JPS6434986A - Production of carbapenem compound in crystal form - Google Patents

Production of carbapenem compound in crystal form

Info

Publication number
JPS6434986A
JPS6434986A JP63117078A JP11707888A JPS6434986A JP S6434986 A JPS6434986 A JP S6434986A JP 63117078 A JP63117078 A JP 63117078A JP 11707888 A JP11707888 A JP 11707888A JP S6434986 A JPS6434986 A JP S6434986A
Authority
JP
Japan
Prior art keywords
protecting group
aqueous solution
formula
compound
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63117078A
Other languages
English (en)
Other versions
JP2665767B2 (ja
Inventor
Jun Sunakawa
Yutaka Takeuchi
Haruki Matsumura
Minoru Isobe
Tetsuo Noguchi
Yukio Ozaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharmaceuticals Co Ltd
Original Assignee
Sumitomo Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharmaceuticals Co Ltd filed Critical Sumitomo Pharmaceuticals Co Ltd
Publication of JPS6434986A publication Critical patent/JPS6434986A/ja
Application granted granted Critical
Publication of JP2665767B2 publication Critical patent/JP2665767B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP63117078A 1986-07-30 1988-05-16 β―ラクタム化合物 Expired - Lifetime JP2665767B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP17932186 1986-07-30
JP62-157769 1987-06-26
JP61-179321 1987-06-26
JP15776987 1987-06-26

Publications (2)

Publication Number Publication Date
JPS6434986A true JPS6434986A (en) 1989-02-06
JP2665767B2 JP2665767B2 (ja) 1997-10-22

Family

ID=26485103

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63117078A Expired - Lifetime JP2665767B2 (ja) 1986-07-30 1988-05-16 β―ラクタム化合物

Country Status (20)

Country Link
US (1) US4888344A (ja)
EP (1) EP0256377B1 (ja)
JP (1) JP2665767B2 (ja)
AR (1) AR243189A1 (ja)
AU (1) AU596857B2 (ja)
CA (1) CA1322371C (ja)
DE (1) DE3781980T2 (ja)
DK (1) DK172666B1 (ja)
ES (1) ES2052524T3 (ja)
FI (1) FI88037C (ja)
GR (1) GR3006254T3 (ja)
HK (1) HK169595A (ja)
HU (1) HU199473B (ja)
IE (1) IE60588B1 (ja)
IL (1) IL83372A (ja)
LU (1) LU88635I2 (ja)
MX (1) MX173359B (ja)
NO (2) NO165543C (ja)
NZ (1) NZ221224A (ja)
PH (1) PH24710A (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998034936A1 (fr) * 1997-02-07 1998-08-13 Kyoto Pharmaceutical Industries, Ltd. Composes de carbapenem, leur utilisation et composes intermediaires de celui-ci
JP2002326985A (ja) * 2001-04-27 2002-11-15 Sumitomo Pharmaceut Co Ltd アゼチジノン誘導体およびその製造方法
JP2006169169A (ja) * 2004-12-16 2006-06-29 Permachem Asia Ltd ペリンドプリルエルブミンのｉ型結晶、及びその製造方法
JP2008501657A (ja) * 2004-06-02 2008-01-24 サンド・アクチエンゲゼルシヤフト 結晶形態のメロペネム中間体
EP1950563A2 (en) 2002-09-11 2008-07-30 Michio Ishibashi Method for screening for a substance for promoting regeneration of macrophages

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CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
KR880006244A (ko) * 1986-11-24 1988-07-22 후지사와 도모 기찌 로 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법
DE69019610D1 (de) * 1989-07-06 1995-06-29 Banyu Pharma Co Ltd Cyclische Derivate des Amidinylthiocarbapenems.
EP0435320B1 (en) * 1989-12-29 1994-10-05 Banyu Pharmaceutical Co., Ltd. 2(2-Cyclopropylpyrrolidin-4-ylthio)-carbapenem derivatives
TW264475B (ja) * 1991-09-20 1995-12-01 Takeda Pharm Industry Co Ltd
JP2696807B2 (ja) * 1992-08-06 1998-01-14 田辺製薬株式会社 カルバペネム誘導体の製法
GB9503717D0 (en) * 1995-02-24 1995-04-12 Smithkline Beecham Plc Novel compounds
FR2735474B1 (fr) * 1995-06-13 1997-08-08 Roussel Uclaf Chlorhydrate de zilpaterol sous une forme cristallisee particuliere, son procede de preparation et les produits intermediaires mis en oeuvre
BR9910098A (pt) 1998-05-01 2000-12-26 Kyoto Pharma Ind Derivados de carbapenem, utilização dos mesmos e compostos intermediários dos mesmos
CA2375601C (en) * 1999-06-03 2008-07-29 Eisai Co., Ltd. Carbapenem compound crystals and injection preparations
TWI250160B (en) * 1999-07-06 2006-03-01 Sankyo Co Crystalline 1-methylcarbapenem compound
US7041660B2 (en) 1999-07-06 2006-05-09 Sankyo Company, Limited Crystalline 1-methylcarbapenem derivatives
ATE352300T1 (de) * 2000-05-12 2007-02-15 Novalar Pharmaceuticals Inc Zusammensetzung bestehend aus phentolaminmesylat und deren verwendung
SK15822003A3 (sk) * 2001-05-21 2004-06-08 Kyoto Pharmaceutical Industries, Ltd. Karbapenémový derivát
KR100451672B1 (ko) * 2001-06-05 2004-10-08 한미약품 주식회사 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법
EP1426376A4 (en) * 2001-08-13 2004-12-22 Eisai Co Ltd PROCESS FOR THE PREPARATION OF CARBAPENEM-BASED ANTIBIOTICS
CA2457642C (en) 2001-09-26 2009-01-06 Merck & Co., Inc. Crystalline forms of ertapenem sodium
EP1474426B8 (en) * 2001-09-26 2011-10-12 Merck Sharp & Dohme Corp. Process for making carbapenem compounds
ITMI20012364A1 (it) * 2001-11-09 2003-05-09 Antibioticos Spa Processo di sintesi della cefixima via alchil-o arilsolfonati
EP2316468A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
US7229630B2 (en) * 2002-06-20 2007-06-12 Novalar Pharmaceuticals, Inc. Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof
US20030236306A1 (en) * 2002-06-20 2003-12-25 Chen Andrew X. Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof
WO2006035300A2 (en) * 2004-09-30 2006-04-06 Ranbaxy Laboratories Limited A process for the preparation of meropenem
US20110039943A1 (en) * 2005-03-14 2011-02-17 Robert Alonso Methods for treating skin disorders with topical nitrogen mustard compositions
US7872050B2 (en) * 2005-03-14 2011-01-18 Yaupon Therapeutics Inc. Stabilized compositions of volatile alkylating agents and methods of using thereof
US8501818B2 (en) * 2005-03-14 2013-08-06 Ceptaris Therapeutics, Inc. Stabilized compositions of alkylating agents and methods of using same
US20070197781A1 (en) * 2005-07-29 2007-08-23 Neera Tewari Processes for the preparation of carbapenems
PL1926732T3 (pl) 2005-09-05 2014-01-31 Ranbaxy Laboratories Ltd Sposób wytwarzania związków karbapenemu
AU2006290416B2 (en) * 2005-09-15 2012-04-12 Orchid Chemicals And Pharmaceuticals Limited An improved process for the preparation of beta-lactam antibiotic
CN100497338C (zh) * 2006-01-05 2009-06-10 上海医药工业研究院 4－甲基－7－氧－1－氮杂双环[3.2.0]庚－2－烯－2－羧酸类衍生物的制备方法
KR100781821B1 (ko) * 2006-02-16 2007-12-03 문순구 카르바페넴계 화합물의 제조방법
TW200801004A (en) * 2006-03-28 2008-01-01 Kaneka Corp Improved process for producing carbapenem compound
TW200815442A (en) * 2006-04-28 2008-04-01 Kaneka Corp Improved method for the crystallization of intermediates of carbapenem antibiotics
JPWO2009075309A1 (ja) * 2007-12-12 2011-04-28 大日本住友製薬株式会社 製剤組成物
US20090216010A1 (en) * 2008-02-22 2009-08-27 Wei-Hong Tseng Crystalline carbapenem compound and produced method thereof
EP2098525A1 (en) 2008-02-26 2009-09-09 Savior Lifetec Corporation Crystalline carbapenem compound and produced method thereof
EP2273876B1 (en) * 2008-03-27 2019-03-06 Helsinn Healthcare SA Stabilized compositions of alkylating agents and methods of using same
US8097719B2 (en) * 2008-07-15 2012-01-17 Genesen Labs Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem
CA2732619A1 (en) * 2008-07-30 2010-02-04 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds
ES2477290T3 (es) * 2009-03-13 2014-07-16 Daewoong Pharmaceutical Co., Ltd. Método mejorado para preparar meropenem usando polvo de zinc
WO2011048583A1 (en) 2009-10-23 2011-04-28 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds
WO2011141847A1 (en) * 2010-05-10 2011-11-17 Orchid Chemicals And Pharmaceuticals Limited An improved process for the preparation of meropenem
US9000150B2 (en) 2010-10-22 2015-04-07 Ranbaxy Laboratories Limited Process for the preparation of pure meropenem trihydrate
CN101962383A (zh) * 2010-11-12 2011-02-02 上海巴迪生物医药科技有限公司 一种美罗培南的合成方法
WO2012081033A2 (en) * 2010-12-06 2012-06-21 Sequent Scientific Limited A process for preparation of imipenem
CN102532140B (zh) * 2010-12-21 2015-03-11 北大方正集团有限公司 一种美罗培南三水合物的制备方法
CN102250096B (zh) * 2011-09-05 2016-04-06 江西华邦药业有限公司 一种美罗培南的制备方法
CN103570720B (zh) * 2012-07-31 2016-02-10 新乡海滨药业有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
CN103570718B (zh) * 2012-07-31 2016-06-29 深圳市海滨制药有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
CN103570719B (zh) * 2012-07-31 2016-03-02 深圳市海滨制药有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
KR101331762B1 (ko) * 2012-12-28 2013-11-20 주식회사 대웅제약 메로페넴의 삼수화물의 제조방법
CN103044429B (zh) * 2013-01-28 2015-04-01 苏州二叶制药有限公司 一种美罗培南的制备方法
AU2014212275B2 (en) 2013-02-01 2018-09-06 Ocuphire Pharma, Inc. Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance
EP2950648B1 (en) 2013-02-01 2019-09-18 Ocuphire Pharma, Inc. Aqueous ophthalmic solutions of phentolamine and medical uses thereof
KR102144777B1 (ko) 2013-06-19 2020-08-18 제이더블유중외제약 주식회사 결정형 메로페넴 삼수화물의 제조방법
CN110922405A (zh) * 2014-03-27 2020-03-27 庄信万丰股份有限公司 制备碳青霉烯抗生素的方法
SG11202104094YA (en) 2018-10-26 2021-05-28 Ocuphire Pharma Inc Methods and compositions for treatment of presbyopia, mydriasis, and other ocular disorders
CN115368310A (zh) 2021-05-18 2022-11-22 奥库菲尔医药公司 合成甲磺酸酚妥拉明的方法

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JPS60104088A (ja) * 1983-11-11 1985-06-08 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物およびその製造法

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CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
US4748238A (en) * 1984-03-14 1988-05-31 Merck & Co., Inc. Crystalline 1R,5S,6S,8R-1-methyl-2-(N,N-dimethylcarbamimidoylmethylthio)-6-(1-hydroxyethyl)-1-carbapen-2-em-3-carboxylic acid
US4713451A (en) * 1984-04-09 1987-12-15 Merck & Co., Inc. Crystalline dimethyliminothienamycin
US4761408A (en) * 1984-11-02 1988-08-02 Ciba-Geigy Corporation Crystalline aminomethyl compound
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Patent Citations (1)

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JPS60104088A (ja) * 1983-11-11 1985-06-08 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物およびその製造法

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998034936A1 (fr) * 1997-02-07 1998-08-13 Kyoto Pharmaceutical Industries, Ltd. Composes de carbapenem, leur utilisation et composes intermediaires de celui-ci
US6342494B1 (en) 1997-02-07 2002-01-29 Kyoto Pharmaceutical Industries, Ltd. Carbapenem compounds, use thereof, and intermediate compounds of the same
JP2002326985A (ja) * 2001-04-27 2002-11-15 Sumitomo Pharmaceut Co Ltd アゼチジノン誘導体およびその製造方法
EP1950563A2 (en) 2002-09-11 2008-07-30 Michio Ishibashi Method for screening for a substance for promoting regeneration of macrophages
JP2008501657A (ja) * 2004-06-02 2008-01-24 サンド・アクチエンゲゼルシヤフト 結晶形態のメロペネム中間体
JP2006169169A (ja) * 2004-12-16 2006-06-29 Permachem Asia Ltd ペリンドプリルエルブミンのｉ型結晶、及びその製造方法

Also Published As

Publication number Publication date
HK169595A (en) 1995-11-10
IL83372A (en) 1992-05-25
DK399087A (da) 1988-01-31
NZ221224A (en) 1989-10-27
PH24710A (en) 1990-10-01
HU199473B (en) 1990-02-28
DK172666B1 (da) 1999-05-10
US4888344A (en) 1989-12-19
IE871959L (en) 1988-01-30
EP0256377A1 (en) 1988-02-24
LU88635I2 (fr) 1995-12-01
FI88037B (fi) 1992-12-15
FI873299A (fi) 1988-01-31
AU596857B2 (en) 1990-05-17
ES2052524T3 (es) 1994-07-16
NO165543B (no) 1990-11-19
AU7619687A (en) 1988-03-03
DE3781980D1 (de) 1992-11-05
MX7534A (es) 1993-10-01
HUT44553A (en) 1988-03-28
NO165543C (no) 1991-02-27
DE3781980T2 (de) 1993-02-18
FI873299A0 (fi) 1987-07-29
NO1997013I1 (no) 1997-10-17
NO873205D0 (no) 1987-07-30
GR3006254T3 (ja) 1993-06-21
DK399087D0 (da) 1987-07-30
MX173359B (es) 1994-02-23
NO873205L (no) 1988-02-01
AR243189A1 (es) 1993-07-30
JP2665767B2 (ja) 1997-10-22
EP0256377B1 (en) 1992-09-30
FI88037C (fi) 1993-03-25
IL83372A0 (en) 1987-12-31
IE60588B1 (en) 1994-07-27
CA1322371C (en) 1993-09-21

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