JPS6152737B2 - - Google Patents

Info

Publication number: JPS6152737B2
Authority: JP; Japan
Prior art keywords: solution; capsule; membrane; cells; capsules
Prior art date: 1981-03-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP57038239A

Other languages

English (en)

Japanese (ja)

Other versions

JPS57197031A (en

Inventor

Rimu Furankurin

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Abbott Biotech Inc

Original Assignee

Damon Biotech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-03-13

Filing date

1982-03-12

Publication date

1986-11-14

1982-03-12 Application filed by Damon Biotech Inc filed Critical Damon Biotech Inc

1982-12-03 Publication of JPS57197031A publication Critical patent/JPS57197031A/ja

1986-11-14 Publication of JPS6152737B2 publication Critical patent/JPS6152737B2/ja

Status Granted legal-status Critical Current

Links

239000002775 capsule Substances 0.000 claims description 71
239000012528 membrane Substances 0.000 claims description 64
239000000243 solution Substances 0.000 claims description 44
238000000034 method Methods 0.000 claims description 40
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 24
239000000661 sodium alginate Substances 0.000 claims description 23
235000010413 sodium alginate Nutrition 0.000 claims description 23
229940005550 sodium alginate Drugs 0.000 claims description 23
239000000126 substance Substances 0.000 claims description 18
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 17
229920000669 heparin Polymers 0.000 claims description 17
229960002897 heparin Drugs 0.000 claims description 17
108010039918 Polylysine Proteins 0.000 claims description 15
229920000656 polylysine Polymers 0.000 claims description 15
239000002609 medium Substances 0.000 claims description 13
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 9
239000011162 core material Substances 0.000 claims description 9
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 8
229910001424 calcium ion Inorganic materials 0.000 claims description 8
239000001110 calcium chloride Substances 0.000 claims description 7
229910001628 calcium chloride Inorganic materials 0.000 claims description 7
-1 EDT ion Chemical class 0.000 claims description 6
238000004132 cross linking Methods 0.000 claims description 6
244000005700 microbiome Species 0.000 claims description 6
239000003094 microcapsule Substances 0.000 claims description 6
239000002504 physiological saline solution Substances 0.000 claims description 6
230000001681 protective effect Effects 0.000 claims description 6
239000012634 fragment Substances 0.000 claims description 5
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 4
239000002344 surface layer Substances 0.000 claims description 4
239000002738 chelating agent Substances 0.000 claims description 3
239000012736 aqueous medium Substances 0.000 claims description 2
230000000903 blocking effect Effects 0.000 claims 1
230000014759 maintenance of location Effects 0.000 claims 1
210000004379 membrane Anatomy 0.000 description 63
210000004027 cell Anatomy 0.000 description 48
210000001519 tissue Anatomy 0.000 description 20
229920000642 polymer Polymers 0.000 description 14
238000005538 encapsulation Methods 0.000 description 11
239000000499 gel Substances 0.000 description 11
239000000463 material Substances 0.000 description 11
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 10
125000000129 anionic group Chemical group 0.000 description 10
230000035699 permeability Effects 0.000 description 10
230000006378 damage Effects 0.000 description 9
239000001509 sodium citrate Substances 0.000 description 9
235000010443 alginic acid Nutrition 0.000 description 8
229920000615 alginic acid Polymers 0.000 description 8
239000001963 growth medium Substances 0.000 description 8
210000004153 islets of langerhan Anatomy 0.000 description 8
239000007788 liquid Substances 0.000 description 8
239000003352 sequestering agent Substances 0.000 description 8
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical group O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 8
239000000725 suspension Substances 0.000 description 8
150000002500 ions Chemical class 0.000 description 7
230000008569 process Effects 0.000 description 7
230000015572 biosynthetic process Effects 0.000 description 6
235000011148 calcium chloride Nutrition 0.000 description 6
210000002950 fibroblast Anatomy 0.000 description 6
125000002091 cationic group Chemical group 0.000 description 5
150000001768 cations Chemical class 0.000 description 5
230000004060 metabolic process Effects 0.000 description 5
FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 4
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
229940072056 alginate Drugs 0.000 description 4
239000007864 aqueous solution Substances 0.000 description 4
229910052791 calcium Inorganic materials 0.000 description 4
239000011575 calcium Substances 0.000 description 4
239000000203 mixture Substances 0.000 description 4
150000003839 salts Chemical class 0.000 description 4
239000011780 sodium chloride Substances 0.000 description 4
238000005406 washing Methods 0.000 description 4
108091003079 Bovine Serum Albumin Proteins 0.000 description 3
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
238000004113 cell culture Methods 0.000 description 3
239000006285 cell suspension Substances 0.000 description 3
239000003610 charcoal Substances 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
230000007717 exclusion Effects 0.000 description 3
239000012894 fetal calf serum Substances 0.000 description 3
210000003494 hepatocyte Anatomy 0.000 description 3
238000000338 in vitro Methods 0.000 description 3
238000012423 maintenance Methods 0.000 description 3
239000011159 matrix material Substances 0.000 description 3
230000011278 mitosis Effects 0.000 description 3
235000015097 nutrients Nutrition 0.000 description 3
229920001282 polysaccharide Polymers 0.000 description 3
239000005017 polysaccharide Substances 0.000 description 3
150000004804 polysaccharides Chemical class 0.000 description 3
239000011148 porous material Substances 0.000 description 3
238000003756 stirring Methods 0.000 description 3
241000894006 Bacteria Species 0.000 description 2
229920002873 Polyethylenimine Polymers 0.000 description 2
230000002378 acidificating effect Effects 0.000 description 2
229910052783 alkali metal Inorganic materials 0.000 description 2
150000001413 amino acids Chemical class 0.000 description 2
125000003277 amino group Chemical group 0.000 description 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
239000007853 buffer solution Substances 0.000 description 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
230000001413 cellular effect Effects 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
238000009792 diffusion process Methods 0.000 description 2
229940079593 drug Drugs 0.000 description 2
239000003814 drug Substances 0.000 description 2
239000000975 dye Substances 0.000 description 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
239000010410 layer Substances 0.000 description 2
210000000265 leukocyte Anatomy 0.000 description 2
210000005229 liver cell Anatomy 0.000 description 2
230000002503 metabolic effect Effects 0.000 description 2
239000011259 mixed solution Substances 0.000 description 2
239000001301 oxygen Substances 0.000 description 2
229910052760 oxygen Inorganic materials 0.000 description 2
239000002245 particle Substances 0.000 description 2
239000012466 permeate Substances 0.000 description 2
229920000447 polyanionic polymer Polymers 0.000 description 2
239000000047 product Substances 0.000 description 2
238000002791 soaking Methods 0.000 description 2
239000007787 solid Substances 0.000 description 2
230000004083 survival effect Effects 0.000 description 2
231100000331 toxic Toxicity 0.000 description 2
230000002588 toxic effect Effects 0.000 description 2
239000003053 toxin Substances 0.000 description 2
231100000765 toxin Toxicity 0.000 description 2
108700012359 toxins Proteins 0.000 description 2
230000035899 viability Effects 0.000 description 2
238000003260 vortexing Methods 0.000 description 2
DVLFYONBTKHTER-UHFFFAOYSA-N 3-(N-morpholino)propanesulfonic acid Chemical compound OS(=O)(=O)CCCN1CCOCC1 DVLFYONBTKHTER-UHFFFAOYSA-N 0.000 description 1
102000008186 Collagen Human genes 0.000 description 1
108010035532 Collagen Proteins 0.000 description 1
239000004971 Cross linker Substances 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
108060003951 Immunoglobulin Proteins 0.000 description 1
102000004877 Insulin Human genes 0.000 description 1
108090001061 Insulin Proteins 0.000 description 1
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
MKWKNSIESPFAQN-UHFFFAOYSA-N N-cyclohexyl-2-aminoethanesulfonic acid Chemical compound OS(=O)(=O)CCNC1CCCCC1 MKWKNSIESPFAQN-UHFFFAOYSA-N 0.000 description 1
108020004511 Recombinant DNA Proteins 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
239000004809 Teflon Substances 0.000 description 1
229920006362 Teflon® Polymers 0.000 description 1
GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 1
102000004142 Trypsin Human genes 0.000 description 1
108090000631 Trypsin Proteins 0.000 description 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000008186 active pharmaceutical agent Substances 0.000 description 1
239000013543 active substance Substances 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
230000002411 adverse Effects 0.000 description 1
230000002776 aggregation Effects 0.000 description 1
238000004220 aggregation Methods 0.000 description 1
238000013019 agitation Methods 0.000 description 1
229960001126 alginic acid Drugs 0.000 description 1
239000000783 alginic acid Substances 0.000 description 1
150000004781 alginic acids Chemical class 0.000 description 1
229910001413 alkali metal ion Inorganic materials 0.000 description 1
150000001340 alkali metals Chemical class 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
150000001450 anions Chemical class 0.000 description 1
230000004888 barrier function Effects 0.000 description 1
230000008901 benefit Effects 0.000 description 1
239000001045 blue dye Substances 0.000 description 1
244000309466 calf Species 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
230000003833 cell viability Effects 0.000 description 1
239000007979 citrate buffer Substances 0.000 description 1
229920001436 collagen Polymers 0.000 description 1
239000000356 contaminant Substances 0.000 description 1
230000001276 controlling effect Effects 0.000 description 1
230000002596 correlated effect Effects 0.000 description 1
239000003431 cross linking reagent Substances 0.000 description 1
239000012531 culture fluid Substances 0.000 description 1
230000008021 deposition Effects 0.000 description 1
230000001627 detrimental effect Effects 0.000 description 1
238000007865 diluting Methods 0.000 description 1
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
229940088679 drug related substance Drugs 0.000 description 1
239000000428 dust Substances 0.000 description 1
230000002124 endocrine Effects 0.000 description 1
210000003527 eukaryotic cell Anatomy 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
239000012530 fluid Substances 0.000 description 1
235000013305 food Nutrition 0.000 description 1
210000003953 foreskin Anatomy 0.000 description 1
230000036541 health Effects 0.000 description 1
229920006158 high molecular weight polymer Polymers 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
102000018358 immunoglobulin Human genes 0.000 description 1
229940072221 immunoglobulins Drugs 0.000 description 1
238000011534 incubation Methods 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
229940125396 insulin Drugs 0.000 description 1
230000003993 interaction Effects 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
210000005228 liver tissue Anatomy 0.000 description 1
230000007102 metabolic function Effects 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
210000000496 pancreas Anatomy 0.000 description 1
210000004923 pancreatic tissue Anatomy 0.000 description 1
230000035515 penetration Effects 0.000 description 1
239000002953 phosphate buffered saline Substances 0.000 description 1
231100000614 poison Toxicity 0.000 description 1
229920000729 poly(L-lysine) polymer Polymers 0.000 description 1
230000001737 promoting effect Effects 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910001415 sodium ion Inorganic materials 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
210000002325 somatostatin-secreting cell Anatomy 0.000 description 1
241000894007 species Species 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
239000011550 stock solution Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1
229910052712 strontium Inorganic materials 0.000 description 1
CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
239000003104 tissue culture media Substances 0.000 description 1
239000003440 toxic substance Substances 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/20—After-treatment of capsule walls, e.g. hardening
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0012—Cell encapsulation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
- A61K2035/128—Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides
- C12N2533/74—Alginate

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Dispersion Chemistry (AREA)
Epidemiology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Cell Biology (AREA)
Medicinal Preparation (AREA)
Manufacturing Of Micro-Capsules (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Separation Using Semi-Permeable Membranes (AREA)

JP57038239A 1981-03-13 1982-03-12 Reversible micro-encapsulation Granted JPS57197031A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US24358481A	1981-03-13	1981-03-13

Publications (2)

Publication Number	Publication Date
JPS57197031A JPS57197031A (en)	1982-12-03
JPS6152737B2 true JPS6152737B2 (da)	1986-11-14

Family

ID=22919328

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP57038239A Granted JPS57197031A (en)	1981-03-13	1982-03-12	Reversible micro-encapsulation

Country Status (11)

Country	Link
JP (1)	JPS57197031A (da)
BE (1)	BE892477A (da)
CA (1)	CA1184518A (da)
CH (1)	CH651579A5 (da)
DE (1)	DE3209045C2 (da)
DK (1)	DK112382A (da)
FR (1)	FR2501528A1 (da)
GB (1)	GB2094750B (da)
IT (1)	IT1150681B (da)
NO (1)	NO158284C (da)
SE (1)	SE454181B (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6348039U (da) *	1986-09-12	1988-04-01

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DD160393A3 (de) *	1980-11-14	1983-07-27	Horst Dautzenberg	Mikrokapseln und verfahren zu ihrer herstellung
NO163060C (no) *	1981-03-13	1990-03-28	Damon Biotech Inc	Fremgangsmaate for fremstilling av substanser som dannes av levende celler som produserer interferoner eller antistoffer.
NO161446C (no) *	1981-03-13	1989-08-16	Damon Biotech Inc	Fremgangsmaate for dyrking av celler som er avhengige av forankring.
US4582799A (en) *	1983-04-15	1986-04-15	Damon Biotech, Inc.	Process for recovering nonsecreted substances produced by cells
EP0127989A3 (en) *	1983-06-01	1986-03-26	Connaught Laboratories Limited	Microencapsulation of living tissue and cells
CA1196862A (en) *	1983-06-01	1985-11-19	Anthony M.F. Sun	Microencapsulation of living tissue and cells
CA1245984A (en) *	1983-09-01	1988-12-06	Damon Biotech, Inc.	Polyionic microencapsulation
US4663286A (en) *	1984-02-13	1987-05-05	Damon Biotech, Inc.	Encapsulation of materials
EP0152898B1 (en) *	1984-02-15	1990-01-17	Massachusetts Institute Of Technology	Process for encapsulation and encapsulated active material system(
US4686098A (en) *	1984-05-14	1987-08-11	Merck & Co., Inc.	Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo
GB8500121D0 (en) *	1985-01-03	1985-02-13	Connaught Lab	Microencapsulation of living cells
EP0213908A3 (en) *	1985-08-26	1989-03-22	Hana Biologics, Inc.	Transplantable artificial tissue and process
JPS62166891A (ja) *	1986-01-20	1987-07-23	Snow Brand Milk Prod Co Ltd	細胞培養による有用物質の製造方法
US4952506A (en) *	1986-04-28	1990-08-28	Rohm And Haas Company	Immobilization of nonanchorage-dependent cells
JPS6379587A (ja) *	1986-09-22	1988-04-09	Saburo Senoo	細胞培養用基材
US5069831A (en) *	1988-12-22	1991-12-03	The Mead Corporation	Method for separation of microcapsules and preparation of printing inks
US5800829A (en) *	1991-04-25	1998-09-01	Brown University Research Foundation	Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
DK0585368T3 (da) *	1991-04-25	1998-03-16	Univ Brown Res Found	Implanterbart biokompatibelt immunisolatorisk vehikel til afgivelse af udvalgte terapeutiske produkter
IL102785A (en) *	1991-08-20	1998-06-15	Univ Leicester	Method for removing protein from a water- soluble gum and a method of making biocompatible capsules using said gum
WO2001041809A1 (fr) *	1999-12-08	2001-06-14	Dmitry Vladimirovich Zybin	Utilisation d'un gel polyacrilamide pour former une capsule dans un tissu d'un mammalien, procede de culture de cellules et procede de traitement des maladies oncologiques et du diabete sucre
GB201408233D0 (en)	2014-05-09	2014-06-25	Austrianova Singapore Pte Ltd	Use of polyanionic composition
WO2020066306A1 (ja) *	2018-09-28	2020-04-02	富士フイルム株式会社	細胞構造体、細胞構造体の製造方法、細胞培養方法及びマイクロ流路
CN114504561B (zh) *	2022-03-01	2023-08-11	陕西科技大学	一种用于制备药物渗透泵制剂的水性包衣方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL129921C (da) *	1958-12-31
FR1542881A (fr) *	1966-10-10	1968-10-18	Ncr Co	Procédé de préparation de capsules minuscules à base de polymère
CH573212A5 (en) *	1973-06-29	1976-03-15	Feller Marc Rech Tech Et Et Sc	Delayed release agricultural formulations - of herbicide or insecticide absorbed on porous carrier and coed with isolating layer
US4352883A (en) *	1979-03-28	1982-10-05	Damon Corporation	Encapsulation of biological material

1982
- 1982-03-11 NO NO820795A patent/NO158284C/no unknown
- 1982-03-12 DE DE3209045A patent/DE3209045C2/de not_active Expired
- 1982-03-12 IT IT20139/82A patent/IT1150681B/it active
- 1982-03-12 SE SE8201557A patent/SE454181B/sv not_active IP Right Cessation
- 1982-03-12 DK DK112382A patent/DK112382A/da not_active Application Discontinuation
- 1982-03-12 CH CH1574/82A patent/CH651579A5/de not_active IP Right Cessation
- 1982-03-12 JP JP57038239A patent/JPS57197031A/ja active Granted
- 1982-03-12 FR FR8204243A patent/FR2501528A1/fr active Granted
- 1982-03-12 CA CA000398210A patent/CA1184518A/en not_active Expired
- 1982-03-12 BE BE0/207557A patent/BE892477A/fr not_active IP Right Cessation
- 1982-03-12 GB GB8207308A patent/GB2094750B/en not_active Expired

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6348039U (da) *	1986-09-12	1988-04-01

Also Published As

Publication number	Publication date
SE8201557L (sv)	1982-09-14
JPS57197031A (en)	1982-12-03
CA1184518A (en)	1985-03-26
CH651579A5 (de)	1985-09-30
DK112382A (da)	1982-09-14
IT8220139A0 (it)	1982-03-12
IT1150681B (it)	1986-12-17
BE892477A (fr)	1982-07-01
FR2501528A1 (fr)	1982-09-17
FR2501528B1 (da)	1984-06-15
GB2094750A (en)	1982-09-22
DE3209045A1 (de)	1982-09-30
NO158284C (no)	1988-08-17
NO158284B (no)	1988-05-09
SE454181B (sv)	1988-04-11
DE3209045C2 (de)	1986-06-19
NO820795L (no)	1982-09-14
GB2094750B (en)	1984-08-22

Publication	Publication Date	Title
US4407957A (en)	1983-10-04	Reversible microencapsulation of a core material
JPS6152737B2 (da)	1986-11-14
US4409331A (en)	1983-10-11	Preparation of substances with encapsulated cells
JPS6244919B2 (da)	1987-09-24
US4495288A (en)	1985-01-22	Method of culturing anchorage dependent cells
JPS6239131B2 (da)	1987-08-21
CA1215922A (en)	1986-12-30	Microencapsulation of living tissue and cells
US4391909A (en)	1983-07-05	Microcapsules containing viable tissue cells
US4673566A (en)	1987-06-16	Microencapsulation of living tissue and cells
US4933185A (en)	1990-06-12	System for controlled release of biologically active compounds
US4806355A (en)	1989-02-21	Microencapsulation of living tissue and cells
US4689293A (en)	1987-08-25	Microencapsulation of living tissue and cells
JPS6038111B2 (ja)	1985-08-30	固定依存性細胞の培養法
EP0127989A2 (en)	1984-12-12	Microencapsulation of living tissue and cells
JPS61189218A (ja)	1986-08-22	カプセル封入方法
US4582799A (en)	1986-04-15	Process for recovering nonsecreted substances produced by cells
GB2145992A (en)	1985-04-11	Microencapsulation of viable cells
WO1988000237A1 (en)	1988-01-14	Covalent membranes
Chang	1993	Living cells and microorganisms immobilized by microencapsulation inside artificial cells
WO1987004367A1 (en)	1987-07-30	Covalent membranes
GB2119734A (en)	1983-11-23	Encapsulated living tissue
CA1280381C (en)	1991-02-19	Entrapment of anchorage-dependent cells
GB2119737A (en)	1983-11-23	Encapsulation of viable tissue
De Smet et al.	1992	EMERGING TECHNIQUES, MATERIALS, AND APPLICATIONS IN CELL IMMOBILIZATION
JPH05176754A (ja)	1993-07-20	細胞の繁殖方法

JPS6152737B2 - - Google Patents

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Applications Claiming Priority (1)

Publications (2)

Family

ID=22919328

Family Applications (1)

Country Status (11)

Cited By (1)

Families Citing this family (23)

Family Cites Families (4)

Cited By (1)

Also Published As

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