JPS637788B2 - - Google Patents

Info

Publication number: JPS637788B2
Authority: JP; Japan
Prior art keywords: adsorbent; cleaning; artificial; dhp; activated carbon
Prior art date: 1980-08-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP55120181A

Other languages

English (en)

Japanese (ja)

Other versions

JPS5743747A (en

Inventor

Yosuke Moriuchi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Terumo Corp

Original Assignee

Terumo Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-08-29

Filing date

1980-08-29

Publication date

1988-02-18

1980-08-29 Application filed by Terumo Corp filed Critical Terumo Corp

1980-08-29 Priority to JP55120181A priority Critical patent/JPS5743747A/ja

1982-03-11 Publication of JPS5743747A publication Critical patent/JPS5743747A/ja

1988-02-18 Publication of JPS637788B2 publication Critical patent/JPS637788B2/ja

Status Granted legal-status Critical Current

Links

239000003463 adsorbent Substances 0.000 claims description 50
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 46
210000000056 organ Anatomy 0.000 claims description 29
239000000084 colloidal system Substances 0.000 claims description 23
150000001875 compounds Chemical class 0.000 claims description 22
230000000694 effects Effects 0.000 claims description 22
239000002504 physiological saline solution Substances 0.000 claims description 18
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
238000000034 method Methods 0.000 claims description 17
238000004519 manufacturing process Methods 0.000 claims description 15
239000007864 aqueous solution Substances 0.000 claims description 14
229920001184 polypeptide Polymers 0.000 claims description 9
102000004196 processed proteins & peptides Human genes 0.000 claims description 9
108090000765 processed proteins & peptides Proteins 0.000 claims description 9
239000004094 surface-active agent Substances 0.000 claims description 8
239000011301 petroleum pitch Substances 0.000 claims description 6
230000001681 protective effect Effects 0.000 claims description 6
238000001035 drying Methods 0.000 claims description 2
238000004140 cleaning Methods 0.000 description 56
239000007788 liquid Substances 0.000 description 26
239000000243 solution Substances 0.000 description 18
239000008280 blood Substances 0.000 description 15
210000004369 blood Anatomy 0.000 description 15
238000001179 sorption measurement Methods 0.000 description 15
238000000576 coating method Methods 0.000 description 14
239000002245 particle Substances 0.000 description 14
238000005406 washing Methods 0.000 description 14
239000011248 coating agent Substances 0.000 description 13
239000011859 microparticle Substances 0.000 description 12
238000004506 ultrasonic cleaning Methods 0.000 description 12
230000000052 comparative effect Effects 0.000 description 10
239000010419 fine particle Substances 0.000 description 10
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 8
229920000669 heparin Polymers 0.000 description 8
229960002897 heparin Drugs 0.000 description 8
239000011148 porous material Substances 0.000 description 8
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
239000000126 substance Substances 0.000 description 6
229920002307 Dextran Polymers 0.000 description 5
230000010412 perfusion Effects 0.000 description 5
239000003208 petroleum Substances 0.000 description 5
108010010803 Gelatin Proteins 0.000 description 4
238000007796 conventional method Methods 0.000 description 4
DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 4
230000006866 deterioration Effects 0.000 description 4
238000010586 diagram Methods 0.000 description 4
239000008273 gelatin Substances 0.000 description 4
229920000159 gelatin Polymers 0.000 description 4
235000019322 gelatine Nutrition 0.000 description 4
235000011852 gelatine desserts Nutrition 0.000 description 4
239000003456 ion exchange resin Substances 0.000 description 4
229920003303 ion-exchange polymer Polymers 0.000 description 4
239000002904 solvent Substances 0.000 description 4
238000003860 storage Methods 0.000 description 4
238000010908 decantation Methods 0.000 description 3
229920001477 hydrophilic polymer Polymers 0.000 description 3
230000002209 hydrophobic effect Effects 0.000 description 3
210000003734 kidney Anatomy 0.000 description 3
210000004185 liver Anatomy 0.000 description 3
239000000463 material Substances 0.000 description 3
229920001282 polysaccharide Polymers 0.000 description 3
239000005017 polysaccharide Substances 0.000 description 3
150000004804 polysaccharides Chemical class 0.000 description 3
230000001954 sterilising effect Effects 0.000 description 3
238000004659 sterilization and disinfection Methods 0.000 description 3
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 2
206010010075 Coma hepatic Diseases 0.000 description 2
229920001612 Hydroxyethyl starch Polymers 0.000 description 2
229920001202 Inulin Polymers 0.000 description 2
241000047703 Nonion Species 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
229910052799 carbon Inorganic materials 0.000 description 2
239000004927 clay Substances 0.000 description 2
FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 description 2
229940109239 creatinine Drugs 0.000 description 2
230000006378 damage Effects 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
238000011049 filling Methods 0.000 description 2
239000012530 fluid Substances 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
230000002949 hemolytic effect Effects 0.000 description 2
201000001059 hepatic coma Diseases 0.000 description 2
208000007386 hepatic encephalopathy Diseases 0.000 description 2
229940050526 hydroxyethylstarch Drugs 0.000 description 2
JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 2
229940029339 inulin Drugs 0.000 description 2
238000002386 leaching Methods 0.000 description 2
238000005259 measurement Methods 0.000 description 2
239000003960 organic solvent Substances 0.000 description 2
230000037452 priming Effects 0.000 description 2
238000003756 stirring Methods 0.000 description 2
238000012360 testing method Methods 0.000 description 2
239000010457 zeolite Substances 0.000 description 2
OELQSSWXRGADDE-UHFFFAOYSA-N 2-methylprop-2-eneperoxoic acid Chemical compound CC(=C)C(=O)OO OELQSSWXRGADDE-UHFFFAOYSA-N 0.000 description 1
SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
102000009027 Albumins Human genes 0.000 description 1
108010088751 Albumins Proteins 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
229920001287 Chondroitin sulfate Polymers 0.000 description 1
208000005189 Embolism Diseases 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
229920002230 Pectic acid Polymers 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
208000007536 Thrombosis Diseases 0.000 description 1
229910021536 Zeolite Inorganic materials 0.000 description 1
239000000853 adhesive Substances 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
239000002390 adhesive tape Substances 0.000 description 1
230000002411 adverse Effects 0.000 description 1
239000000783 alginic acid Substances 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
229920000615 alginic acid Polymers 0.000 description 1
229960001126 alginic acid Drugs 0.000 description 1
150000004781 alginic acids Chemical class 0.000 description 1
150000004996 alkyl benzenes Chemical class 0.000 description 1
230000008081 blood perfusion Effects 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
229940059329 chondroitin sulfate Drugs 0.000 description 1
239000002817 coal dust Substances 0.000 description 1
238000011161 development Methods 0.000 description 1
230000003292 diminished effect Effects 0.000 description 1
HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
239000000428 dust Substances 0.000 description 1
238000001914 filtration Methods 0.000 description 1
238000004388 gamma ray sterilization Methods 0.000 description 1
208000006454 hepatitis Diseases 0.000 description 1
231100000283 hepatitis Toxicity 0.000 description 1
239000000017 hydrogel Substances 0.000 description 1
230000036512 infertility Effects 0.000 description 1
FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
AIHDCSAXVMAMJH-GFBKWZILSA-N levan Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@@H]1[C@@H](O)[C@H](O)[C@](CO)(CO[C@@H]2[C@H]([C@H](O)[C@@](O)(CO)O2)O)O1 AIHDCSAXVMAMJH-GFBKWZILSA-N 0.000 description 1
230000007774 longterm Effects 0.000 description 1
239000012528 membrane Substances 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
239000000203 mixture Substances 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
150000002894 organic compounds Chemical class 0.000 description 1
108010014241 oxypolygelatine Proteins 0.000 description 1
LCLHHZYHLXDRQG-ZNKJPWOQSA-N pectic acid Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)O[C@H](C(O)=O)[C@@H]1OC1[C@H](O)[C@@H](O)[C@@H](OC2[C@@H]([C@@H](O)[C@@H](O)[C@H](O2)C(O)=O)O)[C@@H](C(O)=O)O1 LCLHHZYHLXDRQG-ZNKJPWOQSA-N 0.000 description 1
239000003058 plasma substitute Substances 0.000 description 1
231100000614 poison Toxicity 0.000 description 1
-1 poly(2 -Hydroxyethyl) Polymers 0.000 description 1
239000010318 polygalacturonic acid Substances 0.000 description 1
239000012460 protein solution Substances 0.000 description 1
238000011046 pyrogen test Methods 0.000 description 1
230000001698 pyrogenic effect Effects 0.000 description 1
230000001568 sexual effect Effects 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000012798 spherical particle Substances 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
239000000271 synthetic detergent Substances 0.000 description 1
239000012085 test solution Substances 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
239000003440 toxic substance Substances 0.000 description 1
239000010891 toxic waste Substances 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
239000002699 waste material Substances 0.000 description 1

Landscapes

External Artificial Organs (AREA)

JP55120181A 1980-08-29 1980-08-29 Manufacture of artificial internal organ Granted JPS5743747A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP55120181A JPS5743747A (en)	1980-08-29	1980-08-29	Manufacture of artificial internal organ

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP55120181A JPS5743747A (en)	1980-08-29	1980-08-29	Manufacture of artificial internal organ

Publications (2)

Publication Number	Publication Date
JPS5743747A JPS5743747A (en)	1982-03-11
JPS637788B2 true JPS637788B2 (it)	1988-02-18

Family

ID=14779915

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP55120181A Granted JPS5743747A (en)	1980-08-29	1980-08-29	Manufacture of artificial internal organ

Country Status (1)

Country	Link
JP (1)	JPS5743747A (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1988926B (zh) *	2004-07-23	2010-05-05	株式会社钟化	填充有除去了水不溶性微粒的吸附材料的直接血液灌注用吸附器、与除去了水不溶性微粒的直接血液灌注用吸附材料的取得方法

1980
- 1980-08-29 JP JP55120181A patent/JPS5743747A/ja active Granted

Also Published As

Publication number	Publication date
JPS5743747A (en)	1982-03-11

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