KR100860080B1 - 항염, 항알레르기 및 항천식 활성을 갖는 꼬리풀속 식물추출물을 함유하는 약학조성물 - Google Patents
항염, 항알레르기 및 항천식 활성을 갖는 꼬리풀속 식물추출물을 함유하는 약학조성물 Download PDFInfo
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- KR100860080B1 KR100860080B1 KR1020060048104A KR20060048104A KR100860080B1 KR 100860080 B1 KR100860080 B1 KR 100860080B1 KR 1020060048104 A KR1020060048104 A KR 1020060048104A KR 20060048104 A KR20060048104 A KR 20060048104A KR 100860080 B1 KR100860080 B1 KR 100860080B1
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- inflammatory
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- asthma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A23V2250/20—Natural extracts
- A23V2250/21—Plant extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
Description
펜(Penh) 값/ 메타콜린 처리량 (mg/ml) | ||||
0 | 5 | 10 | 30* | |
OVA 처리군 | 0.66± 0.23 | 1.79± 0.47 | 2.75± 0.91 | 4.59± 1.07 |
OVA+긴산꼬리풀 추출물 처리군 (저하율%) | 0.65± 0.18 (-) | 1.33± 0.53 (25.7%) | 2.46± 0.26 (10.5%) | 2.85± 0.72 (38.0%) |
총 염증세포 | 호산구 | |||
세포수 (× 104 cells/ 마우스) | 저해도 (%) | 세포수 (× 104 cells/ 마우스) | 저해도 (%) | |
(-)대조군 | 3.7± 1.5 | - | 0.5± 0.1 | - |
OVA 처리군 | 241.0± 34.3 | - | 179.5± 16.4 | - |
OVA+긴산꼬리풀 추출물 | 82.0± 31.8 | 66.0± 13.2 | 43.4± 13.6 | 75.8± 7.6 |
OVA+몬테루카스트 | 96.9± 30.3 | 59.8± 12.6 | 73.2± 7.6 | 59.2± 4.2 |
종류 | cytokine (pg/ml) | ||
IL-4 | IL-5 | L-13 | |
OVA 처리군 | 427.0±220.4 | 1,362.4±458 | 145.5±59.6 |
OVA+긴산꼬리풀 추출물 | 437.6±252.8 | 580.6±453.1 | 78.1±46.3 |
사이토카인 생산저해율 | -2.4% | 57.4% | 46.3% |
무처리군 족부종율 (%) | 긴산꼬리풀 추출물 처리군 (50 mg/kg) | 아스피린 처리군 (50 mg/kg) | |||
족부종율 (%) | 저해율 (%) | 족부종율 (%) | 저해율 (%) | ||
0 hr | 100 | - | - | - | - |
1 | 119.2± 15.6 | 139.1± 16.4 | -16.6± 13.8 | 139.3± 40.6 | -16.8± 34.0 |
2 | 158.0± 9.0 | 147.9± 9.5 | 6.4± 6.0 | 170.4± 34.5 | -7.8± 21.8 |
3 | 194.9± 12.4 | 177.6± 12.3 | 8.9± 6.3 | 180.6± 28.6 | 7.3± 14.7 |
4 | 205.9± 19.0 | 193.2± 4.3 | 6.1± 2.1 | 196.9± 15.4 | 4.3± 7.5 |
5 | 201.6± 5.1 | 206.3± 7.2 | -2.3± 3.6 | 198.5± 12.6 | 1.5± 6.3 |
Claims (5)
- 항염, 항알레르기, 항천식 활성을 갖는 긴산꼬리풀(Pseudolysimachion longifolium) 식물의 물, 메탄올, 에탄올 및 부탄올로 이루어진 군으로부터 선택된 어느 하나의 용매의 가용추출물을 유효성분으로 함유하는 염증, 알레르기 및 천식질환의 예방 또는 치료를 위한 약학조성물.
- 삭제
- 삭제
- 항염, 항알레르기, 항천식 활성을 갖는긴산꼬리풀(Pseudolysimachion longifolium) 식물의 물, 메탄올, 에탄올 및 부탄올로 이루어진 군으로부터 선택된 어느 하나의 용매의 가용추출물 및 식품학적으로 허용되는 식품 보조 첨가제를 함유하는 염증, 알레르기 및 천식질환의 예방 및 개선용 건강기능식품.
- 제 4항에 있어서, 정제, 캡슐제, 환제 또는 액제인 염증, 알레르기 및 천식질환의 예방 및 개선용 건강기능식품.
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES06768710T ES2368255T3 (es) | 2005-05-30 | 2006-05-30 | Composición farmacéutica que comprende un extracto de pseudolysimachion longifolium y los derivados de catapol aislados a partir de este, que tiene actividad antiinflamatoria, antialergica y antiasmática. |
CA2610211A CA2610211C (en) | 2005-05-30 | 2006-05-30 | Pharmaceutical composition comprising an extract of pseudolysimachion longifolium and the catalpol derivatives isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity |
EP06768710A EP1904054B1 (en) | 2005-05-30 | 2006-05-30 | Pharmaceutical composition comprising an extract of pseudolysimachion longifolium and the catalpol derivatives isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity |
JP2008514551A JP5033123B2 (ja) | 2005-05-30 | 2006-05-30 | 抗炎、抗アレルギーおよび抗喘息活性を有するPseudolysimachionlongifolium抽出物およびこれから分離されたカタルポール誘導体を含有する薬学組成物 |
AU2006253198A AU2006253198B2 (en) | 2005-05-30 | 2006-05-30 | Pharmaceutical composition comprising an extract of Pseudolysimachion longifolium and the catalpol derivatives isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity |
CN2006800232394A CN101208084B (zh) | 2005-05-30 | 2006-05-30 | 梓醇衍生物在制备用于治疗选自炎性疾病或变应性疾病的药物中的应用 |
AT06768710T ATE524175T1 (de) | 2005-05-30 | 2006-05-30 | Pharmazeutische zusammensetzung aus einem extrakt von pseudolysimachion longifolium und daraus isolierten catalpol-derivativen mit entzündungshemmender, antiallergischer und antiasthmatischer wirkung |
US11/916,216 US8168235B2 (en) | 2005-05-30 | 2006-05-30 | Pharmaceutical composition comprising an extract of Pseudolysimachion longifolium and the catalpol derivatives isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity |
PCT/KR2006/002092 WO2006129964A1 (en) | 2005-05-30 | 2006-05-30 | Pharmaceutical composition comprising an extract of pseudolysimachion longifolium and the catalpol derivatives isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity |
US13/427,334 US8974837B2 (en) | 2005-05-30 | 2012-03-22 | Pharmaceutical composition comprising an extract of Pseudolysimachion longifolium and the catalpol derivatives isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity |
US13/427,352 US8455541B2 (en) | 2005-05-30 | 2012-03-22 | Pharmaceutical composition comprising an extract of pseudolysimachion longifolium and the catalpol derivatives isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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KR20050045755 | 2005-05-30 | ||
KR1020050045755 | 2005-05-30 |
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KR20060125489A KR20060125489A (ko) | 2006-12-06 |
KR100860080B1 true KR100860080B1 (ko) | 2008-09-24 |
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KR1020060048104A KR100860080B1 (ko) | 2005-05-30 | 2006-05-29 | 항염, 항알레르기 및 항천식 활성을 갖는 꼬리풀속 식물추출물을 함유하는 약학조성물 |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014168413A1 (en) | 2013-04-10 | 2014-10-16 | Yungjin Pharmaceutical Co., Ltd. | The composition comprising a purified extract isolated from pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient or the compounds isolated therefrom, as an active ingredient for preventing or treating chronic obstructive pulmonary disease and the use thereof |
WO2016204493A1 (en) | 2015-06-17 | 2016-12-22 | Yungjin Pharmaceutical., Ltd. | A novel compound (ks 513) isolated from pseudolysimachion rotundum var. subintegrum, the composition comprising the same as an active ingredient for preventing or treating allergy disease, inflammatory disease, asthma or chronic obstructive pulmonary disease and the use thereof |
US9592263B2 (en) | 2012-12-31 | 2017-03-14 | Yungjin Pharmaceutical Co., Ltd. | Purified extract (ATC2) isolated from Pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient, the preparation thereof, and the composition comprising the same as an active ingredient for preventing or treating inflammation, allergy and asthma |
US9675658B2 (en) | 2012-12-31 | 2017-06-13 | Yungjin Pharmaceutical Co., Ltd | Method of treating inflammation, allergy and asthma with a purified extract (ATC2) isolated from Pseudolysimachion rotundam var. subintegrum containing abundant amount of active ingredient |
KR20210036451A (ko) * | 2019-09-25 | 2021-04-05 | 주식회사 코씨드바이오팜 | 긴산꼬리풀추출물을 함유하는 피부 가려움증 개선, 보습 및 피부 장벽강화용 화장료 조성물 |
KR20210105641A (ko) | 2020-02-19 | 2021-08-27 | 헬스밸런스 주식회사 | 긴산꼬리풀 추출물을 포함하는 항산화용 조성물 |
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Publication number | Priority date | Publication date | Assignee | Title |
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KR101638795B1 (ko) * | 2014-07-24 | 2016-07-12 | 영진약품공업주식회사 | 산꼬리풀 추출물로부터 분리된 신규 화합물 및 이를 유효성분으로 포함하는 알러지, 염증, 천식 또는 만성 폐쇄성 폐질환의 예방 또는 치료용 조성물 |
WO2020226204A1 (ko) | 2019-05-08 | 2020-11-12 | 주식회사 케이티앤지 | 냉초 추출물을 유효성분으로 포함하는 염증, 알레르기 및 천식의 예방 또는 치료용 조성물 및 이의 용도 |
KR102322075B1 (ko) * | 2019-12-09 | 2021-11-08 | 주식회사 메가코스 | 긴산꼬리풀 추출물을 포함하는 피부보습, 자극완화용 화장료 조성물 |
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생약학회지 34(1), pp.109-117 (2003)* |
Cited By (13)
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US9999646B2 (en) | 2012-12-31 | 2018-06-19 | Yungjin Pharmaceutical Co., Ltd | Method of treating inflammation, allergy and asthma with a purified extract (ATC1) isolated from Pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient |
EP3498287A1 (en) | 2012-12-31 | 2019-06-19 | Yungjin Pharmaceutical Co., Ltd. | A purified extract (atc2) isolated from pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient, the preparation thereof, and the composition comprising the same as an active ingredient for preventing or treating inflammation, allergy and asthma |
US9592263B2 (en) | 2012-12-31 | 2017-03-14 | Yungjin Pharmaceutical Co., Ltd. | Purified extract (ATC2) isolated from Pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient, the preparation thereof, and the composition comprising the same as an active ingredient for preventing or treating inflammation, allergy and asthma |
US10046019B2 (en) | 2012-12-31 | 2018-08-14 | Yungjin Pharmaceutical Co., Ltd | Purified extract (ATC1) isolated from Pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient, the preparation thereof, and the composition comprising the same as an active ingredient for preventing or treating inflammation, allergy and asthma |
US9675658B2 (en) | 2012-12-31 | 2017-06-13 | Yungjin Pharmaceutical Co., Ltd | Method of treating inflammation, allergy and asthma with a purified extract (ATC2) isolated from Pseudolysimachion rotundam var. subintegrum containing abundant amount of active ingredient |
US9655871B2 (en) | 2013-04-10 | 2017-05-23 | Yungjin Pharmaceutical Co., Ltd. | Composition comprising a purified extract isolated from Pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient or the compounds isolated therefrom, as an active ingredient for treating a chronic obstructive pulmonary disease and the use thereof |
WO2014168413A1 (en) | 2013-04-10 | 2014-10-16 | Yungjin Pharmaceutical Co., Ltd. | The composition comprising a purified extract isolated from pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient or the compounds isolated therefrom, as an active ingredient for preventing or treating chronic obstructive pulmonary disease and the use thereof |
US10172816B2 (en) | 2013-04-10 | 2019-01-08 | Yungjin Pharmaceutical Co., Ltd | Method of treating chronic obstructive pulmonary disease (CPD) with verproside |
EP3586859A1 (en) | 2013-04-10 | 2020-01-01 | Yungjin Pharmaceutical Co., Ltd | A composition comprising verproside for use in the treatment of chronic obstructive pulmonary disease (copd) |
WO2016204493A1 (en) | 2015-06-17 | 2016-12-22 | Yungjin Pharmaceutical., Ltd. | A novel compound (ks 513) isolated from pseudolysimachion rotundum var. subintegrum, the composition comprising the same as an active ingredient for preventing or treating allergy disease, inflammatory disease, asthma or chronic obstructive pulmonary disease and the use thereof |
KR20210036451A (ko) * | 2019-09-25 | 2021-04-05 | 주식회사 코씨드바이오팜 | 긴산꼬리풀추출물을 함유하는 피부 가려움증 개선, 보습 및 피부 장벽강화용 화장료 조성물 |
KR102273010B1 (ko) * | 2019-09-25 | 2021-07-06 | 주식회사 코씨드바이오팜 | 긴산꼬리풀추출물을 함유하는 피부 가려움증 개선, 보습 및 피부 장벽강화용 화장료 조성물 |
KR20210105641A (ko) | 2020-02-19 | 2021-08-27 | 헬스밸런스 주식회사 | 긴산꼬리풀 추출물을 포함하는 항산화용 조성물 |
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