JPS6452717A - Piperidine derivative, remedy and preventive for arrhythmia containing said derivative - Google Patents
Piperidine derivative, remedy and preventive for arrhythmia containing said derivativeInfo
- Publication number
- JPS6452717A JPS6452717A JP20972887A JP20972887A JPS6452717A JP S6452717 A JPS6452717 A JP S6452717A JP 20972887 A JP20972887 A JP 20972887A JP 20972887 A JP20972887 A JP 20972887A JP S6452717 A JPS6452717 A JP S6452717A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound shown
- derivative
- arrhythmia
- reacted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A piperidine derivative shown by formula I (R<1> is lower alkyl; R<2> is H, halogen, lower alkyl, lower alkoxy or hydroxyl) sand a salt thereof. EXAMPLE:N-[4-(2-Hydroxyl-1-[4-(4-fluorobenzoyl)piperidyl] ethyl]phenyl]metha nesulfonamide hydrochloride. USE:Having excellent antiarrhythmic activity and high safety, useful as an antiarrhythmic. Especially effective against arrhythmia ineffective by other drugs or against incurable arrhythmia and also usable for preventing human sudden death caused by ventricular fibrillation. PREPARATION:A compound shown by formula II is reduced with a reducing agent such as sodium boron in a solvent at -20 deg.C - room temperature to give a compound shown by formula III. Then this compound is reacted with a compound shown by formula IV and the reaction product is reacted with a halide to give a compound shown by formula I.
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62209728A JP2584454B2 (en) | 1987-08-24 | 1987-08-24 | Piperidine derivative and arrhythmia therapeutic / prophylactic agent containing the same |
PH37372A PH25458A (en) | 1987-08-24 | 1988-08-09 | Piperidine derivatives, therapeutic, preventive agents |
US07/234,468 US4977165A (en) | 1987-08-24 | 1988-08-19 | Piperidine derivative and therapeutic and preventive agents for arrhythmia containing same |
NO88883750A NO883750L (en) | 1987-08-24 | 1988-08-22 | PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PIPERIDE INGREDIENTS. |
CA000575436A CA1263658A (en) | 1987-08-24 | 1988-08-23 | N-(substituted phenyl)alkanesulfonamide derivatives |
DK470488A DK470488A (en) | 1987-08-24 | 1988-08-23 | PIPERIDIN DERIVATIVES AND PHARMACEUTICAL PREPARATIONS M OD ARRHYTHMY WITH CONTENTS |
HU884430A HU207043B (en) | 1987-08-24 | 1988-08-23 | Process for producing sulfonamide derivatives and pharmaceutical compositions comprising such compounds |
KR1019880010711A KR910002581B1 (en) | 1987-08-24 | 1988-08-23 | Piperidine derivatives and therapeutic preventive agents for arrhythmia containing same |
EP88113786A EP0304888B1 (en) | 1987-08-24 | 1988-08-24 | Sulfonamidolphenyl derivates and therapeutic and preventive agents for arrythmia containing same |
ES88113786T ES2045044T3 (en) | 1987-08-24 | 1988-08-24 | DERIVATIVES OF SULFONAMIDOLFENILO AND THERAPEUTIC AGENTS AND PREVENTIVES OF THE ARRHYTHMIA THAT THEY CONTAIN. |
AT88113786T ATE82263T1 (en) | 1987-08-24 | 1988-08-24 | SULFONAMIDOLPHENYL DERIVATIVES AND CONTAINING THERMAL THERAPEUTIC AND PREVENTIVE AGENT AGAINST ARRHYTHMIA. |
DE8888113786T DE3875866T2 (en) | 1987-08-24 | 1988-08-24 | SULFONAMIDOLPHENYL DERIVATIVES AND THERAPEUTIC AND PREVENTIVE AGENTS AGAINST ARRHYTHMIA. |
US07/571,313 US5082850A (en) | 1987-08-24 | 1990-08-22 | Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same |
US07/703,208 US5162347A (en) | 1987-08-24 | 1991-05-20 | Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same |
US07/930,727 US5246946A (en) | 1987-08-24 | 1992-08-14 | Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same |
GR920402142T GR3006380T3 (en) | 1987-08-24 | 1992-11-30 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62209728A JP2584454B2 (en) | 1987-08-24 | 1987-08-24 | Piperidine derivative and arrhythmia therapeutic / prophylactic agent containing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6452717A true JPS6452717A (en) | 1989-02-28 |
JP2584454B2 JP2584454B2 (en) | 1997-02-26 |
Family
ID=16577656
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP62209728A Expired - Lifetime JP2584454B2 (en) | 1987-08-24 | 1987-08-24 | Piperidine derivative and arrhythmia therapeutic / prophylactic agent containing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP2584454B2 (en) |
-
1987
- 1987-08-24 JP JP62209728A patent/JP2584454B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2584454B2 (en) | 1997-02-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313111 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
EXPY | Cancellation because of completion of term | ||
FPAY | Renewal fee payment (prs date is renewal date of database) |
Year of fee payment: 11 Free format text: PAYMENT UNTIL: 20071121 |