KR100913689B1 - 공액리놀레산 함유 수성 나노에멀젼 조성물 - Google Patents
공액리놀레산 함유 수성 나노에멀젼 조성물 Download PDFInfo
- Publication number
- KR100913689B1 KR100913689B1 KR1020090014347A KR20090014347A KR100913689B1 KR 100913689 B1 KR100913689 B1 KR 100913689B1 KR 1020090014347 A KR1020090014347 A KR 1020090014347A KR 20090014347 A KR20090014347 A KR 20090014347A KR 100913689 B1 KR100913689 B1 KR 100913689B1
- Authority
- KR
- South Korea
- Prior art keywords
- linoleic acid
- conjugated linoleic
- weight
- aqueous composition
- present
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 50
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 title claims abstract description 47
- JBYXPOFIGCOSSB-GOJKSUSPSA-N 9-cis,11-trans-octadecadienoic acid Chemical compound CCCCCC\C=C\C=C/CCCCCCCC(O)=O JBYXPOFIGCOSSB-GOJKSUSPSA-N 0.000 title claims abstract description 42
- 229940108924 conjugated linoleic acid Drugs 0.000 title claims abstract description 42
- 239000007908 nanoemulsion Substances 0.000 title 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 18
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 13
- 235000010445 lecithin Nutrition 0.000 claims abstract description 13
- 239000000787 lecithin Substances 0.000 claims abstract description 13
- 229940067606 lecithin Drugs 0.000 claims abstract description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 10
- 235000011187 glycerol Nutrition 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 8
- -1 glycerin ester Chemical class 0.000 claims abstract description 6
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- 235000012000 cholesterol Nutrition 0.000 claims abstract description 4
- 150000002148 esters Chemical class 0.000 claims abstract description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims abstract description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims abstract description 3
- 229940080352 sodium stearoyl lactylate Drugs 0.000 claims abstract description 3
- ODFAPIRLUPAQCQ-UHFFFAOYSA-M sodium stearoyl lactylate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(C)C(=O)OC(C)C([O-])=O ODFAPIRLUPAQCQ-UHFFFAOYSA-M 0.000 claims abstract description 3
- 239000003995 emulsifying agent Substances 0.000 claims description 14
- 238000004090 dissolution Methods 0.000 claims description 7
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims description 5
- 235000020778 linoleic acid Nutrition 0.000 claims description 5
- 229940024606 amino acid Drugs 0.000 claims description 4
- 229940071124 cocoyl glutamate Drugs 0.000 claims description 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 4
- 229920000053 polysorbate 80 Polymers 0.000 claims description 4
- 239000007957 coemulsifier Substances 0.000 claims description 3
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 2
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 claims description 2
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- 229910052749 magnesium Inorganic materials 0.000 claims description 2
- 229940091250 magnesium supplement Drugs 0.000 claims description 2
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 claims description 2
- 235000013923 monosodium glutamate Nutrition 0.000 claims description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 2
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- IWIUXJGIDSGWDN-UQKRIMTDSA-M sodium;(2s)-2-(dodecanoylamino)pentanedioate;hydron Chemical compound [Na+].CCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC(O)=O IWIUXJGIDSGWDN-UQKRIMTDSA-M 0.000 claims description 2
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- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 15
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 12
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- 150000003180 prostaglandins Chemical class 0.000 description 3
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- 241001465754 Metazoa Species 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
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- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 2
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
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- A23D7/0053—Compositions other than spreads
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
- A23D7/01—Other fatty acid esters, e.g. phosphatides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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Abstract
Description
Claims (5)
- 공액리놀레산 5 내지 50 중량%, 레시친 0.01 내지 5 중량%, 용해 보조제로 에탄올 0.01 내지 5 중량%, 보조 유화제 1 내지 15 중량%, 글리세린 10 내지 40 중량% 및 잔량의 물을 포함하는 공액리놀레산 함유 수성 조성물.
- 제1항에 있어서, 점도가 1 내지 100 cP인 것을 특징으로 하는 공액리놀레산 함유 수성 조성물.
- 삭제
- 제1항에 있어서, 보조 유화제가 폴리솔베이트 20, 폴리솔베이트 80, 음이온성 아미노산 계열 유화제, 슈가에스테르, 콜레스테롤, 소듐 라우릴 설페이트, 소듐 스테아로일 락틸레이트 및 글리세린 에스테르로 이루어지는 그룹에서 선택되는 하나 이상인 것을 특징으로 하는 공액리놀레산 함유 수성 조성물.
- 제4항에 있어서, 음이온성 아미노산 계열 유화제가 티이에이-코코일 글루타메이트, 소듐 글루타메이트, 소듐 코코일 글루타메이트, 마그네슘 코코일 글루타메이트 및 소듐 라우로일 글루타메이트로 이루어지는 그룹에서 선택되는 하나 이상인 것을 특징으로 하는 공액리놀레산 함유 수성 조성물.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
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KR1020090014347A KR100913689B1 (ko) | 2009-02-20 | 2009-02-20 | 공액리놀레산 함유 수성 나노에멀젼 조성물 |
JP2011538572A JP5259832B2 (ja) | 2009-02-20 | 2010-02-19 | 共役リノール酸含有水性ナノエマルジョン組成物 |
CN2010800038954A CN102271652B (zh) | 2009-02-20 | 2010-02-19 | 含有共轭亚油酸的纳米水乳液组合物 |
EP10743952.3A EP2398450B1 (en) | 2009-02-20 | 2010-02-19 | Aqueous nanoemulsion composition containing conjugated linoleic acid |
US13/142,626 US8686039B2 (en) | 2009-02-20 | 2010-02-19 | Aqueous nanoemulsion composition containing conjugated linoleic acid |
PCT/KR2010/001029 WO2010095877A2 (en) | 2009-02-20 | 2010-02-19 | Aqueous nanoemulsion composition containing conjugated linoleic acid |
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KR1020090014347A KR100913689B1 (ko) | 2009-02-20 | 2009-02-20 | 공액리놀레산 함유 수성 나노에멀젼 조성물 |
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US (1) | US8686039B2 (ko) |
EP (1) | EP2398450B1 (ko) |
JP (1) | JP5259832B2 (ko) |
KR (1) | KR100913689B1 (ko) |
CN (1) | CN102271652B (ko) |
WO (1) | WO2010095877A2 (ko) |
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WO2016049532A1 (en) | 2014-09-26 | 2016-03-31 | Unitract Syringe Pty Ltd | Sequential chamber drug delivery pumps for drug mixing and delivery |
CN108852890A (zh) * | 2018-08-31 | 2018-11-23 | 高昕文 | 一种温和型卸妆乳及其制备方法 |
IT201900006573A1 (it) * | 2019-05-06 | 2020-11-06 | Gricar Chemical S R L | Composizione liquida per la veicolazione di sostanze a bassa solubilità e bio-accessibilità enterica |
CN113142585A (zh) * | 2021-04-17 | 2021-07-23 | 青岛卓迪生物技术有限公司 | 一种共轭亚油酸纳米乳液及其制备方法 |
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US20060057187A1 (en) * | 2004-09-10 | 2006-03-16 | Rainer Eskuchen | Emulsions containing unsaturated fatty acids and esters thereof |
JP2007282574A (ja) * | 2006-04-17 | 2007-11-01 | T Hasegawa Co Ltd | 共役リノール酸含有乳化組成物および飲料 |
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JPS61293903A (ja) * | 1985-05-20 | 1986-12-24 | Shiseido Co Ltd | 油中水型乳化化粧料 |
JPH07222565A (ja) * | 1994-02-08 | 1995-08-22 | Kanegafuchi Chem Ind Co Ltd | 高粘性水中油型クリーム類の製造方法 |
WO1997018320A1 (en) | 1995-11-14 | 1997-05-22 | Loders Croklaan B.V. | Process for the preparation of materials with a high content of long chain polyunsaturated fatty acids |
JP2002265374A (ja) * | 2001-03-06 | 2002-09-18 | Taiyo Kagaku Co Ltd | 体脂肪減少用組成物 |
US20060051462A1 (en) * | 2004-09-03 | 2006-03-09 | Wang Jimmy X | Self emulsifying compositions for delivering lipophilic coenzyme Q10 and other dietary ingredients |
CN101028313A (zh) * | 2006-02-28 | 2007-09-05 | 北京蜂贝生物工程有限公司 | 一种具有降血脂及抗氧化功能的超临界蜂胶液配方及工艺 |
GB0623838D0 (en) * | 2006-11-29 | 2007-01-10 | Malvern Cosmeceutics Ltd | Novel compositions |
US20080199589A1 (en) * | 2007-02-20 | 2008-08-21 | Cargill, Incorporated | Lipid Microemulsions |
KR100849537B1 (ko) * | 2007-07-04 | 2008-07-31 | 유효경 | 코엔자임 큐텐의 나노에멀젼 조성물 |
DK2548456T3 (en) * | 2008-03-20 | 2015-09-28 | Virun Inc | Emulsions including (comprising) a PEG derivative of tocopherol |
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- 2010-02-19 WO PCT/KR2010/001029 patent/WO2010095877A2/en active Application Filing
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US20060057187A1 (en) * | 2004-09-10 | 2006-03-16 | Rainer Eskuchen | Emulsions containing unsaturated fatty acids and esters thereof |
JP2007282574A (ja) * | 2006-04-17 | 2007-11-01 | T Hasegawa Co Ltd | 共役リノール酸含有乳化組成物および飲料 |
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WO2010095877A2 (en) | 2010-08-26 |
EP2398450A2 (en) | 2011-12-28 |
EP2398450A4 (en) | 2012-08-08 |
EP2398450B1 (en) | 2015-04-01 |
CN102271652B (zh) | 2013-09-18 |
US8686039B2 (en) | 2014-04-01 |
JP5259832B2 (ja) | 2013-08-07 |
WO2010095877A3 (en) | 2010-11-25 |
JP2012510270A (ja) | 2012-05-10 |
CN102271652A (zh) | 2011-12-07 |
US20120053241A1 (en) | 2012-03-01 |
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