JPS6452717A - Piperidine derivative, remedy and preventive for arrhythmia containing said derivative - Google Patents

Piperidine derivative, remedy and preventive for arrhythmia containing said derivative

Info

Publication number
JPS6452717A
JPS6452717A JP20972887A JP20972887A JPS6452717A JP S6452717 A JPS6452717 A JP S6452717A JP 20972887 A JP20972887 A JP 20972887A JP 20972887 A JP20972887 A JP 20972887A JP S6452717 A JPS6452717 A JP S6452717A
Authority
JP
Japan
Prior art keywords
formula
compound shown
derivative
arrhythmia
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP20972887A
Other languages
Japanese (ja)
Other versions
JP2584454B2 (en
Inventor
Hitoshi Oinuma
Motosuke Yamanaka
Kazutoshi Miyake
Tomonori Hoshiko
Norio Minami
Tadao Shoji
Yoshiharu Daiku
Kohei Sawada
Kenichi Nomoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Priority to JP62209728A priority Critical patent/JP2584454B2/en
Priority to PH37372A priority patent/PH25458A/en
Priority to US07/234,468 priority patent/US4977165A/en
Priority to NO88883750A priority patent/NO883750L/en
Priority to KR1019880010711A priority patent/KR910002581B1/en
Priority to CA000575436A priority patent/CA1263658A/en
Priority to DK470488A priority patent/DK470488A/en
Priority to HU884430A priority patent/HU207043B/en
Priority to EP88113786A priority patent/EP0304888B1/en
Priority to ES88113786T priority patent/ES2045044T3/en
Priority to AT88113786T priority patent/ATE82263T1/en
Priority to DE8888113786T priority patent/DE3875866T2/en
Publication of JPS6452717A publication Critical patent/JPS6452717A/en
Priority to US07/571,313 priority patent/US5082850A/en
Priority to US07/703,208 priority patent/US5162347A/en
Priority to US07/930,727 priority patent/US5246946A/en
Priority to GR920402142T priority patent/GR3006380T3/el
Application granted granted Critical
Publication of JP2584454B2 publication Critical patent/JP2584454B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A piperidine derivative shown by formula I (R<1> is lower alkyl; R<2> is H, halogen, lower alkyl, lower alkoxy or hydroxyl) sand a salt thereof. EXAMPLE:N-[4-(2-Hydroxyl-1-[4-(4-fluorobenzoyl)piperidyl] ethyl]phenyl]metha nesulfonamide hydrochloride. USE:Having excellent antiarrhythmic activity and high safety, useful as an antiarrhythmic. Especially effective against arrhythmia ineffective by other drugs or against incurable arrhythmia and also usable for preventing human sudden death caused by ventricular fibrillation. PREPARATION:A compound shown by formula II is reduced with a reducing agent such as sodium boron in a solvent at -20 deg.C - room temperature to give a compound shown by formula III. Then this compound is reacted with a compound shown by formula IV and the reaction product is reacted with a halide to give a compound shown by formula I.
JP62209728A 1987-08-24 1987-08-24 Piperidine derivative and arrhythmia therapeutic / prophylactic agent containing the same Expired - Lifetime JP2584454B2 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
JP62209728A JP2584454B2 (en) 1987-08-24 1987-08-24 Piperidine derivative and arrhythmia therapeutic / prophylactic agent containing the same
PH37372A PH25458A (en) 1987-08-24 1988-08-09 Piperidine derivatives, therapeutic, preventive agents
US07/234,468 US4977165A (en) 1987-08-24 1988-08-19 Piperidine derivative and therapeutic and preventive agents for arrhythmia containing same
NO88883750A NO883750L (en) 1987-08-24 1988-08-22 PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PIPERIDE INGREDIENTS.
CA000575436A CA1263658A (en) 1987-08-24 1988-08-23 N-(substituted phenyl)alkanesulfonamide derivatives
DK470488A DK470488A (en) 1987-08-24 1988-08-23 PIPERIDIN DERIVATIVES AND PHARMACEUTICAL PREPARATIONS M OD ARRHYTHMY WITH CONTENTS
HU884430A HU207043B (en) 1987-08-24 1988-08-23 Process for producing sulfonamide derivatives and pharmaceutical compositions comprising such compounds
KR1019880010711A KR910002581B1 (en) 1987-08-24 1988-08-23 Piperidine derivatives and therapeutic preventive agents for arrhythmia containing same
EP88113786A EP0304888B1 (en) 1987-08-24 1988-08-24 Sulfonamidolphenyl derivates and therapeutic and preventive agents for arrythmia containing same
ES88113786T ES2045044T3 (en) 1987-08-24 1988-08-24 DERIVATIVES OF SULFONAMIDOLFENILO AND THERAPEUTIC AGENTS AND PREVENTIVES OF THE ARRHYTHMIA THAT THEY CONTAIN.
AT88113786T ATE82263T1 (en) 1987-08-24 1988-08-24 SULFONAMIDOLPHENYL DERIVATIVES AND CONTAINING THERMAL THERAPEUTIC AND PREVENTIVE AGENT AGAINST ARRHYTHMIA.
DE8888113786T DE3875866T2 (en) 1987-08-24 1988-08-24 SULFONAMIDOLPHENYL DERIVATIVES AND THERAPEUTIC AND PREVENTIVE AGENTS AGAINST ARRHYTHMIA.
US07/571,313 US5082850A (en) 1987-08-24 1990-08-22 Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same
US07/703,208 US5162347A (en) 1987-08-24 1991-05-20 Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same
US07/930,727 US5246946A (en) 1987-08-24 1992-08-14 Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same
GR920402142T GR3006380T3 (en) 1987-08-24 1992-11-30

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62209728A JP2584454B2 (en) 1987-08-24 1987-08-24 Piperidine derivative and arrhythmia therapeutic / prophylactic agent containing the same

Publications (2)

Publication Number Publication Date
JPS6452717A true JPS6452717A (en) 1989-02-28
JP2584454B2 JP2584454B2 (en) 1997-02-26

Family

ID=16577656

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62209728A Expired - Lifetime JP2584454B2 (en) 1987-08-24 1987-08-24 Piperidine derivative and arrhythmia therapeutic / prophylactic agent containing the same

Country Status (1)

Country Link
JP (1) JP2584454B2 (en)

Also Published As

Publication number Publication date
JP2584454B2 (en) 1997-02-26

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