JPWO2013122188A1 - 血管内皮機能低下の予防または改善剤 - Google Patents
血管内皮機能低下の予防または改善剤 Download PDFInfo
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- JPWO2013122188A1 JPWO2013122188A1 JP2013558748A JP2013558748A JPWO2013122188A1 JP WO2013122188 A1 JPWO2013122188 A1 JP WO2013122188A1 JP 2013558748 A JP2013558748 A JP 2013558748A JP 2013558748 A JP2013558748 A JP 2013558748A JP WO2013122188 A1 JPWO2013122188 A1 JP WO2013122188A1
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- Prior art keywords
- salt
- citrulline
- glutathione
- preventive
- vascular endothelial
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Abstract
Description
(1)シトルリンまたはその塩、およびグルタチオンまたはその塩を有効成分として含有するNO産生増強剤。
(2)シトルリンまたはその塩、およびグルタチオンまたはその塩を有効成分として含有する血管内皮機能低下の予防または改善剤。
(3)シトルリンまたはその塩、およびグルタチオンまたはその塩を有効成分として含有する血管内皮機能低下から生じる症状の予防または改善剤。
(4)血管内皮機能低下から生じる症状が、動脈硬化に関連する症状、血流低下に関連する症状より選ばれる少なくとも一つの症状である、(3)に記載の予防または改善剤。
(5)動脈硬化に関連する症状が虚血性疾患である、(4)に記載の予防または改善剤。
(6)虚血性疾患が、心筋梗塞、狭心症、末梢動脈閉塞より選ばれる少なくとも一つの症状である、(5)に記載の予防または改善剤。
(7)血流低下に関連する症状が、肩凝り、冷え症、むくみ、***不全、肌荒れ、骨格筋活動低下による運動パフォーマンス低下より選ばれる少なくとも一つの症状である、(4)に記載の予防または改善剤。
アンモニウム塩としては、アンモニウム、テトラメチルアンモニウム等の塩があげられる。
L-シトルリン120kg、還元型グルタチオン120kg、環状オリゴ糖19kg、セルロース57kgおよびプルラン1kgを流動層造粒乾燥機で造粒した。得られた造粒物とステアリン酸カルシウム3kgとをコニカルブレンダーで混合した後、ロータリー圧縮成形機で圧縮成形して錠剤を製造する。
実施例1で製造する錠剤の表面をシェラック溶液でコーティングして腸溶錠剤を製造する。
L-シトルリン120kg、還元型グルタチオン120kg、環状オリゴ糖19kg、セルロース57kg、ステアリン酸カルシウム3kgおよびプルラン1kgを、コニカルブレンダーで混合する。得られる混合物20kgと0.2kgの二酸化ケイ素とを混合攪拌して得られた混合物をカプセル充填機に投入、ハードカプセルに充填してハードカプセルを得る。得られるハードカプセルの表面をツェイン溶液でコーティングして腸溶カプセルを製造する。
L-シトルリン1.28kg、酸化型グルタチオン1.28kg、エリスリトール3kg、クエン酸0.05kg、人工甘味料3g、香料0.06kgを液温70℃で水50Lに攪拌溶解し、クエン酸でpHを3.3に調整後、プレート殺菌を用いて滅菌して瓶に充填後、パストライザー殺菌し、飲料を製造する。
シトルリン20mg、酸化型グルタチオン20mg、アルギニン20mgと適当量の果糖ぶどう糖液糖、食塩、クエン酸、香料、クエン酸Na、乳酸Ca、ピロリン酸鉄、グルコン酸Ca、塩化K、塩化Mg、甘味料とを配合し555mlの飲料を製造する。
シトルリン100mg、酸化型グルタチオン100mg、アルギニン100mg、アラニン2.5mg、グリシン2.5mg、ロイシン 2.5mg、イソロイシン 1.3mg、バリン 1.3mgと適当量の香料、甘味料を配合し300mlの飲料を製造する。
エタノール10.0重量%、L-シトルリン2.0重量%、還元型グルタチオン2.0重量%、1,3-ブチレングリコール5.0重量%、精製水83.0重量%を配合し化粧水を製造する。
ポリエチレングリコール(PGE55)、モノステアレート2.00重量%、自己乳化型モノステアリン酸グリセリン5.00重量%、セチルアルコール4.00重量%、スクワラン 6.00重量%、2-エチルヘキサン酸トリグリセリル6.00重量%、1,3-ブチレングリコール7.00重量%、L-ヒスチジン3.00重量%、L-シトルリン1.00重量%、還元型グルタチオン1.00重量%、精製水66.00重量%を配合しクリームを製造する。
L-シトルリン3.00重量%、酸化型グルタチオン3.00重量%、L-セリン1.00重量%、水溶性コラーゲン(1%水溶液)1.00重量%、クエン酸ナトリウム0.10重量%、クエン酸0.05重量%、甘草エキス0.20重量%、1,3-ブチレングリコール3.00重量%、精製水91.65重量%を配合しローションを製造する。
ポリビニールアルコール13.00重量%、L-アスパラギン酸1.00重量%、L-シトルリン5.00重量%、還元型グルタチオン5.00重量%、ラウロイルヒドロキシプロリン1.00重量%、水溶性コラーゲン (1%水溶液)2.00重量%、1,3-ブチレングリコール3.00重量%、エタノール5.00重量%、精製水70.00重量%を配合しパックを製造する。
ヒドロキシエチルセルロース(2%水溶液)12.0重量%、キサンタンガム(2%水溶液) 2.0重量%、L-シトルリン2.0重量%、還元型グルタチオン2.0重量%、1,3-ブチレングリコール6.0重量%、濃グリセリン4.0重量%、ヒアルロン酸ナトリウム(1%水溶液)5.0重量%、精製水69.0重量%を配合し美溶液を製造する。
Claims (7)
- シトルリンまたはその塩、およびグルタチオンまたはその塩を有効成分として含有するNO産生増強剤。
- シトルリンまたはその塩、およびグルタチオンまたはその塩を有効成分として含有する血管内皮機能低下の予防または改善剤。
- シトルリンまたはその塩、およびグルタチオンまたはその塩を有効成分として含有する血管内皮機能低下から生じる症状の予防または改善剤。
- 血管内皮機能低下から生じる症状が、動脈硬化に関連する症状、血流低下に関連する症状より選ばれる少なくとも一つの症状である、請求項3に記載の予防または改善剤。
- 動脈硬化に関連する症状が虚血性疾患である、請求項4に記載の予防または改善剤。
- 虚血性疾患が、心筋梗塞、狭心症、末梢動脈閉塞より選ばれる少なくとも一つの症状である、請求項5に記載の予防または改善剤。
- 血流低下に関連する症状が、肩凝り、冷え症、むくみ、***不全、肌荒れ、骨格筋活動低下による運動パフォーマンス低下より選ばれる少なくとも一つの症状である、請求項4に記載の予防または改善剤。
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WO2016141331A1 (en) * | 2015-03-04 | 2016-09-09 | K.L.R.M., Llc | Methods and compositions for extending the efficacy of phosphodiesterase inhibitors for treating erectile dysfunction |
JP5888574B1 (ja) * | 2015-07-02 | 2016-03-22 | 株式会社東洋新薬 | 血流改善剤 |
EP3629772A4 (en) * | 2017-05-31 | 2020-12-23 | Kyowa Hakko Bio Co., Ltd. | USING CITRULLINE AND GLUTATHIONE TO INCREASE MUSCLE MASS |
WO2019117702A1 (en) * | 2017-12-16 | 2019-06-20 | Kam Faii Yuen | A medicament to control and reduce hypertension |
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WO2013122188A1 (ja) | 2013-08-22 |
EP2815760A4 (en) | 2015-12-09 |
EP2815760A1 (en) | 2014-12-24 |
ES2761224T3 (es) | 2020-05-19 |
US20160296586A1 (en) | 2016-10-13 |
AU2013219258B2 (en) | 2017-05-25 |
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