JPWO2019224713A5 - - Google Patents
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- Publication number
- JPWO2019224713A5 JPWO2019224713A5 JP2020565399A JP2020565399A JPWO2019224713A5 JP WO2019224713 A5 JPWO2019224713 A5 JP WO2019224713A5 JP 2020565399 A JP2020565399 A JP 2020565399A JP 2020565399 A JP2020565399 A JP 2020565399A JP WO2019224713 A5 JPWO2019224713 A5 JP WO2019224713A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- tmeff2
- antibody
- antigen
- binding fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004965 antibodies Human genes 0.000 claims description 248
- 108090001123 antibodies Proteins 0.000 claims description 248
- 239000000427 antigen Substances 0.000 claims description 182
- 102000038129 antigens Human genes 0.000 claims description 182
- 108091007172 antigens Proteins 0.000 claims description 182
- 102100018591 TMEFF2 Human genes 0.000 claims description 69
- 101710023903 TMEFF2 Proteins 0.000 claims description 69
- 201000011510 cancer Diseases 0.000 claims description 20
- 239000012528 membrane Substances 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 18
- 239000008194 pharmaceutical composition Substances 0.000 claims description 18
- 206010060862 Prostate cancer Diseases 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 10
- 229920000023 polynucleotide Polymers 0.000 claims description 10
- 239000002157 polynucleotide Substances 0.000 claims description 10
- 235000004279 alanine Nutrition 0.000 claims description 8
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 239000003638 reducing agent Substances 0.000 claims description 6
- 230000036947 Dissociation constant Effects 0.000 claims description 4
- 238000009167 androgen deprivation therapy Methods 0.000 claims description 4
- 230000003302 anti-idiotype Effects 0.000 claims description 4
- 238000002512 chemotherapy Methods 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 230000003211 malignant Effects 0.000 claims description 4
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims description 4
- 238000001356 surgical procedure Methods 0.000 claims description 4
- 239000008351 acetate buffer Substances 0.000 claims description 3
- 239000004475 Arginine Substances 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims description 2
- 229920001850 Nucleic acid sequence Polymers 0.000 claims description 2
- 229960005190 Phenylalanine Drugs 0.000 claims description 2
- 125000000511 arginine group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims description 2
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 2
- 125000001116 prolino group Chemical group [H]OC(=O)C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 2
- 238000000746 purification Methods 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M buffer Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 241001465754 Metazoa Species 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 3
- 230000004614 tumor growth Effects 0.000 description 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 2
- 210000002307 Prostate Anatomy 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 101700011716 IL2RG Proteins 0.000 description 1
- 230000000259 anti-tumor Effects 0.000 description 1
- 230000003442 weekly Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862675957P | 2018-05-24 | 2018-05-24 | |
| US62/675,957 | 2018-05-24 | ||
| PCT/IB2019/054184 WO2019224713A2 (en) | 2018-05-24 | 2019-05-21 | Monospecific and multispecific anti-tmeff2 antibodies and there uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021524255A JP2021524255A (ja) | 2021-09-13 |
| JPWO2019224713A5 true JPWO2019224713A5 (el) | 2022-05-25 |
Family
ID=67211771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020565399A Pending JP2021524255A (ja) | 2018-05-24 | 2019-05-21 | 単一特異性及び二重特異性抗体抗−ｔｍｅｆｆ２抗体並びにそれらの使用 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US11866499B2 (el) |
| EP (1) | EP3802607A2 (el) |
| JP (1) | JP2021524255A (el) |
| KR (1) | KR20210011999A (el) |
| CN (1) | CN112703203A (el) |
| AR (1) | AR115419A1 (el) |
| AU (1) | AU2019274652A1 (el) |
| BR (1) | BR112020023416A2 (el) |
| CA (1) | CA3101304A1 (el) |
| CL (1) | CL2020003032A1 (el) |
| CO (1) | CO2020014515A2 (el) |
| CR (1) | CR20200564A (el) |
| EA (1) | EA202092849A1 (el) |
| EC (1) | ECSP20075234A (el) |
| IL (1) | IL278862A (el) |
| JO (1) | JOP20200295A1 (el) |
| MA (1) | MA52772A (el) |
| MX (1) | MX2020012589A (el) |
| NI (1) | NI202000087A (el) |
| PE (1) | PE20210634A1 (el) |
| PH (1) | PH12020551948A1 (el) |
| SG (1) | SG11202011268VA (el) |
| TW (1) | TW202003584A (el) |
| UY (1) | UY38243A (el) |
| WO (1) | WO2019224713A2 (el) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20200302A1 (ar) | 2018-05-24 | 2020-11-23 | Janssen Biotech Inc | الأجسام المضادة لـ cd3 واستخداماتها |
| KR20220131517A (ko) * | 2019-12-18 | 2022-09-28 | 얀센 바이오테크 인코포레이티드 | 생체 내 생물학적 표적화를 위한 재료 및 방법 |
| AU2021356681A1 (en) * | 2020-10-09 | 2023-05-18 | Eureka Therapeutics Inc. | Compositions targeting ndc80/mhc complexes and uses thereof |
| CN116635052A (zh) | 2020-10-13 | 2023-08-22 | 詹森生物科技公司 | 用于调节分化簇iv和/或viii的生物工程t细胞介导的免疫、材料和其他方法 |
| WO2023164510A1 (en) | 2022-02-23 | 2023-08-31 | Xencor, Inc. | Anti-cd28 x anti-psma antibodies |
| WO2024052831A1 (en) * | 2022-09-09 | 2024-03-14 | Janssen Biotech, Inc. | Method of treating cancer with an anti tmeff2xcd3 bispecific antibody |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7709A (en) | 1850-10-08 | Chas S Gaylord | Improved spring-grapple | |
| US226A (en) | 1837-06-03 | Samuel goss | ||
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| ATE87659T1 (de) | 1986-09-02 | 1993-04-15 | Enzon Lab Inc | Bindungsmolekuele mit einzelpolypeptidkette. |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
| JP4124480B2 (ja) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
| ATE408012T1 (de) | 1991-12-02 | 2008-09-15 | Medical Res Council | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
| WO1994013804A1 (en) | 1992-12-04 | 1994-06-23 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
| AUPO591797A0 (en) | 1997-03-27 | 1997-04-24 | Commonwealth Scientific And Industrial Research Organisation | High avidity polyvalent and polyspecific reagents |
| DE69833755T2 (de) | 1997-05-21 | 2006-12-28 | Biovation Ltd. | Verfahren zur herstellung von nicht-immunogenen proteinen |
| US6818749B1 (en) | 1998-10-31 | 2004-11-16 | The United States Of America As Represented By The Department Of Health And Human Services | Variants of humanized anti carcinoma monoclonal antibody cc49 |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| PT1354034E (pt) | 2000-11-30 | 2008-02-28 | Medarex Inc | Roedores transgénicos transcromossómicos para produção de anticorpos humanos |
| EP1539233B1 (en) | 2001-07-12 | 2011-04-27 | FOOTE, Jefferson | Super humanized antibodies |
| SI1572087T1 (sl) | 2002-03-08 | 2008-10-31 | Pdl Biopharma Inc | Protitelesa proti antigenu tmeff2 raka in njihovauporaba |
| JP2008511337A (ja) | 2004-09-02 | 2008-04-17 | ジェネンテック・インコーポレーテッド | ヘテロ多量体分子 |
| EP1870459B1 (en) | 2005-03-31 | 2016-06-29 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
| DE102005028778A1 (de) | 2005-06-22 | 2006-12-28 | SUNJÜT Deutschland GmbH | Mehrlagige Folie mit einer Barriere- und einer antistatischen Lage |
| PE20071101A1 (es) | 2005-08-31 | 2007-12-21 | Amgen Inc | Polipeptidos y anticuerpos |
| ES2395969T3 (es) | 2006-03-24 | 2013-02-18 | Merck Patent Gmbh | Dominios de proteínas heterodiméricas genéticamente modificados |
| JP2009541275A (ja) | 2006-06-22 | 2009-11-26 | ノボ・ノルデイスク・エー／エス | 二重特異性抗体の生産 |
| US20090155275A1 (en) | 2007-07-31 | 2009-06-18 | Medimmune, Llc | Multispecific epitope binding proteins and uses thereof |
| BRPI0818780A2 (pt) | 2007-10-19 | 2015-04-22 | Genentech Inc | Anticorpo anti-tenb2 planejados por cisteína e conjugados de medicamento com anticorpos |
| US8748356B2 (en) | 2007-10-19 | 2014-06-10 | Janssen Biotech, Inc. | Methods for use in human-adapting monoclonal antibodies |
| CA2710373A1 (en) | 2007-12-19 | 2009-07-09 | Ping Tsui | Design and generation of human de novo pix phage display libraries via fusion to pix or pvii, vectors, antibodies and methods |
| US8242247B2 (en) | 2007-12-21 | 2012-08-14 | Hoffmann-La Roche Inc. | Bivalent, bispecific antibodies |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| US8227577B2 (en) | 2007-12-21 | 2012-07-24 | Hoffman-La Roche Inc. | Bivalent, bispecific antibodies |
| WO2010045340A1 (en) | 2008-10-14 | 2010-04-22 | Centocor Ortho Biotech Inc. | Methods of humanizing and affinity-maturing antibodies |
| AU2010245011B2 (en) | 2009-04-27 | 2015-09-03 | Oncomed Pharmaceuticals, Inc. | Method for making heteromultimeric molecules |
| CN110066339A (zh) | 2010-04-20 | 2019-07-30 | 根马布股份公司 | 含异二聚体抗体fc的蛋白及其制备方法 |
| CN108341868B (zh) | 2010-11-05 | 2022-06-07 | 酵活有限公司 | 在Fc结构域中具有突变的稳定异源二聚的抗体设计 |
| HRP20211773T1 (hr) | 2011-11-04 | 2022-03-04 | Zymeworks Inc. | Stabilna heterodimerni dizajn antitijela s mutacijama u fc domeni |
| EP2794660A2 (en) * | 2011-12-23 | 2014-10-29 | Phenoquest AG | Antibodies for the treatment and diagnosis of affective and anxiety disorders |
| LT3653049T (lt) | 2012-12-14 | 2023-11-10 | Omniab, Inc. | Polinukleotidai, koduojantys graužikų antikūnus, turinčius žmogaus idiotipus, ir gyvūnai, apimantys juos |
| SI2970980T1 (sl) | 2013-03-15 | 2018-11-30 | Janssen Biotech, Inc. | Postopki izdelave za nadzor vsebnosti C-terminalnega lizina, galaktoze in sialične kisline v rekombinantnih proteinih |
| TWI680138B (zh) * | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗ｐｄ-ｌ１之人類抗體 |
| ES2791249T3 (es) | 2014-09-05 | 2020-11-03 | Janssen Pharmaceutica Nv | Agentes de enlace CD123 y sus utilizaciones |
| EP3288981A1 (en) | 2015-05-01 | 2018-03-07 | Genentech, Inc. | Masked anti-cd3 antibodies and methods of use |
| WO2016204966A1 (en) | 2015-06-16 | 2016-12-22 | Genentech, Inc. | Anti-cd3 antibodies and methods of use |
| SI3370768T1 (sl) * | 2015-11-03 | 2022-04-29 | Janssen Biotech, Inc. | Protitelesa, ki se specifično vežejo na PD-1, in njihove uporabe |
| US20190352421A1 (en) * | 2018-05-16 | 2019-11-21 | Janssen Biotech, Inc. | Methods of Treating Cancers and Enhancing Efficacy of T Cell Redirecting Therapeutics |
| JOP20200302A1 (ar) | 2018-05-24 | 2020-11-23 | Janssen Biotech Inc | الأجسام المضادة لـ cd3 واستخداماتها |
-
2019
- 2019-05-21 MA MA052772A patent/MA52772A/fr unknown
- 2019-05-21 CA CA3101304A patent/CA3101304A1/en active Pending
- 2019-05-21 WO PCT/IB2019/054184 patent/WO2019224713A2/en unknown
- 2019-05-21 JP JP2020565399A patent/JP2021524255A/ja active Pending
- 2019-05-21 CN CN201980034951.1A patent/CN112703203A/zh active Pending
- 2019-05-21 PE PE2020001881A patent/PE20210634A1/es unknown
- 2019-05-21 BR BR112020023416-8A patent/BR112020023416A2/pt unknown
- 2019-05-21 KR KR1020207036922A patent/KR20210011999A/ko active Search and Examination
- 2019-05-21 MX MX2020012589A patent/MX2020012589A/es unknown
- 2019-05-21 US US16/417,889 patent/US11866499B2/en active Active
- 2019-05-21 EA EA202092849A patent/EA202092849A1/ru unknown
- 2019-05-21 AU AU2019274652A patent/AU2019274652A1/en active Pending
- 2019-05-21 SG SG11202011268VA patent/SG11202011268VA/en unknown
- 2019-05-21 JO JOP/2020/0295A patent/JOP20200295A1/ar unknown
- 2019-05-21 CR CR20200564A patent/CR20200564A/es unknown
- 2019-05-21 EP EP19737217.0A patent/EP3802607A2/en active Pending
- 2019-05-22 TW TW108117613A patent/TW202003584A/zh unknown
- 2019-05-24 AR ARP190101399A patent/AR115419A1/es unknown
- 2019-05-24 UY UY0001038243A patent/UY38243A/es unknown
-
2020
- 2020-11-13 PH PH12020551948A patent/PH12020551948A1/en unknown
- 2020-11-19 IL IL278862A patent/IL278862A/en unknown
- 2020-11-23 NI NI202000087A patent/NI202000087A/es unknown
- 2020-11-23 CO CONC2020/0014515A patent/CO2020014515A2/es unknown
- 2020-11-23 CL CL2020003032A patent/CL2020003032A1/es unknown
- 2020-11-23 EC ECSENADI202075234A patent/ECSP20075234A/es unknown
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