KR100945720B1 - 2-(치환된 페닐)-2-하이드록시-에틸 카바메이트의 제조방법 - Google Patents
2-(치환된 페닐)-2-하이드록시-에틸 카바메이트의 제조방법 Download PDFInfo
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- KR100945720B1 KR100945720B1 KR1020047009272A KR20047009272A KR100945720B1 KR 100945720 B1 KR100945720 B1 KR 100945720B1 KR 1020047009272 A KR1020047009272 A KR 1020047009272A KR 20047009272 A KR20047009272 A KR 20047009272A KR 100945720 B1 KR100945720 B1 KR 100945720B1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (21)
- (a) 화학식 (II)의 에스테르를 에스테르-대-알콜 환원제로 환원시켜 화학식 (III)의 알콜을 얻고;(b) 화학식 (III)의 알콜을 화학식 (IV)의 카보닐 화합물과 반응시킨 다음; 화학식 (V)의 아민과 반응시켜 화학식 (VI)의 화합물을 얻고;(c) 보호그룹 P를 제거하여 화학식 (I)의 화합물을 수득함을 특징으로 하여 화학식 (I)의 화합물을 제조하는 방법:상기 식에서,R은 할로겐이고;R1 및 R2는 독립적으로 수소, 또는 페닐 또는 치환된 페닐로 치환되거나 비치환된 C1-4 알킬이며, 여기서 치환된 페닐은 할로겐, C1-4 알킬, C1-4 알킬옥시, 아미노, 니트로 및 시아노에서 선택된 치환체를 가지며;P는 알콜-보호 그룹이고;R3은 C1-4 알킬이며;X 및 Y는 이탈 그룹이다.
- 제 1 항에 있어서, R이 2-클로로이고, R1 및 R2가 수소인 방법.
- 제 1 항 또는 제 2 항에 있어서, 알콜 보호 그룹이 2-(2-메톡시)프로필인 방법.
- 제 1 항 또는 제 2 항에 있어서, 화학식 (IV)의 카보닐 화합물이 디이미다졸릴 카보닐, 아릴 할로포르미에이트 및 할로겐-치환된 아릴 할로포르미에이트로부터 선택되는 방법.
- 제 1 항 또는 제 2 항에 있어서, R3이 메틸인 방법.
- 제 1 항 또는 제 2 항에 있어서, 에스테르-대-알콜 환원제가 금속 하이드라이드 또는 복합 금속 하이드라이드인 방법.
- 제 7 항에 있어서, R이 2-클로로인 방법.
- 제 7 항에 있어서, 에스테르화가 C1-4 알칸올의 존재하에서 수행되는 방법.
- 제 7 항에 있어서, R3가 메틸인 방법.
- 제 7 항에 있어서, 상기 제제가 2-메톡시프로펜인 방법.
- 제 7 항에 있어서, 에스테르화가 하이드록시 보호 그룹이 유도된 다음 수행되는 방법.
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01205097 | 2001-12-21 | ||
EP01205097.7 | 2001-12-21 | ||
US41808402P | 2002-10-11 | 2002-10-11 | |
US60/418,084 | 2002-10-11 | ||
PCT/EP2002/014843 WO2003053916A1 (en) | 2001-12-21 | 2002-12-19 | Process for preparing 2-(substituted phenyl) - 2 - hydroxy-ethyl carbamates |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020097016975A Division KR20090097966A (ko) | 2001-12-21 | 2002-12-19 | 2-(치환된 페닐)-2-하이드록시-에틸 카바메이트의 제조방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20040068588A KR20040068588A (ko) | 2004-07-31 |
KR100945720B1 true KR100945720B1 (ko) | 2010-03-05 |
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ID=35519523
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020107024520A KR20100134082A (ko) | 2001-12-21 | 2002-12-19 | 2-(치환된 페닐)-2-하이드록시-에틸 카바메이트의 제조방법 |
KR1020047009272A KR100945720B1 (ko) | 2001-12-21 | 2002-12-19 | 2-(치환된 페닐)-2-하이드록시-에틸 카바메이트의 제조방법 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020107024520A KR20100134082A (ko) | 2001-12-21 | 2002-12-19 | 2-(치환된 페닐)-2-하이드록시-에틸 카바메이트의 제조방법 |
Country Status (5)
Country | Link |
---|---|
KR (2) | KR20100134082A (ko) |
CN (1) | CN101343243A (ko) |
CA (1) | CA2752518A1 (ko) |
EA (1) | EA007741B1 (ko) |
ZA (1) | ZA200405782B (ko) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997026241A1 (en) * | 1996-01-16 | 1997-07-24 | Sk Corporation | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
WO2001040168A1 (fr) * | 1999-11-29 | 2001-06-07 | Mitsubishi Rayon Co., Ltd. | Derive d'acetalsulfonate, son procede de fabrication et obtention d'un derive d'oxyde styrene |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5504108A (en) * | 1990-01-12 | 1996-04-02 | The Ohio State University Research Foundation | Optically pure 4-aryl-2-hydroxytetronic acids |
JP3010497B2 (ja) * | 1990-05-31 | 2000-02-21 | チッソ株式会社 | 光学活性α―ヒドロキシエステル類の製造方法 |
-
2002
- 2002-12-19 CN CNA2008102106749A patent/CN101343243A/zh active Pending
- 2002-12-19 CA CA2752518A patent/CA2752518A1/en not_active Abandoned
- 2002-12-19 KR KR1020107024520A patent/KR20100134082A/ko not_active Application Discontinuation
- 2002-12-19 EA EA200400850A patent/EA007741B1/ru not_active IP Right Cessation
- 2002-12-19 KR KR1020047009272A patent/KR100945720B1/ko active IP Right Grant
-
2004
- 2004-07-20 ZA ZA200405782A patent/ZA200405782B/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997026241A1 (en) * | 1996-01-16 | 1997-07-24 | Sk Corporation | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
WO2001040168A1 (fr) * | 1999-11-29 | 2001-06-07 | Mitsubishi Rayon Co., Ltd. | Derive d'acetalsulfonate, son procede de fabrication et obtention d'un derive d'oxyde styrene |
Also Published As
Publication number | Publication date |
---|---|
EA007741B1 (ru) | 2006-12-29 |
KR20040068588A (ko) | 2004-07-31 |
ZA200405782B (en) | 2005-08-29 |
CA2752518A1 (en) | 2003-07-03 |
KR20100134082A (ko) | 2010-12-22 |
CN101343243A (zh) | 2009-01-14 |
EA200400850A1 (ru) | 2004-10-28 |
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