JPS6228124B2 - - Google Patents
Info
- Publication number
- JPS6228124B2 JPS6228124B2 JP52005978A JP597877A JPS6228124B2 JP S6228124 B2 JPS6228124 B2 JP S6228124B2 JP 52005978 A JP52005978 A JP 52005978A JP 597877 A JP597877 A JP 597877A JP S6228124 B2 JPS6228124 B2 JP S6228124B2
- Authority
- JP
- Japan
- Prior art keywords
- drug
- particles
- weight
- medicament
- microns
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003814 drug Substances 0.000 claims description 127
- 239000008188 pellet Substances 0.000 claims description 112
- 229940079593 drug Drugs 0.000 claims description 94
- 239000002245 particle Substances 0.000 claims description 93
- 239000008187 granular material Substances 0.000 claims description 84
- 239000000843 powder Substances 0.000 claims description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 33
- 238000000034 method Methods 0.000 claims description 32
- 239000002775 capsule Substances 0.000 claims description 30
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 claims description 27
- 230000009467 reduction Effects 0.000 claims description 22
- 229960000265 cromoglicic acid Drugs 0.000 claims description 19
- 230000004044 response Effects 0.000 claims description 18
- 239000002904 solvent Substances 0.000 claims description 14
- 239000011148 porous material Substances 0.000 claims description 13
- 238000012360 testing method Methods 0.000 claims description 10
- 239000011230 binding agent Substances 0.000 claims description 9
- 239000002002 slurry Substances 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 6
- 238000001125 extrusion Methods 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 239000003086 colorant Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 238000009736 wetting Methods 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 3
- 235000003599 food sweetener Nutrition 0.000 claims description 3
- 238000001694 spray drying Methods 0.000 claims description 3
- 239000003765 sweetening agent Substances 0.000 claims description 3
- 208000026935 allergic disease Diseases 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 238000011221 initial treatment Methods 0.000 claims 2
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 claims 1
- 238000005243 fluidization Methods 0.000 claims 1
- 229960001317 isoprenaline Drugs 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 239000003186 pharmaceutical solution Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 description 12
- 239000000463 material Substances 0.000 description 9
- 239000000047 product Substances 0.000 description 9
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 7
- 230000002776 aggregation Effects 0.000 description 7
- 238000005054 agglomeration Methods 0.000 description 6
- 239000007903 gelatin capsule Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000010419 fine particle Substances 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 239000004098 Tetracycline Substances 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000003595 mist Substances 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 229960002180 tetracycline Drugs 0.000 description 2
- 229930101283 tetracycline Natural products 0.000 description 2
- 235000019364 tetracycline Nutrition 0.000 description 2
- 150000003522 tetracyclines Chemical class 0.000 description 2
- -1 For example Substances 0.000 description 1
- HQARDVLSJLCFBA-UHFFFAOYSA-N 4-[(4-aminophenyl)carbamoyl]-1h-imidazole-5-carboxylic acid Chemical compound C1=CC(N)=CC=C1NC(=O)C1=C(C(O)=O)NC=N1 HQARDVLSJLCFBA-UHFFFAOYSA-N 0.000 description 1
- AHOWSDUPGJRPTJ-UHFFFAOYSA-N 5-[1-(2-carboxy-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylic acid Chemical class O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OC(C(O)C)OC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 AHOWSDUPGJRPTJ-UHFFFAOYSA-N 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 241000978776 Senegalia senegal Species 0.000 description 1
- 239000000150 Sympathomimetic Substances 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- VQKLDJLGLNXQAN-UHFFFAOYSA-L [Na+].[Na+].C1=CC=C2OC(C(=O)[O-])=CC(=O)C2=C1.C1=CC=C2OC(C(=O)[O-])=CC(=O)C2=C1 Chemical compound [Na+].[Na+].C1=CC=C2OC(C(=O)[O-])=CC(=O)C2=C1.C1=CC=C2OC(C(=O)[O-])=CC(=O)C2=C1 VQKLDJLGLNXQAN-UHFFFAOYSA-L 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000012296 anti-solvent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000000280 densification Methods 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 235000012438 extruded product Nutrition 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP19743486A JPS62246571A (ja) | 1976-01-23 | 1986-08-25 | 二ナトリウムクロモグリケ−ト |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB260676A GB1569611A (en) | 1976-01-23 | 1976-01-23 | Pelletised or granular medicament formulation |
GB260876 | 1976-01-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5294413A JPS5294413A (en) | 1977-08-09 |
JPS6228124B2 true JPS6228124B2 (pt) | 1987-06-18 |
Family
ID=26237614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP597877A Granted JPS5294413A (en) | 1976-01-23 | 1977-01-24 | Soft pellet or granular medicine |
Country Status (12)
Country | Link |
---|---|
JP (1) | JPS5294413A (pt) |
AU (1) | AU506878B2 (pt) |
CA (1) | CA1116516A (pt) |
DK (1) | DK27177A (pt) |
ES (1) | ES455273A1 (pt) |
FI (1) | FI67663C (pt) |
FR (1) | FR2361104A2 (pt) |
IE (1) | IE45260B1 (pt) |
LU (1) | LU76618A1 (pt) |
NO (1) | NO148542C (pt) |
SE (1) | SE442950B (pt) |
ZA (1) | ZA77327B (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3268533D1 (en) * | 1981-07-24 | 1986-02-27 | Fisons Plc | Inhalation drugs, methods for their production and pharmaceutical formulations containing them |
US6102036A (en) * | 1994-04-12 | 2000-08-15 | Smoke-Stop | Breath activated inhaler |
-
1977
- 1977-01-05 IE IE14/77A patent/IE45260B1/en not_active IP Right Cessation
- 1977-01-11 FI FI770070A patent/FI67663C/fi not_active IP Right Cessation
- 1977-01-20 ZA ZA770327A patent/ZA77327B/xx unknown
- 1977-01-20 FR FR7701501A patent/FR2361104A2/fr active Granted
- 1977-01-21 LU LU76618A patent/LU76618A1/xx unknown
- 1977-01-21 NO NO770198A patent/NO148542C/no unknown
- 1977-01-21 CA CA000270236A patent/CA1116516A/en not_active Expired
- 1977-01-21 DK DK27177A patent/DK27177A/da not_active Application Discontinuation
- 1977-01-21 SE SE7700665A patent/SE442950B/xx not_active IP Right Cessation
- 1977-01-22 ES ES455273A patent/ES455273A1/es not_active Expired
- 1977-01-24 AU AU21589/77A patent/AU506878B2/en not_active Ceased
- 1977-01-24 JP JP597877A patent/JPS5294413A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
FR2361104B2 (pt) | 1982-09-17 |
DK27177A (da) | 1977-07-24 |
CA1116516A (en) | 1982-01-19 |
ES455273A1 (es) | 1978-04-01 |
AU506878B2 (en) | 1980-01-24 |
FR2361104A2 (fr) | 1978-03-10 |
SE442950B (sv) | 1986-02-10 |
NO148542C (no) | 1983-11-02 |
FI67663C (fi) | 1985-05-10 |
NO148542B (no) | 1983-07-25 |
IE45260L (en) | 1977-07-23 |
ZA77327B (en) | 1977-12-28 |
SE7700665L (sv) | 1977-07-24 |
FI770070A (pt) | 1977-07-24 |
JPS5294413A (en) | 1977-08-09 |
FI67663B (fi) | 1985-01-31 |
AU2158977A (en) | 1978-08-03 |
LU76618A1 (pt) | 1977-08-12 |
NO770198L (no) | 1977-07-26 |
IE45260B1 (en) | 1982-07-28 |
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