KR100855457B1 - 악틴, 악티게닌 또는 그의 혼합물을 유효성분으로 함유하는피부미백용 화장료 조성물 - Google Patents
악틴, 악티게닌 또는 그의 혼합물을 유효성분으로 함유하는피부미백용 화장료 조성물 Download PDFInfo
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- KR100855457B1 KR100855457B1 KR1020070020603A KR20070020603A KR100855457B1 KR 100855457 B1 KR100855457 B1 KR 100855457B1 KR 1020070020603 A KR1020070020603 A KR 1020070020603A KR 20070020603 A KR20070020603 A KR 20070020603A KR 100855457 B1 KR100855457 B1 KR 100855457B1
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- actin
- skin
- arctigenin
- actinigen
- mixture
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
Description
시험 물질 | 최종 실험 농도(㎍/㎖) | 멜라닌 생성 억제율(%) |
악 틴 | 60 | 67.3 |
100 | 78.5 | |
140 | 80.3 | |
180 | 84.2 | |
악티게닌 | 60 | 66.8 |
100 | 79.6 | |
140 | 81.3 | |
180 | 84.3 | |
악틴 및 악티게닌 1:3 혼합물 | 60 | 80.2 |
100 | 85.7 | |
140 | 89.3 | |
180 | 90.2 | |
악틴 및 악티게닌 3:1 혼합물 | 60 | 66.2 |
100 | 69.3 | |
140 | 77.2 | |
180 | 80.3 |
악틴 | 악티게닌 | 악틴 및 악티게닌 3:1 혼합물 | 악틴 및 악티게닌 1:3 혼합물 | 멜라노사이트 자극호르몬 | 티로시나제 밴드 강도 | |
대조예1 | - | - | - | - | 0 | 123 |
대조예2 | - | - | - | - | 100 | 211 |
실시예1 | 100 | - | - | - | 100 | 155 |
실시예2 | - | 100 | - | - | 100 | 135 |
실시예3 | - | - | 100 | - | 100 | 145 |
실시예4 | - | - | - | 100 | 100 | 129 |
시험 물질 | 최종 실험 농도(㎍/㎖) | 세포생존율 (%) |
악 틴 | 20 | 102.1 |
60 | 101.3 | |
100 | 99.8 | |
140 | 98.7 | |
180 | 98.7 | |
악티게닌 | 20 | 101.2 |
60 | 101.0 | |
100 | 99.8 | |
140 | 97.6 | |
180 | 96.7 | |
악틴 및 악티게닌 1:3 혼합물 | 20 | 99.8 |
60 | 98.7 | |
100 | 94.8 | |
140 | 98.3 | |
180 | 96.8 | |
악틴 및 악티게닌 3:1 혼합 | 20 | 101.1 |
60 | 100.3 | |
100 | 99.8 | |
140 | 99.9 | |
180 | 97.7 |
세포 생존율 범위 | 독성판정 |
생존률 70% 이하 | 중독성 |
70% 초과 80% 이하 | 경독성 |
80% 초과 90% 이하 | 미독성 |
90% 초과 | 무독성 |
성분함량(중량%) | 대조예3 | 실시예5 | 실시예6 | 실시예7 | 비교예1 |
악틴 | - | 3.0 | - | 1.5 | - |
악티게닌 | - | - | 3.0 | 1.5 | - |
알부틴 | - | - | - | - | 3.0 |
글리세린 | 5.1 | 5.1 | 5.1 | 5.1 | 5.1 |
프로필렌글리콜 | 4.2 | 4.2 | 4.2 | 4.2 | 4.2 |
토코페릴아세테이트 | 3.0 | 3.0 | 3.0 | 3.0 | 3.0 |
유동파라핀 | 4.6 | 4.6 | 4.6 | 4.6 | 4.6 |
트리에탄올아민 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
스쿠알란 | 3.1 | 3.1 | 3.1 | 3.1 | 3.1 |
마카다미아너트오일 | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 |
폴리솔베이트60 | 1.6 | 1.6 | 1.6 | 1.6 | 1.6 |
솔비탄세스퀴롤레이트 | 1.6 | 1.6 | 1.6 | 1.6 | 1.6 |
프로필파라벤 | 0.6 | 0.6 | 0.6 | 0.6 | 0.6 |
카르복실비닐폴리머 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 |
향 | 미량 | 미량 | 미량 | 미량 | 미량 |
방부제 | 미량 | 미량 | 미량 | 미량 | 미량 |
정제수 | 잔량 | 잔량 | 잔량 | 잔량 | 잔량 |
계 | 100 | 100 | 100 | 100 | 100 |
유효 | 약간 유효 | 무효 | 유효율(%) | |
대조예 3 | 3 | 7 | 10 | 15.0 |
실시예 5 | 15 | 3 | 2 | 90.0 |
실시예 6 | 16 | 2 | 2 | 90.0 |
실시예 7 | 18 | 1 | 1 | 95.0 |
비교예 1 | 12 | 3 | 5 | 75.0 |
기호 | 점수 | 평가기준 |
- | 0 | 무반응, 정상 피부 |
± | 0.5 | 희미한 또는 가벼운 홍반 |
+ | 1.0 | 경계가 뚜렷하나 약한 홍반, 부종 및 구진 |
++ | 2.0 | 뚜렷한 홍반, 구진 및 소수포 |
+++ | 3.0 | 심한 홍반 및 소포형성 |
++++ | 6.0 | 대수포 형성 |
시험 물질 | 24 시간 | 48 시간 | 평균 피부 반응도 (n=20) |
± + ++ | ± + ++ | ||
대조예 3 | 1 - - | 1 - - | 0.42 |
실시예 5 | 1 - - | 1 - - | 0.42 |
실시예 6 | 1 - - | 1 - - | 0.42 |
실시예 7 | 1 - - | 1 - - | 0.42 |
비교예 1 | 1 - - | 1 - - | 0.42 |
점수 | 평가 기준 |
0 | 변화 없음 |
1 | 극히 조금 변함 |
2 | 조금 변함 |
3 | 조금 심하게 변함 |
4 | 심하게 변함 |
5 | 극히 심하게 변함 |
45℃ | 4℃ | |
대조예 3 | 0 | 0 |
실시예 5 | 0 | 0 |
실시예 6 | 0 | 0 |
실시예 7 | 0 | 0 |
비교예 1 | 1 | 0 |
성분(중량%) | 제형예 1 | 제형예 2 | 제형예 3 |
악틴 | 1.0 | - | 2.0 |
악티게닌 | - | 1.0 | 2.0 |
1,3-부틸렌글리콜 | 5.2 | 5.2 | 5.2 |
올레일알코올 | 1.5 | 1.5 | 1.5 |
에탄올 | 3.2 | 3.2 | 3.2 |
폴리솔베이트 20 | 3.2 | 3.2 | 3.2 |
벤조페논-9 | 2.0 | 2.0 | 2.0 |
카르복실비닐폴리머 | 1.0 | 1.0 | 1.0 |
글리세린 | 3.5 | 3.5 | 3.5 |
향 | 미량 | 미량 | 미량 |
방부제 | 미량 | 미량 | 미량 |
정제수 | 잔량 | 잔량 | 잔량 |
계 | 100 | 100 | 100 |
성분(중량%) | 제형예 4 | 제형예 5 | 제형예 6 |
악틴 | 2.5 | - | 1 |
악티게닌 | - | 1.5 | 7 |
글리세린 | 5.1 | 5.1 | 5.1 |
프로필렌글리콜 | 4.2 | 4.2 | 4.2 |
토코페릴아세테이트 | 3.0 | 3.0 | 3.0 |
유동파라핀 | 4.6 | 4.6 | 4.6 |
트리에탄올아민 | 1.0 | 1.0 | 1.0 |
스쿠알란 | 3.1 | 3.1 | 3.1 |
마카다미아너트오일 | 2.5 | 2.5 | 2.5 |
폴리솔베이트60 | 1.6 | 1.6 | 1.6 |
솔비탄세스퀴롤레이트 | 1.6 | 1.6 | 1.6 |
프로필파라벤 | 0.6 | 0.6 | 0.6 |
카르복실비닐폴리머 | 1.5 | 1.5 | 1.5 |
향 | 미량 | 미량 | 미량 |
방부제 | 미량 | 미량 | 미량 |
정제수 | 잔량 | 잔량 | 잔량 |
계 | 100 | 100 | 100 |
성분(중량%) | 제형예 7 | 제형예 8 | 제형예 9 |
악틴 | 1 | - | 7 |
악티게닌 | - | 7 | 1 |
글리세린 | 4.0 | 4.0 | 4.0 |
바셀린 | 3.5 | 3.5 | 3.5 |
트리에탄올아민 | 2.1 | 2.1 | 2.1 |
유동파라핀 | 5.3 | 5.3 | 5.3 |
스쿠알란 | 3.0 | 3.0 | 3.0 |
밀납 | 2.6 | 2.6 | 2.6 |
토코페릴아세테이트 | 5.4 | 5.4 | 5.4 |
폴리솔베이트 60 | 3.2 | 3.2 | 3.2 |
카르복실비닐폴리머 | 1.0 | 1.0 | 1.0 |
솔비탄세스퀴올레이트 | 3.1 | 3.1 | 3.1 |
향 | 미량 | 미량 | 미량 |
방부제 | 미량 | 미량 | 미량 |
정제수 | 잔량 | 잔량 | 잔량 |
계 | 100 | 100 | 100 |
성분(중량%) | 제형예 1 | 제형예 11 | 제형예 12 |
악틴 | 3 | - | 3 |
악티게닌 | - | 5 | 5 |
글리세린 | 4.0 | 4.0 | 4.0 |
바셀린 | 3.5 | 3.5 | 3.5 |
트리에탄올아민 | 0.5 | 0.5 | 0.5 |
유동파라핀 | 24.0 | 24.0 | 24.0 |
스쿠알란 | 3.0 | 3.0 | 3.0 |
밀납 | 2.1 | 2.1 | 2.1 |
토코페릴아세테이트 | 0.1 | 0.1 | 0.1 |
폴리솔베이트 60 | 2.4 | 2.4 | 2.4 |
카르복실비닐폴리머 | 1.0 | 1.0 | 1.0 |
솔비탄세스퀴올레이트 | 2.3 | 2.3 | 2.3 |
향 | 미량 | 미량 | 미량 |
방부제 | 미량 | 미량 | 미량 |
정제수 | 잔량 | 잔량 | 잔량 |
계 | 100 | 100 | 100 |
성 분(중량%) | 제형예 13 | 제형예 14 | 제형예 15 |
악틴 | 2 | - | 3 |
악티게닌 | - | 5 | 3 |
에틸알코올 | 3.0 | 3.0 | 3.0 |
EDTA-2Na | 0.02 | 0.02 | 0.02 |
프로필렌 글리콜 | 5.1 | 5.1 | 5.1 |
글리셀린 | 4.5 | 4.5 | 4.5 |
카보폴 | 1.0 | 1.0 | 1.0 |
폴리옥사이드 | 0.1 | 0.1 | 0.1 |
방부제 | 미량 | 미량 | 미량 |
향 | 미량 | 미량 | 미량 |
정제수 | 잔량 | 잔량 | 잔량 |
계 | 100 | 100 | 100 |
Claims (5)
- 악틴(Arctiin), 악티게닌(Arctigenin) 또는 그의 혼합물을 유효성분으로 함유하는 피부미백용 화장료 조성물.
- 제 1항에 있어서, 상기 악틴(Arctiin), 악티게닌(Arctigenin)또는 그의 혼합물은 화장료의 총 중량에 대하여 0.00001 내지 40.0 중량%를 함유하는 피부미백용 화장료 조성물.
- 제 1 항에 있어서, 상기 악틴 및 악티게닌의 혼합물은 악틴 및 악티게닌이 100:1 내지 1:100의 중량비로 혼합되어 있는 것을 특징으로 하는 피부미백용 화장료 조성물.
- 제 1 항에 있어서, 상기 화장료 조성물은 용액, 현탁액, 유탁액, 페이스트, 겔, 크림, 로션, 파우더, 비누, 계면활성제-함유 클렌징, 오일, 분말 파운데이션, 유탁액 파운데이션, 왁스 파운데이션 및 스프레이로 구성된 군으로부터 선택되는 제형을 갖는 것을 특징으로 하는 피부미백용 화장료 조성물.
- 제 1 항의 화장료 조성물을 인간의 피부에 도포하는 것을 특징으로 하는 화장방법.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020070020603A KR100855457B1 (ko) | 2007-02-28 | 2007-02-28 | 악틴, 악티게닌 또는 그의 혼합물을 유효성분으로 함유하는피부미백용 화장료 조성물 |
EP08723115.5A EP2114362B1 (en) | 2007-02-28 | 2008-02-25 | Cosmetic composition for skin whitening comprising a mixture of arctiin and arctigenin |
CN2008800021710A CN101578092B (zh) | 2007-02-28 | 2008-02-25 | 用于皮肤增白的含有牛蒡子甙、牛蒡子甙元或其混合物作为活性成分的化妆品组合物 |
JP2009551949A JP5675112B2 (ja) | 2007-02-28 | 2008-02-25 | アルクチン、アルクチゲニン又はその混合物を有効成分として含有する皮膚美白用化粧料組成物 |
PCT/KR2008/001077 WO2008105605A1 (en) | 2007-02-28 | 2008-02-25 | Cosmetic composition for skin whitening comprising arctiin, arctigenin or the mixture thereof as active ingredient |
US12/449,727 US20100104524A1 (en) | 2007-02-28 | 2008-02-25 | Cosmetic composition for skin whitening comprising arctiin, arctigenin or the mixture thereof as active |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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KR1020070020603A KR100855457B1 (ko) | 2007-02-28 | 2007-02-28 | 악틴, 악티게닌 또는 그의 혼합물을 유효성분으로 함유하는피부미백용 화장료 조성물 |
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KR100855457B1 true KR100855457B1 (ko) | 2008-09-01 |
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KR1020070020603A KR100855457B1 (ko) | 2007-02-28 | 2007-02-28 | 악틴, 악티게닌 또는 그의 혼합물을 유효성분으로 함유하는피부미백용 화장료 조성물 |
Country Status (6)
Country | Link |
---|---|
US (1) | US20100104524A1 (ko) |
EP (1) | EP2114362B1 (ko) |
JP (1) | JP5675112B2 (ko) |
KR (1) | KR100855457B1 (ko) |
CN (1) | CN101578092B (ko) |
WO (1) | WO2008105605A1 (ko) |
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Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20020080660A (ko) * | 2001-04-17 | 2002-10-26 | 김종헌 | 연교 추출물을 포함하는 미백제 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2977648B2 (ja) * | 1991-07-19 | 1999-11-15 | 鐘紡株式会社 | 養毛化粧料 |
JP3862765B2 (ja) * | 1994-04-11 | 2006-12-27 | 株式会社ナリス化粧品 | メラニン生成抑制物質 |
JP2000119156A (ja) * | 1998-10-14 | 2000-04-25 | Kose Corp | 皮膚外用剤 |
CN1292284A (zh) * | 1999-07-03 | 2001-04-25 | 王淑贞 | 一种湿敷面膜及其制备方法 |
JP3658548B2 (ja) * | 2000-10-24 | 2005-06-08 | 丸善製薬株式会社 | 美白化粧料 |
KR100638056B1 (ko) * | 2000-12-15 | 2006-10-24 | 주식회사 코리아나화장품 | 연교추출물을 함유한 미백제 |
JP2003081748A (ja) * | 2001-09-12 | 2003-03-19 | Pola Chem Ind Inc | メラノサイトのデンドライトの伸長抑制剤及びそれを含有する化粧料 |
JP2003246722A (ja) * | 2002-02-25 | 2003-09-02 | Kanebo Ltd | 美白化粧料 |
DE10223486A1 (de) * | 2002-05-27 | 2003-12-11 | Beiersdorf Ag | Kosmetische und/oder dermatologische Zubereitung mit 2,3-Dibenzylbutyrolactonen |
DE10305965A1 (de) * | 2003-02-12 | 2004-08-26 | Beiersdorf Ag | Kosmetische und/oder dermatologische Zubereitung |
DE10357451A1 (de) * | 2003-12-03 | 2005-07-07 | Beiersdorf Ag | Wirkstoffkombinationen aus 2,3-Dibenzylbutyrolactonen und Licochalcon A oder einem wässrigen Extrakt aus Radix Glycyrrhizae inflatae, enthaltend Licochalcon A |
KR100599491B1 (ko) * | 2005-08-09 | 2006-07-12 | 주식회사 사이버메드 | 수술용 항법장치용 프로브 |
CN100435829C (zh) * | 2005-12-24 | 2008-11-26 | 蒋艳群 | 一种调节人体内分泌、美容祛斑的中草药组合物 |
CN100394911C (zh) * | 2006-01-25 | 2008-06-18 | 郁俊明 | 祛除色斑的中草药面膜 |
KR100825450B1 (ko) * | 2006-06-30 | 2008-04-28 | 주식회사 사임당화장품 | 연교추출물을 함유하는 피부 주름개선용 화장료 조성물 |
-
2007
- 2007-02-28 KR KR1020070020603A patent/KR100855457B1/ko active IP Right Grant
-
2008
- 2008-02-25 EP EP08723115.5A patent/EP2114362B1/en active Active
- 2008-02-25 US US12/449,727 patent/US20100104524A1/en not_active Abandoned
- 2008-02-25 CN CN2008800021710A patent/CN101578092B/zh active Active
- 2008-02-25 WO PCT/KR2008/001077 patent/WO2008105605A1/en active Application Filing
- 2008-02-25 JP JP2009551949A patent/JP5675112B2/ja active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20020080660A (ko) * | 2001-04-17 | 2002-10-26 | 김종헌 | 연교 추출물을 포함하는 미백제 |
Cited By (6)
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KR100968716B1 (ko) | 2007-03-07 | 2010-07-08 | 주식회사 코리아나화장품 | 악티게닌 또는 악티게닌 유도체를 유효성분으로 함유하는피부노화 방지용 화장료 조성물 |
KR101583777B1 (ko) | 2014-07-18 | 2016-01-08 | 경희대학교 산학협력단 | 아크틴의 신규 용도 |
KR20160011398A (ko) * | 2014-07-22 | 2016-02-01 | 주식회사 코리아나화장품 | 리포좀에 포접하여 안정화시킨 악틴 또는 악티게닌을 함유하는 화장료 조성물 |
KR101631924B1 (ko) * | 2014-07-22 | 2016-06-20 | 주식회사 코리아나화장품 | 리포좀에 포접하여 안정화시킨 악틴 또는 악티게닌을 함유하는 화장료 조성물 |
CN115487098A (zh) * | 2022-10-23 | 2022-12-20 | 周嘉奇 | 一种护肤乳液及其制备方法 |
CN115487098B (zh) * | 2022-10-23 | 2024-02-27 | 深圳市理然化妆品有限公司 | 一种护肤乳液及其制备方法 |
Also Published As
Publication number | Publication date |
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JP2010520233A (ja) | 2010-06-10 |
US20100104524A1 (en) | 2010-04-29 |
EP2114362A4 (en) | 2013-12-18 |
EP2114362A1 (en) | 2009-11-11 |
JP5675112B2 (ja) | 2015-02-25 |
CN101578092B (zh) | 2011-08-03 |
EP2114362B1 (en) | 2018-07-18 |
WO2008105605A1 (en) | 2008-09-04 |
CN101578092A (zh) | 2009-11-11 |
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