JPS6461489A - Production of synthetic lecithin - Google Patents

Production of synthetic lecithin

Info

Publication number
JPS6461489A
JPS6461489A JP21776387A JP21776387A JPS6461489A JP S6461489 A JPS6461489 A JP S6461489A JP 21776387 A JP21776387 A JP 21776387A JP 21776387 A JP21776387 A JP 21776387A JP S6461489 A JPS6461489 A JP S6461489A
Authority
JP
Japan
Prior art keywords
acid anhydride
acid
glycerophosphorylcholine
alpha
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP21776387A
Other languages
Japanese (ja)
Other versions
JP2546289B2 (en
Inventor
Satoru Tokuyama
Yoichi Miyamoto
Osamu Nakachi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NOF Corp
Original Assignee
Nippon Oil and Fats Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Oil and Fats Co Ltd filed Critical Nippon Oil and Fats Co Ltd
Priority to JP62217763A priority Critical patent/JP2546289B2/en
Publication of JPS6461489A publication Critical patent/JPS6461489A/en
Application granted granted Critical
Publication of JP2546289B2 publication Critical patent/JP2546289B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)

Abstract

PURPOSE:To obtain the titled compound useful as an emulsifying agent industrially and advantageously, by reacting a carboxylic acid with a carbodiimide in a nonpolar solvent to form an acid anhydride and reacting the acid anhydride with pulverized L-alpha-glycerophosphorylcholine in the presence of a base. CONSTITUTION:An acid (e.g. myristic acid) shown by the formula RCOOH (R is 9-21C hydrocarbon) is reacted with N,N'-dicyclohexylcarbodiimide in a nonpolar solvent to form an acid anhydride shown by the formula (RCO)2O. Then the acid anhydride is reacted with pulverized L-alpha-glycerophosphorylcholine in a nonpolar solvent in the presence of a basic catalyst (e.g. N,N'-dimethyl-4- aminopyridine) to give the aimed lecithin shown by the formula. The diameter of the fine particles of L-alpha-glycerophosphorylcholine is preferably <=500mu.
JP62217763A 1987-09-02 1987-09-02 Method for producing synthetic lecithin Expired - Fee Related JP2546289B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62217763A JP2546289B2 (en) 1987-09-02 1987-09-02 Method for producing synthetic lecithin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62217763A JP2546289B2 (en) 1987-09-02 1987-09-02 Method for producing synthetic lecithin

Publications (2)

Publication Number Publication Date
JPS6461489A true JPS6461489A (en) 1989-03-08
JP2546289B2 JP2546289B2 (en) 1996-10-23

Family

ID=16709351

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62217763A Expired - Fee Related JP2546289B2 (en) 1987-09-02 1987-09-02 Method for producing synthetic lecithin

Country Status (1)

Country Link
JP (1) JP2546289B2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102595126B1 (en) * 2022-09-27 2023-10-30 하나제약 주식회사 Methods for the synthesis of choline alfoscerate ester derivatives and use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62181287A (en) * 1986-02-06 1987-08-08 Nippon Oil & Fats Co Ltd Production of phosphatidylcholine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62181287A (en) * 1986-02-06 1987-08-08 Nippon Oil & Fats Co Ltd Production of phosphatidylcholine

Also Published As

Publication number Publication date
JP2546289B2 (en) 1996-10-23

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Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees