JPS6125359B2 - - Google Patents

Info

Publication number: JPS6125359B2
Authority: JP; Japan
Prior art keywords: dopa; dopamine; streptococcus; microorganism; genus streptococcus
Prior art date: 1979-01-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP838579A

Other languages

English (en)

Japanese (ja)

Other versions

JPS55102394A (en

Inventor

Ichiro Senhata

Toshio Kakimoto

Yoshiaki Kakie

Toshihiko Ujimaru

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Tanabe Seiyaku Co Ltd

Original Assignee

Tanabe Seiyaku Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-01-26

Filing date

1979-01-26

Publication date

1986-06-14

1979-01-26 Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd

1979-01-26 Priority to JP838579A priority Critical patent/JPS55102394A/ja

1980-08-05 Publication of JPS55102394A publication Critical patent/JPS55102394A/ja

1986-06-14 Publication of JPS6125359B2 publication Critical patent/JPS6125359B2/ja

Status Granted legal-status Critical Current

Links

VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims description 51
WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims description 28
241000194017 Streptococcus Species 0.000 claims description 27
244000005700 microbiome Species 0.000 claims description 27
229960003638 dopamine Drugs 0.000 claims description 25
WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims description 24
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 13
239000008103 glucose Substances 0.000 claims description 13
238000004519 manufacturing process Methods 0.000 claims description 13
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 12
238000006243 chemical reaction Methods 0.000 claims description 12
238000000034 method Methods 0.000 claims description 9
229960004441 tyrosine Drugs 0.000 claims description 6
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 3
AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 2
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 2
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 2
229920000053 polysorbate 80 Polymers 0.000 claims description 2
MHUWZNTUIIFHAS-CLFAGFIQSA-N dioleoyl phosphatidic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC MHUWZNTUIIFHAS-CLFAGFIQSA-N 0.000 claims 2
229960004502 levodopa Drugs 0.000 claims 2
230000001580 bacterial effect Effects 0.000 description 15
108090000790 Enzymes Proteins 0.000 description 13
102000004190 Enzymes Human genes 0.000 description 13
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 10
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
239000002609 medium Substances 0.000 description 9
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
238000006911 enzymatic reaction Methods 0.000 description 6
NGVDGCNFYWLIFO-UHFFFAOYSA-N pyridoxal 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O NGVDGCNFYWLIFO-UHFFFAOYSA-N 0.000 description 6
239000001888 Peptone Substances 0.000 description 5
108010080698 Peptones Proteins 0.000 description 5
DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 5
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 5
229910052921 ammonium sulfate Inorganic materials 0.000 description 5
235000011130 ammonium sulphate Nutrition 0.000 description 5
229940041514 candida albicans extract Drugs 0.000 description 5
235000019319 peptone Nutrition 0.000 description 5
239000012138 yeast extract Substances 0.000 description 5
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 4
238000005119 centrifugation Methods 0.000 description 4
CTENFNNZBMHDDG-UHFFFAOYSA-N Dopamine hydrochloride Chemical compound Cl.NCCC1=CC=C(O)C(O)=C1 CTENFNNZBMHDDG-UHFFFAOYSA-N 0.000 description 3
229960001149 dopamine hydrochloride Drugs 0.000 description 3
238000001914 filtration Methods 0.000 description 3
235000007682 pyridoxal 5'-phosphate Nutrition 0.000 description 3
239000011589 pyridoxal 5'-phosphate Substances 0.000 description 3
229960001327 pyridoxal phosphate Drugs 0.000 description 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
235000019270 ammonium chloride Nutrition 0.000 description 2
239000000284 extract Substances 0.000 description 2
239000001963 growth medium Substances 0.000 description 2
150000007524 organic acids Chemical class 0.000 description 2
239000000047 product Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
238000003786 synthesis reaction Methods 0.000 description 2
UHSXRTHJCJGEKG-UQKRIMTDSA-N (1s)-1-[(3,4,5-trimethoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-ium-6,7-diol;chloride Chemical compound Cl.COC1=C(OC)C(OC)=CC(C[C@H]2C3=CC(O)=C(O)C=C3CCN2)=C1 UHSXRTHJCJGEKG-UQKRIMTDSA-N 0.000 description 1
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
JTWUZULPZAALRN-UHFFFAOYSA-N 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde;phosphoric acid Chemical compound OP(O)(O)=O.CC1=NC=C(CO)C(C=O)=C1O JTWUZULPZAALRN-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
108010093096 Immobilized Enzymes Proteins 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
HDYRYUINDGQKMC-UHFFFAOYSA-M acetyloxyaluminum;dihydrate Chemical compound O.O.CC(=O)O[Al] HDYRYUINDGQKMC-UHFFFAOYSA-M 0.000 description 1
239000002253 acid Substances 0.000 description 1
229940009827 aluminum acetate Drugs 0.000 description 1
230000003698 anagen phase Effects 0.000 description 1
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
239000000679 carrageenan Substances 0.000 description 1
235000010418 carrageenan Nutrition 0.000 description 1
229920001525 carrageenan Polymers 0.000 description 1
229940113118 carrageenan Drugs 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
239000013078 crystal Substances 0.000 description 1
238000012258 culturing Methods 0.000 description 1
239000003814 drug Substances 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
230000012010 growth Effects 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
239000003456 ion exchange resin Substances 0.000 description 1
229920003303 ion-exchange polymer Polymers 0.000 description 1
159000000014 iron salts Chemical class 0.000 description 1
238000002955 isolation Methods 0.000 description 1
239000008101 lactose Substances 0.000 description 1
159000000003 magnesium salts Chemical class 0.000 description 1
150000002696 manganese Chemical class 0.000 description 1
239000011785 micronutrient Substances 0.000 description 1
235000013369 micronutrients Nutrition 0.000 description 1
239000011707 mineral Substances 0.000 description 1
239000000203 mixture Substances 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
229920002401 polyacrylamide Polymers 0.000 description 1
239000002994 raw material Substances 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
238000009210 therapy by ultrasound Methods 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1

Landscapes

Preparation Of Compounds By Using Micro-Organisms (AREA)

JP838579A 1979-01-26 1979-01-26 Novel enzymatic preparation of dopamine Granted JPS55102394A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP838579A JPS55102394A (en)	1979-01-26	1979-01-26	Novel enzymatic preparation of dopamine

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP838579A JPS55102394A (en)	1979-01-26	1979-01-26	Novel enzymatic preparation of dopamine

Publications (2)

Publication Number	Publication Date
JPS55102394A JPS55102394A (en)	1980-08-05
JPS6125359B2 true JPS6125359B2 (de)	1986-06-14

Family

ID=11691741

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP838579A Granted JPS55102394A (en)	1979-01-26	1979-01-26	Novel enzymatic preparation of dopamine

Country Status (1)

Country	Link
JP (1)	JPS55102394A (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0630566B2 (ja) *	1983-03-02	1994-04-27	株式会社ニツピ	溶血性連鎖状球菌の選択増菌培地
EP0859060A3 (de) *	1997-02-14	2000-07-26	DAICEL CHEMICAL INDUSTRIES, Ltd.	Verfahren zur Herstellung einer D-Aminosäure und eines Amins
US11357803B2 (en)	2017-09-22	2022-06-14	Iowa State University Research Foundation, Inc.	Probiotic compositions for production of dopamine

1979
- 1979-01-26 JP JP838579A patent/JPS55102394A/ja active Granted

Also Published As

Publication number	Publication date
JPS55102394A (en)	1980-08-05

Publication	Publication Date	Title
US4080259A (en)	1978-03-21	Process of preparing L and D α-amino acids by enzyme treatment of DL-α-amino acid amide
JPS6320520B2 (de)	1988-04-27
JPH0218072B2 (de)	1990-04-24
JP3951008B2 (ja)	2007-08-01	カプサイシン分解合成酵素及びその生産方法
JPS63273486A (ja)	1988-11-10	１−（４−メトキシフェニル）−２−アミノプロパンの製法
JPS6125359B2 (de)	1986-06-14
JPS6129953B2 (de)	1986-07-10
JP3116102B2 (ja)	2000-12-11	Ｌ−３，４−ジヒドロキシフェニルアラニンの製造方法
JPH01320991A (ja)	1989-12-27	Ｄ−ホモフエニルアラニン類の製造方法
JP2009225705A (ja)	2009-10-08	テアニンの製造法
JPH06141888A (ja)	1994-05-24	Ｄ−マンデル酸の製法
JPH0148758B2 (de)	1989-10-20
JPS58201992A (ja)	1983-11-25	微生物によるβ−置換プロピオン酸またはそのアミドの製造法
JPS61274690A (ja)	1986-12-04	Ｄ−α−アミノ酸の製造方法
JPS6319158B2 (de)	1988-04-21
JPH04341195A (ja)	1992-11-27	光学活性マンデル酸の製法
JPH01104194A (ja)	1989-04-21	Ｄ−（−）−酒石酸の製造法
KR910007849B1 (ko)	1991-10-02	신균주 스트렙토마이세스 sp.Y-183 및 이로부터 생산되는 히단토인에이즈의 생산방법
JP2674076B2 (ja)	1997-11-05	Ｄ−α−アミノ酸の製造方法
JPS63219389A (ja)	1988-09-13	ジ−ｄ−フラクトシルフラノ−ス１，２′：２，３′ジアンハイドライドの製造法
JPH0591895A (ja)	1993-04-16	Ｄ−セリンの製造法
JPH04152895A (ja)	1992-05-26	光学活性１，３―ブタンジオールの製法
GB1577087A (en)	1980-10-15	Enzyme preparation having l-amino acyl amidase activity
JPS6243679B2 (de)	1987-09-16
JPS61260889A (ja)	1986-11-19	リンゴ酸カルシウムの製造方法