JPS61268613A - Composition for oral cavity containing evening primrose seed oil - Google Patents
Composition for oral cavity containing evening primrose seed oilInfo
- Publication number
- JPS61268613A JPS61268613A JP60110834A JP11083485A JPS61268613A JP S61268613 A JPS61268613 A JP S61268613A JP 60110834 A JP60110834 A JP 60110834A JP 11083485 A JP11083485 A JP 11083485A JP S61268613 A JPS61268613 A JP S61268613A
- Authority
- JP
- Japan
- Prior art keywords
- seed oil
- composition
- evening primrose
- primrose seed
- oral cavity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
本発明はう蝕予防効果を有する口腔用組成物に関し、更
に詳しくは、ｓ ｔｒｅｐｔｏｃｏｃｃｕｓ ｍｕｔ
ａｎｓ（ストレプトコッカスミュータンス１．以下Ｓ、
ミュータンスという）に対する特異的抗菌作用および／
またはＳ、ミュータンス並びにその菌体外酵素が産生ず
る不溶性グルカンの歯面への付着阻止作用を有する月見
草種子油（Ｅｖｅｎｉｎｇ ｐｒｉｍｒｏｓｅ ｏＨ）
を必須成分として含有する、う蝕予防効果を有する口腔
用組成物、特にチューインガム組成物に関する。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an oral composition having a caries preventive effect, and more particularly, to
ans (Streptococcus mutans 1. hereafter S,
Streptococcus mutans) and/or
or evening primrose oH, which has the effect of inhibiting the adhesion of insoluble glucans produced by S. mutans and its extracellular enzymes to the tooth surface.
The present invention relates to an oral composition, particularly a chewing gum composition, which contains as an essential ingredient and has a caries preventive effect.
う蝕の原因については過去多数の研究者によって多くの
説が唱えられて来たが、今日では、ミラー（Ｍｉｌｌｅ
ｒ）らの化学細菌説から発展した細菌感染疾患説が有力
である。この説によれば、う蝕は以下に述べる機構によ
って発生する。即ち、口腔内の微生物、特にＳ、ミュー
タンスの菌体外酵素であるグルコシルトランスフェラー
ゼ（以下ＧＴａｓｅという）によって、食物中の蔗糖が
粘着性を有する多糖類（グルカン）に変換され、このグ
ルカンが歯面に付着して菌体の凝集塊、即ち歯垢を形成
する。この歯垢中で微生物が繁殖し、解糖系により乳酸
などの有機酸が産生ずる。この有機酸により歯面のｐｌ
が５．４以下になるとエナメル質に脱灰がおこり、う蝕
が発生、進行する。In the past, many researchers have proposed many theories about the causes of tooth decay, but today, Miller (Miller)
The bacterial infection disease theory developed from the chemical bacteria theory of R. According to this theory, caries occurs by the mechanism described below. That is, sucrose in food is converted into sticky polysaccharide (glucan) by glucosyltransferase (hereinafter referred to as GTase), which is an extracellular enzyme of microorganisms in the oral cavity, especially S. mutans, and this glucan is transferred to the teeth. It adheres to surfaces and forms aggregates of bacterial cells, that is, dental plaque. Microorganisms multiply in this plaque, and organic acids such as lactic acid are produced through glycolysis. This organic acid causes pl on the tooth surface.
When the ratio is less than 5.4, demineralization occurs in the enamel, and dental caries develops and progresses.
上に述べたう蝕発生機構から明らかな様に、Ｓ。As is clear from the caries development mechanism described above, S.
ミュータンスを殺菌することはう蝕予防に最も有効であ
り、従来から種々の殺菌剤（例えばクロルヘキシジン、
塩化ベンザルコニウム、パラオキシ安息香酸ブチル、安
息香酸ナトリウムなど）および各種抗生物質が使用され
て来た。しかしながら、これらの殺菌剤や抗生物質は、
Ｓ、ミュータンスのみならず口腔内常在菌を無差別に殺
菌するため、口腔内あるいは腸内殺菌層を変化させ、口
内炎、鵞口癒、歯周病の悪化などをひき起こす。これは
、口腔内常在菌が死滅することにより、それらによって
増殖がさまたげられて来た悪性の細菌が繁殖しはじめる
ことによる。従って、口腔内常在菌を無差別に死滅させ
る殺菌剤や抗生物質は、良好なう蝕子防剤とはなり得な
い。Sterilizing P. mutans is the most effective way to prevent dental caries, and various fungicides (e.g. chlorhexidine,
benzalkonium chloride, butyl paraoxybenzoate, sodium benzoate, etc.) and various antibiotics have been used. However, these disinfectants and antibiotics
Since it indiscriminately sterilizes not only S. mutans but also bacteria resident in the oral cavity, it changes the sterilizing layer in the oral cavity or intestines, causing stomatitis, thrush, and aggravation of periodontal disease. This is because, as the indigenous bacteria in the oral cavity die, malignant bacteria, whose growth has been hindered by them, begin to proliferate. Therefore, bactericidal agents and antibiotics that indiscriminately kill bacteria resident in the oral cavity cannot serve as good caries prevention agents.
本Ｘ班箆艮停
本発明者らは、１）Ｓ、 ミュータンスに対する特異的
抗菌作用、あるいは、２）Ｓ、ミュータンスをはじめと
する各種微生物並びに不溶性グルカンの歯面への付着を
阻止しく以、下、微生物付着阻止作用という）、歯垢の
生成を防止する作用、のいずれか、またはその両者を持
った物質を求めて種々検討を行った結果、月見草種子油
がこの目的に合った物質であることを見い出し、本発明
を完成するに至った。The inventors of the present invention have proposed the following: 1) specific antibacterial action against S. mutans, or 2) prevention of adhesion of various microorganisms including S. mutans and insoluble glucans to tooth surfaces. As a result of various studies in search of a substance that has either the action of inhibiting microbial adhesion (hereinafter referred to as the action of inhibiting microbial adhesion) or the action of preventing the formation of dental plaque, or both, we found that evening primrose seed oil was suitable for this purpose. They discovered that it is a substance and completed the present invention.
即ち本発明は、月見草種子油を必須成分とじて含有する
う蝕予防効果を有する口腔用組成物、特にチューインガ
ム組成物を提供するものである。That is, the present invention provides an oral composition, particularly a chewing gum composition, containing evening primrose seed oil as an essential ingredient and having a caries preventive effect.
月見草種子油には、ビタミン、ミネラルをはじめ、各種
の脂肪酸が含まれているが、本発明者らは、種々検討の
結果、上記の特異的抗菌作用および微生物付着阻止作用
は、月見草種子油の主成分であるγ−リルン酸およびリ
ノール酸によるものであることをつきとめた。Evening primrose seed oil contains various fatty acids, including vitamins and minerals. As a result of various studies, the present inventors found that the above-mentioned specific antibacterial effect and microbial adhesion inhibiting effect were found in evening primrose seed oil. It was determined that this was due to the main components, γ-lylunic acid and linoleic acid.
月見草種子油中に含まれているこのγ−リルン酸は、不
飽和系必須脂肪酸の１つであって、生体内に広く分布し
、血管や血液、各種の臓器や組織の細胞を正常な状態に
保つ上で重要な役割を果たしている。更に、最近では、
γ−リルン酸は多種多様の生理活性を有するプロスタグ
ランジンの前駆体として重要な物質であることもわかっ
て来た。この様に、生体の重要な構成成分の１つである
γ−リルン酸は、月見草種子油中に含まれているもうｌ
っの脂肪酸成分でもあるリノール酸から、生体内で生合
成される脂肪酸である。従って、偏食（特に飽和脂肪酸
の過剰摂取）やアルコールの多飲により、あるいは糖尿
病、悪性腫瘍、感染などによる代謝機能の衰えによって
リノール酸からの転換が阻害されると、γ−リルン酸不
足を来たし、種々の弊害が現れる。γ−リルン酸は、自
然界では母乳とこの月見草種子油中にのみ存在する物質
であるので、通常、食物摂取によってこの不足を補うこ
とはむつかしい。従って、この不足を補うためには、人
為的にγ−リルン酸またはリノール酸を補給する必要が
ある。γ-Lilunic acid contained in evening primrose seed oil is one of the unsaturated essential fatty acids, and is widely distributed in the body, maintaining blood vessels, blood, and cells of various organs and tissues in a normal state. plays an important role in keeping the Furthermore, recently,
It has also been found that γ-lylunic acid is an important substance as a precursor of prostaglandins that have a wide variety of physiological activities. In this way, γ-lylunic acid, which is one of the important constituents of living organisms, is also present in evening primrose seed oil.
It is a fatty acid that is biosynthesized in living organisms from linoleic acid, which is also a fatty acid component. Therefore, if the conversion from linoleic acid is inhibited by an unbalanced diet (particularly excessive intake of saturated fatty acids), excessive alcohol consumption, or by a decline in metabolic function due to diabetes, malignant tumors, infection, etc., a deficiency of γ-lylunic acid may occur. , various adverse effects appear. Since γ-lylunic acid is a substance that exists only in breast milk and evening primrose seed oil in the natural world, it is usually difficult to compensate for this deficiency through food intake. Therefore, in order to compensate for this deficiency, it is necessary to artificially supplement γ-lylunic acid or linoleic acid.
上に述べたことから明らかな様に、月見草種子油中に含
まれるγ−リルン酸およびリノール酸は、う蝕予防効果
としての特異的抗菌作用および微生物付着阻止作用を発
揮するほか、これを唖下した場合には、健康保持物質と
しても役立つのであるから、月見草種子油は、う蝕予防
口腔用組成物の理想的な活性成分であるということがで
きる。As is clear from the above, the γ-linolenic acid and linoleic acid contained in evening primrose seed oil not only exhibit specific antibacterial and microbial adhesion inhibiting effects as caries prevention effects, but also have the ability to inhibit the adhesion of microorganisms. Evening primrose seed oil can be said to be an ideal active ingredient for caries-preventing oral compositions since it also serves as a health-preserving substance when removed.
月見草種子油は、各種製造業者のものが市販されて知り
、それらはいづれも本発明の口腔用組成物の製造に使用
することができる。これらの市販の月見草種子油には、
製造業者およびロフトによりて多少の差はあるが、通常
的７％のγ−リルン酸、約７０％めリノール酸および約
２０％のその他の脂肪酸が含まれている。Evening primrose seed oil is commercially available from various manufacturers, and any of them can be used to prepare the oral composition of the present invention. These commercially available evening primrose seed oils include:
It typically contains 7% gamma-lylunic acid, about 70% linoleic acid, and about 20% other fatty acids, although this varies by manufacturer and loft.
本発明に係る口腔用組成物は、月見草種子油を適当な担
体または補助剤などと混合することにより調製されるが
、その形体は液剤、固形剤、半固形剤のいずれであって
もよい。好ましい組成物の剤型としては、歯みがき剤、
含轍剤、トローチ剤、塗布液剤、張り薬およびチューイ
ンガムなどが挙げられるが、既述した理由でチューイン
ガム組成物が最も好ましい。従って、以下チューインガ
ム組成物について詳述するが、本発明に係る口腔用組成
物はこれに限定されると解釈してはならない。The oral composition according to the present invention is prepared by mixing evening primrose seed oil with a suitable carrier or adjuvant, and may be in the form of a liquid, solid, or semisolid. Preferred dosage forms of the composition include dentifrice,
Examples include rutting agents, troches, coating solutions, plasters, and chewing gums, but chewing gum compositions are most preferred for the reasons already mentioned. Therefore, although the chewing gum composition will be described in detail below, the oral composition according to the present invention should not be interpreted as being limited thereto.
月見草種子油を必須成分とする本発明に係るチューイン
ガム組成物は、常法に従って製造することができる。ガ
ムベース、賦形剤および補助剤は、通常のチューインガ
ム製造に用いられるものから適宜選択すればよく、特に
制限されるものではないが、チクル、酢酸ビニル樹脂、
ポリイソブチレン、ワックス類などのガムベース、粉糖
、ブドウ糖、水あめ、ソルビトール、マンニトール、サ
ッカリン等の甘味料、スペアミント、ペパーミント、σ
−メントールやフルーツ香料などの香料などが好適に使
用される。 また、必要に応じて歯垢除去効果を高める
ためにセルロース粉末やタルク、ハイドロキシアパタイ
ト粉末などの研摩剤、デキストラナーゼ、ムタナーゼ、
リゾチーム、Ｎ−アセチルムラミダーゼなどの酵素類を
適宜添加することができる。The chewing gum composition according to the present invention containing evening primrose seed oil as an essential ingredient can be manufactured according to a conventional method. The gum base, excipients, and auxiliary agents may be appropriately selected from those used in ordinary chewing gum manufacturing, and are not particularly limited, but include chicle, vinyl acetate resin,
Gum bases such as polyisobutylene and waxes, powdered sugar, glucose, starch syrup, sweeteners such as sorbitol, mannitol, and saccharin, spearmint, peppermint, and σ
- Flavors such as menthol and fruit flavors are preferably used. In addition, abrasives such as cellulose powder, talc, and hydroxyapatite powder, dextranase, mutanase,
Enzymes such as lysozyme and N-acetylmuramidase can be added as appropriate.
本発明に係ろう蝕子防用のチューインガム組成物中に占
める月見草種子油の量は、組成物全量に対して０．０１
〜３０重量％、好ましくは０．１〜１０重量％である。The amount of evening primrose seed oil in the chewing gum composition for preventing dental caries according to the present invention is 0.01% of the total amount of the composition.
-30% by weight, preferably 0.1-10% by weight.
以下に実験例を示し、月見草種子油の特異的抗菌作用お
よび歯面への微生物付着阻止作用について詳述する。Experimental examples are shown below, and the specific antibacterial action and action of inhibiting microbial adhesion to tooth surfaces of evening primrose seed oil will be explained in detail.
実験例１ 抗菌活性の測定
試験管に２゜８吋のプレインハートインヒユージョン（
ＢＨＩ）培地を加え、これにジメチルスルホキシドに溶
解した各種濃度の月見草種子油０゜１ｘＱと、予め面培
養した下記の菌液０．１好を加え、３７℃で静置培養す
る。−夜放置後、２日後および４日後に観察し、最小発
育阻止濃度を測定する。結果を表１に示す。Experimental Example 1 Measurement of antibacterial activity Add 2.8 inches of plain heart infusion (
BHI) medium is added, evening primrose seed oil 0°1xQ of various concentrations dissolved in dimethyl sulfoxide and 0.1xQ of the following bacterial solution previously surface cultured are added, and cultured statically at 37°C. - After leaving overnight, observe after 2 and 4 days and determine the minimum inhibitory concentration. The results are shown in Table 1.
試験に用いた菌株
ｌ、ストレプトコッカス・ミュータンス、イングリッド
（Ｓ ｔｒｅｐｆｏｃｏｃｃｕｓ ｍｕｔａｎｓ
Ｉ ｎｇｂｒｉｔｔＸ血清型Ｃ）・・・・・・グラム陽
性菌
２、ストレプトコッカス・ミュータンス（Ｓｔｒｅｐｆ
ｏｃｏｃｃｕｓ ｍｕｔａｎｓ）ＯＭＺ Ｉ ７６
（血清型ｄ）・・・・・・グラム陽性菌
３、ストレプトコッカス・サリバリウス（Ｓｔｒｅｐｆ
ｏｃｏｃｃｕ＋ｓ ５ａｌｉｖａｒｉｕｓ）ＡＴＣＣ
９２２２・・・・・・グラム陽性菌
４、バチルス・メガテリ゛ウム
（Ｂａｃｉｌｌｕｓ ｍｅｇａｔｅｒｉｕｍ）ＱＭＢ
ｌ ５５１−グラム陽性菌
５、スタフィロコッカス・アウレウス
（Ｓ ｔｒｅｐｆｏｃｏｃｃｕｓ ａｕｒｅｕｓ）
２０ Ｑ Ｐ−・・・・・グラム陽性菌
６、エシェリヒア・コリ（Ｅ ５ｈｅｒｉｃｈｉａ
ｃｏｌｉ）Ｋ１２・・・・・・グラム陰性菌
７、セラチア・マルセッセンス（Ｓｅｒｒａｔｉａｍａ
ｒｃｅｓｃｅｎｓ） Ｉ Ｆ ０１２６４８−・−用グ
ラム陰性菌８、シュードモナス・アエルギノーサ
（Ｐ ｓｅｕｄｏｍｏｎａｓ ａｅｒｕｇｉｎｏｓａ
）ＫＭ ３３ Ｂ ＝ダラム陰性菌
表１から明らかなように、月見草種子油はＳ。Strains used in the test, Streptococcus mutans, Ingrid (Streptococcus mutans)
IngbrittX serotype C)... Gram-positive bacteria 2, Streptococcus mutans (Strepf
ococcus mutans) OMZ I 76
(Serotype d)... Gram-positive bacteria 3, Streptococcus salivarius (Strepf
ococcu+s 5alivarius) ATCC
9222...Gram-positive bacterium 4, Bacillus megaterium QMB
l 551 - Gram-positive bacteria 5, Staphylococcus aureus (S trepfococcus aureus)
20 Q P-... Gram-positive bacteria 6, Escherichia coli (E 5herichia
coli) K12...Gram-negative bacterium 7, Serratia marcescens
Pseudomonas aeruginosa (Pseudomonas aeruginosa)
) KM 33 B = Durham negative bacteria As is clear from Table 1, evening primrose seed oil is S.
ミュータンス、Ｓ、サリバリウスおよびバチルス・メガ
テリウムに作用し、他のスタフィロコッカス・アウレウ
ス、エシェリヒア・コリ、セラチア・マルセヅセンスお
よびシュードモナス・アエルギノーサなどにはほとんど
抗菌性を示さない。従って月見草種子油はう蝕原性のＳ
、ミュータンスなどに比較的特異的な、狭い抗菌スペク
トルを有するといえる。It acts on Bacillus mutans, S. salivarius, and Bacillus megaterium, and shows almost no antibacterial activity against other species such as Staphylococcus aureus, Escherichia coli, Serratia marseduscens, and Pseudomonas aeruginosa. Therefore, evening primrose seed oil is cariogenic.
It can be said that it has a narrow antibacterial spectrum that is relatively specific to P. mutans.
尚、表１には示さなかったが、この抗菌活性を示す活性
本体が何であるかを検討した段階に於いて、月見草種子
油の主成分であるγ−リルン酸とリノール酸について同
様の実験を行なったが、その実験結果は表１に示した。Although not shown in Table 1, at the stage of examining the active substance that exhibits this antibacterial activity, similar experiments were conducted on γ-lylunic acid and linoleic acid, which are the main components of evening primrose seed oil. The experimental results are shown in Table 1.
ものとほぼ同じであった。It was almost the same.
実験例２ 月見草種子油のＳ、ミュータンス試験管壁付
着阻止作用
５％蔗糖を含むプレインハートインヒユージョン（ＢＨ
Ｉ）培地２ 、８ ｘＱに、ジメチルスルホキシドに溶
解した各種濃度の月見草種子油０ 、１ ｗ（ｌと、予
めＢＨ［培地中３７℃で一夜培養したＳ、ミュータンス
ＯＭＺ １７６菌液０．１麗Ｑを加え、３７°Ｃで２０
時間、３０°の角度に傾けて静置培養する。Experimental Example 2 Plain heart infusion (BH) containing S of evening primrose seed oil and 5% sucrose that inhibits mutans test tube wall adhesion.
I) 0,1 w (l) of evening primrose seed oil at various concentrations dissolved in dimethyl sulfoxide was added to 2,8 x Q medium, and 0.1 w (l) of evening primrose seed oil dissolved in dimethyl sulfoxide and 0.1 of S. mutans OMZ 176 bacterial solution cultured overnight at 37°C in BH [medium]. Add Rei-Q and heat at 37°C for 20
Incubate for a while at an angle of 30°.
試験管を静かに回転させ（２〜３回）、付着していない
菌液を別の試験管■にとる。もとの試験管■に５０ｍＭ
リン酸緩衝液（ｐＨ＝７．５）３村を加え、試験管を２
〜３回静かに回転して洗い、付着していない菌液をさら
に別の試験管■にとる。■。Gently rotate the test tube (2 to 3 times) and remove the non-adherent bacterial solution into another test tube. 50mM in the original test tube
Add 3 ml of phosphate buffer (pH = 7.5) and divide the test tube into 2
Gently rotate and wash ~3 times, and remove the non-adherent bacterial solution into another test tube (■). ■.
■を遠心分離（２５００ｒｐｍ、 １５分）し、上澄液
を捨てる。試験管■、■、■に０．５Ｍ ＮａＯＨ溶
液３峠を加えて攪拌して菌を懸濁させ、６６０ｎｍで濁
度を測定し、Ａ■、Ａ■、Ａ■とする。Centrifuge (2500 rpm, 15 minutes) and discard the supernatant. Three 0.5M NaOH solutions were added to the test tubes (■, ■, ■) and stirred to suspend the bacteria, and the turbidity was measured at 660 nm and designated as A■, A■, and A■.
コントロールにはジメチルスルホキシド０．１．ｗ１２
を用いて同様の操作を行う。Ａ■は試験管壁に付着して
いる菌体を、Ａ■およびＡ■は付着していない菌体の量
をあられす。For control, dimethyl sulfoxide 0.1. w12
Perform the same operation using . A■ represents the amount of bacterial cells attached to the test tube wall, and A■ and A■ represent the amount of bacterial cells that are not attached.
菌体の付着率および付着阻止率を次式により求める。The adhesion rate and adhesion inhibition rate of bacterial cells are calculated using the following formula.
以上の実験の結果を以下の表２に示す。The results of the above experiments are shown in Table 2 below.
表２ 月見草種子油のＳ、ミュータンス※月見草種子油
１０および２５μｇ／ｍｌはＭＩＣ以上の濃度であるが
、蔗糖５％を加えた培地中ではコントロールの５％〜１
５％程度の増殖がみられたので試験管壁付着阻止活性の
検定が可能であった。Table 2 Evening primrose seed oil S, mutans * Evening primrose seed oil 10 and 25 μg/ml have concentrations above the MIC, but in a medium containing 5% sucrose, 5% to 1 of the control
Since a proliferation of about 5% was observed, it was possible to assay the test tube wall adhesion inhibiting activity.
表２から明らかなように月見草種子油はＳ、ミュータン
スの試験管壁付着を５μ９／ＩＩＱ以上の濃度で、はぼ
完全に阻止し、またこの濃度で、培地中にワイヤーでつ
る■７た％ｍ歯面への菌体の付着を完全に防止した。As is clear from Table 2, evening primrose seed oil almost completely inhibits the adhesion of S. and S. mutans to the test tube walls at a concentration of 5μ9/IIQ or higher, and at this concentration, it also inhibits the adhesion of S. mutans to the test tube wall. % m Completely prevented bacterial cells from adhering to tooth surfaces.
以下に実施例を挙げて本発明のチューインガム組成物の
処方を具体的に説明するが、既述した様に、本発明に係
る組成物はこれらに限定されるものではない。The formulation of the chewing gum composition of the present invention will be specifically explained below with reference to Examples, but as already mentioned, the composition of the present invention is not limited to these.
例１ 板ガム
酢酸ビニル樹脂 ２０．０
ポリイソブチレン ３．０
炭酸カルシウム ２．０
ソルビトール ６０．０
マンニトール ９．０
香料 １．０
月見草種子油 ５．０
計 １００．０重量（％）肚 風船ガ
ム
酢酸ビニル樹脂 １６．０
エステルガム １０．０
タルク １．５ソルビトール
４８．０
マンニトール ２０，０
香料 １．５
几艮臭鼠ヱ辿−３−東−−一一Example 1 Gum vinyl acetate resin 20.0 Polyisobutylene 3.0 Calcium carbonate 2.0 Sorbitol 60.0 Mannitol 9.0 Flavor 1.0 Evening primrose seed oil 5.0 Total 100.0 Weight (%) Bubbles gum acetic acid Vinyl resin 16.0 Ester gum 10.0 Talc 1.5 Sorbitol
48.0 Mannitol 20.0 Fragrance 1.5 Odor 1.
Claims (1)
効果を有する口腔用組成物。 ２、チューインガム組成物である第１項に記載の口腔用
組成物。[Scope of Claims] 1. An oral composition containing evening primrose seed oil as an essential ingredient and having a caries preventive effect. 2. The oral composition according to item 1, which is a chewing gum composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60110834A JPS61268613A (en) | 1985-05-22 | 1985-05-22 | Composition for oral cavity containing evening primrose seed oil |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60110834A JPS61268613A (en) | 1985-05-22 | 1985-05-22 | Composition for oral cavity containing evening primrose seed oil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS61268613A true JPS61268613A (en) | 1986-11-28 |
Family
ID=14545844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60110834A Pending JPS61268613A (en) | 1985-05-22 | 1985-05-22 | Composition for oral cavity containing evening primrose seed oil |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61268613A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005041912A1 (en) * | 2003-10-30 | 2005-05-12 | Ntnu Technology Transfer As | Oral hygiene product |
| US6905672B2 (en) | 1999-12-08 | 2005-06-14 | The Procter & Gamble Company | Compositions and methods to inhibit tartar and microbes using denture adhesive compositions with colorants |
| JP2006298913A (en) * | 2005-03-25 | 2006-11-02 | Lion Corp | Periodontal tissue disruption-inhibitory/ameliorative agent and method for screening the same |
| JP2006306844A (en) * | 2005-03-31 | 2006-11-09 | Kobayashi Pharmaceut Co Ltd | Oral hygiene composition |
| CN113456546A (en) * | 2021-06-24 | 2021-10-01 | 上海乐宝日化股份有限公司 | Oral care solution |
| KR20220114396A (en) * | 2021-02-08 | 2022-08-17 | 바이오스펙트럼 주식회사 | A composition for preventing, improving, or treating striae distensae comprising Oenothera biennis water extracts |
-
1985
- 1985-05-22 JP JP60110834A patent/JPS61268613A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6905672B2 (en) | 1999-12-08 | 2005-06-14 | The Procter & Gamble Company | Compositions and methods to inhibit tartar and microbes using denture adhesive compositions with colorants |
| WO2005041912A1 (en) * | 2003-10-30 | 2005-05-12 | Ntnu Technology Transfer As | Oral hygiene product |
| JP2006298913A (en) * | 2005-03-25 | 2006-11-02 | Lion Corp | Periodontal tissue disruption-inhibitory/ameliorative agent and method for screening the same |
| JP2006306844A (en) * | 2005-03-31 | 2006-11-09 | Kobayashi Pharmaceut Co Ltd | Oral hygiene composition |
| KR20220114396A (en) * | 2021-02-08 | 2022-08-17 | 바이오스펙트럼 주식회사 | A composition for preventing, improving, or treating striae distensae comprising Oenothera biennis water extracts |
| CN113456546A (en) * | 2021-06-24 | 2021-10-01 | 上海乐宝日化股份有限公司 | Oral care solution |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI566699B (en) | Biofilm disruptive compositions and the use thereof | |
| US4606911A (en) | Pharmaceutical composition for the prevention of dental caries | |
| JPH01501000A (en) | Enzyme-containing disinfectant composition and dental and wound care products containing this composition | |
| JPH08502970A (en) | Antibacterial mouthwash | |
| JPH06505745A (en) | Non-antibacterial tetracycline composition with anti-plaque properties | |
| JP3614479B2 (en) | Periodontal disease-causing bacteria or caries-causing bacteria inhibitor, oral composition and food containing them | |
| JP5705537B2 (en) | Composition comprising the use of an aqueous grape seed extract in combination with at least one fluoride salt and combinations thereof to address the formation or accumulation of dental biofilms | |
| CN107693392A (en) | A kind of toothpaste of enzyme-containing formulation and preparation method thereof | |
| JPS61268613A (en) | Composition for oral cavity containing evening primrose seed oil | |
| US3940476A (en) | Oral preparations for preventing dental plaque | |
| US4060602A (en) | Oral preparations for preventing dental caries | |
| JP2540892B2 (en) | Oral composition | |
| JPS61260017A (en) | Composition for oral cavity application having caries-preventive effect | |
| WO2022145325A1 (en) | Composition for oral cavity | |
| JPS5835484B2 (en) | Oral composition | |
| KR102000521B1 (en) | Oral spray composition | |
| JPH0687752A (en) | Antimicrobial water and its production | |
| JPS5936882B2 (en) | Oral composition | |
| JP2568833B2 (en) | Caries prevention agent | |
| JPH07133222A (en) | Glucosyl transferase inhibitor | |
| US4374124A (en) | Dental plaque-preventive oxazolidine containing compositions and method | |
| JPS5812254B2 (en) | Oral composition | |
| US4435381A (en) | Thiouronium phosphonates for use in dental treatments | |
| JP3749604B2 (en) | Plaque formation inhibitor | |
| JP2986991B2 (en) | Oral composition |