KR100794846B1 - 지용성 물질을 함유하는 비들렛의 제조 방법 - Google Patents
지용성 물질을 함유하는 비들렛의 제조 방법 Download PDFInfo
- Publication number
- KR100794846B1 KR100794846B1 KR1020000044740A KR20000044740A KR100794846B1 KR 100794846 B1 KR100794846 B1 KR 100794846B1 KR 1020000044740 A KR1020000044740 A KR 1020000044740A KR 20000044740 A KR20000044740 A KR 20000044740A KR 100794846 B1 KR100794846 B1 KR 100794846B1
- Authority
- KR
- South Korea
- Prior art keywords
- crosslinking
- gelatin
- emulsion
- fat
- enzyme
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09H—PREPARATION OF GLUE OR GELATINE
- C09H7/00—Preparation of water-insoluble gelatine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Medicinal Preparation (AREA)
- General Preparation And Processing Of Foods (AREA)
- Cosmetics (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
- Edible Oils And Fats (AREA)
- Jellies, Jams, And Syrups (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (18)
- (i) 지용성 물질, 젤라틴, 환원제 및 선택적으로 항산화제 및/또는 습윤제의 수중 유(水中油)형 유화액을 형성하는 단계; (ii) 선택적으로 가교결합 효소를 첨가하는 단계; (iii) 유화액을 건조 입자로 전환하는 단계; 및 (iv) 방사선에 노출시키거나, 또는 효소가 존재하는 경우, 항온처리에 의해서 입자내의 젤라틴과 환원제를 가교결합시키는 단계를 포함하는, 지용성 물질을 함유하는 비들렛의 제조 방법.
- 제 1 항에 있어서,지용성 물질이 비타민 A, D, E, K 및 이의 유도체로 구성된 군에서 선택된 지용성 비타민; 카로테노이드, 다중불포화 지방산, 향미료 또는 방향성 물질, 또는 이들의 혼합물인 방법.
- 제 2 항에 있어서,지용성 물질이 비타민 A 및 이의 유도체인 방법.
- 제 1 항 내지 제 3 항 중 어느 한 항에 있어서,환원제가 환원당 또는 환원당 유도체인 방법.
- 제 4 항에 있어서,환원당이 글루코스, 프럭토스, 갈락토스, 만노스, 탈로스, 전화당, 아라비노스, 리보스, 크실로스, 락토스, 말토스 및 고 프럭토스 옥수수 시럽으로 구성된 군에서 선택되는 방법.
- 제 1 항 내지 제 3 항 중 어느 한 항에 있어서,가교결합이 방사선원에 노출되어 유도되는 방법.
- 제 6 항에 있어서,가교결합이 극초단파에 의해서 유도되는 방법.
- 제 1 항 내지 제 3 항 중 어느 한 항에 있어서,가교결합이 효소에 의해서 유도되는 방법.
- 제 8 항에 있어서,효소가 트란스퍼라제인 방법.
- 제 9 항에 있어서,효소가 트란스글루타미나제인 방법.
- 제 1 항 내지 제 3 항 중 어느 한 항에 있어서,유화액이 1 내지 80중량%의 지용성 물질; 5 내지 70중량%의 젤라틴; 2 내지 20중량%의 환원제; 선택적으로 2 내지 15중량%의 항산화제; 및 선택적으로 2 내지 20중량%의 습윤제로 구성되는 방법.
- 제 1 항 내지 제 3 항 중 어느 한 항에 있어서,항산화제 및 습윤제가 존재하는 방법.
- 제 1 항 내지 제 3 항 중 어느 한 항에 있어서,유화액을 수집 분말로 분무 건조하여 건조 입자로 전환시키는 방법.
- 삭제
- 제 3 항에 있어서,지용성 물질이 비타민 A 아세테이트 또는 비타민 A 팔미테이트인 방법.
- 제 10 항에 있어서,트란스글루타미나제가 젤라틴 1g 당 0.01g 내지 0.10g의 양으로 존재하는 방법.
- 제 11 항에 있어서,유화액이 5 내지 40중량%의 지용성 물질; 20 내지 60중량%의 젤라틴; 5 내지 10중량%의 환원제; 선택적으로 5 내지 10중량%의 항산화제; 및 선택적으로 5 내지 10중량%의 습윤제로 구성되는 방법.
- 제 13 항에 있어서,유화액을 전분성 분말로 분무 건조하여 건조 입자로 전환시키는 방법.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99115458 | 1999-08-05 | ||
EP99115458.4 | 1999-08-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20010049964A KR20010049964A (ko) | 2001-06-15 |
KR100794846B1 true KR100794846B1 (ko) | 2008-01-15 |
Family
ID=8238731
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020000044740A KR100794846B1 (ko) | 1999-08-05 | 2000-08-02 | 지용성 물질을 함유하는 비들렛의 제조 방법 |
Country Status (14)
Country | Link |
---|---|
US (1) | US6444227B1 (ko) |
EP (1) | EP1074592B1 (ko) |
JP (1) | JP2001131060A (ko) |
KR (1) | KR100794846B1 (ko) |
CN (1) | CN1167414C (ko) |
AT (1) | ATE342316T1 (ko) |
AU (1) | AU773280B2 (ko) |
BR (1) | BR0003377B1 (ko) |
CA (1) | CA2314848C (ko) |
DE (1) | DE60031208T2 (ko) |
ES (1) | ES2272223T3 (ko) |
ID (1) | ID26741A (ko) |
NO (1) | NO328117B1 (ko) |
TW (1) | TWI229678B (ko) |
Cited By (1)
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---|---|---|---|---|
KR20140060341A (ko) * | 2011-09-13 | 2014-05-19 | 리켄 비타민 가부시키가이샤 | 다심형 젤라틴 마이크로캅셀의 제조 방법 |
Families Citing this family (25)
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US6936279B2 (en) * | 2002-06-18 | 2005-08-30 | Zeavision Llc | Microcrystalline zeaxanthin with high bioavailability in oily carrier formulations |
KR100616133B1 (ko) * | 2002-11-15 | 2006-08-28 | 주식회사 그린바이오텍 | 유지함유 미세캡슐 제조방법 |
WO2004084862A1 (en) * | 2003-03-27 | 2004-10-07 | Dsm Ip Assets B.V. | Process for the production of cross-linked gelatin beadlets |
AU2004228008B2 (en) * | 2003-04-03 | 2008-11-06 | Jessie L.-S. Au | Tumor-targeting drug-loaded particles |
KR101109802B1 (ko) * | 2003-07-15 | 2012-02-17 | 디에스엠 아이피 어셋츠 비.브이. | 지용성 활성 성분의 분말 제형 |
ES2549258T3 (es) * | 2004-03-18 | 2015-10-26 | Dsm Ip Assets B.V. | Composiciones de ácidos grasos poli-insaturados estables a la extrusión para productos alimenticios |
JP4525529B2 (ja) * | 2005-08-29 | 2010-08-18 | 味の素株式会社 | 加工食品の製造法 |
US8221809B2 (en) * | 2006-06-22 | 2012-07-17 | Martek Biosciences Corporation | Encapsulated labile compound compositions and methods of making the same |
JP5275561B2 (ja) * | 2006-10-30 | 2013-08-28 | 富士フイルム株式会社 | 水分散可能なナノ粒子 |
US9707185B2 (en) * | 2007-05-07 | 2017-07-18 | Board Of Supervisors Of Louisana State University And Agricultural And Mechanical College | Water-soluble nanoparticles containing water-insoluble compounds |
JP2008297241A (ja) * | 2007-05-31 | 2008-12-11 | Fujifilm Corp | ニキビ用皮膚外用剤 |
TWI437962B (zh) * | 2007-06-19 | 2014-05-21 | Dsm Ip Assets Bv | 微包封組成物、其製造方法、使用方法及其產物 |
EP2153732A1 (en) | 2008-08-04 | 2010-02-17 | DSM IP Assets B.V. | Production of Beadlets Comprising Hygroscopic Plant Extracts |
FR2953409B1 (fr) * | 2009-12-09 | 2011-12-23 | Adisseo France Sas | Particules de principes actifs liposolubles stables |
EP2804489A1 (en) | 2012-01-19 | 2014-11-26 | DSM IP Assets B.V. | Beadlets comprising hop acid salts in a protein matrix |
BR112014017831A8 (pt) | 2012-01-19 | 2017-07-11 | Dsm Ip Assets Bv | Microesferas compreendendo sais de ácidos de lúpulo em uma matriz de amido |
GB2515749B (en) * | 2013-07-01 | 2016-08-31 | Biodynamic Armor Ltd | Pressure impulse mitigation |
CN103549157B (zh) * | 2013-11-14 | 2015-09-02 | 厦门金达威集团股份有限公司 | 斥水型维生素微胶囊的制备方法 |
CN104587920B (zh) * | 2015-01-06 | 2016-08-31 | 华中科技大学 | 一种微波加热制备生物大分子包裹微球的方法 |
CN105688269B (zh) * | 2016-02-03 | 2021-04-16 | 广州迈普再生医学科技股份有限公司 | 一种改性明胶止血材料及其制备方法 |
EP3669663A1 (en) | 2018-12-17 | 2020-06-24 | DSM IP Assets B.V. | Novel beadlets |
EP3718412A1 (en) | 2019-04-04 | 2020-10-07 | DSM IP Assets B.V. | Novel beadlets |
EP3718411A1 (en) | 2019-04-04 | 2020-10-07 | DSM IP Assets B.V. | Novel beadlets |
WO2022129004A1 (en) | 2020-12-15 | 2022-06-23 | Dsm Ip Assets B.V. | Coated statin tablet comprising vitamin e acetate powder |
WO2022129003A1 (en) | 2020-12-15 | 2022-06-23 | Dsm Ip Assets B.V. | Multiparticulate solid oral dosage form comprising statin and vitamin e |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS58149645A (ja) * | 1982-03-01 | 1983-09-06 | Ajinomoto Co Inc | ゲル化物の製造法 |
EP0285682A1 (en) * | 1987-04-06 | 1988-10-12 | F. Hoffmann-La Roche Ag | Process for the manufacture of vitamin preparations |
JPS6449645A (en) * | 1987-08-20 | 1989-02-27 | Komori Printing Mach | Sheet tail holder of grooved cylinder in press |
JPH02457Y2 (ko) * | 1982-06-04 | 1990-01-08 | ||
JPH0565457A (ja) * | 1991-03-01 | 1993-03-19 | Nitta Gelatin Inc | 不溶化ゼラチンの製造方法 |
JPH065457A (ja) * | 1992-06-16 | 1994-01-14 | Murata Mfg Co Ltd | 積層電子部品 |
Family Cites Families (7)
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GB993138A (en) | 1961-11-22 | 1965-05-26 | Pfizer & Co C | Improvements in the preparation of vitamin-containing beadlets |
US4670247A (en) * | 1983-07-05 | 1987-06-02 | Hoffman-Laroche Inc. | Process for preparing fat-soluble vitamin active beadlets |
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US5126328A (en) | 1991-01-10 | 1992-06-30 | Bower David K | Process for crosslinking gelatin |
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JP4494539B2 (ja) | 1997-02-28 | 2010-06-30 | ディーエスエム アイピー アセッツ ビー.ブイ. | 流動自由な乾燥粒子 |
DE19838189A1 (de) | 1998-08-24 | 2000-03-02 | Basf Ag | Stabile pulverförmige Vitamin- und Carotinoid-Zubereitungen und Verfahren zu deren Herstellung |
-
2000
- 2000-07-27 US US09/626,976 patent/US6444227B1/en not_active Expired - Lifetime
- 2000-07-31 AT AT00116502T patent/ATE342316T1/de not_active IP Right Cessation
- 2000-07-31 ES ES00116502T patent/ES2272223T3/es not_active Expired - Lifetime
- 2000-07-31 EP EP00116502A patent/EP1074592B1/en not_active Expired - Lifetime
- 2000-07-31 DE DE60031208T patent/DE60031208T2/de not_active Expired - Lifetime
- 2000-08-01 AU AU48963/00A patent/AU773280B2/en not_active Ceased
- 2000-08-02 KR KR1020000044740A patent/KR100794846B1/ko active IP Right Grant
- 2000-08-02 TW TW089115504A patent/TWI229678B/zh not_active IP Right Cessation
- 2000-08-02 JP JP2000233863A patent/JP2001131060A/ja active Pending
- 2000-08-02 CA CA002314848A patent/CA2314848C/en not_active Expired - Fee Related
- 2000-08-02 ID IDP20000652D patent/ID26741A/id unknown
- 2000-08-04 CN CNB001225251A patent/CN1167414C/zh not_active Expired - Lifetime
- 2000-08-04 NO NO20003948A patent/NO328117B1/no not_active IP Right Cessation
- 2000-08-07 BR BRPI0003377-4A patent/BR0003377B1/pt not_active IP Right Cessation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58149645A (ja) * | 1982-03-01 | 1983-09-06 | Ajinomoto Co Inc | ゲル化物の製造法 |
JPH02457Y2 (ko) * | 1982-06-04 | 1990-01-08 | ||
EP0285682A1 (en) * | 1987-04-06 | 1988-10-12 | F. Hoffmann-La Roche Ag | Process for the manufacture of vitamin preparations |
JPS6449645A (en) * | 1987-08-20 | 1989-02-27 | Komori Printing Mach | Sheet tail holder of grooved cylinder in press |
JPH0565457A (ja) * | 1991-03-01 | 1993-03-19 | Nitta Gelatin Inc | 不溶化ゼラチンの製造方法 |
JPH065457A (ja) * | 1992-06-16 | 1994-01-14 | Murata Mfg Co Ltd | 積層電子部品 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20140060341A (ko) * | 2011-09-13 | 2014-05-19 | 리켄 비타민 가부시키가이샤 | 다심형 젤라틴 마이크로캅셀의 제조 방법 |
KR101978361B1 (ko) * | 2011-09-13 | 2019-05-14 | 리켄 비타민 가부시키가이샤 | 다심형 젤라틴 마이크로캅셀의 제조 방법 |
Also Published As
Publication number | Publication date |
---|---|
AU773280B2 (en) | 2004-05-20 |
ES2272223T3 (es) | 2007-05-01 |
US6444227B1 (en) | 2002-09-03 |
CN1167414C (zh) | 2004-09-22 |
CA2314848A1 (en) | 2001-02-05 |
BR0003377B1 (pt) | 2011-03-09 |
ATE342316T1 (de) | 2006-11-15 |
CA2314848C (en) | 2007-04-10 |
CN1283454A (zh) | 2001-02-14 |
TWI229678B (en) | 2005-03-21 |
NO20003948L (no) | 2001-02-06 |
DE60031208D1 (de) | 2006-11-23 |
BR0003377A (pt) | 2001-12-04 |
AU4896300A (en) | 2001-02-15 |
DE60031208T2 (de) | 2007-01-18 |
NO20003948D0 (no) | 2000-08-04 |
ID26741A (id) | 2001-02-08 |
EP1074592B1 (en) | 2006-10-11 |
EP1074592A1 (en) | 2001-02-07 |
KR20010049964A (ko) | 2001-06-15 |
JP2001131060A (ja) | 2001-05-15 |
NO328117B1 (no) | 2009-12-14 |
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