WO2004048318A8 - Improved process for the preparation of 1,3-substituted indenes - Google Patents

Improved process for the preparation of 1,3-substituted indenes

Info

Publication number
WO2004048318A8
WO2004048318A8 PCT/IB2003/005121 IB0305121W WO2004048318A8 WO 2004048318 A8 WO2004048318 A8 WO 2004048318A8 IB 0305121 W IB0305121 W IB 0305121W WO 2004048318 A8 WO2004048318 A8 WO 2004048318A8
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
improved process
substituted indenes
indenes
substituted
Prior art date
Application number
PCT/IB2003/005121
Other languages
French (fr)
Other versions
WO2004048318A1 (en
Inventor
Robert Eugene Handfield Jr
Phillip James Johnson
Peter Robert Rose
Timothy James Norman Watson
Original Assignee
Pfizer Prod Inc
Robert Eugene Handfield Jr
Phillip James Johnson
Peter Robert Rose
Timothy James Norman Watson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc, Robert Eugene Handfield Jr, Phillip James Johnson, Peter Robert Rose, Timothy James Norman Watson filed Critical Pfizer Prod Inc
Priority to CA002511762A priority Critical patent/CA2511762A1/en
Priority to EP03769810A priority patent/EP1567483A1/en
Priority to KR1020057009301A priority patent/KR100655848B1/en
Priority to AU2003278510A priority patent/AU2003278510B8/en
Priority to BR0316482-9A priority patent/BR0316482A/en
Priority to MXPA05005517A priority patent/MXPA05005517A/en
Priority to CNA2003801040364A priority patent/CN1714075A/en
Priority to YUP-2005/0393A priority patent/RS20050393A/en
Priority to JP2004554771A priority patent/JP2006507342A/en
Publication of WO2004048318A1 publication Critical patent/WO2004048318A1/en
Publication of WO2004048318A8 publication Critical patent/WO2004048318A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/47—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Circuit Arrangements For Discharge Lamps (AREA)

Abstract

An improved process for the preparation of 1,3 substituted indenes which are useful intermediates in the synthesis of aryl fused azapolycyclic compounds as agents for the treatment of neurological and psychological disorders.
PCT/IB2003/005121 2002-11-25 2003-11-12 Improved process for the preparation of 1,3-substituted indenes WO2004048318A1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CA002511762A CA2511762A1 (en) 2002-11-25 2003-11-12 Improved process for the preparation of 1,3-substituted indenes
EP03769810A EP1567483A1 (en) 2002-11-25 2003-11-12 Improved process for the preparation of 1,3-substituted indenes
KR1020057009301A KR100655848B1 (en) 2002-11-25 2003-11-12 Improved process for the preparation of 1,3-substituted indenes
AU2003278510A AU2003278510B8 (en) 2002-11-25 2003-11-12 Improved process for the preparation of 1,3-substituted indenes
BR0316482-9A BR0316482A (en) 2002-11-25 2003-11-12 Improved process for preparing 1.3 substituted indenes
MXPA05005517A MXPA05005517A (en) 2002-11-25 2003-11-12 Improved process for the preparation of 1,3-substituted indenes.
CNA2003801040364A CN1714075A (en) 2002-11-25 2003-11-12 Improved process for the preparation of 1,3-substituted indenes
YUP-2005/0393A RS20050393A (en) 2002-11-25 2003-11-12 Improved process for the preparation of 1,3-substituted indenes
JP2004554771A JP2006507342A (en) 2002-11-25 2003-11-12 Improved method for producing 1,3-substituted indene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42902902P 2002-11-25 2002-11-25
US60/429,029 2002-11-25

Publications (2)

Publication Number Publication Date
WO2004048318A1 WO2004048318A1 (en) 2004-06-10
WO2004048318A8 true WO2004048318A8 (en) 2005-05-12

Family

ID=32393492

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2003/005121 WO2004048318A1 (en) 2002-11-25 2003-11-12 Improved process for the preparation of 1,3-substituted indenes

Country Status (16)

Country Link
US (1) US7285686B2 (en)
EP (1) EP1567483A1 (en)
JP (1) JP2006507342A (en)
KR (1) KR100655848B1 (en)
CN (1) CN1714075A (en)
AR (1) AR042205A1 (en)
AU (1) AU2003278510B8 (en)
BR (1) BR0316482A (en)
CA (1) CA2511762A1 (en)
MX (1) MXPA05005517A (en)
PL (1) PL377292A1 (en)
RS (1) RS20050393A (en)
RU (1) RU2284319C2 (en)
TW (1) TWI245756B (en)
WO (1) WO2004048318A1 (en)
ZA (1) ZA200503190B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009504852A (en) 2005-08-11 2009-02-05 ユニバーシティ オブ マサチューセッツ ロウエル Process for forming copolymers containing olefins and protected or unprotected hydroxystyrene units
EP2268639A2 (en) 2008-05-22 2011-01-05 Teva Pharmaceutical Industries Ltd. Varenicline tosylate, an intermediate in the preparation process of varenicline l-tartrate
WO2009155403A2 (en) * 2008-06-19 2009-12-23 Teva Pharmaceutical Industries Ltd. Processes for the preparation of varenicline and intermediates thereof
US20100010221A1 (en) * 2008-07-10 2010-01-14 Revital Lifshitz-Liron Processes for purifying varenicline l-tartrate salt and preparing crystalline forms of varenicline l-tartrate salt
WO2010151524A1 (en) 2009-06-22 2010-12-29 Teva Pharmaceutical Industries Ltd Solid states forms of varenicline salts and processes for preparation thereof
US20160296438A1 (en) * 2015-04-08 2016-10-13 Kemin Industries, Inc. Protective action of lutein against blue light on human skin cell lines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL136727A0 (en) 1997-12-31 2001-06-14 Pfizer Prod Inc Aryl fused azapolycyclic compounds
US6605610B1 (en) 1997-12-31 2003-08-12 Pfizer Inc Aryl fused azapolycyclic compounds
BR0208992A (en) * 2001-04-20 2004-04-27 Pfizer Prod Inc Process for the preparation of 1,3-substituted indenes and aryl fused azapolytic compounds
WO2004046077A1 (en) 2002-11-20 2004-06-03 Pfizer Products Inc. A method for preparing indan-1,3-dicarboxylic acid
MXPA05007565A (en) 2003-01-15 2005-09-21 Pfizer Prod Inc Process for the preparation of aryl fused polycyclic lactams.

Also Published As

Publication number Publication date
MXPA05005517A (en) 2005-07-25
WO2004048318A1 (en) 2004-06-10
BR0316482A (en) 2005-10-11
AU2003278510A1 (en) 2004-06-18
RU2005115881A (en) 2006-02-27
AU2003278510B8 (en) 2008-07-10
TW200413301A (en) 2004-08-01
EP1567483A1 (en) 2005-08-31
ZA200503190B (en) 2006-07-26
AU2003278510B2 (en) 2008-06-05
PL377292A1 (en) 2006-01-23
KR20050087801A (en) 2005-08-31
TWI245756B (en) 2005-12-21
JP2006507342A (en) 2006-03-02
US20050004379A1 (en) 2005-01-06
RU2284319C2 (en) 2006-09-27
KR100655848B1 (en) 2006-12-11
US7285686B2 (en) 2007-10-23
CN1714075A (en) 2005-12-28
RS20050393A (en) 2007-12-31
CA2511762A1 (en) 2004-06-10
AR042205A1 (en) 2005-06-15

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