JPWO2005053790A1 - Non-pharmacological reproductive function control method and apparatus - Google Patents
Non-pharmacological reproductive function control method and apparatus Download PDFInfo
- Publication number
- JPWO2005053790A1 JPWO2005053790A1 JP2005515961A JP2005515961A JPWO2005053790A1 JP WO2005053790 A1 JPWO2005053790 A1 JP WO2005053790A1 JP 2005515961 A JP2005515961 A JP 2005515961A JP 2005515961 A JP2005515961 A JP 2005515961A JP WO2005053790 A1 JPWO2005053790 A1 JP WO2005053790A1
- Authority
- JP
- Japan
- Prior art keywords
- electric field
- reproductive function
- male animal
- control device
- function control
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Electrotherapy Devices (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
非薬理的に雄性動物の生殖機能を治療又は改善する方法もしくは性行動を制御する方法である。電極を前記雄性動物に対して非接触にして、低周波交流電界を前記雄性動物の全体又は一部に曝露する。上記電界の曝露は、１日のうち一定時間だけ前記電界を曝露し、これを毎日繰り返す。A method for non-pharmacologically treating or improving the reproductive function of a male animal or a method for controlling sexual behavior. An electrode is brought out of contact with the male animal and a low frequency alternating electric field is exposed to all or part of the male animal. In the exposure of the electric field, the electric field is exposed for a certain period of time in a day, and this is repeated every day.
Description
本発明は、非薬理的な雄性動物の生殖機能の制御方法及びその装置に関する。 The present invention relates to a method and apparatus for controlling the reproductive function of a non-pharmacological male animal.
統計的に、通常の生活の中で２年以上子供ができない夫婦は、不妊症の可能性が高いとされている。不妊で悩む夫婦は我が国で１８０万人と推定され、増加する傾向にある。このうち男性不妊に由来するものは約７０万人（約４０％）といわれている。性機能障害には***障害や***障害、または***の減退、絶頂感の欠除などがあげられるが、その主たるものは***障害である。***障害はストレスなどが原因でおこる心因性***障害と糖尿病や骨盤内手術後などに起こる器質性***障害とに分けられる。 Statistically, couples who have no children for more than two years in normal life are likely to have infertility. The number of married couples suffering from infertility is estimated to be 1.8 million in Japan and is increasing. Of these, about 700,000 people (about 40%) are said to originate from male infertility. Sexual dysfunction may include erectile dysfunction, ejaculatory dysfunction, decreased libido, lack of climax, etc. The main one is erectile dysfunction. Erectile dysfunction is divided into psychogenic erectile dysfunction caused by stress and the like, and organic erectile dysfunction that occurs after diabetes or pelvic surgery.
中でも、***障害の患者は日本で約９８０万人いると推定されているが、実際に医療機関を受診し、治療を受けているのはその約３％にしかすぎず、やはり男性にとってはかなり受診しにくい疾患である。なお、ヒトの***障害に対する治療薬として、特許文献１に記載の治療薬が知られている。
また、ヒトに限らず、競走馬を含むウマやウシなどの家畜の繁殖においても、交配率の低下は馬主や酪農家にとって深刻な問題であり、繁殖能力を向上させる方法が望まれている。 Moreover, in breeding not only humans but also livestock such as horses and cows including racehorses, a decrease in the mating rate is a serious problem for horse owners and dairy farmers, and a method for improving the breeding ability is desired.
上述のように、***障害の治療において、治療薬を投薬する方法が採られている。しかし、治療薬に起因する副作用の問題は皆無ではなかった。そのため、別途の性機能障害を改善又は治療する方法が望まれてきた。また、動物の性行動を制御（促進）して繁殖能力を向上させる方法も望まれてきた。
本発明の目的は、非薬理学的手法により性機能を制御する方法を提供することにある。また本発明の目的は、非薬理学的手法により性機能を治療又は改善する方法あるいは性行動を制御する方法及びその装置を提供することにある。As described above, in the treatment of erectile dysfunction, a method of administering a therapeutic agent has been adopted. However, there was no problem of side effects caused by therapeutic drugs. Therefore, a separate method for improving or treating sexual dysfunction has been desired. In addition, there has been a demand for a method for improving (or promoting) the sexual behavior of animals to improve the reproduction ability.
An object of the present invention is to provide a method for controlling sexual function by a non-pharmacological method. Another object of the present invention is to provide a method for treating or improving sexual function or a method for controlling sexual behavior by a non-pharmacological method and a device therefor.
上記課題を解決するため、鋭意検討した結果、非薬理的に雄性動物の生殖機能を制御する方法であって、電極を前記雄性動物に対して非接触にして、電界を前記雄性動物の全体又は一部に曝露する非薬理的な雄性動物の生殖機能の制御方法を提供できる。 As a result of intensive studies to solve the above problems, a method for non-pharmacologically controlling the reproductive function of a male animal, wherein an electrode is not contacted with the male animal, and an electric field is applied to the entire male animal or A method of controlling the reproductive function of a non-pharmacological male animal exposed to a part can be provided.
なお、本件発明において「非接触」とは、２つ以上の電極間において、電流を通じるところの接触がないことをいう。従って、両方の電極に雄性動物が接触しないことのみならず、一方の電極に接触しているが、他方の対電極に接触しない場合や、複数の同一の電極に接触しているが他方の対電極に接触していない場合も含むものである。なお、両方の電極に雄性動物が接触しない「非接触」が望ましい。 In the present invention, “non-contact” means that there is no contact between two or more electrodes through which current flows. Therefore, not only does the male animal not contact both electrodes, but it contacts one electrode but does not contact the other counter electrode, or it contacts the same electrode but the other pair. This includes the case where the electrode is not in contact. Note that “non-contact” in which a male animal does not contact both electrodes is desirable.
本発明に係る治療又は改善方法は、雄性動物に電界を曝露して生殖機能の制御し、性機能障害を治療又は改善する方法である。電界と生殖機能との関係はまだ詳しく解明されていないが、電界の曝露により、生殖機能に深く関与しているといわれている血中のＮＯ濃度が増加すると考えられる。ＮＯは血管中の弛緩効果が明らかにされており、ＮＯによる弛緩は尿道海綿体小柱筋（trabecular smooth muscle）の隙間を生じさせて周辺静脈を圧し、また海綿体（corpus cevernosum）内細動脈の拡張が血流の量を上げるため***（penile erection）が起こると考えられる。 The treatment or improvement method according to the present invention is a method for treating or improving sexual dysfunction by exposing a male animal to an electric field to control reproductive function. The relationship between the electric field and reproductive function has not yet been elucidated in detail, but it is thought that exposure to the electric field increases the concentration of NO in the blood, which is said to be deeply involved in reproductive function. NO has been shown to relax in the blood vessels, and relaxation by NO creates gaps in the trabecular trabecular trabecular muscles, presses the peripheral veins, and corpus cevernosum inner arterioles It is thought that erection (penile erection) occurs because the expansion of the blood flow increases the amount of blood flow.
また、男性の第二次性徴の発現や維持に欠かせないテストステロンや、ストレスの指標と知られているコルチゾール、ＡＣＴＨ、また交配行動の促進に関与していると考えられるホルモンの分泌が促進され、性機能障害が治療や改善されるとも考えられる。 It also promotes the secretion of testosterone, which is essential for the development and maintenance of secondary sex characteristics in men, cortisol, which is known as an indicator of stress, ACTH, and hormones that are thought to be involved in promoting mating behavior. Sexual dysfunction may be treated or improved.
本発明は、電流を流す方法ではなく、電界を曝露させる方法であるので、電極と雄性動物とを非接触にするものである。 Since the present invention is not a method of passing an electric current but a method of exposing an electric field, the electrode and the male animal are brought into contact with each other.
なお、前記電界が低周波交流電界であることが好ましい。 The electric field is preferably a low frequency alternating electric field.
また、電界は少なくとも前記雄性動物の生殖器に曝露することが望ましい。 In addition, it is desirable that the electric field be exposed to at least the genital organ of the male animal.
したがって、雄性動物の生体内部への電界の浸透を考慮すると、交流電界であって周波数が低周波であることが好ましく、また、生殖機能の制御し、***障害の治療又は改善には少なくとも生殖器に電界を曝露可能であることが好ましい。 Therefore, considering the penetration of the electric field into the living body of a male animal, it is preferable that the frequency is an alternating electric field and the frequency is low, and at least for the genitals to control reproductive function and treat or improve erectile dysfunction. It is preferred that the electric field can be exposed.
曝露は、１日のうち一定時間だけ前記電界を曝露し、これを毎日繰り返すことが望ましい。１日のうち一定時間だけ前記電界を曝露し、これを毎日繰り返すことにより、生殖機能の制御することができ、性機能障害の治療又は改善が得られる。 In the exposure, it is desirable to expose the electric field for a certain period of time in a day and repeat this every day. By exposing the electric field for a certain time of the day and repeating this daily, the reproductive function can be controlled, and treatment or improvement of sexual dysfunction can be obtained.
生殖機能の制御して生殖機能を治療又は改善するが、その障害としては***障害、***障害、***の減退又は絶頂感の欠如が含まれる。 Control of reproductive function to treat or improve reproductive function, including disorders of erectile dysfunction, ejaculation disorder, decreased libido or lack of climax.
電界の曝露により、血中のＮＯ濃度の増大やホルモン分泌の促進が図られると考えられ、***障害、***障害、***の減退又は絶頂感の欠如に対して有効な方法である。なお、雄性動物はヒトを含む動物でありその種を選ばないが、ヒトの他、競走馬を含むウマやウシやブタなどの家畜に特に有効である。 Exposure to an electric field is thought to increase the concentration of NO in the blood and promote hormone secretion, and is an effective method for erectile dysfunction, ejaculation disorders, decreased libido, or lack of climax. A male animal is an animal including a human, and its species is not selected, but is particularly effective for humans and domestic animals such as horses including racehorses, cows and pigs.
また本発明の他の態様は、上述のいずれかに記載の生殖機能の制御方法を用いて動物の性行動を制御する方法を提供することができる。
例えば、動物の性行動を制御する方法であって、電界を前記動物の全体又は一部に曝露する性行動の制御方法である。また雄雌両方に同時に曝露して雄性動物の性行動を制御する方法を採用することもできる。Moreover, the other aspect of this invention can provide the method of controlling the sexual behavior of an animal using the control method of the reproductive function in any one of the above-mentioned.
For example, there is a method for controlling sexual behavior of an animal, which is a method for controlling sexual behavior in which an electric field is exposed to all or a part of the animal. It is also possible to adopt a method in which both males and females are exposed simultaneously to control the sexual behavior of male animals.
これらの方法により、動物の性行動を制御（促進）することができる。電界の曝露によりホルモンの分泌が促進されると考えることから、雌雄を問わず動物に対して電界を曝露することにより、当該動物の性行動が制御できる。例えば、競走馬を含むウマやウシやブタなどの家畜に対して電界を曝露し、繁殖能力の向上させることができる。 By these methods, the sexual behavior of the animal can be controlled (promoted). Since it is considered that hormone secretion is promoted by exposure to an electric field, sexual behavior of the animal can be controlled by exposing the animal to an electric field regardless of sex. For example, an electric field can be exposed to livestock such as horses, cows, and pigs including racehorses to improve the breeding ability.
また本発明の他の態様としては、雄性動物の性機能障害を治療又は改善する生殖機能の制御装置であって、前記雄性動物の全体又は一部に対して電界を曝露可能な一対の電極と、前記一対の電極に電圧を印加する電源とを備えた生殖機能の制御装置である。
これにより、雄性動物の生殖機能を制御することができ、性機能障害を治療又は改善する装置とすることができる。In another aspect of the present invention, there is provided a reproductive function control apparatus for treating or improving a male animal's sexual dysfunction, comprising a pair of electrodes capable of exposing an electric field to all or a part of the male animal. A reproductive function control device comprising a power source for applying a voltage to the pair of electrodes.
Thereby, the reproductive function of a male animal can be controlled, and it can be set as the apparatus which treats or improves a sexual dysfunction.
さらに本発明の態様として、前記雄性動物またはその一部を配置せしめ得るように所定間隔を隔てて配置された一対の電極対と、前記電極対に所定の電圧を印加して前記電極対間に電界を発生させるための電源とを備えていることが好ましい。 Further, as an aspect of the present invention, a pair of electrode pairs arranged at a predetermined interval so that the male animal or a part thereof can be arranged, and a predetermined voltage is applied to the electrode pair to It is preferable to provide a power source for generating an electric field.
本装置は、一対の電極に電圧を印加し、当該電極間に発生する電界を雄性動物に曝露する装置である。上述のように、電界と生殖機能との関係があると考えられ、雄性動物の性機能障害を治療又は改善に効果がある。 This apparatus is an apparatus that applies a voltage to a pair of electrodes and exposes an electric field generated between the electrodes to a male animal. As described above, it is considered that there is a relationship between the electric field and reproductive function, which is effective in treating or improving sexual dysfunction in male animals.
さらに、本装置において、前記電界が低周波交流電界であることが好ましい。 Furthermore, in this apparatus, it is preferable that the said electric field is a low frequency alternating current electric field.
また本装置において、少なくとも印加電圧、周波数、曝露時間の１つが制御可能な電源制御部を更に備えていることが好ましい。 The apparatus preferably further includes a power supply control unit capable of controlling at least one of applied voltage, frequency, and exposure time.
また少なくとも前記雄性動物の生殖器に前記電界が曝露可能な装置が好ましい。 A device capable of exposing the electric field to at least the genital organ of the male animal is preferable.
雄性動物の生体内部への電界の浸透を考慮すると、交流電界であって周波数が低周波であることが好ましく、***障害の治療又は改善には少なくとも生殖器に電界を曝露可能である装置が好ましい。また、電界を曝露する雄性動物の大きさや体重に応じて、少なくとも印加電圧（被爆電界強度）、周波数、曝露時間の１つが制御可能であることが好ましい。 Considering penetration of the electric field into the living body of the male animal, it is preferable that the frequency is an alternating electric field and the frequency is low, and a device capable of exposing the electric field to at least the genitals is preferable for treating or improving erectile dysfunction. Further, it is preferable that at least one of applied voltage (exposure electric field strength), frequency, and exposure time can be controlled according to the size and weight of the male animal to which the electric field is exposed.
前記性機能障害としては、***障害、***障害、***の減退又は絶頂感の欠如を含まれる。 The sexual dysfunction includes erectile dysfunction, ejaculation disorder, decreased libido, or lack of climax.
上述のように、電界の曝露により、血中のＮＯ濃度の増大やホルモン分泌の促進が図られると考えられるため、***障害、***障害、***の減退又は絶頂感の欠如の治療又は改善に効果がある装置である。 As mentioned above, exposure to an electric field is thought to increase the concentration of NO in blood and promote hormone secretion, so it is effective in treating or improving erectile dysfunction, ejaculation disorders, decreased libido, or lack of climax. There is a device.
なお、本装置においては、前記一対の電極は、前記雄性動物に対して非接触に配置されることが望ましい。 In the present apparatus, it is desirable that the pair of electrodes is disposed in a non-contact manner with respect to the male animal.
電界を曝露させる装置であるので雄性動物に電流を流す必要はなく、電極と雄性動物とを非接触にすることができる。そのため、当該雄性動物を電極により拘束する心配がない。 Since it is a device that exposes an electric field, it is not necessary to pass an electric current through the male animal, and the electrode and the male animal can be brought into contact with each other. Therefore, there is no worry that the male animal is restrained by the electrode.
また本装置は、前記雄性動物としてヒト、哺乳動物に適用でき、特に哺乳動物としてウマ、ウシ、ブタ、マウスに適用される。 The apparatus can be applied to humans and mammals as the male animals, and particularly to horses, cows, pigs, and mice as mammals.
すなわち、雄性動物はヒトを含む動物でありその種を選ばないが、ヒトの他、競走馬を含むウマやウシやブタなどの家畜（哺乳動物）に特に有効である。 That is, male animals are animals including humans and their species are not selected, but are particularly effective for humans and domestic animals (mammals) such as horses, horses and pigs including racehorses.
本装置は、前記雄性動物の全体又は一部を安定状態に戴置可能な戴置台を更に備えることが好ましい。 It is preferable that the apparatus further includes a placing table that can place all or part of the male animal in a stable state.
安定状態に戴置可能な戴置台を付加することにより、対象となる雄性動物の拘束せずに移動を最小限に抑えることができる。その結果、当該雄性動物を挟む電極を必要最小限にすることができる。 By adding a mounting table that can be placed in a stable state, movement can be minimized without restraining the target male animal. As a result, the electrodes sandwiching the male animal can be minimized.
本装置は、前記雄性動物がヒトであって、前記戴置台は前記ヒトが着座可能な背凭れ部、座板部および足置き部を備えた椅子であることが好ましい。 In this apparatus, it is preferable that the male animal is a human, and the mounting table is a chair provided with a backrest portion, a seat plate portion, and a footrest portion on which the human can be seated.
また本装置において、前記一対の電極の一方は、前記椅子の背凭れ部から延びる電極支持部により前記ヒトの頭部の上方に配置され、前記一対の電極の他方は前記足置き部に配置されることが好ましい。 Further, in the present apparatus, one of the pair of electrodes is disposed above the human head by an electrode support portion extending from a backrest portion of the chair, and the other of the pair of electrodes is disposed on the footrest portion. It is preferable.
雄性動物がヒトである場合、ヒトが着座可能な椅子を備えた装置であると、着座した状態でリラックスして性機能障害を治療又は改善することが可能である。特に、頭部の上方と足置き部に電極を配置することにより、ヒトの頭部から足部にかけて電界を曝露することができ、効果的に性機能障害を治療又は改善を行う装置とすることができる。 When the male animal is a human, a device having a chair on which a human can be seated can relax and treat or improve sexual dysfunction while sitting. In particular, by placing electrodes on the upper part of the head and on the footrest, an electric field can be exposed from the human head to the foot, and the device effectively treats or improves sexual dysfunction. Can do.
これらの装置は、動物の性行動を制御（促進）する装置である。電界の曝露によりホルモンの分泌が促進されると考えることから、動物（雌雄を問わない）に対して電界を曝露することにより、当該動物の性行動が制御できる装置である。例えば、競走馬を含むウマやウシやブタなどの家畜に対して電界を曝露し、繁殖能力の向上させることができる。 These devices are devices that control (promote) the sexual behavior of animals. Since it is thought that hormone secretion is promoted by exposure to an electric field, it is a device that can control the sexual behavior of an animal by exposing the animal (regardless of sex) to an electric field. For example, an electric field can be exposed to livestock such as horses, cows, and pigs including racehorses to improve the breeding ability.
本発明に係る前記方法及び前記装置は、雄性動物に電界を曝露する非薬理学的方法により、雄性動物の生殖機能の制御する方法である。したがって、投薬による副作用が発生することなく、雄性動物の性機能障害を治療又は改善する方法として適用でき、性機能障害を治療又は改善できる。また、電界と生殖機能との関係において、動物（雌雄を問わない）の性行動を制御することも可能となる。 The method and apparatus according to the present invention is a method for controlling the reproductive function of a male animal by a non-pharmacological method of exposing an electric field to the male animal. Therefore, it can be applied as a method for treating or improving sexual dysfunction in male animals without causing side effects due to medication, and sexual dysfunction can be treated or improved. Moreover, it becomes possible to control the sexual behavior of an animal (regardless of sex) in the relationship between the electric field and the reproductive function.
１ａ、１ｂ 電極
２ 交流電源
３ 制御部
５ 椅子（戴置台）1a, 1b Electrode 2 AC power supply 3 Control unit 5 Chair (mounting table)
以下、図面を用いて説明する。図１は、本発明に係る方法に使用される電界治療改善装置の一例を示す。図において、背凭れ部５ａ、足置き部５ｂ及び座板部５ｃを備えた椅子５（戴置台）に着座したヒトＨ（オス）に電界を曝露する装置である。足置き部５ｂの内部には一対の電極の一方１ａが配置されている。背凭れ部５ａから延びる電極支持部６に一対の電極の一方１ｂが取り付けられている。すなわち、ヒトＨの頭部と電極１ｂとの間には空隙があるので接触せず、電極１ａは足置き部５ｂの内部にあるのでヒトＨの足部と接触しない。よって、一対の電極１はヒトＨに対して非接触に配置されている。 Hereinafter, it demonstrates using drawing. FIG. 1 shows an example of an electric field therapy improving apparatus used in the method according to the present invention. In the figure, it is a device that exposes an electric field to a human H (male) seated on a chair 5 (mounting table) having a backrest portion 5a, a footrest portion 5b, and a seat plate portion 5c. One of a pair of electrodes 1a is disposed inside the footrest portion 5b. One electrode 1b of the pair of electrodes is attached to an electrode support 6 extending from the backrest 5a. That is, since there is a gap between the head of human H and the electrode 1b, there is no contact, and since the electrode 1a is inside the footrest 5b, it does not contact the foot of human H. Therefore, the pair of electrodes 1 are arranged in non-contact with the human H.
一対の電極１ａ、１ｂに交流電源２からの電圧を印加することにより、一対の電極１の間に電界が発生する。かかる電極１の配置により、生殖器のみならずヒトＨの頭部から足部にかけて電界を曝露することができる。また、交流電源２は制御部３により、周波数、印加電圧、曝露時間などを制御することができ、ヒトＨの身長や体重に応じて、これらの値を制御することができる。なお、ヒトＨ内部への電界の浸透を考慮すると、電界は低周波交流電界であることが好ましい。 An electric field is generated between the pair of electrodes 1 by applying a voltage from the AC power supply 2 to the pair of electrodes 1a and 1b. With the arrangement of the electrode 1, an electric field can be exposed not only from the genital organs but also from the head of the human H to the foot. The AC power supply 2 can control the frequency, applied voltage, exposure time, and the like by the control unit 3, and can control these values according to the height and weight of the human H. In consideration of penetration of the electric field into the human H, the electric field is preferably a low-frequency AC electric field.
上述したように電界と生殖機能との関係は詳しく解明されていないが、電界の曝露により、ヒトＨの血中のＮＯ濃度が増加し、又は／及び交配行動の促進に関与していると考えられるホルモンなどの分泌が促進されと考えられ、ヒトＨの性機能障害が治療又は改善される。また、１日のうち一定時間だけ電界を曝露し、これを毎日繰り返すことにより、徐々にホルモン分泌が促進されと考えられ、治療（改善）効果が現れる。 As described above, the relationship between the electric field and reproductive function has not been elucidated in detail, but it is thought that exposure to the electric field increases the concentration of NO in human H blood and / or is involved in promoting mating behavior. It is considered that the secretion of hormones and the like is promoted, and sexual dysfunction of human H is treated or improved. Moreover, it is thought that hormonal secretion is gradually accelerated | stimulated by exposing an electric field only for the fixed time for one day, and repeating this every day, and a therapeutic (improvement) effect appears.
ヒトに対する方法及び装置を説明したが、一対の電極１を適切な大きさにし、適切な間隔に配置することにより、他の雄性動物、例えば、競走馬を含むウマやウシやブタなどの家畜に対しても治療や改善が可能となる。また、電界曝露により交配行動の促進に関与していると考えられるホルモンなどの分泌が促進されると考えられることから、動物（雌雄を問わない）の性行動を制御（促進）することもできる。以下、実施例において、本発明に係る方法及び装置について説明する。 Although the method and apparatus for humans have been described, by setting the pair of electrodes 1 to an appropriate size and arranging them at an appropriate interval, other male animals such as horses including racehorses, livestock such as cows and pigs can be used. Even treatment and improvement are possible. In addition, since it is thought that secretion of hormones that are thought to be involved in promoting mating behavior is promoted by exposure to electric fields, it is possible to control (promote) sexual behavior in animals (both male and female). . Hereinafter, the method and apparatus according to the present invention will be described in Examples.
（実施例１）
本発明の電界曝露による性機能障害治療及び改善方法の有効性を確認するために、マウスによる実験を行った。Ｃ５７ＢＬ／６Ｊ系雄性マウス（５週齢、体重：１７〜２０ｇ）６０匹、同系の雌性マウス（７週齢、体重：１８〜２１ｇ）６０匹を日本クレア株式会社より入手した。ＳＰＦ(Specific Pathogen Free)室（温度：２５±５℃、湿度：５０±５％、明期：０７：００〜１９：００）にて馴化させた後に実験に供した。Example 1
In order to confirm the effectiveness of the sexual dysfunction treatment and improvement method by electric field exposure of the present invention, experiments with mice were conducted. 60 C57BL / 6J male mice (5 weeks old, body weight: 17 to 20 g) and 60 syngeneic female mice (7 weeks old, body weight: 18 to 21 g) were obtained from CLEA Japan. The sample was acclimated in an SPF (Specific Pathogen Free) room (temperature: 25 ± 5 ° C., humidity: 50 ± 5%, light period: 07: 0 to 19:00) and then subjected to the experiment.
なお、発明者らは、これに先立ち、ＩＣＲ系雄性マウスとＣ５７ＢＬ／６Ｊ系雌性マウス、Ｃ５７ＢＬ／６Ｊ系雄性マウスとＣ５７ＢＬ／６Ｊ系雌性マウスの２組に対する交配実験を行った。実験結果を示す表１によれば、ＩＣＲ系雄性マウスと比較して、Ｃ５７ＢＬ／６Ｊ系雄性マウスは交尾率が低い。よって、同マウスの交尾率が向上すれば、本発明に係る性機能障害治療及び改善方法は有効であるといえる。 Prior to this, the inventors performed a mating experiment on two sets of ICR male mice and C57BL / 6J female mice, C57BL / 6J male mice and C57BL / 6J female mice. According to Table 1 showing the experimental results, the C57BL / 6J male mouse has a low mating rate compared to the ICR male mouse. Therefore, if the mating rate of the mouse is improved, the sexual dysfunction treatment and improvement method according to the present invention can be said to be effective.
雄性マウス（Ｃ５７ＢＬ／６Ｊ系）と雌性マウス（Ｃ５７ＢＬ／６Ｊ系）の馴化期間はそれぞれ１９日（８週齢）と２９日（１１週齢）とした。 The acclimatization periods of male mice (C57BL / 6J strain) and female mice (C57BL / 6J strain) were 19 days (8 weeks old) and 29 days (11 weeks old), respectively.
電界曝露には図２に示すマウス用電界曝露装置（電界治療改善装置）を用いた。一対の電極１ａ、１ｂに交流電源２からの電圧が印加される。電極１ａはステンレス鋼（ＳＵＳ）の板で、電極１ｂは通気性のためのメッシュ状を有し、いずれの電極の大きさも６０ｃｍ四方である。電極１ａ、１ｂ間の略中央にはアクリル製の円筒状スペーサ４（直径２０ｃｍ、高さ２０ｃｍ）が挿入され、スペーサ４内に雄性マウスＭが置かれる。したがって、マウスＭに対して、電極が非接触の状態で一様な電界を曝露することができる。 For the electric field exposure, the electric field exposure apparatus for mice (electric field treatment improving apparatus) shown in FIG. 2 was used. A voltage from the AC power supply 2 is applied to the pair of electrodes 1a and 1b. The electrode 1a is a stainless steel (SUS) plate, the electrode 1b has a mesh shape for air permeability, and the size of each electrode is 60 cm square. An acrylic cylindrical spacer 4 (diameter 20 cm, height 20 cm) is inserted in the approximate center between the electrodes 1 a and 1 b, and a male mouse M is placed in the spacer 4. Therefore, a uniform electric field can be exposed to the mouse M in a state where the electrodes are not in contact with each other.
曝露条件は周波数５０Ｈｚ、電界強度４５ｋＶ／ｍ、曝露時間３０分／日で、曝露時間帯は１０：３０〜１４：００とし、これらの条件は制御部３によって制御される。対照群は電界曝露を０ｋＶ／ｍとする以外、全て曝露群と同様に扱った。 The exposure conditions are a frequency of 50 Hz, an electric field strength of 45 kV / m, an exposure time of 30 minutes / day, and an exposure time zone of 10:30 to 14:00. These conditions are controlled by the control unit 3. The control group was treated in the same manner as the exposure group except that the electric field exposure was 0 kV / m.
１１日間の電界曝露後、電界曝露群と対照群の雄性マウスは、１１日目の１７：００より同系の雌性マウスと翌日９：００まで（１６時間）同居させた。雌性マウスには、過***処理の為、交配２日前に妊馬血清性性腺刺激ホルモン（５ＩＵ）、交配直前にヒト胎盤性性腺刺激ホルモン（５ＩＵ）をそれぞれ腹腔内投与した。交尾翌日の０９：００より交尾成立の有無を膣栓検査で確認し、同日１８：００より雌性マウスを頸椎脱臼後、卵管を採取し、卵管還流によって卵を回収した。回収した卵の前核期細胞の有無（受精の有無）を確認した。この実験は、曝露群１０匹、対照群１０匹を用いて３回繰り返しおこなった（実験１〜３）。 After 11 days of electric field exposure, the male mice in the electric field exposure group and the control group were allowed to coexist with the female mice of the same line from 17:00 on the 11th day until 9:00 (16 hours) the next day. Female mice were intraperitoneally administered with pregnant maternal serum gonadotropin (5 IU) two days before mating and human placental gonadotropin (5 IU) just before mating for superovulation treatment. From 09:00 on the next day of mating, the presence or absence of mating was confirmed by vaginal plug examination. At 18:00 on the same day, female mice were dislocated from the cervical vertebrae, and the oviducts were collected and the eggs were collected by oviduct reflux. The presence or absence (presence or absence of fertilization) of pronuclear phase cells in the collected eggs was confirmed. This experiment was repeated 3 times using 10 exposed groups and 10 control groups (Experiments 1-3).
肉眼による観察では、電界曝露中及び前後に行動学的異常を含む実験区間の差異は観察されなかった。図３に曝露群、対照群それぞれのＣ５７ＢＬ／６Ｊ系マウスの体重推移における電界曝露の影響を示している。１１日間の電界曝露期間における体重推移を平均値で示した。個体数nは３０である。
図３によれば、群間の体重変動にほとんど差は認められず、同時に両群とも正常に体重増加を示していることから、本実験で用いた電界曝露はマウス個体の成長に影響を及ぼしていないことが認められる。In the observation with the naked eye, no difference was observed in the experimental section including behavioral abnormalities during and after exposure to the electric field. FIG. 3 shows the influence of electric field exposure on the weight transition of C57BL / 6J mice in each of the exposure group and the control group. The body weight change during the electric field exposure period of 11 days was shown as an average value. The number n of individuals is 30.
According to FIG. 3, there is almost no difference in the weight fluctuation between the groups, and both groups showed normal weight gain at the same time. Therefore, the electric field exposure used in this experiment had an influence on the growth of the individual mice. It is recognized that it is not.
交尾の成立率(総合評価)を表２に示す。表３は実験１〜３の各実験における交尾の成立結果を示している。交尾成立の翌日に交尾成立を認めた雌性マウスの割合は、電界曝露群９０％に対し、対照群６３％を示した（student’s t test，Ｐ＜０．０５）。
なお、表２及び表３中、電界曝露群及び対照群のそれぞれについての交尾成立、交尾不成立の固体数を示しており、括弧内は同固体数のそれぞれの割合（比率）を示している。Table 2 shows the mating establishment rate (overall evaluation). Table 3 shows the results of mating in each of the experiments 1 to 3. The percentage of female mice that were found to be mated the day after mating was established was 63% of the control group compared to 90% of the electric field exposure group (student's test, P <0.05).
In Tables 2 and 3, the number of solids with or without mating for each of the electric field exposure group and the control group is shown, and the ratio (ratio) of the number of solids is shown in parentheses.
受精卵率(総合評価)を表４に示す。表５は実験１〜３の各実験における受精卵率を示している。表４より、交尾日の翌日に受精卵子が得られた雌性マウス割合は、電界曝露群８６．７％に対し、対照群５６．７％を示した（student’s t test，Ｐ＜０．０５）。 The fertilized egg rate (overall evaluation) is shown in Table 4. Table 5 shows the fertilized egg rate in each experiment of Experiments 1-3. From Table 4, the ratio of female mice from which fertilized eggs were obtained on the day after the mating day was 56.7% in the control group compared to 86.7% in the electric field exposure group (student's t test, P <0.05). .
（実施例２）
Ｃ５７ＢＬ／６Ｊ系雄性マウス（７週齢）、同系の雌性マウス（７週齢）、ＩＣＲ系雄性マウス（７週齢）を業者より入手した。これらのマウスは全てポリカーボネートのケージに入れて特定の病原菌のない状態で飼育した。照明を調整（７：００〜１９：００まで点灯）し、空調で温度・湿度（温度２４±１℃、湿度５０±１０％）を調整した。これらのマウスは、電界曝露時間を除いては自由に行動させ、帯広畜産大学の実験動物ガイドラインに従い飼育された。(Example 2)
C57BL / 6J male mice (7 weeks old), syngeneic female mice (7 weeks old), and ICR male mice (7 weeks old) were obtained from a vendor. All of these mice were kept in polycarbonate cages free of specific pathogens. The lighting was adjusted (lights up from 7:00 to 19:00), and the temperature and humidity (temperature 24 ± 1 ° C., humidity 50 ± 10%) were adjusted by air conditioning. These mice were allowed to move freely except for the electric field exposure time, and were bred according to the laboratory animal guidelines of Obihiro University of Agriculture and Veterinary Medicine.
図４に、本実施例に使用した電界曝露システムを示す。電界曝露システムは高電圧ユニット（ヘルストロン、最大出力９０００Ｖ、株式会社白寿生科学研究所製、日本国東京）、定電圧ユニット（東京精電社製、日本国東京）、電界曝露ケージの３つの主要な部分から構成される。図５に示すように電界曝露ケージは円筒状のプラスチックケージ（直径２００ｍｍ、高さ２００ｍｍ）、プラスチックケージの上下においたステンレススチール製の２つの電極(４００×４００ｍｍ)を含んでいる。円筒状のケージには５ｍｍ間隔でスリットがついている（長さ：１００ｍｍ、幅：５ｍｍ）。スリットは、安定した電界形成の妨げとなる糞便や唾液などの汚れを防止する。ケージに電界（５０Ｈｚ、４５ｋＶ／ｍ）を発生させるため、安定した交流(５０Ｈｚ、９０００Ｖ)が上電極に供給されるようにした。 FIG. 4 shows the electric field exposure system used in this example. The electric field exposure system has three main components: a high-voltage unit (Healthtron, maximum output 9000 V, manufactured by Hakuju Bioscience Institute, Tokyo, Japan), a constant voltage unit (manufactured by Tokyo Seiden, Tokyo, Japan), and an electric field exposure cage. It consists of various parts. As shown in FIG. 5, the electric field exposure cage includes a cylindrical plastic cage (diameter 200 mm, height 200 mm), and two stainless steel electrodes (400 × 400 mm) placed above and below the plastic cage. The cylindrical cage has slits at intervals of 5 mm (length: 100 mm, width: 5 mm). The slits prevent contamination such as feces and saliva that hinders stable electric field formation. In order to generate an electric field (50 Hz, 45 kV / m) in the cage, a stable alternating current (50 Hz, 9000 V) was supplied to the upper electrode.
（実験手順）
雄性マウス（３０匹）を電界ケージに入れ、１日３０分、計１１日間にわたり５０Ｈｚ、４５ｋＶ／ｍにて電界曝露させた。最終的な電界曝露の後、雄性マウスを過***処理した雌性マウス（３０匹）のケージに入れ、交尾させた。交配２日前に５ＩＵの妊馬血清性性腺刺激ホルモン（ｅＣＧ；Ｓｅｒｏｔｒｏｐｈｉｎ、帝国臓器製薬社製、日本国東京）、交配直前に５ＩＵのヒト胎盤性性腺刺激ホルモン（ｈＣＧ；Ｐｕｂｅｒｏｇｅｎ、三共株式会社社製、日本国東京）をそれぞれ雌性マウスの腹腔内に投与し、過***を誘引した。コントロールとして、雄性マウスを１日３０分計１１日間、電界曝露していない状態の電界ケージに入れた後、過***処理した雌性マウス（３０匹）と交尾させた。交尾の成立は交尾の翌朝、膣栓の有無をチェックして確認した。(Experimental procedure)
Male mice (30 mice) were placed in an electric field cage and exposed to an electric field at 50 Hz and 45 kV / m for 30 minutes per day for a total of 11 days. After the final electric field exposure, male mice were placed in the cages of superovulated female mice (30 mice) and mated. Two days before mating, 5 IU of pregnant mare serum gonadotropin (eCG; Serotrophin, manufactured by Imperial Organ Pharmaceuticals, Tokyo, Japan), 5 IU of human placenta gonadotropin (hCG; Puberogen, Sankyo Co., Ltd.) just before mating , Tokyo, Japan) was administered intraperitoneally to female mice to induce superovulation. As a control, male mice were placed in an electric field cage that was not exposed to an electric field for 30 minutes a day for a total of 11 days, and then mated with superovulated female mice (30 mice). The establishment of mating was confirmed by checking the presence or absence of vaginal plugs the morning after mating.
（統計分析）
本実施例のデータをカイ二乗法により統計的に分析した。全ての統計テストにおいて、ｐ＜０．０５の場合、有意差があるとした。(Statistical analysis)
The data of this example was statistically analyzed by the chi-square method. In all statistical tests, there was a significant difference when p <0.05.
（実験結果）
電界曝露がない場合、Ｃ５７ＢＬ／６Ｊ系の雄性マウスと過***処理された雌性マウスとの交尾率は、ＩＣＲ系の雄性マウスと過***処理された雌性マウスとの交尾率に比較して有意に低かった。すなわち、ＩＣＲ系の雄性マウスと過***処理された雌性マウスとを交尾させると、Ｃ５７ＢＬ／６Ｊ系の雌性マウス全てに膣栓が確認された。一方、Ｃ５７ＢＬ／６Ｊ系の雄性マウスと交尾させたＣ５７ＢＬ／６Ｊ系の雌性マウスのうち、約半数（５１％）において膣栓が確認された。これらの結果は、Ｃ５７ＢＬ／６Ｊ系マウスにおける交尾率の低さの原因は、メスよりもむしろオスの生殖能力によることは、明らかである。(Experimental result)
In the absence of electric field exposure, the mating rate between C57BL / 6J male mice and superovulated female mice was significantly greater than the mating rate between ICR male mice and superovulated female mice. It was low. That is, when ICR male mice and superovulated female mice were mated, vaginal plugs were confirmed in all C57BL / 6J female mice. On the other hand, vaginal plugs were confirmed in about half (51%) of C57BL / 6J female mice mated with C57BL / 6J male mice. These results clearly indicate that the cause of the low mating rate in C57BL / 6J mice is due to male fertility rather than females.
電界曝露によるＣ５７ＢＬ／６Ｊ系の雄性マウスと過***処理された雌性マウスとの交尾率への効果は、顕著であった。表６に示すように、交尾の前に５０Ｈｚの電界曝露を１１日間行い、過***処理された雌性マウスのケージに入れると交尾成功率は９０％であった。コントロール（電界曝露しない）のＣ５７ＢＬ／６Ｊ系の雄性マウスと一緒に入れた過***処理されたメスの６３％に膣栓があった。この差は、統計的に有意である（Ｐ＜０．０５）。 The effect on the mating rate of C57BL / 6J male mice and superovulated female mice by electric field exposure was remarkable. As shown in Table 6, the 50% electric field exposure was carried out for 11 days before mating, and the mating success rate was 90% when placed in the cage of a female mouse subjected to superovulation treatment. There was a vaginal plug in 63% of superovulated females placed in control (no electric field exposure) C57BL / 6J male mice. This difference is statistically significant (P <0.05).
なお、本実施例に使用された雄性マウスは、電界曝露中及び曝露後において、病気の兆候や異常な行動をみせなかった。膣栓ポジティブの雌性マウスにおいて見られた卵母細胞における受精率は実験グループ間（電界曝露の有無）で統計上誤差はなかった（Ｐ＞０．０５）。 The male mice used in this example did not show signs of disease or abnormal behavior during and after electric field exposure. The fertilization rate in oocytes seen in vaginal plug-positive female mice was not statistically error between experimental groups (with or without electric field exposure) (P> 0.05).
交尾率を改善するため必要な電界曝露時間を特定するために、Ｃ５７ＢＬ／６Ｊ系の雄性マウスを５０Ｈｚ、４５ｋＶ／ｍの電界に１日３０分計１、３、１１日曝露させた。その後、過***されたＣ５７ＢＬ／６Ｊ系の雌性マウスと交尾させた。図６によれば、Ｃ５７ＢＬ／６Ｊ系の雄性マウスが１１日間電界曝露されたとき、表６に示した結果と同様に、Ｃ５７ＢＬ／６Ｊ系の雌性マウスとの交尾率は著しく改善された（Ｐ＜０．０５）。しかし、、Ｃ５７ＢＬ／６Ｊ系の雄性マウスへの１日、３日の電界曝露は、電界曝露しなかった場合と比較しても、過***されたＣ５７ＢＬ／６Ｊ系の雌性マウスとの交尾率を著しく改善するものではなかった。この結果は、過***された雌性マウスとＣ５７ＢＬ／６Ｊ系の雌性マウスとの交尾率の改善には電界曝露の累積的効果が必要であることを示唆している。 In order to specify the electric field exposure time required to improve the mating rate, C57BL / 6J male mice were exposed to an electric field of 50 Hz and 45 kV / m for 30 minutes per day for a total of 1, 3 and 11 days. Thereafter, they were mated with superovulated C57BL / 6J female mice. According to FIG. 6, when C57BL / 6J male mice were exposed to an electric field for 11 days, similar to the results shown in Table 6, the mating rate with C57BL / 6J female mice was significantly improved (P <0.05). However, 1-day and 3-day electric field exposure to male C57BL / 6J mice resulted in a higher mating rate with superovulated C57BL / 6J female mice than when no electric field exposure was performed. It was not a significant improvement. This result suggests that the cumulative effect of electric field exposure is required to improve the mating rate between superovulated female mice and C57BL / 6J female mice.
過***されたＣ５７ＢＬ／６Ｊ系の雌性マウスと一緒にしたＣ５７ＢＬ／６Ｊ系の雄性マウスにおいて見受けられた低い交尾率が、自然に***したメスと一緒にした場合には見出せなかった理由はいまだに解明されていない。しかしながら、この低い成功率は発生学、生物発生学における研究の向上同様、卵母細胞、胚の十分な採集における困難性の一理由である。本発明において、Ｃ５７ＢＬ／６Ｊ系の雄性マウスへの電界曝露が過***された雌性マウスとの交尾率を改善させたことを明確化した（表６、図６）。 The reasons why the low mating rate found in C57BL / 6J male mice combined with superovulated C57BL / 6J female mice could not be found when combined with naturally ovulated females are still elucidated. It has not been. However, this low success rate is one of the reasons for the difficulty in fully collecting oocytes and embryos, as well as improved research in embryology and biogenesis. In the present invention, it was clarified that electric field exposure to C57BL / 6J male mice improved the mating rate with superovulated female mice (Table 6, FIG. 6).
電界曝露は細胞シグナル同様、内分泌機能、免疫機能に影響を及ぼすことが示唆されている。電界を利用する種々の医療機器が広範に使用されていることから、経皮の電気的神経刺激が、軟組織に働きかけて慢性腰痛などの患者に有益であることが示唆されてきた。さらに皮膚への機械による振動（５〜５０Ｈｚ）が刺激部位に応じて主要な皮質ニューロンを活性化することが報告された。さらには、より最近の事例であるが、頭痛、肩こり、腹痛などの種々の痛みに対する電界治療の改善的な効果は、１０００以上の臨床事例にて報告されている。しかしながら、生殖機能における電界曝露の効果に関しては、一部の毒物研究を除いてはいままで報告がなかった。表６及び図６に示すようにＣ５７ＢＬ／６Ｊ系の雄性マウスを電界曝露することで、その累積的な効果から、過***されたマウスとの交尾率が著しく改善した。この結果は、電界曝露の治療が加齢や慢性疾患による男性の性的機能の向上に寄与する可能性を示唆している。 Electric field exposure has been suggested to affect endocrine and immune functions as well as cellular signals. Various medical devices using electric fields have been widely used, and it has been suggested that transcutaneous electrical nerve stimulation works on soft tissues and is beneficial to patients such as chronic low back pain. Furthermore, it was reported that mechanical vibrations (5-50 Hz) to the skin activate major cortical neurons depending on the stimulation site. Furthermore, as a more recent example, the improving effect of electric field treatment on various pains such as headache, stiff shoulders and abdominal pain has been reported in more than 1000 clinical cases. However, there have been no reports on the effects of electric field exposure on reproductive function, except for some toxicological studies. As shown in Table 6 and FIG. 6, exposure of C57BL / 6J male mice to an electric field significantly improved the mating rate with superovulated mice due to its cumulative effect. This result suggests that the treatment of electric field exposure may contribute to the improvement of sexual function in men due to aging and chronic diseases.
電界曝露のＣ５７ＢＬ／６Ｊ系の雄性マウスにみられた生殖能力の改善がおきるメカニズムを明確にするには、さらなる研究が必要である。種を超えた研究も種全体に効果があるのか特定の条件下のマウスにのみ効果があるのか見極める上で重要である。種全体に効果がある場合は、電界曝露のヒトへの応用の可能性がある。 Further studies are needed to clarify the mechanism of reproductive improvements seen in electric field exposed C57BL / 6J male mice. Cross-species studies are important in determining whether an entire species is effective or only in mice under certain conditions. If the whole species is effective, there is potential for human exposure to electric field exposure.
以上より、電界曝露群では対照群と比較して統計学的に有意な交尾成立を観察した。すなわち、交尾率が低いＣ５７ＢＬ／６Ｊ系雄性マウスに対して、電界曝露による交配行動の増加及び受精卵率を示した。したがって、本発明に係る性機能障害治療及び改善方法は有効であるといえる。 Based on the above, statistically significant mating was observed in the electric field exposure group compared to the control group. That is, C57BL / 6J male mice with low mating rate showed increased mating behavior and fertilized egg rate due to electric field exposure. Therefore, it can be said that the sexual dysfunction treatment and improvement method according to the present invention is effective.
本発明は、電界曝露による非薬理学的手法により雄性動物の性機能を制御することができ、性機能障害を治療又は改善することができ、並びに動物の性行動を制御することが可能となる。従って、ヒトのみならず、ウマ、マウスなどの雄性動物の性機能障害を治療又は改善することができる。また、雄雌問わず、当該動物の繁殖を制御することができる。
The present invention can control the sexual function of a male animal by a non-pharmacological technique using electric field exposure, can treat or improve sexual dysfunction, and can control the sexual behavior of an animal. . Therefore, it is possible to treat or improve sexual dysfunction not only in humans but also in male animals such as horses and mice. In addition, the reproduction of the animal can be controlled regardless of whether it is male or female.
Claims (20)
One of the pair of electrodes is disposed above the human head by an electrode support portion extending from a backrest portion of the chair, and the other of the pair of electrodes is disposed on the footrest portion. Item 20. A reproductive function control device according to item 19.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003402739 | 2003-12-02 | ||
| JP2003402739 | 2003-12-02 | ||
| PCT/JP2004/017942 WO2005053790A1 (en) | 2003-12-02 | 2004-12-02 | Nonpharmacological generative function control method and its apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPWO2005053790A1 true JPWO2005053790A1 (en) | 2007-06-28 |
Family
ID=34650040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005515961A Pending JPWO2005053790A1 (en) | 2003-12-02 | 2004-12-02 | Non-pharmacological reproductive function control method and apparatus |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070287937A1 (en) |
| EP (1) | EP1695735A1 (en) |
| JP (1) | JPWO2005053790A1 (en) |
| KR (1) | KR20060129194A (en) |
| CN (1) | CN1886174A (en) |
| WO (1) | WO2005053790A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102652670A (en) * | 2011-03-01 | 2012-09-05 | 三维医疗科技江苏股份有限公司 | Neurophysiological male sexual function detector |
| US9149634B2 (en) * | 2012-12-03 | 2015-10-06 | Alpha Medic Co., Ltd. | Device for strengthening pelvic floor muscles and method for controlling the same |
| CN203469232U (en) * | 2013-07-11 | 2014-03-12 | 精能医学股份有限公司 | Neural-drop-sensitive transdermal stimulator |
| US9370652B2 (en) | 2013-07-24 | 2016-06-21 | Gimer Medical Co. Ltd. | Desensitizing device |
| US10335594B2 (en) | 2013-07-24 | 2019-07-02 | GiMer Medical Co., Ltd. | Desensitizing device |
| WO2015111656A1 (en) * | 2014-01-24 | 2015-07-30 | 独立行政法人情報通信研究機構 | Electric-field detection output device, electric-field adjustment system, and electric-field adjustment method |
| JP2021053037A (en) * | 2019-09-30 | 2021-04-08 | テルモ株式会社 | Medical appliance |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0661253U (en) * | 1993-01-28 | 1994-08-30 | 株式会社白寿生科学研究所 | Potential therapy device |
| JP2002113115A (en) * | 2000-05-18 | 2002-04-16 | Seung Kee Mo | Electrotherapeutical device utilizing variant system |
| JP3090043U (en) * | 2002-05-16 | 2002-11-22 | 瑞光 楊 | Close-fitting trouser structure that can train human genital muscles |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6167304A (en) * | 1993-05-28 | 2000-12-26 | Loos; Hendricus G. | Pulse variability in electric field manipulation of nervous systems |
| GB9301192D0 (en) * | 1993-06-09 | 1993-06-09 | Trott Francis W | Flower shaped mechanised table |
-
2004
- 2004-12-02 WO PCT/JP2004/017942 patent/WO2005053790A1/en active Application Filing
- 2004-12-02 CN CNA2004800352382A patent/CN1886174A/en active Pending
- 2004-12-02 EP EP04819894A patent/EP1695735A1/en not_active Withdrawn
- 2004-12-02 US US10/581,110 patent/US20070287937A1/en not_active Abandoned
- 2004-12-02 JP JP2005515961A patent/JPWO2005053790A1/en active Pending
- 2004-12-02 KR KR1020067009824A patent/KR20060129194A/en not_active Application Discontinuation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0661253U (en) * | 1993-01-28 | 1994-08-30 | 株式会社白寿生科学研究所 | Potential therapy device |
| JP2002113115A (en) * | 2000-05-18 | 2002-04-16 | Seung Kee Mo | Electrotherapeutical device utilizing variant system |
| JP3090043U (en) * | 2002-05-16 | 2002-11-22 | 瑞光 楊 | Close-fitting trouser structure that can train human genital muscles |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1695735A1 (en) | 2006-08-30 |
| WO2005053790A1 (en) | 2005-06-16 |
| CN1886174A (en) | 2006-12-27 |
| US20070287937A1 (en) | 2007-12-13 |
| KR20060129194A (en) | 2006-12-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Beach | A review of physiological and psychological studies of sexual behavior in mammals | |
| Post et al. | Transcranial magnetic stimulation as a therapeutic tool in psychiatry: what do we know about the neurobiological mechanisms? | |
| Slimp et al. | Heterosexual, autosexual and social behavior of adult male rhesus monkeys with medial preoptic-anterior hypothalamic lesions | |
| Beach | Evolutionary changes in the physiological control of mating behavior in mammals. | |
| Clark et al. | Handbook of nitrous oxide and oxygen sedation | |
| Baum et al. | Increased expression of c-fos in the medial preoptic area after mating in male rats: role of afferent inputs from the medial amygdala and midbrain central tegmental field | |
| Sandercock et al. | The impact of prenatal stress on basal nociception and evoked responses to tail-docking and inflammatory challenge in juvenile pigs | |
| Chan et al. | Acupuncture for general veterinary practice | |
| Hesselberg et al. | Antidepressant efficacy of high and low frequency transcranial magnetic stimulation in the FSL/FRL genetic rat model of depression | |
| Buetefisch et al. | Neuroprotection of Low‐Frequency Repetitive Transcranial Magnetic Stimulation after Ischemic Stroke in Rats | |
| JPWO2005053790A1 (en) | Non-pharmacological reproductive function control method and apparatus | |
| Romano et al. | Continuous presence of male on estrus onset, estrus duration, and ovulation in estrus-synchronized Boer goats | |
| Schaffer et al. | Viable spermatozoa in the bladder after electroejaculation of lion-tailed macaques (Macaca silenus) | |
| Wen et al. | Parameter optimization analysis of prolonged analgesia effect of tDCS on neuropathic pain rats | |
| Prunier et al. | Evidence of pain in piglets subjected to invasive management procedures | |
| Bianca et al. | Pupil dilatation in response to vagal afferent electrical stimulation is mediated by inhibition of parasympathetic outflow in the rat | |
| RU2471473C2 (en) | Method for providing higher clinical effectiveness in cow's ovarian hypofunction | |
| RU2404827C1 (en) | Method of reducing frequency of urgency incontinence in women | |
| Johnson | Laser therapy and pain management | |
| Kobayashi et al. | Therapeutic Effect of Magnetic Stimulation Therapy on Pelvic Floor Muscle Dysfunction | |
| Fitria et al. | Innovation relaxation belts to reduce labor pain itensity and increase β-endoprhine levels | |
| KLING | The anatomy of aggression and affiliation | |
| RU2066535C1 (en) | Method for normalizing sow lactation function | |
| Steadman | The effect of spinal cord injury on sexual function. | |
| Gülanber | The clinical effectiveness and application of veterinary acupuncture |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20071130 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20071206 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100714 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20101108 |