KR100655848B1 - 1,3-치환된 인덴의 개선된 제조 방법 - Google Patents

1,3-치환된 인덴의 개선된 제조 방법 Download PDF

Info

Publication number
KR100655848B1
KR100655848B1 KR1020057009301A KR20057009301A KR100655848B1 KR 100655848 B1 KR100655848 B1 KR 100655848B1 KR 1020057009301 A KR1020057009301 A KR 1020057009301A KR 20057009301 A KR20057009301 A KR 20057009301A KR 100655848 B1 KR100655848 B1 KR 100655848B1
Authority
KR
South Korea
Prior art keywords
formula
alkyl
compound
group
alcohol
Prior art date
Application number
KR1020057009301A
Other languages
English (en)
Korean (ko)
Other versions
KR20050087801A (ko
Inventor
로버트 유진 주니어 핸드필드
필립 제임스 존슨
피터 로버트 로즈
티모시 제임스 노먼 왓슨
Original Assignee
화이자 프로덕츠 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 화이자 프로덕츠 인크. filed Critical 화이자 프로덕츠 인크.
Publication of KR20050087801A publication Critical patent/KR20050087801A/ko
Application granted granted Critical
Publication of KR100655848B1 publication Critical patent/KR100655848B1/ko

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00Preparation of carboxylic acid nitriles
    • C07C253/30Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/45Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/47Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Circuit Arrangements For Discharge Lamps (AREA)
KR1020057009301A 2002-11-25 2003-11-12 1,3-치환된 인덴의 개선된 제조 방법 KR100655848B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42902902P 2002-11-25 2002-11-25
US60/429,029 2002-11-25
PCT/IB2003/005121 WO2004048318A1 (en) 2002-11-25 2003-11-12 Improved process for the preparation of 1,3-substituted indenes

Publications (2)

Publication Number Publication Date
KR20050087801A KR20050087801A (ko) 2005-08-31
KR100655848B1 true KR100655848B1 (ko) 2006-12-11

Family

ID=32393492

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057009301A KR100655848B1 (ko) 2002-11-25 2003-11-12 1,3-치환된 인덴의 개선된 제조 방법

Country Status (16)

Country Link
US (1) US7285686B2 (sr)
EP (1) EP1567483A1 (sr)
JP (1) JP2006507342A (sr)
KR (1) KR100655848B1 (sr)
CN (1) CN1714075A (sr)
AR (1) AR042205A1 (sr)
AU (1) AU2003278510B8 (sr)
BR (1) BR0316482A (sr)
CA (1) CA2511762A1 (sr)
MX (1) MXPA05005517A (sr)
PL (1) PL377292A1 (sr)
RS (1) RS20050393A (sr)
RU (1) RU2284319C2 (sr)
TW (1) TWI245756B (sr)
WO (1) WO2004048318A1 (sr)
ZA (1) ZA200503190B (sr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1919973A1 (en) 2005-08-11 2008-05-14 University Of Massachusetts Lowell Novel methods for forming copolymers comprising olefin and protected or unprotected hydroxystyrene units
CA2709774C (en) 2008-05-22 2012-10-02 Teva Pharmaceutical Industries Ltd. Varenicline tosylate, an intermediate in the preparation process of varenicline l-tartrate
WO2009155403A2 (en) * 2008-06-19 2009-12-23 Teva Pharmaceutical Industries Ltd. Processes for the preparation of varenicline and intermediates thereof
WO2010005643A1 (en) * 2008-07-10 2010-01-14 Teva Pharmaceutical Industries Ltd. Processes for purifying varenicline l-tartrate salt and preparing crystalline forms of varenicline l-tartrate salt
EP2438054A1 (en) 2009-06-22 2012-04-11 Teva Pharmaceutical Industries Ltd. Solid states forms of varenicline salts and processes for preparation thereof
KR20170132855A (ko) * 2015-04-08 2017-12-04 케민 인더스트리즈, 인코포레이티드 인간 피부 세포주를 향한 청색광에 대한 루테인의 보호 작용

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69839131T3 (de) 1997-12-31 2015-05-07 Pfizer Products Inc. Arylkondensierte azapolycyclische derivate
US6605610B1 (en) 1997-12-31 2003-08-12 Pfizer Inc Aryl fused azapolycyclic compounds
WO2002085843A2 (en) 2001-04-20 2002-10-31 Pfizer Products Inc. Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds
PL377065A1 (pl) 2002-11-20 2006-01-23 Pfizer Products Inc. Sposób wytwarzania kwasu indano-1,3-dikarboksylowego
RU2291862C2 (ru) 2003-01-15 2007-01-20 Пфайзер Продактс Инк. Способ получения арилконденсированных полициклических лактамов

Also Published As

Publication number Publication date
CA2511762A1 (en) 2004-06-10
JP2006507342A (ja) 2006-03-02
MXPA05005517A (es) 2005-07-25
AU2003278510A1 (en) 2004-06-18
TWI245756B (en) 2005-12-21
US7285686B2 (en) 2007-10-23
PL377292A1 (pl) 2006-01-23
ZA200503190B (en) 2006-07-26
AU2003278510B8 (en) 2008-07-10
AR042205A1 (es) 2005-06-15
US20050004379A1 (en) 2005-01-06
RS20050393A (en) 2007-12-31
BR0316482A (pt) 2005-10-11
CN1714075A (zh) 2005-12-28
KR20050087801A (ko) 2005-08-31
AU2003278510B2 (en) 2008-06-05
RU2005115881A (ru) 2006-02-27
EP1567483A1 (en) 2005-08-31
WO2004048318A8 (en) 2005-05-12
RU2284319C2 (ru) 2006-09-27
TW200413301A (en) 2004-08-01
WO2004048318A1 (en) 2004-06-10

Similar Documents

Publication Publication Date Title
JP4172717B2 (ja) 置換2,5−ジアミノ−3−ヒドロキシヘキサンの製造方法
EP2399912A2 (en) An exo-selective synthesis of himbacine analogs
KR100655848B1 (ko) 1,3-치환된 인덴의 개선된 제조 방법
ZA200503009B (en) A method for preparing indan-1,3-diaborxylic acid
ZA200505103B (en) Process for the preparation of aryl fused polycyclic lactams
EP1638971B1 (en) Preparation of substituted quinoxalines from the dianiline with 2,3-dihydroxy-1,4-dioxane
WO2023000135A1 (en) Processes of making onapristone and intermediates thereof
OA11152A (en) Process for preparing trovafloxacin acid salts

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
LAPS Lapse due to unpaid annual fee