palmitic acid, stearic acid and behenic acid depending on the length of the hydrocarbon chain By weight, preferably 0.1 to 4% by weight. If the content is less than the above-mentioned content, the effect on the solidification of the particle interface is too small, and if it is larger than the above-mentioned content, there is a problem that the gel structure is destroyed by forming a liquid crystal of pearl pattern itself.

Examples of useful active ingredients constituting the lipid-enriched part (a) include tocopherol and its derivatives excellent in skin-improving effects such as skin moisturizing, elasticity, anti-aging and wrinkle improvement, coenzyme Q 10, vitamin C lipophilic derivatives, retinol at least one active substance selected from the group consisting of retinol and derivatives thereof, oleanolic acid, ursolic acid, diacetyl boldine, idebenone and lipophilic licorice extract, The content is determined depending on the activity and solubility of each substance, preferably 0.01 to 5% by weight, and the above range is not particularly limited as long as it can exert the solubility and efficacy of these physiologically active ingredients And the scope of the present invention is not limited to the above range.

The emollient oil for imparting a moisturizing feeling and a soft feeling to the skin when the emulsion and the oil soluble active ingredient constituting the lipid thickening part (a) mentioned above are dissolved, To 3% by weight up to 40% by weight, so long as it does not interfere with the formation of the concentrate capsules of the size.

At this time, it is preferable to use at least one non-polar oil in the group consisting of squalane, hydrogenated polydecene, hydrogenated polyisobutene and mineral oil. As the polar oil, capric / caprylic triglyceride , Neopentylene glycol diheptanoate, dicapryl carbonate, glyceryl trioctanoate, octyldodecyl myristate, cetyl hexyl hexanoate, isostearyl isostearate, isopropyl palmitate, isopropyl myristate and isopropyl myristate Octyl palmitate, and at the same time, it is preferable to use at least one silicone oil selected from the group consisting of dimethicone, cyclomethicone, and cetyl dimethicone. Thus, in the embodiment of the present invention, the formation of the emulsion of the nano gel type containing up to 35% by weight of the three kinds of oil components has been described, but the present invention is not limited thereto.

(b)

Because the phospholipid of the water-gelated part has one hydrophilic group and two lipophilic groups at the same time, the polyglyceryl type emulsifier of the lipid thickening part has a stable high density at the interface between the oil and the water due to its unique interfacial property and multi- Helping to form a gel structure.

In addition, the phospholipid component is the main component of the cell membrane. Excellent skin safety and moisturizing effect. At this time, the phospholipid may be either saturated or unsaturated. Depending on the type of each functional group, phosphatidylcholine, phosphatidylethanolamine, phosphatidyl At least one selected from the group consisting of phosphatidylserine, phosphatidylinositol, and phosphatidylserine is preferably contained in an amount of 0.1 to 3% by weight. When the amount is smaller than the above-mentioned content, the effect of helping to form a high-density gel structure is insignificant. When the amount is used in excess of the above-mentioned content, there arises a problem in solubility and forms a liquid crystal gel itself, There is a problem of impairing the structure of the nano gel emulsion.

In addition, the anionic emulsifier constituting the water-gelated portion (b) serves to compensate for the instability due to temperature through ionic repulsion between particles after formation of the nanogel emulsion. Preferable examples of the anionic emulsifier include at least one selected from the group consisting of sodium stearoyl-L-glutamate, potassium cetyl phosphate, dipotassium cetyl phosphate, diaicetyl phosphate, sodium cetyl phosphate and disodium cetyl phosphate do. If the content of the anionic emulsifier is preferably from 0.05 to 1% by weight, if the content is less than the above-mentioned content, the effect of the particles on the stability is insufficient due to insufficient anti-ionic force. If the content is more than the above-mentioned content, The formation of the nanogel emulsion is hindered by the formation of many bubbles.

Another emulsifier and polymer emulsifier constituting the water-gel-forming part (b) prevent the Ostwald ripening phenomenon which is the kinetic instability of the nano-sized particles, and the present nano gel emulsion composition itself In addition, it is a material which disperses it in a general water gel as a base composition to prevent instability caused by dispersion in various cosmetics through a strong hydration coating, preferably Inulin lauryl carbamate, polyquaternium-51 ( Polyquaternium-51), polyglutamic acid (polyglutamic acid), phage-150 distearate and phage-30 polystearate are preferably used.

In this case, the polymer emulsifier is contained in an amount of 0.01 to 0.5% by weight. When the amount is smaller than the above-mentioned content, the effect of the particles on the stability of the nanogel emulsion with time is insignificant. there is a problem.

The solvent of the water-gelled portion (b) is an important substance that determines the viscosity and transparency in terms of miscibility with the gel structure formed at the interface of the polyglyceryl type emulsifier in the lipid thickening portion, Methylpropanediol, 1,3-butylene glycol, propylene glycol, glycerin, 1,2-hexanediol, 1,2-pentanediol, D - Panthenol, dipropylene glycol, diglycerin, or a mixture of two or more thereof. The content can be determined according to the contents of oils and emulsifiers of the lipid thickening part.

The water-soluble active ingredient of the water-gelatinous portion (b) used in the present invention may be selected from the group consisting of adenosine, arbutin, vitamin C and its hydrophilic derivatives having excellent skin improving effect, various hydrophilic vitamins such as vitamin B3, vitamin B5 and vitamin H, , A fermented product obtained by fermentation of yeast and lactic acid bacteria, various plant extracts, various peptide components obtained through cell culture, or a mixture of two or more thereof, for example, acetylglucosamine, acetylglucosamine, It is preferable to use at least one selected from the group consisting of the active ingredient and the active ingredient in accordance with the activity and the solubility of the active ingredient. The above ranges are within a range that can exert the solubility and efficacy of these active ingredients As applied examples, the present invention is not limited to the above-mentioned range.

(c) Ethanol

Ethanol improves the dispersibility when the fragrance is dissolved and blended and the particles are nanoized using a high-pressure emulsifier, thereby affecting the transparency of the final composition.

The nanogel-type emulsion of the present invention using the above-described high-pressure emulsifier has a polyglyceryl-type emulsifier having a self-associating gel property according to temperature and has a structure similar to a cell membrane through combination with lipids constituting the skin, Is concentrated and stabilized to a size of 50 to 300 nm to provide an appearance of a transparent gel phase.

FIG. 3 is a graph showing the results of dispersing the nanogel emulsion (A) prepared in Example 3 of the present invention and the nanogel emulsion in water gels at 10% by weight, 20% by weight, 30% by weight, 40% by weight and 50% 4A and 4B are actual photographs of FIGS . 3 (A), 3 (B), 3 (C), 3 (D), and 3 ) And (F). &Lt; tb >< TABLE >

The above results also show that even in the cases of (B), (C), (D), (E), and (F) dispersed in the nano gel emulsion (A) and the viscous water gel, Stability can be confirmed. From the above results, it can be confirmed that the nano-sized particles have a viscosity of 50 to 300 nm and a viscosity of 2000 to 120,000 cps.

In addition, the nanogel type emulsion of the present invention may be prepared by mixing a polyglyceryl type emulsifier having a self-associating gel property, a polymer emulsifier capable of hydration coating, and an electrostatic repulsive force To form a stable viscosity without use of a thickening agent, and to provide a specific feeling of feeling that changes from moisture gel to oil at the time of coating while nano-forming almost transparently while containing up to 40% by weight of oil do.

As a result, FIG. 5 shows the transformation of the phase when the nanogel emulsion prepared in Example 3 of the present invention was applied to the skin. When the gel was applied in the form of a water gel before application, And the moisture feeling at the initial application is gradually imparted to the skin due to the formation of the soft oil film.

FIG. 6 is a result of measuring the skin moisturizing effect of the nano gel emulsion prepared in Example 3 of the present invention. From the above results, it can be seen that the nano-gel emulsion of the present invention has a unique feeling of changing from a water-gel to oil upon application to the skin by the self-associating nano gel emulsion technique, and stabilizes the oil- Promotes transepidermal absorption of drugs and forms a strong barrier to the skin to give a high moisturizing effect, and provides a unique appearance and immediate skin improvement effect.

Further, the present invention provides a method for producing the nanogel-type emulsion. Concretely, it is preferable to use 1 to 10% by weight of a polyglyceryl type emulsifier, 0.1 to 4% by weight of a higher alcohol, 0.1 to 4% by weight of a fatty acid, 0.01 to 5% by weight of an oil soluble active ingredient and 3 to 40% &Lt; / RTI > to < RTI ID = 0.0 > 85 C < / RTI > to prepare a lipid concentrate;

(6) cooling the high-density gel to 30 to 40 占 폚 to stabilize the emulsion.

In the method of manufacturing the nano-gel type emulsion of the present invention, heating the lipid thickening portion and the water-gelatinous portion in the range of 70 to 85 ° C in the above (1) to (4) If the temperature is lower than the above temperature, there is a problem that some of the lipids do not dissolve and precipitation occurs in the process. If the temperature is higher than the above temperature, there may be a problem of discoloration and detachment.

The step of forming the nano-gel emulsion phase (5) may be carried out by using a water-in-oil type gel emulsion having a size of several to several tens of micrometers, a particle size of 50 to 300 nm, If the treatment temperature is lower than 50 占 폚, the solubilization temperature of the higher alcohol, fatty acid and polyglyceryl emulsifier including the phospholipid itself is lower than the solubilization temperature of the high-pressure emulsifier. If the temperature is higher than 80 ° C, the active ingredient itself may be destroyed by thermal energy generated in the high-pressure emulsifier itself, and the gelation property may become stronger on the continuous phase other than the particle interface, so that a desired high-density nano-gel can not be obtained.

In addition, since the processing pressure is an important factor as energy applied to make nanoparticles having a size of several to several tens of micrometers, if the processing pressure is less than 500 bar, it is difficult to form homogeneous nanogel emulsion particles at 50 to 300 nm, bar, there is a problem that not only the active ingredient is damaged due to the friction due to too strong force but also the stability is deteriorated due to the removal of stable lipid components.

The high-pressure emulsifier may be understood to be known to those skilled in the art to such an extent that a commercially available emulsifier such as Microfluidics (M-110F, USA) may be purchased and used.

Further, the present invention provides a high moisture cosmetic composition in which the above-mentioned nanogel type emulsion is used as a base composition and dispersion stabilized in a water gel having a viscosity.

7 is a photograph (B) of the nano gel emulsion composition (A) prepared in Example 9 of the present invention and 20% by weight of the nano gel emulsion composition dispersed in 80% by weight of water gel, the nano-gel emulsion composition of (C) and the nano-gel and the picture of the (D) when sikyeoteul dispersing the emulsion composition 20% by weight to 80% by weight of water gel, 8 is the FIG. 7 (a), (B) , ( C < / RTI > and (D).

From the above results, it can be seen that the nanogel emulsion composition of the present invention maintains its nanoparticle size and transparency in the form of a water gel having a viscosity, so that the formulation stability is confirmed. Therefore, Since the composition can be stabilized, it can be applied to various skin care cosmetics.

As the base composition, the nanogel type emulsion is applied from a low viscosity skin, a mask sheet to a high viscosity cream, and examples thereof include a skin, a lotion, an essence, a cream, an eye cream, an ampule, a body lotion, a body cream, Sheet, and the like. At this time, the cosmetic composition of the present invention transitions from a water gel to an oil film upon application of a skin to form a protective film on the skin to impart a high moisturizing effect.

9 shows the results of measurement of the percutaneous absorption amount of each of the active substances contained in the cosmetic composition in which the nanogel type emulsion of the present invention is dispersed and stabilized in a viscous water gel, tocopherol (Example 8), retinol (Example 9) (Example 10) and ascorbic acid-2-glucoside (Example 11) exhibited similar elution curves, and after 12 hours, an excellent elution amount of 80% or more of the initial introduced amount was obtained see.

Hereinafter, the present invention will be described in more detail with reference to Examples.

The present invention is intended to more specifically illustrate the present invention, and the scope of the present invention is not limited to these embodiments.

< Example 1 to 7> High moisture Nano gel emulsion Preparation of composition

The composition and content of the lipid concentrate shown in Table 1 below were added to separate dissolution tank and heated to 80 DEG C to dissolve. The composition and content of the water-gelated portion shown in Table 1 were added to a separate dissolution tank and heated to 80 DEG C to dissolve And the composition and content of the ethanol portion shown in the following Table 1 were added to separate dissolution baths and dissolved at room temperature to prepare each. The prepared water-gelated portion was put into a dissolution tank containing the lipid concentration portion and emulsified for 5 minutes at a rate of 2,500 rpm using a homomixer while maintaining the temperature at 80 ° C. Subsequently, the ethanol part was added again and emulsified for 5 minutes at a speed of 2,500 rpm using a homomixer (HOMO MIXER) to prepare an underwater type gel emulsion phase of several to several tens of micrometers in size. The water-in-oil type gel emulsion phase was put into a high-pressure emulsifier at 65 ° C and treated three times at a pressure of 900 bar to form a nanogel emulsion phase having a size of 50 to 300 nm and forming a high-density gel at the interface between the particles and the continuous phase. Thereafter, the nanogel emulsion phase was cooled to 35 DEG C with a paddle mixer at 25 rpm while slowly stirring to stabilize the nanogel emulsion, thereby preparing a viscous nanogel emulsion composition.

In the case of the compositions of Examples 1 to 4 prepared in Table 1, a stabilized nanogel emulsion at 50 to 300 nm was obtained through balancing of the emulsifier, the higher alcohol, the fatty acid and the water-gelled emulsifiers of the lipid concentrate according to the change of the respective oil contents .

As a result of examining the average particle size of the compositions of Examples 1 to 4 using a particle size analyzer, particle formation with a uniform particle size distribution at 65, 110, 97 and 160 nm was confirmed, and at 45 ° C for 3 months, , 0 ° C, 25 ° C, 40 ° C for 6 hours / day circulation) for 3 months, the transparency and properties were stably maintained.

In Table 1, the composition of Example 5 is a composition prepared under the same conditions as in Example 3 except that the amount of sodium stearoyl-L-glutamate as an anionic emulsifier in the water-gelation portion is increased to 0.5% by weight , An average particle size of 105 nm, a transparent property was maintained, and its stability was also excellent as in Example 3.

In Table 1, the composition of Example 6 was prepared in the same manner as in Example 3 except that the content of inulin lauryl carbamate, which is a polymer emulsifier, in the water-gelation portion was increased to 0.5% by weight, Was 82 nm, and showed no particular difference in transparency, and its stability was also excellent as in Example 3.

In Table 1, the composition of Example 7 was prepared under the same conditions as Example 3 except that the ethanol content was increased to 8.0 wt%, and the average particle size was 72 nm, similar to Examples 3 to 6 The transparency was the most excellent, and the stability was also excellent as in Example 3.

< Comparative Example 1 to 12>

The results are shown in Tables 2 and 3 , except that the contents of the lipid thickening portion, the water-gelatinized portion and the ethanol portion are different according to the composition.

Of the compositions prepared in Tables 2 and 3, when the content of the polyglyceryl-based emulsifier as the main emulsifier was as low as 0.5% by weight, the composition of Comparative Example 1 was not formed with a point spread and an opaque emulsion was obtained. .

On the other hand, in Comparative Example 2, the composition was prepared with the content of the polyglyceryl type emulsifier exceeding the preferable range, and the viscosity was too high since the high pressure type emulsifier treatment, resulting in a difficulty in the process and a milky creamy phase of high viscosity was obtained .

The composition of Comparative Example 3 was obtained when the content of the higher alcohol which firmly supports the outer wall of the nano gel emulsion was smaller than the preferable content range and the average particle size of the composition was clear to 110 nm, The results were clear from 1 month at 45 ℃ for 2 months, at cycles of -5 ℃, 0 ℃, 25 ℃ and 40 ℃ for 6 hours / day.

On the other hand, the composition of Comparative Example 4 formed a non-transparent suspension state and an extremely high viscosity emulsion when the content of the higher alcohol was larger than the preferred content range. However, the formulation stability was excellent due to the high viscosity.

In addition, the composition of Comparative Example 5 contained a fatty acid in an amount lower than the preferred range of content, which helps the stability of the nanogel emulsion with time, as in the case of the higher alcohol. The average particle size of the composition was clear at 96 nm, The results showed that the viscosity was low and the properties were cloudy from 1 month at 45 ℃ for 2 months, at cycles of -5 ℃, 0 ℃, 25 ℃ and 40 ℃ for 6 hours / day.

On the other hand, the composition of Comparative Example 6 contained an emulsion having an average non-transparent suspension phase and a very high viscosity when the content of the fatty acid exceeded the preferable range.

In addition, the composition of Comparative Example 7 contained less phospholipid than the preferred content, and did not contribute to the formation of a high-density gel structure, so that a desired viscosity could not be obtained. Even with the above-described stability over time, turbidity generation and fine separation phenomenon Lt; / RTI >

On the other hand, Comparative Example 8 was a composition using a phospholipid content of more than the preferable range, and the viscosity of the composition was increased during the manufacturing process, which made it difficult to treat the high pressure emulsifier, And the like.

Comparative Example 9 is a composition containing an anionic emulsifier, which is less than the preferable content range, which helps to compensate for instability due to temperature through ionic repulsion between particles after the formation of a nano gel emulsion. The initial transparency and viscosity are somewhat good However, the viscosity decreased with time and changed to milky white due to particle coalescence.

On the other hand, the composition of Comparative Example 10 contained more than the content of the anionic emulsifier in the range of more than the preferable content range, so that too much bubbles were generated during the primary emulsification process and the emulsification was not properly performed. After the high- The nanogel itself was not formed.

In the composition of Comparative Example 11, when the content of the polymer emulsifier was less than the preferable content range, a nanogel emulsion having initial transparency and desired viscosity was obtained. However, the problem of turbidity and viscosity decrease with increasing particle size Respectively.

On the other hand, in Comparative Example 12, the polymer emulsifier was contained in an amount exceeding the preferred range, and was formed with a good viscosity and a particle size of 3 to 5 mu m.

< Example 8-13> High moisture Nano gel emulsion Preparation of composition

In order to observe the phenomenon depending on the characteristics of the active ingredient used for imparting pharmacological effect to cosmetics, except that a substance having a representative of water-soluble and oil-soluble active ingredients was selected and added to the lipid thickening portion and the water- Was carried out in the same manner as in Example 1 to prepare a nano gel emulsion composition.

As can be seen from the results of the above Table 4, the compositions of Examples 8 to 10 were obtained by adding an oil soluble active ingredient to a lipid thickening part to provide a sufficient pharmacological effect. The composition of the oil soluble active ingredient had an intramolecular degree of unsaturation and a chain number As a result, there was a difference in viscosity. As a result, the viscosity was increased in the order of higher unsaturation and retinol with 1 chain, followed by tocopherol and ascorbyl tetraisostearate having the highest viscosity of 4 chains in the order of transparency and aging All of the stability was excellent.

In addition, the compositions of Examples 11 to 13 were obtained by adding a water-soluble active ingredient to the water-gelatinized portion to provide a sufficient pharmacological effect. The viscosity of the water-soluble active ingredient molecule varied depending on the polarity of the active ingredient molecule. In the case of acid-2-glucoside, it was microscopic translucent and had the lowest viscosity. In the case of Bifidobacterium flavum including many proteins, it was transparent and showed high viscosity in the middle. Finally, acetylhexapeptide-8, which has the least polarity, , And all of them showed the highest viscosity.

< Experimental Example 1> Observation of particle size

The particle shape and particle size of the nanogel emulsion composition prepared in Example 3 were measured by a high-resolution microscope and a freezing electron microscope.

FIG. 2 is a photograph of the nanogel emulsion prepared by the above-mentioned method. As a result, it was found that spherical particles having a very uniform shape were observed. As a result of examining the shape and size of the nanoparticles, the particle size was 50 nm to 300 nm .

FIG. 1 is a schematic view illustrating the formation of the nano-gel emulsion. As shown in FIG. 1, a plurality of glyceryl groups having a strong hydrogen bond in the cooling process after high-temperature emulsification using a homomixer and a high- Self-assembled properties and can form stable viscosities without the use of commonly used thickeners through particle-particle bonding.

3 is a graph showing the results of measurement of the viscosity of the nanogel emulsion composition (A) prepared in Example 3 of the present invention and the viscosity of the nanogel emulsion composition of 10 wt%, 20 wt%, 30 wt%, 40 wt% and 50 wt% (B), (C), (D), (E) and (F) when dispersed in water gel. FIG. 4 is a photograph of the dispersions (A) (D), (E) and (F) were measured with a particle size analyzer.

As a result, the nanogel emulsion composition (A) prepared in Example 3 was 97 nm, and the dispersed diluted (B), (C), (D), (E) , And 203 nm, 288 nm, and 314 nm, respectively.

< Experimental Example 2> When applying skin Phase transformation observation

The change of the image when the nano gel emulsion prepared in Example 3 was applied to the skin was observed.

As can be seen from the results of FIG. 5, when the nano gel emulsion prepared in Example 3 was applied to the skin, it was in the form of a water gel before application and then applied to the skin, and then transferred to oil in the high viscosity water gel, The sensation of feeling of moisture gives moisture to the skin due to the increasingly smooth oil film formation.

From the above results, it can be seen that the nano-gel emulsion of the present invention not only has a unique feeling of changing from a water-gel to an oil upon application to the skin by the self-associating nano-gel emulsion technique, but also has a transepidermal absorption of drugs And a strong protective film is formed on the skin to give a high moisturizing effect.

< Experimental Example 3> Evaluation of moisturizing effect

The moisturizing effect of the nano gel emulsion prepared in Example 3 and the emulsion prepared in Comparative Example 1 in which the nano gel emulsion was not formed properly was evaluated. At this time, a skin moisture meter (Corneometer, CK electronics, Germany) was used and the results are shown in FIG.

As a result, the nanogel emulsion prepared in Example 3 maintained a high water content of 60% or more as compared with that before use even after 12 hours of use, whereas Comparative Example 1 maintained the moisturizing effect to some extent until 2 hours, The effect was reduced. Thus, it was confirmed that the nano gel emulsion composition of the present invention itself provides a high moisturizing effect to the skin.

< Experimental Example 4>

20% by weight of each of the nano gel emulsion compositions prepared in Examples 1 to 13 and Comparative Examples 1 to 12 was dissolved in a water gel containing 0.2% by weight of carbomer, 0.12% by weight of sodium hydroxide, 79.68% by weight of purified water %), And the properties and particle sizes prepared by simple stirring are shown in Table 5 below. At this time, the particle size was observed using a particle size analyzer (NANOPHOX, Sympatec, Germany).

As shown in Table 5, the nanogel emulsion composition of the present invention was contained as a continuous phase in a viscous water gel to evaluate applicability to basic cosmetic compositions. As a result, it was found that the nanogel emulsion composition prepared in Examples 1 to 7 had a desirable The particle size and its transparency were maintained after 3 months.

On the other hand, in the case of the samples using the compositions prepared in Comparative Examples 1 to 12, since the composition itself is highly turbid and has a large particle size of several 탆, when the dispersion is dispersed in a viscous water gel, transparency is lost, The formulation itself is separated and it is difficult to be practically commercialized.

FIG. 7 is a graph showing the results obtained by dispersing 20% by weight of the nanogel emulsion composition (A) of Example 9, which contains an active ingredient soluble in water and a water-soluble active ingredient in the present composition into a nano gel of the present invention, (D) when the nanogel emulsion composition (C) prepared in Example 12 and 20% by weight of the nanogel emulsion composition were dispersed in 80% by weight of a water gel, Fig. 8 shows the result of the particle size analysis.

As a result, the nanogel emulsion composition (A) of Example 9 showed uniform distribution at 106 nm and the dispersed solution (B) at a particle size of 135 nm. The nanogel emulsion composition (C) of Example 12 was uniformly distributed at a particle size of 175 nm and the dispersed solution (D) was 247 nm. From the above results, it can be seen that the nano gel emulsion composition of the present invention Since the nanoparticle size and transparency are maintained on a water gel having a viscosity, stability of the formulation is confirmed. Therefore, it is possible to stabilize the water-soluble active ingredient while stabilizing the oil-soluble and water-soluble active ingredient, .

< Experimental Example 5> Percutaneous absorption Measure

When the nanogel emulsion compositions prepared in Examples 8, 9, 10 and 11 were applied to actual skin, the amount of percutaneous absorption of the active ingredients used was measured.

Specifically, 0.1 g of each of the nanogel emulsion compositions prepared in Examples 8, 9, 10 and 11 was applied to an enhancer cell (ERWEKA, Germany) equipped with an actual human skin (65-year-old man's back plate, Hans Biomed) ), 500 ml of a buffer solution having a pH of about 7.0 was filled with sodium chloride, and the elution amount of each lipophilic active substance was periodically measured by high performance liquid chromatography (HPLC, Japan, Shimadzu, LC-10VP). At this time, a dissolution tester (ERWEKA DT800 Dissolution Tester, Germany) was used for transdermal absorption, which indicates the skin penetration effect of each active ingredient.

As a result, as shown in FIG. 9, the elution amount curve after 12 hours of the active ingredient and the elution amount curve with time showed a slight difference depending on the kind of the active ingredient, but tocopherol (Example 8), retinol 9), ascorbyltetraisostearate (Example 10), and ascorbic acid-2-glucoside (Example 11) showed similar elution curves. From the above results, it was confirmed that the elution effect of the active ingredient with respect to the generally obtained elution amount was confirmed by confirming the elution amounts of 83%, 87%, 92% and 81% of the initial introduced amounts after 12 hours.

As described above, the present invention provides a nanogel-type emulsion which is effective in imparting a high moisturizing effect to cosmetics, stabilizing an active ingredient, promoting skin penetration, and also differentiating appearance.

The nanogel-type emulsion of the present invention is characterized in that a polyglyceryl-type emulsifier having a self-associating gel property according to temperature is mainly composed of a nanogel-type emulsion using a high-pressure emulsifier and a structure similar to a cell membrane , The active ingredient is concentrated and stabilized to a size of 50 to 300 nm to have a transparent gel-like appearance, a unique feeling of changing from a water-gel to an oil upon application, a transepidermal absorption of active ingredients, A strong barrier is formed to give high moisturization.

While the invention has been shown and described with reference to certain exemplary embodiments thereof, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention as defined by the appended claims.

Claims

(a) 1 to 10% by weight of a polyglyceryl type emulsifier having self-assembling properties between particles and particles by hydrogen bonding of two or more glyceryl groups, 0.1 to 10% by weight of a higher alcohol having an aliphatic alcohol having 6 or more carbon atoms To 4% by weight of fatty acids, 0.1 to 4% by weight of fatty acids, 0.01 to 5% by weight of an oil active ingredient and 3.0 to 40% by weight of an oil component;
(b) 0.1 to 3% by weight of a phospholipid, 0.05 to 1% by weight of an anionic emulsifier, 0.01 to 0.5% by weight of a polymeric emulsifier, 5.0 to 15% by weight of a solvent having two or more hydroxyl groups, 0.01 to 5% An aqueous gelation part comprising; And
(c) an ethanol moiety comprising 1.0 to 10% by weight of ethanol and 0.001 to 0.005% by weight of an oil-in-water type gel emulsion in a high pressure emulsifier, wherein the nanosized particles have a viscosity of 25,000 to 120,000 cps emulsion.

The polyglyceryl type emulsifier according to claim 1, wherein the polyglyceryl type emulsifier (a) is an emulsifier combined with at least one fatty acid selected from the group consisting of 2 or more glyceryl groups and 12 to 18 hydrocarbon chains Nano-gel type emulsion.

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The lubricating oil composition according to claim 1, wherein the oil component contains 8 to 35% by weight of at least two members selected from the group consisting of a nonpolar oil, a polar oil and a silicone oil,
Wherein the non-polar oil is at least one selected from the group consisting of squalane, hydrogenated polydecene, hydrogenated polyisobutene, and mineral oil,
Wherein the polar oil is selected from the group consisting of capric / caprylic triglyceride, neopentylene glycol diheptanoate, dicapryl carbonate, glyceryl trioctanoate, octyldodecyl myristate, cetyl hexyl hexanoate, isostearyl isostearate At least one member selected from the group consisting of isopropyl palmitate, isopropyl myristate, and octyl palmitate;
Wherein the silicone oil is at least one selected from the group consisting of dimethicone, cyclomethicone, and cetyl dimethicone.

The composition according to claim 1, wherein the oil soluble active ingredient of (a) is selected from the group consisting of tocopherol and its derivatives, coenzyme Q10, vitamin C lipophilic derivatives, retinol and its derivatives, oleanolic acid, wherein the emulsifying agent is at least one selected from the group consisting of ursolic acid, diacetyl boldine, idebenone and lipophilic licorice extract.

The composition of claim 1, wherein the anionic emulsifier of (b) is selected from the group consisting of sodium stearoyl-L-glutamate, potassium cetyl phosphate, dipotassium cetyl phosphate, diaicetyl phosphate, sodium cetyl phosphate and disodium cetyl phosphate And at least one selected from the group consisting of a surfactant and a surfactant.

The composition according to claim 1, wherein the polymer emulsifier (b) is at least one selected from the group consisting of Inulin lauryl carbamate, Polyquarternium-51, Polyglutamic acid, And phage-30 polystearate. The nano-gel type emulsion according to claim 1,

The pharmaceutical composition according to claim 1, wherein the water-soluble active ingredient of (b) is adenosine, arbutin, vitamin C and its hydrophilic derivatives, various hydrophilic vitamins and derivatives thereof such as vitamin B3, vitamin B5 and vitamin H, acetyl glucosamine, At least one member selected from the group consisting of Centella asiatica extract including Cassoside, fermented product obtained by fermentation of yeast and lactic acid bacteria, various plant extracts, various peptide components obtained through cell culture, or a mixture of two or more thereof By weight or more based on the total weight of the emulsion.

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(1) 0.1 to 4% by weight of a higher alcohol as an aliphatic alcohol having 6 or more carbon atoms, 0.1 to 4% by weight of fatty acids, 0.01 to 5% by weight of an oil soluble active ingredient and 3.0 to 40% by weight of an oil component, At 70 to 85 占 폚 to prepare a lipid concentrate;
(2) 0.1 to 3% by weight of a phospholipid, 0.05 to 1% by weight of an anionic emulsifier, 0.01 to 0.5% by weight of a polymeric emulsifier, 5.0 to 15% by weight of a solvent having two or more hydroxyl groups, 0.01 to 5% At 70 to 85 占 폚 to prepare an aqueous gelatinized portion;
(3) dissolving 1.0 to 10% by weight of ethanol and 0.001 to 0.005% by weight of an ethanol at room temperature to prepare an ethanol portion;
(4) The water-gelatinized portion of the step (2) is added to the lipid thickening part of the step (1) and stirred at 2,000 to 3,000 rpm. The ethanol part of the step (3) is then stirred at 2,000 to 3,000 rpm, To form an oil-in-water gel emulsion;
(5) The underwater type gel emulsion of step (4) is introduced into a high-pressure emulsifier at 50 to 80 ° C and treated at a pressure of 500 to 1,500 bar to form a high-density gel at the interface between the particles having a size of 50 to 300 nm step; And
(6) cooling the high-density gel to 30 to 40 占 폚 to stabilize the emulsion.

A cosmetic composition comprising a nanogel type emulsion according to any one of claims 1, 2 and 4 to 8 as a base composition and dispersed and stabilized in a water gel having a viscosity.

12. The cosmetic composition according to claim 11, wherein the nano gel type emulsion is applied to a product selected from the group consisting of a skin, lotion, essence, cream, eye cream, ampoule, body lotion, body cream, Composition.

12. The cosmetic composition according to claim 11, wherein the cosmetic composition is phase-transferred from a water gel to an oil film upon application of the skin to moisturize the skin.