JPS644789B2 - - Google Patents
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- Publication number
- JPS644789B2 JPS644789B2 JP18748586A JP18748586A JPS644789B2 JP S644789 B2 JPS644789 B2 JP S644789B2 JP 18748586 A JP18748586 A JP 18748586A JP 18748586 A JP18748586 A JP 18748586A JP S644789 B2 JPS644789 B2 JP S644789B2
- Authority
- JP
- Japan
- Prior art keywords
- blood
- header
- hollow fiber
- processing device
- continuous helical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008280 blood Substances 0.000 claims description 99
- 210000004369 blood Anatomy 0.000 claims description 99
- 239000012510 hollow fiber Substances 0.000 claims description 45
- 230000007423 decrease Effects 0.000 claims description 5
- 230000017531 blood circulation Effects 0.000 claims description 4
- 208000007536 Thrombosis Diseases 0.000 description 4
- 238000009825 accumulation Methods 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 238000005192 partition Methods 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 238000009563 continuous hemofiltration Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000001631 haemodialysis Methods 0.000 description 2
- 230000000322 hemodialysis Effects 0.000 description 2
- 238000002615 hemofiltration Methods 0.000 description 2
- 230000002685 pulmonary effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000000108 ultra-filtration Methods 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 239000011796 hollow space material Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920005749 polyurethane resin Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
Description
（産業上の利用分野）
本発明は改良された血液入口ヘツダを有する中
空繊維型血液処理装置に関するものである。
（従来の技術）
従来より中空繊維を用いた血液処理装置は、血
液透析装置、人工肝臓装置、血液濾過装置、血漿
分離装置、あるいは人工肺装置として広く用いら
れている。
このような血液処理装置（血液濾過装置）とし
て、通常第４図に示すような血液導入出口が軸対
称位置に設けられた装置が用いられている。
第４図において、１ａは血液を中空繊維５の内
部に導き、かつ外部と隔離するための断面が円形
の血液入口ヘツダであり、血液はヘツダの上部に
設けた血液導入口２０ａよりヘツダ内に導入され
る。１ｂは中空繊維の内部を通過した血液を集合
させて血液導出口２０ｂより導出するための断面
が円形の血液出口ヘツダである。２は血液の入口
及び出口ヘツダ１ａ，１ｂをパツキン１２を介し
て、中空繊維束を固定する隔壁６に密着させるた
めの固定キヤツプである。ハウジング３は通常円
筒形であつて透明で硬質の合成樹脂（ポリプロピ
レン、ポリカーボネートなど）で作られ、その内
部には数百〜数万本程度の中空繊維５が充填され
ている。またこのハウジング３には、濾液導出口
４が設けられている。中空繊維５は、ハウジング
３内に多数本充填され、その両端はポリウレタン
樹脂などの血液適合性に優れた隔壁６で液密に固
定され、しかも中空繊維５の内部はヘツダ１ａ，
１ｂに設けられた空間と連通している。血液は血
液入口ヘツダ１ａの血液導入口２０ａより装置内
に導入され中空繊維の壁膜を介して血液中の有害
物質をハウジング３の内部に排出した後、血液出
口ヘツダ１ｂの血液導出口２を経由して体内にも
どされる。一方ハウジング３の内部に排出された
有害物質は導出口４から外部へとり出される。
また最近、各中空繊維に均一に血液を導入する
ために血液入口ヘツダに設けられた空間に接線方
向から血液を導入する血液処理装置が提案されて
いる（特公昭60−5308号、特開昭57−86361号な
ど）。第５図は、かかる装置の例であり、図中共
通のものは第１図と同一番号が付されている。こ
の装置では血液は血液入口ヘツダ１ａの外部から
内部へ向けて接線方向に開口した血液導入口２０
ａより導入されヘツダ内に設けられた空間の上端
の内壁面に沿つてラセン状に設けられた血液誘導
路１０にそつて旋回しながら下降し、中空繊維束
の切断面の外周部に達し、次いで中心に向かうラ
セン流となつて切断面から各中空繊維内部に導入
されるようになつている。
（発明が解決しようとする問題点）
しかしながら、このような従来の血液処理装置
には次のような欠点があり、特にヘバリンのよう
な抗血液凝固剤を全く使用しないか、あるいは使
用量を減らした血液透析（ノンヘパあるいは減ヘ
パ透析）や、持続的血液濾過（CAVH）、体外循
環肺補助（ECMO）などの数日におよぶ長期使
用の場合においては実用上種々の問題がある。す
なわち第４図に示す血液処理装置では構造上、血
液導入口２０ａより導入された血液は、まず中空
繊維の端面中央部に衝突し、次いで外周部の中空
繊維へ分散される。従つてヘツダの内部の空間を
流れる血液の速度は、血液の導入口の直下付近で
は大きく、周辺に向うに従つて小さくなる。その
結果、ヘツダの空間内で血液のよどみを生じ、ま
たヘツダに設けられた空間の周辺部では、血液が
停滞する恐れがある。そのため血液処理装置とし
ての性能が低下し、しかも返血する際に、返血速
度が中央部と周辺部で異なるため、周辺部に近い
中空繊維の内部や、血液がよどみをつくつた領域
に残血現象を起こす。一方、第５図に示す装置で
は、中空繊維の切断面において相対的に広い面積
を占める外周部に対して接線方向から血液が導か
れ、その後、ラセン流路の厚みが漸減するために
外周部と内周部の中空繊維内部への血液流入速度
は第４図に示す装置よりは均一に保たれ、かつ、
切断面に対して平行な血流速度も大きな値をとり
得る。しかし、ヘツダに設けられた空間での血液
の流れは、固定された流路でないため、ラセン流
路をとるものの、ハウジングに収容された中空繊
維の分布状態や、中空繊維の切断面の起伏、ヘツ
ダの血液との接触面の起伏の状態によつてかえつ
て部分的なうず流と、それに伴う血栓形成および
気泡の滞留を起し易く、しかもヘツダがかさ高く
なるため血液充填量が増加するなどの問題があつ
た。
（問題点を解決するための手段）
従つて本発明の目的は気泡の滞留や血栓、血餅
の発生が少なく、長時間連続使用しても中空繊維
の閉塞が起こらないような血液入口ヘツダを有す
る血液処理装置を提供することにある。
すなわち本発明は、一端に血液入口ヘツダと、
他端に血液出口ヘツダを備えた筒状ハウジング内
に中空繊維束が収容された中空繊維型血液処理装
置において、該血液入口ヘツダ内側に中心から周
辺部にかけて連続ラセン状溝を形成するととも
に、該連続ラセン状壁と中空繊維束の切断面との
間に、間隙を設け、該連続ラセン状溝の端部に外
部に向けて接線方向に開口する血液導入口を設け
たことを特徴とする中空繊維型血液処理装置であ
る。
（作用）
本発明の血液処理装置は、血液入口ヘツダ内側
に連続ラセン状溝が設けられているので、血液導
入口からヘツダ内に導かれた血液は、該連続ラセ
ン状溝に沿つてラセン状に回りつつ、また、連続
ラセン壁の頂部が、中空繊維束の切断面に密着し
ていないため、中空繊維束の切断面上、すなわち
全ての中空繊維の内部に導入される。その際、血
液圧は各中空繊維切断面上に均一に加わるので、
血液は一様に中空繊維内部に導入される。そのた
め、中空繊維束の開口端面上における気泡の滞留
や血栓形成の原因となるよどみ、血小板の粘着の
抑止や、中空糸の閉塞を解消できるものと推測さ
れる。
（実施例）
次に本発明の血液処理装置の一実施例を図面に
よつて説明する。第１図は本発明装置の一部断面
図、第２図は連続ラセン状溝の溝の深さがヘツダ
中心部に向つて漸減している場合の血液入口ヘツ
ダ１ａの断面図であり、図中共通のものは第４図
と同一番号が付されている。また、第３図はヘツ
ダ部形状を拡大した斜視図である。第１図の装置
はヘツダ部分を中心とした構造に特徴がある。本
発明装置では血液入口ヘツダ１ａの血液導入口２
０ａより導入された血液は、ヘツダ内側の中心か
ら周辺部に延在する連続ラセン状壁７で形成され
た連続ラセン状溝８の端部へ接線方向から導入さ
れる。該連続ラセン状壁７の頂部と中空繊維束の
切断面との間には、第１図に示すように、中空繊
維の切断面に対し、連続ラセン状溝に沿つてラセ
ン状に回る流れが損なわれない程度の間隙、すな
わちシヨートパスしない程度の間隙が設けられて
いるので、血液導入口２０ａよりヘツダ内に導入
された血液は、連続ラセン状溝８を移動しなが
ら、中空繊維内部に導入される。ここで、処理液
体流量とシヨートパスしない間隙は、本発明者ら
の研究結果によれば、処理液体を牛新鮮血とし、
血液流速をＱml／minとし、間隙をＨmmとすれ
ば、通常50≦Ｑ≦200であるので、
0.1≦Ｈ≦0.01×Ｑ
の関係を満たすことが好ましいことを見いだし
た。すなわち、Ｈがこれより大きいとシヨートパ
スが起こりやすくなり、連続ラセン状溝に沿つて
処理液体が流れにくい傾向がある。また、Ｈがこ
の範囲より小さいと連続ラセン状壁頂部と中空繊
維束切断面との間に血栓が生じたり、中空糸内に
均一に血液が流れにくくなる。上記ラセン状溝の
深さを第２図に示すように徐々に小さくすること
は、連続ラセン状溝の全ての場所において血液の
速度を一定とすることができるため好ましい。
また、血液出口ヘツダ１ｂも入口ヘツダ１ａと
同様に、血液導出口２０ｂをヘツダの接線方向に
設けると、装置の長さ方向の寸法を小とすること
ができるので、コンパクトになり、望ましい。そ
の際には血液出口ヘツダ１ｂの凹所にはラセン状
壁を設けないほうが好ましい。
次に本発明装置と従来装置との性能の比較を行
う。
本発明装置として血液入口ヘツダに第１図に示
すような連続ラセン状溝を有し、血液出口ヘツダ
にはラセン状溝を設けない装置を用いた。一方、
従来装置として第４図と第５図に示す装置を用い
た。（内径235μmのポリスルホン膜を使用、中空
糸本数4300本、有効膜面積0.5m2）
上記各血液処理装置に牛新鮮血（ヘマトクリツ
ト値38％、全蛋白質濃度６ｇ/dl）を用い、血液
流速200ml／min、膜間圧力差100mmHgの条件で
血液濾過試験を行つた。80時間血液濾過後の限外
濾過量および返血後の残血本数について測定した
結果を表１に示す。
INDUSTRIAL APPLICATION This invention relates to a hollow fiber blood processing device having an improved blood inlet header. (Prior Art) Blood processing devices using hollow fibers have conventionally been widely used as hemodialysis devices, artificial liver devices, blood filtration devices, plasma separation devices, or artificial lung devices. As such a blood processing device (blood filtration device), a device in which blood inlet ports are provided at axially symmetrical positions as shown in FIG. 4 is usually used. In FIG. 4, reference numeral 1a denotes a blood inlet header with a circular cross section for guiding blood into the inside of the hollow fiber 5 and isolating it from the outside. be introduced. Reference numeral 1b denotes a blood outlet header having a circular cross section for collecting blood that has passed through the hollow fibers and leading it out from the blood outlet 20b. Reference numeral 2 designates a fixing cap for bringing the blood inlet and outlet headers 1a and 1b into close contact with the partition wall 6, which fixes the hollow fiber bundle, through the packing 12. The housing 3 is usually cylindrical and made of transparent, hard synthetic resin (polypropylene, polycarbonate, etc.), and its interior is filled with hundreds to tens of thousands of hollow fibers 5. The housing 3 is also provided with a filtrate outlet 4. A large number of hollow fibers 5 are packed in the housing 3, and both ends of the hollow fibers 5 are fixed liquid-tightly with partition walls 6 made of polyurethane resin or the like having excellent blood compatibility.
It communicates with the space provided in 1b. Blood is introduced into the device through the blood inlet port 20a of the blood inlet header 1a, and harmful substances in the blood are discharged into the housing 3 through the wall membrane of the hollow fibers. It is returned to the body via On the other hand, harmful substances discharged into the interior of the housing 3 are taken out from the outlet 4. Recently, a blood processing device has been proposed that introduces blood tangentially into a space provided in a blood inlet header in order to introduce blood uniformly into each hollow fiber (Japanese Patent Publication No. 60-5308, 57-86361 etc.). FIG. 5 shows an example of such a device, and common parts in the figure are given the same numbers as in FIG. 1. In this device, blood is passed through a blood inlet 20 which opens tangentially from the outside of the blood inlet header 1a to the inside.
a, descends while turning along the blood guide path 10 provided in a spiral shape along the inner wall surface of the upper end of the space provided in the header, and reaches the outer periphery of the cut surface of the hollow fiber bundle; Then, it becomes a spiral flow toward the center and is introduced into each hollow fiber from the cut surface. (Problems to be Solved by the Invention) However, such conventional blood processing devices have the following drawbacks. There are various practical problems in the case of long-term use over several days, such as hemodialysis (non-hepadialysis or reduced hepadialysis), continuous hemofiltration (CAVH), and extracorporeal circulation pulmonary support (ECMO). That is, in the blood processing apparatus shown in FIG. 4, due to the structure, blood introduced from the blood inlet 20a first collides with the center of the end face of the hollow fiber, and then is dispersed into the hollow fiber at the outer periphery. Therefore, the velocity of blood flowing through the internal space of the header is high near the area immediately below the blood inlet, and decreases toward the periphery. As a result, blood may stagnate within the space of the header, and blood may stagnate around the space provided in the header. As a result, the performance of the blood processing device deteriorates, and when blood is returned, the speed of blood return differs between the center and the periphery, so blood remains inside the hollow fibers near the periphery or in areas where blood stagnates. Causes blood phenomena. On the other hand, in the device shown in FIG. 5, blood is guided from the tangential direction to the outer periphery that occupies a relatively large area on the cut surface of the hollow fiber, and then the thickness of the helical flow path gradually decreases. The velocity of blood flowing into the hollow fibers at the inner circumference is kept more uniform than in the device shown in FIG. 4, and
The blood flow velocity parallel to the cutting plane can also take large values. However, the flow of blood in the space provided in the header is not a fixed flow path, and although it takes a helical flow path, the distribution of the hollow fibers accommodated in the housing and the undulations of the cut surface of the hollow fibers, Depending on the undulations of the contact surface of the header with the blood, local eddy flow and accompanying thrombus formation and air bubble retention are likely to occur, and the volume of blood filling increases as the header becomes bulkier. There was a problem. (Means for Solving the Problems) Therefore, the object of the present invention is to provide a blood inlet header which has less accumulation of air bubbles, less occurrence of thrombi, and less blood clots, and which does not cause blockage of hollow fibers even when used continuously for a long time. An object of the present invention is to provide a blood processing device having the following features. That is, the present invention includes a blood inlet header at one end;
In a hollow fiber type blood processing device in which a hollow fiber bundle is housed in a cylindrical housing having a blood outlet header at the other end, a continuous helical groove is formed inside the blood inlet header from the center to the periphery; A hollow space characterized in that a gap is provided between the continuous helical wall and the cut surface of the hollow fiber bundle, and a blood inlet opening tangentially toward the outside is provided at the end of the continuous helical groove. This is a fiber type blood processing device. (Function) In the blood processing device of the present invention, a continuous helical groove is provided inside the blood inlet header, so that the blood guided from the blood inlet into the header flows in a helical shape along the continuous helical groove. Since the top of the continuous helical wall is not in close contact with the cut surface of the hollow fiber bundle, it is introduced onto the cut surface of the hollow fiber bundle, that is, into the inside of all the hollow fibers. At that time, blood pressure is applied uniformly to each hollow fiber cut surface, so
Blood is uniformly introduced inside the hollow fiber. Therefore, it is presumed that stagnation that causes accumulation of air bubbles and thrombus formation on the open end surface of the hollow fiber bundle, inhibition of platelet adhesion, and occlusion of the hollow fibers can be eliminated. (Example) Next, an example of the blood processing apparatus of the present invention will be described with reference to the drawings. FIG. 1 is a partial sectional view of the device of the present invention, and FIG. 2 is a sectional view of the blood inlet header 1a in which the depth of the continuous spiral groove gradually decreases toward the center of the header. Common parts inside are numbered the same as in Fig. 4. Further, FIG. 3 is an enlarged perspective view of the shape of the header portion. The device shown in FIG. 1 is characterized by its structure centered around the header portion. In the device of the present invention, the blood inlet 2 of the blood inlet header 1a
Blood introduced from Oa is introduced tangentially to the end of a continuous helical groove 8 formed by a continuous helical wall 7 extending from the center inside the header to the periphery. Between the top of the continuous helical wall 7 and the cut surface of the hollow fiber bundle, as shown in FIG. Since a gap is provided that does not cause damage, that is, a gap that does not cause the blood to pass, the blood introduced into the header from the blood introduction port 20a is introduced into the hollow fiber while moving in the continuous helical groove 8. Ru. Here, according to the research results of the present inventors, the processing liquid flow rate and the gap at which no shot passes are determined when the processing liquid is fresh bovine blood,
If the blood flow rate is Qml/min and the gap is Hmm, then usually 50≦Q≦200, so it has been found that it is preferable to satisfy the relationship 0.1≦H≦0.01×Q. That is, if H is larger than this, short passes are likely to occur, and the processing liquid tends to be difficult to flow along the continuous helical groove. Furthermore, if H is smaller than this range, a blood clot may occur between the top of the continuous spiral wall and the cut surface of the hollow fiber bundle, or blood may become difficult to flow uniformly within the hollow fibers. It is preferable to gradually reduce the depth of the helical groove as shown in FIG. 2 because the blood velocity can be kept constant at all locations in the continuous helical groove. Further, it is preferable that the blood outlet header 1b is also provided with the blood outlet 20b in the tangential direction of the header, as in the case of the inlet header 1a, since this makes it possible to reduce the lengthwise dimension of the apparatus, thereby making it more compact. In this case, it is preferable not to provide a helical wall in the recess of the blood outlet header 1b. Next, the performance of the device of the present invention and the conventional device will be compared. As the device of the present invention, a device was used in which the blood inlet header had a continuous helical groove as shown in FIG. 1, and the blood outlet header had no helical groove. on the other hand,
As a conventional device, the devices shown in FIGS. 4 and 5 were used. (A polysulfone membrane with an inner diameter of 235 μm is used, the number of hollow fibers is 4300, and the effective membrane area is 0.5 m 2 ) Fresh bovine blood (hematocrit value 38%, total protein concentration 6 g/dl) is used in each of the above blood processing devices, and the blood flow rate is 200 ml. A hemofiltration test was conducted under the conditions of 100 mmHg/min and a transmembrane pressure difference of 100 mmHg. Table 1 shows the results of measuring the amount of ultrafiltration after 80 hours of hemofiltration and the number of blood remaining after blood return.
【表】
以上の結果から、本発明の装置は従来装置に比
較して、限外濾過量は多く、また残血本数は極度
に少ないことが明らかである。さらに、肉眼での
観察の結果、本発明の血液処理装置ではヘツダに
導入された血液が、ほぼ均一に各中空繊維に導入
されていることが確認された。
従つて、本発明の血液処理装置は長時間連続し
て使用される体外循環肺補助や持続的血液濾過、
あるいは減ヘパリン透析などに好適に用いられ
る。
（発明の効果）
以上のように、本発明の血液処理装置は、ヘツ
ダ内側に血液を誘導する連続ラセン状溝が中空繊
維束の切断面との間に間隙を保つて設けられてい
るので、中空繊維束の開口端面に平行な血液速度
を好適に維持することができる。かかる構造は中
空繊維内部への血液流入速度に与える影響を少な
くすることができ、従つて、本発明の血液処理装
置においては、ほぼ均一な流入速度が得られるた
め、ヘツダ内凹所での気泡の滞留、全栓や血餅の
発生の抑止効果が強く発現し、従来装置では不可
能であつた長時間連続使用や、ノンヘパ、減ヘパ
透析が可能である。[Table] From the above results, it is clear that the device of the present invention has a larger amount of ultrafiltration and an extremely smaller number of residual blood tubes than the conventional device. Furthermore, as a result of visual observation, it was confirmed that in the blood processing apparatus of the present invention, the blood introduced into the header was almost uniformly introduced into each hollow fiber. Therefore, the blood processing device of the present invention can be used for extracorporeal circulation pulmonary support or continuous hemofiltration that is used continuously for a long time.
Alternatively, it is suitably used for reduced heparin dialysis. (Effects of the Invention) As described above, in the blood processing device of the present invention, since the continuous helical groove for guiding blood inside the header is provided with a gap maintained between it and the cut surface of the hollow fiber bundle, Blood velocity parallel to the open end surface of the hollow fiber bundle can be suitably maintained. Such a structure can reduce the influence on the blood inflow speed into the hollow fibers, and therefore, in the blood processing device of the present invention, a substantially uniform inflow speed can be obtained, so that air bubbles in the recesses in the header can be reduced. It has a strong effect of inhibiting the accumulation of blood and the formation of total plugs and clots, and enables continuous use for long periods of time, as well as non-hepatodialysis and reduced-hepadialysis, which were impossible with conventional devices.
第１図は本発明の血液処理装置の一部断面図で
あり、第２図は連続ラセン状溝の溝の深さがヘツ
ダ中心部に向つて漸減している場合のヘツダの断
面図であり、第３図は本発明の装置のヘツダ部形
状を拡大した斜視図であり、第４図及び第５図は
従来の血液処理装置の一部断面図である。
１ａ，１ｂ…血液入口、出口ヘツダ、２…固定
キヤツプ、３…ハウジング、４…濾液導出口、５
…中空繊維、６…隔壁、７…連続ラセン状壁、８
…連続ラセン状溝。
FIG. 1 is a partial sectional view of the blood processing device of the present invention, and FIG. 2 is a sectional view of a header in which the depth of the continuous spiral groove gradually decreases toward the center of the header. , FIG. 3 is an enlarged perspective view of the shape of the header portion of the device of the present invention, and FIGS. 4 and 5 are partial sectional views of a conventional blood processing device. 1a, 1b...Blood inlet, outlet header, 2...Fixed cap, 3...Housing, 4...Filtrate outlet, 5
...Hollow fiber, 6...Partition wall, 7...Continuous helical wall, 8
...Continuous spiral groove.
Claims (1)
ツダを備えた筒状ハウジング内に中空繊維束が収
容された中空繊維型血液処理装置において、該血
液入口ヘツダ内側に中心から周辺部にかけて連続
ラセン状溝を形成するとともに、該連続ラセン状
壁の頂部と中空繊維束の切断面との間に、間隙を
設け、該連続ラセン状溝の端部に外部に向けて接
線方向に開口する血液導入口を設けたことを特徴
とする中空繊維型血液処理装置。 ２ 該間隙（Ｈmm）が、血液流速をＱml／minと
した場合、0.1≦Ｈ≦0.01×Ｑである特許請求の
範囲第１項記載の血液処理装置。 ３ 該ラセン状溝の溝の深さがヘツダ中心部に向
つて漸減している特許請求の範囲第１項または第
２項記載の血液処理装置。[Scope of Claims] 1. A hollow fiber blood processing device in which a hollow fiber bundle is housed in a cylindrical housing having a blood inlet header at one end and a blood outlet header at the other end, in which a hollow fiber bundle is housed inside the blood inlet header. A continuous helical groove is formed from the wall to the periphery, and a gap is provided between the top of the continuous helical wall and the cut surface of the hollow fiber bundle, and a tangential line is formed at the end of the continuous helical groove toward the outside. A hollow fiber type blood processing device characterized by being provided with a blood introduction port that opens in the direction. 2. The blood processing device according to claim 1, wherein the gap (Hmm) satisfies 0.1≦H≦0.01×Q, where the blood flow rate is Qml/min. 3. The blood processing device according to claim 1 or 2, wherein the depth of the spiral groove gradually decreases toward the center of the header.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18748586A JPS6343670A (en) | 1986-08-08 | 1986-08-08 | Hollow fiber type blood treatment apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18748586A JPS6343670A (en) | 1986-08-08 | 1986-08-08 | Hollow fiber type blood treatment apparatus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6343670A JPS6343670A (en) | 1988-02-24 |
| JPS644789B2 true JPS644789B2 (en) | 1989-01-26 |
Family
ID=16206892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP18748586A Granted JPS6343670A (en) | 1986-08-08 | 1986-08-08 | Hollow fiber type blood treatment apparatus |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6343670A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015100288A1 (en) * | 2013-12-23 | 2015-07-02 | University Of Maryland, Baltimore | Blood oxygenator |
-
1986
- 1986-08-08 JP JP18748586A patent/JPS6343670A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6343670A (en) | 1988-02-24 |
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