JPS6422874A - Amorphos aztreonum - Google Patents
Amorphos aztreonumInfo
- Publication number
- JPS6422874A JPS6422874A JP63162369A JP16236988A JPS6422874A JP S6422874 A JPS6422874 A JP S6422874A JP 63162369 A JP63162369 A JP 63162369A JP 16236988 A JP16236988 A JP 16236988A JP S6422874 A JPS6422874 A JP S6422874A
- Authority
- JP
- Japan
- Prior art keywords
- aztreonum
- amorphos
- methylethoxy
- ami
- imino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6839287A | 1987-07-01 | 1987-07-01 | |
US68,392 | 1987-07-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6422874A true JPS6422874A (en) | 1989-01-25 |
JP2701869B2 JP2701869B2 (ja) | 1998-01-21 |
Family
ID=22082279
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP63162369A Expired - Lifetime JP2701869B2 (ja) | 1987-07-01 | 1988-06-29 | 非晶形のアズトレオナム |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0297580B1 (ja) |
JP (1) | JP2701869B2 (ja) |
KR (1) | KR890002141A (ja) |
CN (1) | CN1028234C (ja) |
AT (1) | ATE175965T1 (ja) |
CA (1) | CA1339136C (ja) |
DE (1) | DE3856297T2 (ja) |
ES (1) | ES2127178T3 (ja) |
GR (1) | GR3029873T3 (ja) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006137474A1 (ja) * | 2005-06-23 | 2006-12-28 | Eisai R & D Management Co., Ltd. | 4-(3-クロロ-4-(シクロプロピルアミノカルボニル)アミノフェノキシ)-7-メトキシ-6-キノリンカルボキサミドの塩のアモルファスおよびその製造方法 |
JP2007521306A (ja) * | 2003-07-02 | 2007-08-02 | コーラス ファーマ,インコーポレイティド | アズトレオナムl−リジン及びそれを調製するための方法 |
US7550483B2 (en) | 2005-06-23 | 2009-06-23 | Eisai R&D Management Co., Ltd. | Amorphous salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide and process for preparing the same |
CN101912356A (zh) * | 2010-08-02 | 2010-12-15 | 王明 | 一种氨曲南/精氨酸药物组合物脂微球注射剂 |
US7994159B2 (en) | 2003-03-10 | 2011-08-09 | Eisai R&D Management Co., Ltd. | c-Kit kinase inhibitor |
WO2014098176A1 (ja) * | 2012-12-21 | 2014-06-26 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | キノリン誘導体のアモルファス及びその製造方法 |
US8969379B2 (en) | 2004-09-17 | 2015-03-03 | Eisai R&D Management Co., Ltd. | Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide |
US9945862B2 (en) | 2011-06-03 | 2018-04-17 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds |
US10259791B2 (en) | 2014-08-28 | 2019-04-16 | Eisai R&D Management Co., Ltd. | High-purity quinoline derivative and method for manufacturing same |
US10517861B2 (en) | 2013-05-14 | 2019-12-31 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds |
US11090386B2 (en) | 2015-02-25 | 2021-08-17 | Eisai R&D Management Co., Ltd. | Method for suppressing bitterness of quinoline derivative |
US11369623B2 (en) | 2015-06-16 | 2022-06-28 | Prism Pharma Co., Ltd. | Anticancer combination of a CBP/catenin inhibitor and an immune checkpoint inhibitor |
US11547705B2 (en) | 2015-03-04 | 2023-01-10 | Merck Sharp & Dohme Llc | Combination of a PD-1 antagonist and a VEGF-R/FGFR/RET tyrosine kinase inhibitor for treating cancer |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN191492B (ja) * | 1999-05-25 | 2003-12-06 | Ranbaxy Lab Ltd | |
ES2282299T3 (es) | 2000-10-20 | 2007-10-16 | EISAI R&D MANAGEMENT CO., LTD. | Compuestos aromaticos con anillos de nitrogeno como agentes anticancerigenos. |
US7138419B2 (en) | 2000-12-27 | 2006-11-21 | Corus Pharma, Inc. | Process for manufacturing bulk solutions and a lyophilized pure α-aztreonam lysinate |
DE122011100043I1 (de) | 2000-12-27 | 2011-12-15 | Gilead Sciences Inc | Inhalierbares aztreonam zur behandlung und vorbeugung von bakteriellen lungeninfektionen. |
US7214364B2 (en) | 2000-12-27 | 2007-05-08 | Corus Pharma, Inc. | Inhalable aztreonam lysinate formulation for treatment and prevention of pulmonary bacterial infections |
KR100687001B1 (ko) | 2002-08-05 | 2007-02-27 | 테바 기오기스제르갸르 자르트쾨렌 뮈쾨되 레스즈베니타르사사그 | 아즈트레오남의 제법 |
AU2002356646A1 (en) * | 2002-12-11 | 2004-06-30 | Pari Gmbh | Pharmaceutical compositions for the pulmonary delivery of aztreonam |
CN1802371A (zh) | 2003-05-15 | 2006-07-12 | 特瓦药厂有限公司 | 残余溶剂含量极低的阿兹托南β多晶型 |
JP4648835B2 (ja) | 2003-12-25 | 2011-03-09 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 4−(3−クロロ−4−(シクロプロピルアミノカルボニル)アミノフェノキシ)−7−メトキシ−6−キノリンカルボキサミドの塩またはその溶媒和物の結晶およびそれらの製造方法 |
EP1888576B1 (en) | 2005-05-09 | 2009-02-18 | Sicor Inc. | Process for making aztreonam |
EP1925676A4 (en) | 2005-08-02 | 2010-11-10 | Eisai R&D Man Co Ltd | TEST METHOD FOR THE EFFECT OF A VASCULARIZATION INHIBITOR |
JP5190361B2 (ja) | 2006-05-18 | 2013-04-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 甲状腺癌に対する抗腫瘍剤 |
EP2065372B1 (en) | 2006-08-28 | 2012-11-28 | Eisai R&D Management Co., Ltd. | Antitumor agent for undifferentiated gastric cancer |
CA2676796C (en) | 2007-01-29 | 2016-02-23 | Eisai R & D Management Co., Ltd. | Composition for treatment of undifferentiated gastric cancer |
CA2704000C (en) | 2007-11-09 | 2016-12-13 | Eisai R&D Management Co., Ltd. | Combination of anti-angiogenic substance and anti-tumor platinum complex |
CN101579336B (zh) * | 2009-07-07 | 2010-06-23 | 重庆市庆余堂制药有限公司 | 一种注射用氨曲南及其生产方法 |
KR101677790B1 (ko) | 2010-06-25 | 2016-11-18 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 키나제 저해 작용을 갖는 화합물의 병용에 의한 항종양제 |
AU2012246490B2 (en) | 2011-04-18 | 2016-08-04 | Eisai R&D Management Co., Ltd. | Therapeutic agent for tumor |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5823689A (ja) * | 1981-07-13 | 1983-02-12 | イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド | 置換アゼチジノン誘導体 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU44680B (en) * | 1982-07-30 | 1990-12-31 | Glaxo Lab Ltd | Process for obtaining very pure amorphous form of cephuroxim axetile |
-
1988
- 1988-06-28 CA CA000570624A patent/CA1339136C/en not_active Expired - Fee Related
- 1988-06-29 JP JP63162369A patent/JP2701869B2/ja not_active Expired - Lifetime
- 1988-06-29 CN CN88104073A patent/CN1028234C/zh not_active Expired - Fee Related
- 1988-06-30 KR KR1019880007972A patent/KR890002141A/ko not_active Application Discontinuation
- 1988-06-30 AT AT88110480T patent/ATE175965T1/de not_active IP Right Cessation
- 1988-06-30 DE DE3856297T patent/DE3856297T2/de not_active Expired - Fee Related
- 1988-06-30 ES ES88110480T patent/ES2127178T3/es not_active Expired - Lifetime
- 1988-06-30 EP EP88110480A patent/EP0297580B1/en not_active Expired - Lifetime
-
1999
- 1999-04-05 GR GR990400962T patent/GR3029873T3/el unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5823689A (ja) * | 1981-07-13 | 1983-02-12 | イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド | 置換アゼチジノン誘導体 |
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7994159B2 (en) | 2003-03-10 | 2011-08-09 | Eisai R&D Management Co., Ltd. | c-Kit kinase inhibitor |
JP2007521306A (ja) * | 2003-07-02 | 2007-08-02 | コーラス ファーマ,インコーポレイティド | アズトレオナムl−リジン及びそれを調製するための方法 |
US8969379B2 (en) | 2004-09-17 | 2015-03-03 | Eisai R&D Management Co., Ltd. | Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide |
US7550483B2 (en) | 2005-06-23 | 2009-06-23 | Eisai R&D Management Co., Ltd. | Amorphous salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide and process for preparing the same |
JP4733700B2 (ja) * | 2005-06-23 | 2011-07-27 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 4−(3−クロロ−4−(シクロプロピルアミノカルボニル)アミノフェノキシ)−7−メトキシ−6−キノリンカルボキサミドの塩のアモルファスおよびその製造方法 |
WO2006137474A1 (ja) * | 2005-06-23 | 2006-12-28 | Eisai R & D Management Co., Ltd. | 4-(3-クロロ-4-(シクロプロピルアミノカルボニル)アミノフェノキシ)-7-メトキシ-6-キノリンカルボキサミドの塩のアモルファスおよびその製造方法 |
CN101912356A (zh) * | 2010-08-02 | 2010-12-15 | 王明 | 一种氨曲南/精氨酸药物组合物脂微球注射剂 |
US9945862B2 (en) | 2011-06-03 | 2018-04-17 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds |
US11598776B2 (en) | 2011-06-03 | 2023-03-07 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds |
JPWO2014098176A1 (ja) * | 2012-12-21 | 2017-01-12 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | キノリン誘導体のアモルファス及びその製造方法 |
WO2014098176A1 (ja) * | 2012-12-21 | 2014-06-26 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | キノリン誘導体のアモルファス及びその製造方法 |
US10517861B2 (en) | 2013-05-14 | 2019-12-31 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds |
US10259791B2 (en) | 2014-08-28 | 2019-04-16 | Eisai R&D Management Co., Ltd. | High-purity quinoline derivative and method for manufacturing same |
US10407393B2 (en) | 2014-08-28 | 2019-09-10 | Eisai R&D Management Co., Ltd. | High-purity quinoline derivative and method for manufacturing same |
US10822307B2 (en) | 2014-08-28 | 2020-11-03 | Eisai R&D Management Co., Ltd. | High-purity quinoline derivative and method for manufacturing same |
US11186547B2 (en) | 2014-08-28 | 2021-11-30 | Eisai R&D Management Co., Ltd. | High-purity quinoline derivative and method for manufacturing same |
US11090386B2 (en) | 2015-02-25 | 2021-08-17 | Eisai R&D Management Co., Ltd. | Method for suppressing bitterness of quinoline derivative |
US11547705B2 (en) | 2015-03-04 | 2023-01-10 | Merck Sharp & Dohme Llc | Combination of a PD-1 antagonist and a VEGF-R/FGFR/RET tyrosine kinase inhibitor for treating cancer |
US11369623B2 (en) | 2015-06-16 | 2022-06-28 | Prism Pharma Co., Ltd. | Anticancer combination of a CBP/catenin inhibitor and an immune checkpoint inhibitor |
Also Published As
Publication number | Publication date |
---|---|
KR890002141A (ko) | 1989-04-08 |
GR3029873T3 (en) | 1999-07-30 |
DE3856297D1 (de) | 1999-03-04 |
DE3856297T2 (de) | 1999-06-02 |
CN1030238A (zh) | 1989-01-11 |
EP0297580B1 (en) | 1999-01-20 |
EP0297580A1 (en) | 1989-01-04 |
ES2127178T3 (es) | 1999-04-16 |
CA1339136C (en) | 1997-07-29 |
JP2701869B2 (ja) | 1998-01-21 |
ATE175965T1 (de) | 1999-02-15 |
CN1028234C (zh) | 1995-04-19 |
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