JPS6122780B2 - - Google Patents
Info
- Publication number
- JPS6122780B2 JPS6122780B2 JP53008977A JP897778A JPS6122780B2 JP S6122780 B2 JPS6122780 B2 JP S6122780B2 JP 53008977 A JP53008977 A JP 53008977A JP 897778 A JP897778 A JP 897778A JP S6122780 B2 JPS6122780 B2 JP S6122780B2
- Authority
- JP
- Japan
- Prior art keywords
- hydroperoxide
- mixture
- composition
- borate
- test
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 claims description 104
- 238000012360 testing method Methods 0.000 claims description 103
- 239000003085 diluting agent Substances 0.000 claims description 35
- HHVIBTZHLRERCL-UHFFFAOYSA-N sulfonyldimethane Chemical compound CS(C)(=O)=O HHVIBTZHLRERCL-UHFFFAOYSA-N 0.000 claims description 30
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethyl sulfoxide Natural products CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 27
- -1 0-toluidine Chemical compound 0.000 claims description 22
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 21
- 150000002432 hydroperoxides Chemical class 0.000 claims description 20
- HJVAFZMYQQSPHF-UHFFFAOYSA-N 2-[bis(2-hydroxyethyl)amino]ethanol;boric acid Chemical compound OB(O)O.OCCN(CCO)CCO HJVAFZMYQQSPHF-UHFFFAOYSA-N 0.000 claims description 19
- FRIBMENBGGCKPD-UHFFFAOYSA-N 3-(2,3-dimethoxyphenyl)prop-2-enal Chemical compound COC1=CC=CC(C=CC=O)=C1OC FRIBMENBGGCKPD-UHFFFAOYSA-N 0.000 claims description 19
- 150000002978 peroxides Chemical class 0.000 claims description 15
- 239000013543 active substance Substances 0.000 claims description 14
- 239000004327 boric acid Substances 0.000 claims description 14
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 11
- 125000003118 aryl group Chemical group 0.000 claims description 10
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 9
- 125000000217 alkyl group Chemical group 0.000 claims description 9
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 7
- UAIUNKRWKOVEES-UHFFFAOYSA-N 3,3',5,5'-tetramethylbenzidine Chemical compound CC1=C(N)C(C)=CC(C=2C=C(C)C(N)=C(C)C=2)=C1 UAIUNKRWKOVEES-UHFFFAOYSA-N 0.000 claims description 6
- HFACYLZERDEVSX-UHFFFAOYSA-N benzidine Chemical group C1=CC(N)=CC=C1C1=CC=C(N)C=C1 HFACYLZERDEVSX-UHFFFAOYSA-N 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 6
- 230000004044 response Effects 0.000 claims description 6
- SNCJAJRILVFXAE-UHFFFAOYSA-N 9h-fluorene-2,7-diamine Chemical compound NC1=CC=C2C3=CC=C(N)C=C3CC2=C1 SNCJAJRILVFXAE-UHFFFAOYSA-N 0.000 claims description 4
- GPAPPPVRLPGFEQ-UHFFFAOYSA-N 4,4'-dichlorodiphenyl sulfone Chemical compound C1=CC(Cl)=CC=C1S(=O)(=O)C1=CC=C(Cl)C=C1 GPAPPPVRLPGFEQ-UHFFFAOYSA-N 0.000 claims description 3
- CIYSQIBVUOZMOU-UHFFFAOYSA-N 4-morpholin-4-ylbenzenethiol Chemical compound C1=CC(S)=CC=C1N1CCOCC1 CIYSQIBVUOZMOU-UHFFFAOYSA-N 0.000 claims description 3
- ITBPIKUGMIZTJR-UHFFFAOYSA-N [bis(hydroxymethyl)amino]methanol Chemical group OCN(CO)CO ITBPIKUGMIZTJR-UHFFFAOYSA-N 0.000 claims description 3
- HTMQZWFSTJVJEQ-UHFFFAOYSA-N benzylsulfinylmethylbenzene Chemical compound C=1C=CC=CC=1CS(=O)CC1=CC=CC=C1 HTMQZWFSTJVJEQ-UHFFFAOYSA-N 0.000 claims description 3
- SPTHWAJJMLCAQF-UHFFFAOYSA-M ctk4f8481 Chemical compound [O-]O.CC(C)C1=CC=CC=C1C(C)C SPTHWAJJMLCAQF-UHFFFAOYSA-M 0.000 claims description 3
- 238000005502 peroxidation Methods 0.000 claims description 3
- CIHOLLKRGTVIJN-UHFFFAOYSA-N tertâbutyl hydroperoxide Chemical group CC(C)(C)OO CIHOLLKRGTVIJN-UHFFFAOYSA-N 0.000 claims description 3
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical group [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 claims 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- SKKKJNPBIGQNEJ-UHFFFAOYSA-N 9h-fluorene-1,9-diamine Chemical compound C1=CC(N)=C2C(N)C3=CC=CC=C3C2=C1 SKKKJNPBIGQNEJ-UHFFFAOYSA-N 0.000 claims 1
- 239000000243 solution Substances 0.000 description 36
- RNVCVTLRINQCPJ-UHFFFAOYSA-N o-toluidine Chemical compound CC1=CC=CC=C1N RNVCVTLRINQCPJ-UHFFFAOYSA-N 0.000 description 24
- 238000000034 method Methods 0.000 description 23
- 230000035945 sensitivity Effects 0.000 description 21
- 239000003153 chemical reaction reagent Substances 0.000 description 20
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 18
- 230000000052 comparative effect Effects 0.000 description 15
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 11
- 239000008280 blood Substances 0.000 description 11
- 239000011159 matrix material Substances 0.000 description 11
- 239000000126 substance Substances 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 210000002700 urine Anatomy 0.000 description 8
- HFDLDPJYCIEXJP-UHFFFAOYSA-N 6-methoxyquinoline Chemical compound N1=CC=CC2=CC(OC)=CC=C21 HFDLDPJYCIEXJP-UHFFFAOYSA-N 0.000 description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 6
- 239000001509 sodium citrate Substances 0.000 description 6
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 6
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 6
- 229940038773 trisodium citrate Drugs 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 239000004033 plastic Substances 0.000 description 5
- 229920003023 plastic Polymers 0.000 description 5
- 239000002390 adhesive tape Substances 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000006641 stabilisation Effects 0.000 description 4
- 238000011105 stabilization Methods 0.000 description 4
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 4
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical group [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000007598 dipping method Methods 0.000 description 3
- FJLHLDBEZKTSOK-UHFFFAOYSA-N n-ethyl-n-methylformamide Chemical compound CCN(C)C=O FJLHLDBEZKTSOK-UHFFFAOYSA-N 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 102000001554 Hemoglobins Human genes 0.000 description 2
- 108010054147 Hemoglobins Proteins 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 125000003368 amide group Chemical group 0.000 description 2
- 125000004429 atom Chemical group 0.000 description 2
- 229940090012 bentyl Drugs 0.000 description 2
- 229910052796 boron Inorganic materials 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- YQHLDYVWEZKEOX-UHFFFAOYSA-N cumene hydroperoxide Chemical compound OOC(C)(C)C1=CC=CC=C1 YQHLDYVWEZKEOX-UHFFFAOYSA-N 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- DMBHHRLKUKUOEG-UHFFFAOYSA-N diphenylamine Chemical compound C=1C=CC=CC=1NC1=CC=CC=C1 DMBHHRLKUKUOEG-UHFFFAOYSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000003365 glass fiber Substances 0.000 description 2
- 239000004312 hexamethylene tetramine Substances 0.000 description 2
- 235000010299 hexamethylene tetramine Nutrition 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 150000001451 organic peroxides Chemical class 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- IMNIMPAHZVJRPE-UHFFFAOYSA-N triethylenediamine Chemical compound C1CN2CCN1CC2 IMNIMPAHZVJRPE-UHFFFAOYSA-N 0.000 description 2
- YBJCDTIWNDBNTM-UHFFFAOYSA-N 1-methylsulfonylethane Chemical compound CCS(C)(=O)=O YBJCDTIWNDBNTM-UHFFFAOYSA-N 0.000 description 1
- JGBAASVQPMTVHO-UHFFFAOYSA-N 2,5-dihydroperoxy-2,5-dimethylhexane Chemical compound OOC(C)(C)CCC(C)(C)OO JGBAASVQPMTVHO-UHFFFAOYSA-N 0.000 description 1
- JCAYXDKNUSEQRT-UHFFFAOYSA-N 2-aminoethoxyboronic acid Chemical compound NCCOB(O)O JCAYXDKNUSEQRT-UHFFFAOYSA-N 0.000 description 1
- LTQUYHOGYCOTIT-UHFFFAOYSA-N 2-methylaniline;dihydrochloride Chemical compound Cl.Cl.CC1=CC=CC=C1N LTQUYHOGYCOTIT-UHFFFAOYSA-N 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000272201 Columbiformes Species 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 102000036675 Myoglobin Human genes 0.000 description 1
- 108010062374 Myoglobin Proteins 0.000 description 1
- 108700020962 Peroxidase Proteins 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000010420 art technique Methods 0.000 description 1
- AGLSQWBSHDEAHB-UHFFFAOYSA-N azane;boric acid Chemical compound N.OB(O)O AGLSQWBSHDEAHB-UHFFFAOYSA-N 0.000 description 1
- 125000002648 azanetriyl group Chemical group *N(*)* 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 125000002619 bicyclic group Chemical group 0.000 description 1
- 150000001642 boronic acid derivatives Chemical class 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- NLUNLVTVUDIHFE-UHFFFAOYSA-N cyclooctylcyclooctane Chemical class C1CCCCCCC1C1CCCCCCC1 NLUNLVTVUDIHFE-UHFFFAOYSA-N 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 125000000118 dimethyl group Chemical class [H]C([H])([H])* 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- NJSUFZNXBBXAAC-UHFFFAOYSA-N ethanol;toluene Chemical compound CCO.CC1=CC=CC=C1 NJSUFZNXBBXAAC-UHFFFAOYSA-N 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000002550 fecal effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- WPHGSKGZRAQSGP-UHFFFAOYSA-N methylenecyclohexane Natural products C1CCCC2CC21 WPHGSKGZRAQSGP-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- QUPCNWFFTANZPX-UHFFFAOYSA-M paramenthane hydroperoxide Chemical compound [O-]O.CC(C)C1CCC(C)CC1 QUPCNWFFTANZPX-UHFFFAOYSA-M 0.000 description 1
- 150000003012 phosphoric acid amides Chemical class 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 238000012764 semi-quantitative analysis Methods 0.000 description 1
- 238000007614 solvation Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
- G01N33/725—Haemoglobin using peroxidative activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2326/00—Chromogens for determinations of oxidoreductase enzymes
- C12Q2326/10—Benzidines
- C12Q2326/14—Ortho-Tolidine, i.e. 3,3'-dimethyl-(1,1'-biphenyl-4,4'-diamine)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Description
æ¬çºæã¯ãè©Šæäžæåã®åæã«é¢ãããã®ã§ã
ããããã«è©³ããã¯ãéé žå掻æ§ãæããæåã«
ã€ããŠè©Šæãå®éçãããã¯åå®éçã«åæãã
ããšã«é¢ãããã®ã§ããã å°¿ãç³äŸ¿äžæžæ¿è³ªããã³èè žå ç©è³ªã®ããšãè©Š
æäžã®éé žå掻æ§ç©è³ªã®ååšã枬å®ããããã«ã
çŸåšãå€ãã®åææ³ãé©çšã§ããããã¢ã°ããã³
ããã³ãã®èªå°äœã¯ãããããéé žåé µçŽ ã«é¡äŒŒ
ããæåã瀺ãããããããéé žå掻æ§ç©è³ªã®å ž
åçãªãã®ã§ãããšèšããããã®ãããªç©è³ªã¯
åãæ¬éé žåé µçŽ ãšãåŒã°ããŠãããéé žå掻æ§
ç©è³ªã¯ãããããéé žåç©ãšãã³ãžãžã³ãïœâã
ã«ã€ãžã³ãïŒïŒ3â²ïŒïŒïŒ5â²âããã©ã¡ãã«ãã³ãž
ãžã³ãïŒïŒïŒâãžã¢ãããã«ãªã¬ã³åã¯ãããã«
é¡äŒŒããæ瀺ç©è³ªã®éã®é žåéå åå¿ã®è§Šåªãšãª
ã€ãŠãè²ã®å€åã®ããšãæ€åºå¯èœãªå¿çã瀺ãç¹
ã§é µçŽ ã«é¡äŒŒããŠãããåŸã€ãŠãè©Šæäžæœè¡ã®å
åšãæ€åºããã»ãšãã©ã®æ¹æ³ã¯ããã®æ¬éé žåé µ
çŽ æŽ»æ§ã«ãã€ãŠããã åè²æ瀺è¬ã®éé žååå¿ã®é µçŽ é¡äŒŒã®è§ŠåªæŽ»æ§
ã«åºã¥ããããã€ãã®æ¹æ³ããé·å¹Žã«äºã€ãŠéçº
ãããŠãããå ãã第ïŒã«ããããã®æ¹æ³ã«ã¯æ¹¿
最ååŠåå¿æäœããã³æµžæŒ¬ã»èªã¿åãåã®è©Šè¬å«
æã¹ããªããïŒçŽ°çïŒãçšããæ¹æ³ãå«ãŸããã
åè ã«ã€ããŠå žåçãªäŸããªãã€ãŒãã»ãšã ã»ã
ã³ãªãŒïŒRichard M.HenryïŒçã«ãããèšåºå
åŠããã®åçãšæè¡ïŒClincal Chemistry
Principles and TechniquesïŒããããŒãžã€ãŒãºã¿
ãŠã³ïŒHegerstownïŒãã¡ãªãŒã©ã³ã
ïŒMarylandïŒïŒããŒããŒã»ã¢ã³ãã»ããŠ
ïŒHarper and RowïŒã1974ã1124â1125ããŒãžã«
è¿°ã¹ãããŠããããã®æ¹æ³ã¯ãæ°·é ¢é žïŒç·©è¡
å€ïŒããžããšãã«ã¢ãã³ïŒæ瀺è¬ïŒããã³éé žå
æ°ŽçŽ ãçšããŠãããããã湿最系ãçšããæ¹æ³ã«
ãã€ãŠãåæã¯å¯èœã§ããããããã€ãã®æçœãª
æ¬ ç¹ãæãããããæ¬ ç¹ã®å€ãã¯è©Šè¬ãäžå®å®ã§
ããããšãšãæ床ãäžå åã§ããããšã§ãããã
ããè©Šè¬æº¶æ¶²ã«ç¹åŸŽçãªããšã§ããããå®å®æ§
ïŒãããã€ãŠãæ床ïŒã®äœäžãæ¥æ¿ã§ãããã溶
液ãæ°æ¥é貯èµããåŸã§ã¯æ°é®®ãªè©Šè¬æº¶æ¶²ã調補
ããŠãããã°ãªããããã®å¿ èŠæ§ã¯åæè ã«äœå
ã®æéã課ããããšã«ãªããšå ±ã«ãé«äŸ¡ãªè©Šè¬ã
浪費ããªããã°ãªããªãããäžçµæžãšãªãã éé žå掻æ§ç©è³ªãå®éããããã®ç¬¬ïŒã®æ¹æ³ã
ããªãã¡ãçŸåšèšåºæ€æ»å¡ãåæè ã«å¥œãŸããŠã
ãæ¹æ³ã¯ãããã浞挬âèªã¿åãæ¹åŒã®è©Šè¬ã¹ã
ãªãããçšããæ¹æ³ã§ããããããåæçšå ·ã®ä»£
è¡šçãªãã®ã¯ããã€ã«ã¹ã»ã©ãã©ããªãŒãºã»ã€ã³
ã³ãŒãã¬ãŒãããïŒMiles Laboratories Inc.ïŒ
ã®ãšãŒã ã¹ã»ã«ã³ãããŒã»ãã€ããžãšã³ïŒAmes
Company DevisionïŒã«ãã€ãŠãŠè£œé ããããã
ã¹ããã¯ã¹ïŒHEMASTIXãç»é²åæšïŒãªãåã®
äžã«è²©å£²ãããŠããè©Šè¬ã¹ããªããã§ããããã®
è©Šè¬ã¹ããªããã¯ããã®æ¬è³ªã«ãããŠããã©ã¹ã
ãã¯è£œã®çŽ°çãããã¯æã¡æã«åºå®ãããå€å質
çŽã®ãããªãã¯ã¹ãããªãããã®çŽã«ã¯ãææ©é
é žåç©ãšïœâãã«ã€ãžã³ã®ç·©è¡åãããæ··åç©ã
å«æµžãããŠããããã®çŽçãããã¢ã°ããã³ãã
ãªã°ããã³ãèµ€è¡çåã¯ä»ã®æ¬éé žåé µçŽ ãå«ã
液äœäžã«æµžæŒ¬ãããšçŽçã¯éè²ãåãããããã®
åè²ã®åŒ·ãã¯è©Šæäžã®éé žå掻æ§ç©è³ªã®æ¿åºŠã«æ¯
äŸãããããããŠãè©Šè¬ã¹ããªããäžã«çŸããã
è²ãæšæºè²ç¥šãšæ¯èŒããããšã«ãããåæè ã¯ã
è©Šæäžæªç¥ç©è³ªã®éãåå®éçã«æž¬å®ããããšã
ã§ããã åŸã€ãŠãè©Šè¬ã¹ããªããã湿最ååŠæäœæ³ã«å¯Ÿ
ããŠæããå©ç¹ã¯ãäž»ãšããŠïŒã€æãããããã
ãªãã¡ã第ïŒã«ãè©Šè¬ã®èª¿è£œãä»åž¯è£ 眮ãäžå¿ èŠ
ã§ãããããã¹ããªããã¯äœ¿çšã«äŸ¿å©ã§ããã第
ïŒã«ãè©Šè¬ãéåžžã«å®å®åããããããåæãã
ãæ£ç¢ºã«ãã€é«æ床ã§è¡ãªãããããã«ã¯çµæžæ§
ã倧å€è¯ããªãã ããããªããã湿最ååŠæäœæ³ã«å¯Ÿããè©Šè¬ã¹
ããªããæ¬æ¥ã®å©ç¹ãããã«ããããããããã®
å®å®æ§ããã³æ床ã«ã€ããŠã¯æªã ããã«æ¹åã®å¿
èŠæ§ããããæ¬éé žåé µçŽ ãå®éããããã®çŸåš
ã®æè¡æ°Žæºã«ããè©Šè¬ã¹ããªããã«ãããŠã¯ãã
ããã®æ§è³ªã¯æ¹¿æœ€ååŠæäœæ³ã®ãããã«æ¯ããŠå€§
ããåäžããããããŠã¯ãããããããè©Šè¬ã¹ã
ãªããã貯èµæããã«å®å®åãããéé žå掻æ§ç©
質ã«å¯Ÿãããã«é«æ床ãšãªããªãã°ãæè¡ã«å€§ã
ãªé²æ©ãããããã§ããããæ¬çºæã«å°ãç 究掻
åãæåããã®ããæ£ã«ããããã®ç¹ãæ¹è¯ãã
ããšã§ãã€ãã äžè¿°ã®ç®çãéæããããã«å°ãªããšãäžã€ã®
è©Šã¿ãå è¡æç®ã«èšé²ãããŠãããã±ãã«ã«ã»ã¢
ãã¹ãã©ã¯ãïŒChemical AbstractïŒã第85å·»ã
186ããŒãžïŒ1976幎ïŒã«ã¯ãïœâãã«ã€ãžã³ãã
ã³ããšãã«ã€ãœãããã«ããããã«ãªãã·ããå«
æããè©Šè¬ã¹ããªããã調補ããããã®ïŒæ®µæµžæŒ¬
æ³ãèšé²ãããŠããããã®æ¹æ³ã«ãããŠã溶液ã¯
æ瀺è¬ïŒïœâãã«ã€ãžã³ã»äºå¡©é žå¡©ïŒããã³ããª
ããã«ãããªãã³ããšã¿ããŒã«ã«æº¶ããããšã«ã
ã€ãŠèª¿è£œãããããã®æº¶æ¶²ã«ãå°éã®çé¢æŽ»æ§å€
ãšPHã3.7ã«èª¿è£œããã«å åãªã¯ãšã³é žç·©è¡æ¶²ã
å ããããŠããããšãã«ã»ã«ããŒã¹ãå«æµžãã
çŽçããã®æº¶æ¶²äžã«æµžæŒ¬ããåŸã也ç¥ããŠããã
ããããŠå«æµžãè¡ãªã€ãçŽã次ã«ïŒïŒïŒâãžã¢
ã¶ãã·ã¯ããïŒïŒïŒïŒïŒããªã¯ã¿ã³ãããšãã«ã€
ãœãããã«ããããã«ãªãã·ãããã³ããªããã«
ãããªãã³ããšã¿ããŒã«âãã«ãšã³æ··å液ã«æº¶ã
ããŠåŸããã第ïŒã®æº¶æ¶²ã«æµžæŒ¬ããŠããããã®å®
éšã®ç®çã¯ããã·ã¯ããªã¯ã¿ã³èªå°äœãšããªãã
ã«ãããªãã³ãçšããããšã«ããããã«ãªãã·ã
ïŒéé žåç©ïŒãšæ瀺è¬ã®çµåããå®å®åããããš
ã§ãã€ãã 第ïŒã®æ¹æ³ã¯ãç±³åœç¹èš±ç¬¬3853471å·ã«é瀺ã
ããŠããããã®ç¹èš±ã¯ã眮æã¢ããåºãäž»ãšããŠ
âã¢ã«ããªã³åºã§ãããªã³é žã¢ããåã¯ã¹ã«ã
ã³é žã¢ããã®äœ¿çšãæ瀺ããŠããã ãããã®è©Šã¿ã®ä»ã«ãç±³åœç¹èš±ç¬¬3252762å·ã«
ã¯ãææ©ããããã«ãªãã·ãããŒã©ãã³ã®ããšã
è 質ç©è³ªå ã«ç©ççã«å°å ¥ãããšããé瀺ãã
ããããããŠããããè©Šéšçšã¹ããªããïŒãã¹
ãã»ã¹ããªããïŒã䜿çšããæãæ°Žæ§ã®äŸè©Šè©Šæ
ã¯ãŒã©ãã³ã®ã«ãã»ã«ã溶ãããããã«ãããã
ãããã«ãªãã·ããéé¢ããããã«ãéé žå掻æ§
ç©è³ªã®ååšäžã«æ瀺è¬ãšåå¿ããã ãããå è¡æè¡ã¯ãã¹ãŠãæœåšçã«çžå ¥ããªã
åå¿æ§æåïŒããããã«ãªãã·ãããã³æ瀺è¬ïŒ
ãæ©ã ãšæ··ããåããªãããã«è©Šè¬ãå®å®åãã
ãããšãç®çãšããŠããããããã«ãã€ãŠãã¹
ãã»ã¹ããªããã®æ床ã¯äœäžããŠããããããã€
ãŠãå è¡æç®ã®æ¹æ³ã¯å®å®æ§ãé«ãããšåæã«æ
床ããé«ãããšããããšãç®çãšãããã®ã§ã¯ãª
ããä¿åäžã«è©Šè¬ã®å解ãé²æ¢ããããšã«ãã€ãŠ
çŸã«åããæ床ãä¿æãããšãããã®ã§ããã èå³æ·±ãããïŒã€ã®å è¡æç®ã¯ç±³åœç¹èš±ç¬¬
3236850å·ã§ããããã®ç¹èš±ã¯ã觊åªããã³é žå
å€ãšããŠçšããããææ©ããããã«ãªãã·ãé¡ã®
å®å®åãç®çãšããŠããããã®ç¹èš±æç®ã®ç¹èš±æš©
è ã¯ãææ©ããããã«ãªãã·ããšå ±ã«ç¬¬ïŒïŒïŒå
ã¯ïŒçŽã¢ãã³å¡©ã䜿çšããããšãé瀺ããŠããã
ããããªããããã®å è¡æè¡ã¯è©Šè¬å«æãã¹ãã»
ã¹ããªãããç®çãšãããã®ã§ã¯ãªãã æ¬çºæè ã¯ãäžèšããæ¹æ³ã¯ãããããéé žå
掻æ§ç©è³ªãå®éããããã®ãã¹ãã»ã¹ããªããã«
èŠæ±ããããããªå®å®æ§ãšæ床ãéæã§ããªãã§
ããããšããããšã«æ°ä»ããã®ã§ãå šãç°ãªã€ã
æ¹éãæ¡ãããšã«ããããã®ç°ãªã€ãææ³ã¯ç 究
äžã«èŠåºããããã®ã§ããããæ¬çºæã«ã€ãªãã€
ãŠãåäžããå®å®æ§ãšæ床ãšããç®çãå®å šã«å
足ãããçµæç©ããã³è©Šéšå ·ãçãŸããããšã«ãª
ã€ãã ããããªãããããã«é©ãã¹ãããšã«ãåå¥ã®
ããïŒã€ã®å©ç¹ãæ¬é¡ã®ç 究ããçãŸãåºããã
ãã¯æ¬é¡ã«æŒãŠé瀺ãããè©Šéšå ·ã®æ¹è¯ããã補
é æ¹æ³ã§ãã€ãŠãããã«ããã°è£œé ã¯åè¿°ããå
è¡æç®äžã«åæãããæ¹æ³ã«æ¯ã¹ãŠæ Œæ®µã«ç°¡ç¥å
ããããããªãã¡ãããã¯ãïŒæ®µæµžæŒ¬æ³ã§ããã ç°¡åã«èšãã°ãæ¬çºæã¯äŸè©Šè©Šæäžã®æ¬éé žå
é µçŽ ã®ååšãæ€åºããããã®è©Šéšçšçµæç©ã«é¢ã
ããã®ã§ãããæ¬é¡ã®è©Šéšçšçµæç©ã¯ãææ©ãã
ããã«ãªãã·ãïŒããããã«ãªãã·ãããã³æ¬é
é žåé µçŽ ã®ååšäžã§æ€åºå¯èœãªå¿çãçºããæ瀺
è¬ïŒãªãã³ã«äžèš(i)ãããã¯(i)ããã³(ii)ãå«æã
ãã (i) 次åŒïŒ
ããããã«è©³ããã¯ãéé žå掻æ§ãæããæåã«
ã€ããŠè©Šæãå®éçãããã¯åå®éçã«åæãã
ããšã«é¢ãããã®ã§ããã å°¿ãç³äŸ¿äžæžæ¿è³ªããã³èè žå ç©è³ªã®ããšãè©Š
æäžã®éé žå掻æ§ç©è³ªã®ååšã枬å®ããããã«ã
çŸåšãå€ãã®åææ³ãé©çšã§ããããã¢ã°ããã³
ããã³ãã®èªå°äœã¯ãããããéé žåé µçŽ ã«é¡äŒŒ
ããæåã瀺ãããããããéé žå掻æ§ç©è³ªã®å ž
åçãªãã®ã§ãããšèšããããã®ãããªç©è³ªã¯
åãæ¬éé žåé µçŽ ãšãåŒã°ããŠãããéé žå掻æ§
ç©è³ªã¯ãããããéé žåç©ãšãã³ãžãžã³ãïœâã
ã«ã€ãžã³ãïŒïŒ3â²ïŒïŒïŒ5â²âããã©ã¡ãã«ãã³ãž
ãžã³ãïŒïŒïŒâãžã¢ãããã«ãªã¬ã³åã¯ãããã«
é¡äŒŒããæ瀺ç©è³ªã®éã®é žåéå åå¿ã®è§Šåªãšãª
ã€ãŠãè²ã®å€åã®ããšãæ€åºå¯èœãªå¿çã瀺ãç¹
ã§é µçŽ ã«é¡äŒŒããŠãããåŸã€ãŠãè©Šæäžæœè¡ã®å
åšãæ€åºããã»ãšãã©ã®æ¹æ³ã¯ããã®æ¬éé žåé µ
çŽ æŽ»æ§ã«ãã€ãŠããã åè²æ瀺è¬ã®éé žååå¿ã®é µçŽ é¡äŒŒã®è§ŠåªæŽ»æ§
ã«åºã¥ããããã€ãã®æ¹æ³ããé·å¹Žã«äºã€ãŠéçº
ãããŠãããå ãã第ïŒã«ããããã®æ¹æ³ã«ã¯æ¹¿
最ååŠåå¿æäœããã³æµžæŒ¬ã»èªã¿åãåã®è©Šè¬å«
æã¹ããªããïŒçŽ°çïŒãçšããæ¹æ³ãå«ãŸããã
åè ã«ã€ããŠå žåçãªäŸããªãã€ãŒãã»ãšã ã»ã
ã³ãªãŒïŒRichard M.HenryïŒçã«ãããèšåºå
åŠããã®åçãšæè¡ïŒClincal Chemistry
Principles and TechniquesïŒããããŒãžã€ãŒãºã¿
ãŠã³ïŒHegerstownïŒãã¡ãªãŒã©ã³ã
ïŒMarylandïŒïŒããŒããŒã»ã¢ã³ãã»ããŠ
ïŒHarper and RowïŒã1974ã1124â1125ããŒãžã«
è¿°ã¹ãããŠããããã®æ¹æ³ã¯ãæ°·é ¢é žïŒç·©è¡
å€ïŒããžããšãã«ã¢ãã³ïŒæ瀺è¬ïŒããã³éé žå
æ°ŽçŽ ãçšããŠãããããã湿最系ãçšããæ¹æ³ã«
ãã€ãŠãåæã¯å¯èœã§ããããããã€ãã®æçœãª
æ¬ ç¹ãæãããããæ¬ ç¹ã®å€ãã¯è©Šè¬ãäžå®å®ã§
ããããšãšãæ床ãäžå åã§ããããšã§ãããã
ããè©Šè¬æº¶æ¶²ã«ç¹åŸŽçãªããšã§ããããå®å®æ§
ïŒãããã€ãŠãæ床ïŒã®äœäžãæ¥æ¿ã§ãããã溶
液ãæ°æ¥é貯èµããåŸã§ã¯æ°é®®ãªè©Šè¬æº¶æ¶²ã調補
ããŠãããã°ãªããããã®å¿ èŠæ§ã¯åæè ã«äœå
ã®æéã課ããããšã«ãªããšå ±ã«ãé«äŸ¡ãªè©Šè¬ã
浪費ããªããã°ãªããªãããäžçµæžãšãªãã éé žå掻æ§ç©è³ªãå®éããããã®ç¬¬ïŒã®æ¹æ³ã
ããªãã¡ãçŸåšèšåºæ€æ»å¡ãåæè ã«å¥œãŸããŠã
ãæ¹æ³ã¯ãããã浞挬âèªã¿åãæ¹åŒã®è©Šè¬ã¹ã
ãªãããçšããæ¹æ³ã§ããããããåæçšå ·ã®ä»£
è¡šçãªãã®ã¯ããã€ã«ã¹ã»ã©ãã©ããªãŒãºã»ã€ã³
ã³ãŒãã¬ãŒãããïŒMiles Laboratories Inc.ïŒ
ã®ãšãŒã ã¹ã»ã«ã³ãããŒã»ãã€ããžãšã³ïŒAmes
Company DevisionïŒã«ãã€ãŠãŠè£œé ããããã
ã¹ããã¯ã¹ïŒHEMASTIXãç»é²åæšïŒãªãåã®
äžã«è²©å£²ãããŠããè©Šè¬ã¹ããªããã§ããããã®
è©Šè¬ã¹ããªããã¯ããã®æ¬è³ªã«ãããŠããã©ã¹ã
ãã¯è£œã®çŽ°çãããã¯æã¡æã«åºå®ãããå€å質
çŽã®ãããªãã¯ã¹ãããªãããã®çŽã«ã¯ãææ©é
é žåç©ãšïœâãã«ã€ãžã³ã®ç·©è¡åãããæ··åç©ã
å«æµžãããŠããããã®çŽçãããã¢ã°ããã³ãã
ãªã°ããã³ãèµ€è¡çåã¯ä»ã®æ¬éé žåé µçŽ ãå«ã
液äœäžã«æµžæŒ¬ãããšçŽçã¯éè²ãåãããããã®
åè²ã®åŒ·ãã¯è©Šæäžã®éé žå掻æ§ç©è³ªã®æ¿åºŠã«æ¯
äŸãããããããŠãè©Šè¬ã¹ããªããäžã«çŸããã
è²ãæšæºè²ç¥šãšæ¯èŒããããšã«ãããåæè ã¯ã
è©Šæäžæªç¥ç©è³ªã®éãåå®éçã«æž¬å®ããããšã
ã§ããã åŸã€ãŠãè©Šè¬ã¹ããªããã湿最ååŠæäœæ³ã«å¯Ÿ
ããŠæããå©ç¹ã¯ãäž»ãšããŠïŒã€æãããããã
ãªãã¡ã第ïŒã«ãè©Šè¬ã®èª¿è£œãä»åž¯è£ 眮ãäžå¿ èŠ
ã§ãããããã¹ããªããã¯äœ¿çšã«äŸ¿å©ã§ããã第
ïŒã«ãè©Šè¬ãéåžžã«å®å®åããããããåæãã
ãæ£ç¢ºã«ãã€é«æ床ã§è¡ãªãããããã«ã¯çµæžæ§
ã倧å€è¯ããªãã ããããªããã湿最ååŠæäœæ³ã«å¯Ÿããè©Šè¬ã¹
ããªããæ¬æ¥ã®å©ç¹ãããã«ããããããããã®
å®å®æ§ããã³æ床ã«ã€ããŠã¯æªã ããã«æ¹åã®å¿
èŠæ§ããããæ¬éé žåé µçŽ ãå®éããããã®çŸåš
ã®æè¡æ°Žæºã«ããè©Šè¬ã¹ããªããã«ãããŠã¯ãã
ããã®æ§è³ªã¯æ¹¿æœ€ååŠæäœæ³ã®ãããã«æ¯ããŠå€§
ããåäžããããããŠã¯ãããããããè©Šè¬ã¹ã
ãªããã貯èµæããã«å®å®åãããéé žå掻æ§ç©
質ã«å¯Ÿãããã«é«æ床ãšãªããªãã°ãæè¡ã«å€§ã
ãªé²æ©ãããããã§ããããæ¬çºæã«å°ãç 究掻
åãæåããã®ããæ£ã«ããããã®ç¹ãæ¹è¯ãã
ããšã§ãã€ãã äžè¿°ã®ç®çãéæããããã«å°ãªããšãäžã€ã®
è©Šã¿ãå è¡æç®ã«èšé²ãããŠãããã±ãã«ã«ã»ã¢
ãã¹ãã©ã¯ãïŒChemical AbstractïŒã第85å·»ã
186ããŒãžïŒ1976幎ïŒã«ã¯ãïœâãã«ã€ãžã³ãã
ã³ããšãã«ã€ãœãããã«ããããã«ãªãã·ããå«
æããè©Šè¬ã¹ããªããã調補ããããã®ïŒæ®µæµžæŒ¬
æ³ãèšé²ãããŠããããã®æ¹æ³ã«ãããŠã溶液ã¯
æ瀺è¬ïŒïœâãã«ã€ãžã³ã»äºå¡©é žå¡©ïŒããã³ããª
ããã«ãããªãã³ããšã¿ããŒã«ã«æº¶ããããšã«ã
ã€ãŠèª¿è£œãããããã®æº¶æ¶²ã«ãå°éã®çé¢æŽ»æ§å€
ãšPHã3.7ã«èª¿è£œããã«å åãªã¯ãšã³é žç·©è¡æ¶²ã
å ããããŠããããšãã«ã»ã«ããŒã¹ãå«æµžãã
çŽçããã®æº¶æ¶²äžã«æµžæŒ¬ããåŸã也ç¥ããŠããã
ããããŠå«æµžãè¡ãªã€ãçŽã次ã«ïŒïŒïŒâãžã¢
ã¶ãã·ã¯ããïŒïŒïŒïŒïŒããªã¯ã¿ã³ãããšãã«ã€
ãœãããã«ããããã«ãªãã·ãããã³ããªããã«
ãããªãã³ããšã¿ããŒã«âãã«ãšã³æ··å液ã«æº¶ã
ããŠåŸããã第ïŒã®æº¶æ¶²ã«æµžæŒ¬ããŠããããã®å®
éšã®ç®çã¯ããã·ã¯ããªã¯ã¿ã³èªå°äœãšããªãã
ã«ãããªãã³ãçšããããšã«ããããã«ãªãã·ã
ïŒéé žåç©ïŒãšæ瀺è¬ã®çµåããå®å®åããããš
ã§ãã€ãã 第ïŒã®æ¹æ³ã¯ãç±³åœç¹èš±ç¬¬3853471å·ã«é瀺ã
ããŠããããã®ç¹èš±ã¯ã眮æã¢ããåºãäž»ãšããŠ
âã¢ã«ããªã³åºã§ãããªã³é žã¢ããåã¯ã¹ã«ã
ã³é žã¢ããã®äœ¿çšãæ瀺ããŠããã ãããã®è©Šã¿ã®ä»ã«ãç±³åœç¹èš±ç¬¬3252762å·ã«
ã¯ãææ©ããããã«ãªãã·ãããŒã©ãã³ã®ããšã
è 質ç©è³ªå ã«ç©ççã«å°å ¥ãããšããé瀺ãã
ããããããŠããããè©Šéšçšã¹ããªããïŒãã¹
ãã»ã¹ããªããïŒã䜿çšããæãæ°Žæ§ã®äŸè©Šè©Šæ
ã¯ãŒã©ãã³ã®ã«ãã»ã«ã溶ãããããã«ãããã
ãããã«ãªãã·ããéé¢ããããã«ãéé žå掻æ§
ç©è³ªã®ååšäžã«æ瀺è¬ãšåå¿ããã ãããå è¡æè¡ã¯ãã¹ãŠãæœåšçã«çžå ¥ããªã
åå¿æ§æåïŒããããã«ãªãã·ãããã³æ瀺è¬ïŒ
ãæ©ã ãšæ··ããåããªãããã«è©Šè¬ãå®å®åãã
ãããšãç®çãšããŠããããããã«ãã€ãŠãã¹
ãã»ã¹ããªããã®æ床ã¯äœäžããŠããããããã€
ãŠãå è¡æç®ã®æ¹æ³ã¯å®å®æ§ãé«ãããšåæã«æ
床ããé«ãããšããããšãç®çãšãããã®ã§ã¯ãª
ããä¿åäžã«è©Šè¬ã®å解ãé²æ¢ããããšã«ãã€ãŠ
çŸã«åããæ床ãä¿æãããšãããã®ã§ããã èå³æ·±ãããïŒã€ã®å è¡æç®ã¯ç±³åœç¹èš±ç¬¬
3236850å·ã§ããããã®ç¹èš±ã¯ã觊åªããã³é žå
å€ãšããŠçšããããææ©ããããã«ãªãã·ãé¡ã®
å®å®åãç®çãšããŠããããã®ç¹èš±æç®ã®ç¹èš±æš©
è ã¯ãææ©ããããã«ãªãã·ããšå ±ã«ç¬¬ïŒïŒïŒå
ã¯ïŒçŽã¢ãã³å¡©ã䜿çšããããšãé瀺ããŠããã
ããããªããããã®å è¡æè¡ã¯è©Šè¬å«æãã¹ãã»
ã¹ããªãããç®çãšãããã®ã§ã¯ãªãã æ¬çºæè ã¯ãäžèšããæ¹æ³ã¯ãããããéé žå
掻æ§ç©è³ªãå®éããããã®ãã¹ãã»ã¹ããªããã«
èŠæ±ããããããªå®å®æ§ãšæ床ãéæã§ããªãã§
ããããšããããšã«æ°ä»ããã®ã§ãå šãç°ãªã€ã
æ¹éãæ¡ãããšã«ããããã®ç°ãªã€ãææ³ã¯ç 究
äžã«èŠåºããããã®ã§ããããæ¬çºæã«ã€ãªãã€
ãŠãåäžããå®å®æ§ãšæ床ãšããç®çãå®å šã«å
足ãããçµæç©ããã³è©Šéšå ·ãçãŸããããšã«ãª
ã€ãã ããããªãããããã«é©ãã¹ãããšã«ãåå¥ã®
ããïŒã€ã®å©ç¹ãæ¬é¡ã®ç 究ããçãŸãåºããã
ãã¯æ¬é¡ã«æŒãŠé瀺ãããè©Šéšå ·ã®æ¹è¯ããã補
é æ¹æ³ã§ãã€ãŠãããã«ããã°è£œé ã¯åè¿°ããå
è¡æç®äžã«åæãããæ¹æ³ã«æ¯ã¹ãŠæ Œæ®µã«ç°¡ç¥å
ããããããªãã¡ãããã¯ãïŒæ®µæµžæŒ¬æ³ã§ããã ç°¡åã«èšãã°ãæ¬çºæã¯äŸè©Šè©Šæäžã®æ¬éé žå
é µçŽ ã®ååšãæ€åºããããã®è©Šéšçšçµæç©ã«é¢ã
ããã®ã§ãããæ¬é¡ã®è©Šéšçšçµæç©ã¯ãææ©ãã
ããã«ãªãã·ãïŒããããã«ãªãã·ãããã³æ¬é
é žåé µçŽ ã®ååšäžã§æ€åºå¯èœãªå¿çãçºããæ瀺
è¬ïŒãªãã³ã«äžèš(i)ãããã¯(i)ããã³(ii)ãå«æã
ãã (i) 次åŒïŒ
ãåŒãåã¯
ãåŒã
ãåŒäžãR1ããã³R2ã¯åäžã§ããããããã¯
ç°ãªã€ãŠããŠããããããããæ°ŽçŽ ååãççŽ æ°
ïŒãçŽïŒã®ã¢ã«ãã«åºãããã¯ã¢ãªãŒã«åºãè¡šã
ãïŒãã ãã
ç°ãªã€ãŠããŠããããããããæ°ŽçŽ ååãççŽ æ°
ïŒãçŽïŒã®ã¢ã«ãã«åºãããã¯ã¢ãªãŒã«åºãè¡šã
ãïŒãã ãã
ãåŒãããã³
ãåŒã
ã«ãããŠãR1ããã³R2ãåæã«æ°ŽçŽ ååã§ãã
å Žåãé€ããïŒãR3ã¯æ°ŽçŽ ååãççŽ æ°ïŒãçŽïŒ
ã®ã¢ã«ãã«åºãããã¯ã¢ãªãŒã«åºãè¡šãããã ã§ç€ºãããçšéå€ãããã¯ãããã®æ··åç©ã (ii) 次åŒïŒ ïŒåŒäžãïœãïœããã³ïœã¯åäžã§ããç°ãªã€ãŠã
ãŠããããããããïŒãçŽïŒã®æŽæ°ãè¡šãããïŒ
ã§ç€ºãããæ§é ã®ããŠé žãšã¹ãã«ã æ¬çºæã«ä¿ãè©Šéšå ·ã¯æ äœãããªãã¯ã¹ã«å å«
ãããäžèšã®çµæç©ããæã€ãŠãããæ¬çºæã«ä¿
ãæ¹æ³ã¯ãè©Šéšçšçµæç©ã調補ããå·¥çšãªãã³ã«
ããããããªãã¯ã¹äžã«çµèŸŒãå·¥çšããæã€ãŠã
ãã è©Šéšçšçµæç©äžã«äœ¿çšãããšããææ©ãããã
ã«ãªãã·ãã¯è¯ãç¥ãããå€ãã®ææ©ããããã«
ãªãã·ãããéžæããããšãã§ãããããããã
ãã¯éé žåç©ã«æåæ§ãæããæ瀺è¬ã®ååšäžã«
éé žå掻æ§ç©è³ªãšåå¿ããŠãè²ã®å€ååã¯è©Šéšçš
çµæç©ã«ãã€ãŠåžåããããåå°ããããããå
ã®åŒ·ãã®å€åã®ããšãæ€åºå¯èœãªå¿çãçºããã
ãšãã§ãããã®ã§ãªããã°ãªããªãã奜é©ãªãã
ããã«ãªãã·ãã¯ãïœâããã«ããããã«ãªãã·
ããã¯ã¡ã³ããããã«ãªãã·ãããžã€ãœãããã«
ãã³ãŒã³ããããã«ãªãã·ããïŒïŒïŒâãžã¡ãã«
ãããµã³âïŒïŒïŒâãžããããã«ãªãã·ãããã©
ã¡ã³ã¿ã³ããããã«ãªãã·ãåã¯ãããã®æ··åç©
ã§ããããã¡ãããã¯ã¡ã³ããããã«ãªãã·ãã
æã奜ãŸããããšãå€ã€ãŠããã ããããã«ãªãã·ãããã³æ¬éé žåé µçŽ ã®ååš
äžã§æ€åºå¯èœãªå¿çãçºããããšãã§ããå€ãã®
æ瀺è¬ãååšãããããããã¯ãã®æ§è³ªã®ãã
ã«ãæ¬çºæã«å¥œé©ã«äœ¿çšã§ãããã®ã§ããããã
ãã®æ瀺è¬ã«ã¯ããããããã³ãžãžã³åãååç©
ãå«ãŸããã®ä»£è¡šçãªãã®ãšããŠããã³ãžãžã³ã
ïœâãã«ã€ãžã³ãïŒïŒ3â²ïŒïŒïŒ5â²âããã©ã¡ãã«
ãã³ãžãžã³ãïŒïŒïŒâãžã¢ãããã«ãªã¬ã³åã¯ã
ãããçš®ã ã®å²åã§å«ãæ··åç©ãæããããã æ¬çºæã«ãããŠãå®å®æ§ããã³æ床ã®å¢å€§ã«å¯
äžãããšèããããçšéå€ã¯åèšã®æ§é ãæã
ããäžè¬åŒã§è¡šããããååç©ã®äžã§ããïŒ
Nâ²âãžã¡ãã«ãã«ã ã¢ããããžã¡ãã«ã¹ã«ãã
ã·ãããžã¡ãã«ã¹ã«ãã³ããããã¯ãããã®æ··å
ç©ãç¹ã«å¥œé©ãªãã®ã§ãããæå¹ã§ããããšãå€
ã€ãŠããä»ã®çšéå€ã¯ããã³ãžã«ã¹ã«ããã·ãã
ïŒâã¯ããããšãã«ã¹ã«ãã³ãïŒâãã«ãªãâïŒ
âãããããšãã«ã¹ã«ãã³çã§ããããããã®å¥œ
é©ãªååç©ã¯ãR1ããã³R2ãããããã¡ãã«åº
ã§ããåèšã®æ§é ã«å¯Ÿå¿ããã æ¬çºæã«å«ãŸããR1ïŒR2ããã³R3ã®ç¯å²ã¯åº
ãR1ïŒR2ããã³R3ã¯æ°ŽçŽ ååãççŽ æ°ïŒãçŽïŒ
ã®çœ®æãããã¯é眮æã®ã¢ã«ãã«åºãæå³ãã
ïŒãã ãã
å Žåãé€ããïŒãR3ã¯æ°ŽçŽ ååãççŽ æ°ïŒãçŽïŒ
ã®ã¢ã«ãã«åºãããã¯ã¢ãªãŒã«åºãè¡šãããã ã§ç€ºãããçšéå€ãããã¯ãããã®æ··åç©ã (ii) 次åŒïŒ ïŒåŒäžãïœãïœããã³ïœã¯åäžã§ããç°ãªã€ãŠã
ãŠããããããããïŒãçŽïŒã®æŽæ°ãè¡šãããïŒ
ã§ç€ºãããæ§é ã®ããŠé žãšã¹ãã«ã æ¬çºæã«ä¿ãè©Šéšå ·ã¯æ äœãããªãã¯ã¹ã«å å«
ãããäžèšã®çµæç©ããæã€ãŠãããæ¬çºæã«ä¿
ãæ¹æ³ã¯ãè©Šéšçšçµæç©ã調補ããå·¥çšãªãã³ã«
ããããããªãã¯ã¹äžã«çµèŸŒãå·¥çšããæã€ãŠã
ãã è©Šéšçšçµæç©äžã«äœ¿çšãããšããææ©ãããã
ã«ãªãã·ãã¯è¯ãç¥ãããå€ãã®ææ©ããããã«
ãªãã·ãããéžæããããšãã§ãããããããã
ãã¯éé žåç©ã«æåæ§ãæããæ瀺è¬ã®ååšäžã«
éé žå掻æ§ç©è³ªãšåå¿ããŠãè²ã®å€ååã¯è©Šéšçš
çµæç©ã«ãã€ãŠåžåããããåå°ããããããå
ã®åŒ·ãã®å€åã®ããšãæ€åºå¯èœãªå¿çãçºããã
ãšãã§ãããã®ã§ãªããã°ãªããªãã奜é©ãªãã
ããã«ãªãã·ãã¯ãïœâããã«ããããã«ãªãã·
ããã¯ã¡ã³ããããã«ãªãã·ãããžã€ãœãããã«
ãã³ãŒã³ããããã«ãªãã·ããïŒïŒïŒâãžã¡ãã«
ãããµã³âïŒïŒïŒâãžããããã«ãªãã·ãããã©
ã¡ã³ã¿ã³ããããã«ãªãã·ãåã¯ãããã®æ··åç©
ã§ããããã¡ãããã¯ã¡ã³ããããã«ãªãã·ãã
æã奜ãŸããããšãå€ã€ãŠããã ããããã«ãªãã·ãããã³æ¬éé žåé µçŽ ã®ååš
äžã§æ€åºå¯èœãªå¿çãçºããããšãã§ããå€ãã®
æ瀺è¬ãååšãããããããã¯ãã®æ§è³ªã®ãã
ã«ãæ¬çºæã«å¥œé©ã«äœ¿çšã§ãããã®ã§ããããã
ãã®æ瀺è¬ã«ã¯ããããããã³ãžãžã³åãååç©
ãå«ãŸããã®ä»£è¡šçãªãã®ãšããŠããã³ãžãžã³ã
ïœâãã«ã€ãžã³ãïŒïŒ3â²ïŒïŒïŒ5â²âããã©ã¡ãã«
ãã³ãžãžã³ãïŒïŒïŒâãžã¢ãããã«ãªã¬ã³åã¯ã
ãããçš®ã ã®å²åã§å«ãæ··åç©ãæããããã æ¬çºæã«ãããŠãå®å®æ§ããã³æ床ã®å¢å€§ã«å¯
äžãããšèããããçšéå€ã¯åèšã®æ§é ãæã
ããäžè¬åŒã§è¡šããããååç©ã®äžã§ããïŒ
Nâ²âãžã¡ãã«ãã«ã ã¢ããããžã¡ãã«ã¹ã«ãã
ã·ãããžã¡ãã«ã¹ã«ãã³ããããã¯ãããã®æ··å
ç©ãç¹ã«å¥œé©ãªãã®ã§ãããæå¹ã§ããããšãå€
ã€ãŠããä»ã®çšéå€ã¯ããã³ãžã«ã¹ã«ããã·ãã
ïŒâã¯ããããšãã«ã¹ã«ãã³ãïŒâãã«ãªãâïŒ
âãããããšãã«ã¹ã«ãã³çã§ããããããã®å¥œ
é©ãªååç©ã¯ãR1ããã³R2ãããããã¡ãã«åº
ã§ããåèšã®æ§é ã«å¯Ÿå¿ããã æ¬çºæã«å«ãŸããR1ïŒR2ããã³R3ã®ç¯å²ã¯åº
ãR1ïŒR2ããã³R3ã¯æ°ŽçŽ ååãççŽ æ°ïŒãçŽïŒ
ã®çœ®æãããã¯é眮æã®ã¢ã«ãã«åºãæå³ãã
ïŒãã ãã
ãåŒãããã³
ãåŒãã«
ãããŠãR1ããã³R2ãåæã«æ°ŽçŽ ååã§ããå Ž
åãé€ããïŒãã¢ã«ãã«åºã®äŸãšããŠã¯ãã¡ãã«ã
ãšãã«ããããã«ãã€ãœãããã«ãïœâããã«ã
ã€ãœããã«ãsecâããã«ãïœâãã³ãã«ãã€ãœ
ãã³ãã«ãããªãã³ãã«ãïœâãã³ãã«ããã³ã
ããµã³ã®ç°æ§äœãã¯ãããšããä»ã®ç°æ§äœãæã
ãããã R1ïŒR2ããã³R3ãã¢ãªãŒã«åºã®å Žåãç¯å²ã¯
åæ§ã«åºããããã§çšããããã¢ãªãŒã«ãªãçšèª
ã¯ãããšãã«ããã³ãžã«ãããªã«ãã¢ããªããã
ããã«çã®ããšã眮æåã¯é眮æã®ã¢ãªãŒã«åºã
å å«ããã R1ïŒR2ããã³R3ãã¢ã«ãã«åºãããã¯ã¢ãªãŒ
ã«åºã§ããå Žåã«R1ïŒR2ããã³R3ãæããŠãã
ã眮æåºã®å žåçãªãã®ã¯ãã¢ããåºãããã
åºãã¢ããåºããããªãåºãããããã·ã«åºãã¢
ã«ã³ãã·åºãããã²ã³ååãããšãã«åºãã¹ã«ã
ã³é žåºãã«ã«ãã³é žåºçã§ããã æ¬æ现æžäžã«ãããŠé瀺ãããçµæç©ãè©Šéšå ·
ããã³æ¹æ³äžã§çšããããçšéå€ã®éã¯åºãå€å
ãããããšãã§ããããã¯å®éšå®€å ã«å®¹æã«æ±ºå®
ããããšãã§ãããããããŠãçšéå€ããžã¡ãã«
ã¹ã«ããã·ãã®ãããªæ¶²äœã§ããå Žåã«ã¯ããã®
éã¯æº¶åªãããã¯æžæ¿å€ïŒåªäœïŒïŒå®æœäŸãã«ã
ããŠã¯æ°ŽïŒã®äœç©ã«å¯Ÿããçµæç©ã«æ·»å ãããçš
éå€ã®äœç©ã§èšç®ããŠçŽ10ïŒ ããçŽ100ïŒ ã®ç¯å²
ã§å€åããããïŒåŸæ²ã®è¡šïŒåç §ïŒã奜ãŸããç¯
å²ã¯çŽ25ãçŽ100ïŒ ã§ããã åæ§ã«ãçšéå€ããæ¬æ现æžäžã«ãããŠé瀺ã
ããçšéå€ã®ïŒçš®ä»¥äžã®æ··åç©ã§ããå Žåã«ã¯ã
çšéå€æ··åç©äžã«çšããããæ°çš®ã®ååç©ã®éæ¯
ã¯åºãç¯å²ã§å€åãããããšãã§ããããã¯å®éš
宀çã«å®¹æã«æ±ºå®ã§ããã æ¬çºæã®çµæç©ãšããŠãäžèšããçµæç©ã«ãæŽ
ã«ãããŠé žãšã¹ãã«ãå«æãããã®ãæããã
ãã æ¬çºæã«ãããŠãå®å®æ§ããã³æ床ã®åäžã«å¯
äžãããšèããããããŠé žãšã¹ãã«ã¯ãå ã«ç€ºã
ããæ§é ãæããŠããããã®äžè¬çãªæ§é ãæã
ãååç©ãšããŠã¯ãããªã¡ã¿ããŒã«ã¢ãã³ ãã¬
ãŒããããªãšã¿ããŒã«ã¢ãã³ ãã¬ãŒãããã³ã
ãªïŒïœâãããããŒã«ïŒã¢ãã³ ãã¬ãŒããç¹ã«
é©ããŠããããããã®ååç©ã¯äžèšäžè¬åŒã«ãã
ãŠãïœãïœãããã³ïœãåãæŽæ°ã§ãã€ãŠããã
ãïŒïŒïŒããã³ïŒã§ããå Žåã«å¯Ÿå¿ããŠããã æ¬çºæã®çµæç©ããã³ãããçšããè©Šéšå ·ã«æ
çšãªããŠé žãšã¹ãã«ã®äœ¿çšéã¯å·Ÿåºãå€åããã
ãããããã¯åŸè¿°ããå®æœäŸã«ãããŠç€ºãããŠã
ããäŸãã°ãå®æœäŸïŒã«ãããŠãã¯ã¡ã³ãããã
ã«ãªãã·ãã«å¯Ÿããããªãšã¿ããŒã«ã¢ãã³ ãã¬
ãŒãã®ã¢ã«æ¯ã¯4.71ã§ããã ããããå®æœäŸäžã«ç€ºãããŠãããããªçŽ1.4
ãçŽïŒã®åœéæ¯ã®ç¯å²ã¯æ¬çºæã«ãšã€ãŠæçšãªã
ãŠé žãšã¹ãã«ã®éã«é¢ããŠå¶éãšãªããã®ã§ã¯ãª
ããè©Šéšçšçµæç©ã®ç®çãšããçšåºŠã®å®å®æ§ãšæ
床ãéæã§ãããªãã°ããããªãéã§ãã€ãŠãã
ãããã®éã¯ãå®éšå®€çã«å®¹æã«æ±ºå®ã§ãããã
ã¯æ¬æ现æžã®é瀺äžã«äžããããŠããã æ¬çºæã®å¥œãŸããå®æœæ æ§ã«ãããŠãçµæç©ã¯
ã¡ã³ããããã«ãªãã·ããïœâãã«ã€ãžã³ããžã¡
ãã«ã¹ã«ãã³ãšãžã¡ãã«ã¹ã«ããã·ãã®æ··åç©ã
å«æãããããã¯ãããã«ãæŽã«ãããªãšã¿ããŒ
ã«ã¢ãã³ ãã¬ãŒããå«æããã è©Šéšçšçµæç©ã¯ãå žåçã«ã¯ã䜿çšãããã¹ã
åæåããå°ããã€ãæ°Žåã¯ä»ã®é©åœãªæžæ¿åªäœ
ãããã¯æº¶åªäžã«æº¶è§£åã¯æžæ¿ãããããšã«ãã€
ãŠèª¿è£œããããããã溶åªåã¯åªäœãšããŠã¯ãã¯
ãããã«ã ãã¡ã¿ããŒã«ããšã¿ããŒã«ãã¡ãã¬ã³
ã¯ããªããã·ã¯ããããµã³çãæããããã è©Šéšå ·ã¯ïŒæ®µæµžæŒ¬æ³ã«ãã€ãŠèª¿è£œããããããª
ãã¡ãæ äœãããªãã¯ã¹ã®äžéšåã溶液åã¯æžæ¿
液ã«æµžæŒ¬ããåŸã也ç¥ãããããããŠèª¿è£œããã
è©Šéšå ·ã¯ãçŽ60âãçŽ70âã§ïŒãïŒæ¥ãããã¯ã
ã以äžã«äºããããªä¿é²æ¡ä»¶äžã«ãããä¿ååŸã«
ãããŠãåå¿æ§ã®äœäžã¯ã»ãšãã©èŠ³å¯ãããªãã€
ããæ¯èŒã®ããã«ãçšéå€ãããã¯çšéå€ããã³
ããŠé žãšã¹ãã«ãçšããããšãªãåæ§ã«è©Šéšå ·ã
調補ããããããã®ã¹ããªãããå®è³ªçã«åäžã®
ä¿é²è©Šéšæ¡ä»¶äžã«ä¿åãããšãåå¿æ§ããã³æ床
ã®èããäœäžã芳å¯ãããã æ¬çºæã«ä¿ãè©Šéšå ·ãäœæããããã®æ äœãã
ãªãã¯ã¹ãšããŠã¯å€ãã®çš®é¡ã®ãã®ãçšããã
ããç±³åœç¹èš±ç¬¬3846247å·ã¯ããšã«ããå€å質ã»
ã©ããã¯ã¹çŽ°çãããã³ã¬ã©ã¹ç¹ç¶ã®ç¹åžåã¯ã
ããã®äœ¿çšãæ瀺ããŠãããããã«ãç±³åœç¹èš±ç¬¬
3552938å·ã¯æšçãåžãã¹ãã³ãžãããã¯ç²å質
ç©è³ªã®äœ¿çšãæ瀺ããŠãããè±åœç¹èš±ç¬¬1369139
å·ã«ã¯ãæ äœãããªãã¯ã¹ãšããŠçŸæ¯ç¶ã®åææš¹
èããã³ã¬ã©ã¹ç¹ç¶ã®ããšã«ãã䜿çšããããšã
瀺åãããŠãããããïŒã€ã®è±åœç¹èš±ç¬¬1349623
å·ã«ã¯äžå°ã®çŽè£œãããªãã¯ã¹ã®è¢«èŠãšããŠæ¥µçŽ°
ãã€ã©ã¡ã³ãã®å ééæ§ã®ç¶²ã®äœ¿çšãææ¡ãããŠ
ãããããªã¢ããç¹ç¶ãä»åœç¹èš±ç¬¬2170397å·ã«
é瀺ãããŠããããããã®ç€ºåã«ããããããã
åŸæ¥ãæ äœãããªãã¯ã¹ãšããŠäž»ãšããŠçšããã
ãŠããææã§ãã€ãŠãæ¬çºæã«ç¹ã«é©ããææ
ã¯ãçŽã®ããšãåžæ°Žæ§ã®çŽã§ãããããããŠæ
äœãããªãã¯ã¹çšã®å¥œé©ãªææãéžæããã«åœã€
ãŠã¯ã倧ããªå·Ÿãããããšã該ãããªãã¯ã¹ã¯å
çš®ã®ç©çç圢ç¶ãåãããããšãç解ã§ãããã
ãããã¹ãŠã®åãæ¬çºæã®ç¯å²ã«å ¥ããã®ã§ã
ãã æ¬çºæã«ãããŠã¯ãçšéå€ãçšããããšã«ãã€
ãŠé¡èã«å¢å€§ããå®å®æ§ãåŸãããããé©ãã¹ã
ããšã«ãçšéå€ãšäžèšããããŠé žãšã¹ãã«ãè©Šéš
çšçµæç©äžã«äœµçšããããšã«ãã€ãŠããã«å€§ããª
å®å®æ§ãšæ床ãåŸãããããšãå€æããã å®å®æ§ããã³æ床ãåäžãããæ¬çºæã®æ¹æ³ã
å®çŸãããæ©æ§ã¯æããã§ã¯ãªãããæ¬çºæã«æŒ
ãŠèšè¿°ããã䞻匵ãããããŠé žãšã¹ãã«ã®ç¹ç°ãª
ååŠçæ§è³ªã¯ããã®æšå®ã«å¯ŸããŠåççãªæ ¹æ ã
äžãããã®ã§ãããéé žåç©ãäžè¬ã«äžå®å®ãªå
åç©ã§ãå°ãªããšãèªç¶çã«ååšãã倧æµã®åå
ç©ãããäžå®å®ã§ããããšã¯ç¥ãããŠããããã
ãã®ã¯ççºæ§ã§ãããææ©ããããã«ãªãã·ã
ïŒäŸãã°ãã¯ã¡ã³ããããã«ãªãã·ãïŒã®ããš
ããä»ã®ãã®ã¯æ¯èŒçå®å®ã§ããããæœè¡æåæ§
è©Šéšå ·ã«éåžžçšãããããããªé žã®ååšäžã«ãã
ãŠã¯å®¹æã«å解ãããšèããããããã®å解åå¿
ãããã«è¿°ã¹ãããšãè¢«é žåæ§æ瀺è¬ã®ååšäžã§
èµ·ããªãã°ãé žåéå åå¿ãèµ·ãããã®æ©ã ãšã
ãåå¿ã¯éé žåæåæ§è©Šè¬ã¹ããªããã®æ床äœäž
ã®åå ãšãªããã®ãšèããããã äžæ¹ãããã«è¿°ã¹ãããšãããŠé žãšã¹ãã«ã«ã
ããŠã¯ãäºç°æ§é ïŒbicylic strutureïŒäžã®çªçŽ
ååããã³ããŠçŽ ååã®é 眮ãç¹ç°ã§ãããåã
ã¯å¥ã ã®æ©é ååãšãªã€ãŠãããçæ¹ã®æ©é ã«ã
ãçªçŽ ååã¯é»åå¯åºŠã倧ã§ãã€ãŠãååã®è»žã
ãå€æ¹ã«çªåºããéå ±æé»å察ãæããŠãããä»
ã®æ©é ååã§ããããŠçŽ ååã¯ååã®è»žã®ä»ç«¯ã«
äœçœ®ããé»åãäžè¶³ããç¶æ ã§ãããé»åå¯åºŠã®
é«ãé°ã€ãªã³ãšé äœçµåãæãã ãããã€ãŠãååã®çªçŽ åå端ããé»åå¯åºŠã
é«ãããã«ãããã³ãšçµåãããããšã¯å åèã
ãããäžæ¹ãé»åãäžè¶³ããŠããæ©é ã®ããŠçŽ å
åã¯é°æ§ã®ãã«ãªãã·ãæ®åºãšé äœçµåãããã
ããããŠãããã«è°è«ããäºç°æ§ååã«ãããã
ã®ç¹ç°ãªé»åã®ååžãããã®ååããã«ãªãã·ã
ã®ãããã³ãšé žçŽ ååã®éã«ååŠçã«æ¿å ¥ããã
é äœçµåããã€ãªã³å¯Ÿã圢æããããšã«ããæ¬çº
æã®è©Šéšçšçµæç©äžã®ææ©éé žåç©ãå®å®åãã
ãŠãããã®ãšèããããã ããããŠãæ¬çºæã®è©Šéšçšçµæç©ã«ãããŠã¯ã
äŸè©Šè©Šæã®æº¶åªååããã«ãªãã·ãâãã¬ãŒãã»
ã³ã³ãã¬ãã¯ã¹ãç Žå£ãããã«ãªãã·ããéé¢ã
ãŠããããéé žå掻æ§ç©è³ªã®ååšäžã§æ瀺è¬ãé ž
åãããŸã§ãææ©ããããã«ãªãã·ããæ瀺è¬ãš
ã€ãªã³çã«åå¿ããããšã劚ããããããã«å®å®
æ§ãèããå¢å€§ãããã®ãšèããããã æ¬çºæãåŠäœã«ãªããã€çšããããããã«æ確
ã«ç€ºãããã«ãããã«ã¯æ¬çºæã®å¥œãŸããå®æœæ
æ§ã説æããããã«ã次ã«å®æœäŸãæ²ããã A.è©Šéšçšçµæç©ããã³è©Šéšå ·ã®èª¿è£œ å®æœäŸ ïŒ è©Šéšçšçµæç© è±ã€ãªã³æ°Ž150mlã«æ¬¡ã®æåã溶解ãããããš
ã«ãããè©Šéšçšçµæç©ã調補ãããåæåã¯ãèš
èŒãããé åºã§æ°Žäžã«æ·»å ããã ã¯ãšã³é žäžãããªãŠã 3.2ïœ ã¯ãšã³é ž 2.2ïœ ãšãã¬ã³ãžã¢ãã³åé ¢é žåãããªãŠã å¡© 0.1ïœ ãžã¡ãã«ã¹ã«ãã³ 10.0ïœ ã©ãŠãªã«ç¡«é žãããªãŠã 1.0ïœ ïŒâã¡ããã·ãããªã³ 0.5ïœ ãžã¡ãã«ã¹ã«ããã·ã 25.0ml ã¢ã»ãã³ 25.0ml ã¯ã¡ã³ããããã«ãªãã·ã 2.0ïœ ããªãšã¿ããŒã«ã¢ãã³ ãã¬ãŒã 10.0ïœ ïŒã¢ã«ããªããã»ã±ãã«ã«ã»ã³ã³ãããŒã»ã€ã³
ã³ãŒãã¬ãŒãããïŒ ïœâãã«ã€ãžã³ 0.4ïœ å®æœäŸ ïŒ è©Šéšå · ã¯ãããã³3MMçŽçãå®æœäŸïŒã®è©Šéšå ·ã«
浞挬ãããç¢æŒ¬ããçŽçãçŽ15åé70âã§ä¹Ÿç¥
ããè©Šéšçšçµæç©ãå«æµžããæ äœãããªãã¯ã¹ã
äœæããã次ã«ä¹Ÿç¥ããæ äœãããªãã¯ã¹ãã
3M瀟ããè³Œå ¥ããäž¡é¢æ¥çããŒããçšããŠãã©
ã¹ããã¯ïŒããªã¹ãã¬ã³ïŒçãããã¯ãã©ã¹ãã
ã¯ã®æãæã«è²Œãä»ãããåŸãããè©Šéšå ·ã¯éé ž
å掻æ§ç©è³ªãå«æããŠãããšæãããå°¿ã®åŠãäŸ
è©Šè©Šæäžã«æµžããæ äœãããªãã¯ã¹ã®åè²ã芳å¯
ããããšã«ãã€ãŠè©²ç©è³ªãå®éããããã«çšãã
ããšãã§ããã B.å皮詊éšçšçµæç©ã®å®å®æ§è©Šéš å®æœäŸ ïŒ çšéå€ã®å¹æ 500mlã®ããŒã«ã«æ¬¡ã®æåãå ããã ã¯ãããã«ã 100ml ã¯ã¡ã³ããããã«ãªãã·ã 4.0ïœ ïœâãã«ã€ãžã³ 0.4ïœ ãžã¡ãã«ã¹ã«ããã·ã 25.0ml åèšã®æŽ»æ§æåãšæ··åãããšæ·¡é»è²ãåããã
åŸãããè©Šéšçšçµæç©ããšã«ã¬ã³ãã€ã€ãŒãã©ã¹
ã³ïŒäžè§ãã©ã¹ã³ïŒã«ç§»ãæ ãããŠå®éšå°äžã«å®€
æž©ïŒçŽ18.3âïŒã§äžæ©æŸçœ®ãããäžæ¥åŸãè©Šéšçš
çµæç©ã¯èª¿è£œæã«æ¯ã¹ãŠãããã«æè²ã«å€åãã
ã ãã§ãã€ãã æ¯èŒäŸ ïŒ å®æœäŸïŒãšã®æ¯èŒ æ¬é¡çºæãšæ¯èŒãè¡ãªãããã«ãå¯Ÿç §ãšãªãè©Š
éšçšçµæç©ãããžã¡ãã«ã¹ã«ããã·ãã®ä»£ãã«ã
ãã«25mlã®ã¯ãããã«ã ãå ãã以å€ãå®æœäŸïŒ
ã®æäœæ³ã«åŸã€ãŠèª¿è£œããããã®ãžã¡ãã«ã¹ã«ã
ãã·ããå«ãŸãªãè©Šéšçšçµæç©ãäžè§ãã©ã¹ã³ã«
å ¥ããŠæ ãããå®æœäŸïŒãšåæ§ïŒããªãã¡18.3â
ã§äžæ¥éïŒã«ããå®éšå°äžã«æŸçœ®ãããå®æœäŸïŒ
ã®çµæç©ãšç°ãªããå¯Ÿç §ã®çµæç©ã¯ã»ãšãã©é»è²
ãšãªã€ãããã®ããšã¯ãçšéå€ã®æ·»å ã«ãã€ãŠè©Š
éšçšçµæç©ã®å®å®æ§ãæ¹è¯ãããŠããããšã瀺ã
ãŠããã C.ããŠé žãšã¹ãã«ã«ããè©Šéšå ·ã®å®å®å æ¯èŒäŸ ïŒ å¯Ÿç §è©Šéš æ¬éé žåé µçŽ ã«å¯ŸããŠæåæ§ãæããè©Šè¬å«æã¹
ããªããã®äœæã®ããã«ã次ã«ç€ºãè©Šéšçšçµæç©
溶液ã調補ããããã®é åäžã«ã¯æ¬çºæã®ããŠé ž
ãšã¹ãã«æåã¯å«ãŸããŠããªãã æ°Ž 150ml ã¯ãšã³é žäžãããªãŠã 3.2ïœ ã¯ãšã³é ž 22ïœ ãšãã¬ã³ãžã¢ãã³åé ¢é žåãããªãŠã å¡© 0.1ïœ ãžã¡ãã«ã¹ã«ãã³ 10.0ïœ ã©ãŠãªã«ç¡«é žãããªãŠã 1.0ïœ ïŒâã¡ããã·ãããªã³ 0.5ïœ ãžã¡ãã«ã¹ã«ããã·ã 25.0ml ã¢ã»ãã³ 25.0ml ã¯ã¡ã³ããããã«ãªãã·ã 2.0ïœ ïœâãã«ã€ãžã³ 0.4ïœ ã¯ãããã³3MMçŽã®ïŒéšåãäžèšã®è©Šéšçš
çµæç©æº¶æ¶²ã«æµžæŒ¬ããåŸã70âã«ä¹Ÿç¥ããã也ç¥
ããçŽãçŽïŒmmè§ã«åæããããããŠããçã
äž¡é¢æ¥çããŒãïŒ3M瀟ããå ¥æå¯èœïŒãçšããŠ
ãã©ã¹ããã¯è£œã®æã¡æã«è²ŒçããŠè©Šéšå ·ãäœæ
ããã å®æœäŸ ïŒ æ¬çºæ ã¯ã¡ã³ããããã«ãªãã·ããæ·»å ããåã«ã10
ïœã®ããªãšã¿ããŒã«ã¢ãã³ ãã¬ãŒããæ·»å ãã
ä»ã¯äžèšã®æ¯èŒäŸïŒãšåæ§ã«ããŠæº¶æ¶²ã調補ã
ãããã®æº¶æ¶²ããæ¯èŒäŸïŒãšåæ§ã«ããŠè©Šéšå ·ã
äœæããã å®æœäŸ ïŒ 1.4âãžã¢ã¶ãã·ã¯ããïŒïŒïŒïŒïŒããªã¯ã¿ã³ ã¯ã¡ã³ããããã«ãªãã·ããæ·»å ããåã«ã10
ïœã®ïŒïŒïŒâãžã¢ã¶ãã·ã¯ããïŒïŒïŒïŒïŒããªã¯
ã¿ã³ãæ·»å ããä»ã¯äžèšã®æ¯èŒäŸ22ãšåæ§ã«ããŠ
溶液ã調補ããããã®æº¶æ¶²ãæ¯èŒäŸïŒãšåæ§ã«ã
ãŠè©Šéšå ·ãäœæããããã«äœ¿çšããã å®æœäŸ ïŒ ãããµã¡ãã¬ã³ããã©ãã³ ã¯ã¡ã³ããããã«ãªãã·ããæ·»å ããåã«ã10
ïœã®ãããµã¡ãã¬ã³ããã©ãã³ãæ·»å ããŠä»ã¯ã
äžèšã®æ¯èŒäŸïŒãšåæ§ã«ããŠæº¶æ¶²ã調補ãããã
ã®æº¶æ¶²ããäžèšã®æ¯èŒäŸïŒãšåæ§ã«ããŠè©Šéšå ·ã
äœæããã å®æœäŸ ïŒ å®å®æ§åã³æ床ã®æ¯èŒ æ¯èŒäŸïŒããã³å®æœäŸïŒãïŒã®è©Šéšå ·ãä¿é²æ¡
件äžã«ãããããçã®çžå¯Ÿçãªå®å®æ§ãšæ床ã枬
å®ãããæ¯èŒäŸïŒããã³å®æœäŸïŒãïŒã®è©Šéšå ·ã¯
çŽ60âã§ïŒæ¥éä¿åãããå®æœäŸïŒã®è©Šéšå ·ã¯çŽ
70âã§ïŒæ¥éæŸçœ®ããããããçã®ä¿é²æ¡ä»¶äžã«
ããããè©Šéšå ·ã¯ã次ã«çŸäžåã®äžïŒïŒppmïŒã®è¡
液ãå«æããå°¿äžã«æµžæŒ¬ããããšã«ãã€ãŠãã®æ
床ã枬å®ããããããªãšã¿ããŒã«ã¢ãã³ ãã¬ãŒ
ããå«ãè©Šéšå ·ïŒå®æœäŸïŒïŒã®ã¿ããã®æœè¡æ¿åºŠ
ïŒããªãã¡ã1dåœã0.015mgïŒã§è²ã®å€åã瀺ã
ããä»ã®è©Šéšå ·ã¯ãã®æœè¡æ¿åºŠã«å¯ŸããŠã¯æåæ§
ã瀺ããªãã€ãã D.çšéå€ã«ããè©Šéšå ·ã®å®å®å å®æœäŸ ïŒ æ¬¡ã«ç€ºãè¡šïŒã«èšèŒãããåçš®ã®éã®ãžã¡ãã«
ã¹ã«ããã·ããå«ãïŒçš®ã®è©Šéšçšçµæç©ããïŒçš®
ã®è©Šéšå ·ãäœæããããïŒçš®ã®è©Šéšçšçµæç©æº¶æ¶²
ã¯ãã¹ãŠæ¬¡ã®é åãçšããŠèª¿è£œãããã æ°Ž 75ml ã¯ãšã³é žäžãããªãŠã 3.2ïœ ã¯ãšã³é ž 4.5ïœ ããªãšã¿ããŒã«ã¢ãã³ ãã¬ãŒã 10.0ïœ ãšãã¬ã³ãžã¢ãã³åé ¢é žåãããªãŠã å¡© 0.1ïœ ãžã¡ãã«ã¹ã«ãã³ 5.0ïœ ã©ãŠãªã«ç¡«é žãããªãŠã 1.0ïœ ïŒâã¡ããã·ãããªã³ 0.5ïœ ã¯ã¡ã³ããããã«ãªãã·ã 2.0ïœ ïœâãã«ã€ãžã³ 0.4ïœ ïŒçš®ã®è©Šéšçšçµæç©æº¶æ¶²ã®åã ã«ããããã次
ã«ç€ºãéã®ãžã¡ãã«ã¹ã«ããã·ããšã¡ã¿ããŒã«ã
æ·»å ããã
åãé€ããïŒãã¢ã«ãã«åºã®äŸãšããŠã¯ãã¡ãã«ã
ãšãã«ããããã«ãã€ãœãããã«ãïœâããã«ã
ã€ãœããã«ãsecâããã«ãïœâãã³ãã«ãã€ãœ
ãã³ãã«ãããªãã³ãã«ãïœâãã³ãã«ããã³ã
ããµã³ã®ç°æ§äœãã¯ãããšããä»ã®ç°æ§äœãæã
ãããã R1ïŒR2ããã³R3ãã¢ãªãŒã«åºã®å Žåãç¯å²ã¯
åæ§ã«åºããããã§çšããããã¢ãªãŒã«ãªãçšèª
ã¯ãããšãã«ããã³ãžã«ãããªã«ãã¢ããªããã
ããã«çã®ããšã眮æåã¯é眮æã®ã¢ãªãŒã«åºã
å å«ããã R1ïŒR2ããã³R3ãã¢ã«ãã«åºãããã¯ã¢ãªãŒ
ã«åºã§ããå Žåã«R1ïŒR2ããã³R3ãæããŠãã
ã眮æåºã®å žåçãªãã®ã¯ãã¢ããåºãããã
åºãã¢ããåºããããªãåºãããããã·ã«åºãã¢
ã«ã³ãã·åºãããã²ã³ååãããšãã«åºãã¹ã«ã
ã³é žåºãã«ã«ãã³é žåºçã§ããã æ¬æ现æžäžã«ãããŠé瀺ãããçµæç©ãè©Šéšå ·
ããã³æ¹æ³äžã§çšããããçšéå€ã®éã¯åºãå€å
ãããããšãã§ããããã¯å®éšå®€å ã«å®¹æã«æ±ºå®
ããããšãã§ãããããããŠãçšéå€ããžã¡ãã«
ã¹ã«ããã·ãã®ãããªæ¶²äœã§ããå Žåã«ã¯ããã®
éã¯æº¶åªãããã¯æžæ¿å€ïŒåªäœïŒïŒå®æœäŸãã«ã
ããŠã¯æ°ŽïŒã®äœç©ã«å¯Ÿããçµæç©ã«æ·»å ãããçš
éå€ã®äœç©ã§èšç®ããŠçŽ10ïŒ ããçŽ100ïŒ ã®ç¯å²
ã§å€åããããïŒåŸæ²ã®è¡šïŒåç §ïŒã奜ãŸããç¯
å²ã¯çŽ25ãçŽ100ïŒ ã§ããã åæ§ã«ãçšéå€ããæ¬æ现æžäžã«ãããŠé瀺ã
ããçšéå€ã®ïŒçš®ä»¥äžã®æ··åç©ã§ããå Žåã«ã¯ã
çšéå€æ··åç©äžã«çšããããæ°çš®ã®ååç©ã®éæ¯
ã¯åºãç¯å²ã§å€åãããããšãã§ããããã¯å®éš
宀çã«å®¹æã«æ±ºå®ã§ããã æ¬çºæã®çµæç©ãšããŠãäžèšããçµæç©ã«ãæŽ
ã«ãããŠé žãšã¹ãã«ãå«æãããã®ãæããã
ãã æ¬çºæã«ãããŠãå®å®æ§ããã³æ床ã®åäžã«å¯
äžãããšèããããããŠé žãšã¹ãã«ã¯ãå ã«ç€ºã
ããæ§é ãæããŠããããã®äžè¬çãªæ§é ãæã
ãååç©ãšããŠã¯ãããªã¡ã¿ããŒã«ã¢ãã³ ãã¬
ãŒããããªãšã¿ããŒã«ã¢ãã³ ãã¬ãŒãããã³ã
ãªïŒïœâãããããŒã«ïŒã¢ãã³ ãã¬ãŒããç¹ã«
é©ããŠããããããã®ååç©ã¯äžèšäžè¬åŒã«ãã
ãŠãïœãïœãããã³ïœãåãæŽæ°ã§ãã€ãŠããã
ãïŒïŒïŒããã³ïŒã§ããå Žåã«å¯Ÿå¿ããŠããã æ¬çºæã®çµæç©ããã³ãããçšããè©Šéšå ·ã«æ
çšãªããŠé žãšã¹ãã«ã®äœ¿çšéã¯å·Ÿåºãå€åããã
ãããããã¯åŸè¿°ããå®æœäŸã«ãããŠç€ºãããŠã
ããäŸãã°ãå®æœäŸïŒã«ãããŠãã¯ã¡ã³ãããã
ã«ãªãã·ãã«å¯Ÿããããªãšã¿ããŒã«ã¢ãã³ ãã¬
ãŒãã®ã¢ã«æ¯ã¯4.71ã§ããã ããããå®æœäŸäžã«ç€ºãããŠãããããªçŽ1.4
ãçŽïŒã®åœéæ¯ã®ç¯å²ã¯æ¬çºæã«ãšã€ãŠæçšãªã
ãŠé žãšã¹ãã«ã®éã«é¢ããŠå¶éãšãªããã®ã§ã¯ãª
ããè©Šéšçšçµæç©ã®ç®çãšããçšåºŠã®å®å®æ§ãšæ
床ãéæã§ãããªãã°ããããªãéã§ãã€ãŠãã
ãããã®éã¯ãå®éšå®€çã«å®¹æã«æ±ºå®ã§ãããã
ã¯æ¬æ现æžã®é瀺äžã«äžããããŠããã æ¬çºæã®å¥œãŸããå®æœæ æ§ã«ãããŠãçµæç©ã¯
ã¡ã³ããããã«ãªãã·ããïœâãã«ã€ãžã³ããžã¡
ãã«ã¹ã«ãã³ãšãžã¡ãã«ã¹ã«ããã·ãã®æ··åç©ã
å«æãããããã¯ãããã«ãæŽã«ãããªãšã¿ããŒ
ã«ã¢ãã³ ãã¬ãŒããå«æããã è©Šéšçšçµæç©ã¯ãå žåçã«ã¯ã䜿çšãããã¹ã
åæåããå°ããã€ãæ°Žåã¯ä»ã®é©åœãªæžæ¿åªäœ
ãããã¯æº¶åªäžã«æº¶è§£åã¯æžæ¿ãããããšã«ãã€
ãŠèª¿è£œããããããã溶åªåã¯åªäœãšããŠã¯ãã¯
ãããã«ã ãã¡ã¿ããŒã«ããšã¿ããŒã«ãã¡ãã¬ã³
ã¯ããªããã·ã¯ããããµã³çãæããããã è©Šéšå ·ã¯ïŒæ®µæµžæŒ¬æ³ã«ãã€ãŠèª¿è£œããããããª
ãã¡ãæ äœãããªãã¯ã¹ã®äžéšåã溶液åã¯æžæ¿
液ã«æµžæŒ¬ããåŸã也ç¥ãããããããŠèª¿è£œããã
è©Šéšå ·ã¯ãçŽ60âãçŽ70âã§ïŒãïŒæ¥ãããã¯ã
ã以äžã«äºããããªä¿é²æ¡ä»¶äžã«ãããä¿ååŸã«
ãããŠãåå¿æ§ã®äœäžã¯ã»ãšãã©èŠ³å¯ãããªãã€
ããæ¯èŒã®ããã«ãçšéå€ãããã¯çšéå€ããã³
ããŠé žãšã¹ãã«ãçšããããšãªãåæ§ã«è©Šéšå ·ã
調補ããããããã®ã¹ããªãããå®è³ªçã«åäžã®
ä¿é²è©Šéšæ¡ä»¶äžã«ä¿åãããšãåå¿æ§ããã³æ床
ã®èããäœäžã芳å¯ãããã æ¬çºæã«ä¿ãè©Šéšå ·ãäœæããããã®æ äœãã
ãªãã¯ã¹ãšããŠã¯å€ãã®çš®é¡ã®ãã®ãçšããã
ããç±³åœç¹èš±ç¬¬3846247å·ã¯ããšã«ããå€å質ã»
ã©ããã¯ã¹çŽ°çãããã³ã¬ã©ã¹ç¹ç¶ã®ç¹åžåã¯ã
ããã®äœ¿çšãæ瀺ããŠãããããã«ãç±³åœç¹èš±ç¬¬
3552938å·ã¯æšçãåžãã¹ãã³ãžãããã¯ç²å質
ç©è³ªã®äœ¿çšãæ瀺ããŠãããè±åœç¹èš±ç¬¬1369139
å·ã«ã¯ãæ äœãããªãã¯ã¹ãšããŠçŸæ¯ç¶ã®åææš¹
èããã³ã¬ã©ã¹ç¹ç¶ã®ããšã«ãã䜿çšããããšã
瀺åãããŠãããããïŒã€ã®è±åœç¹èš±ç¬¬1349623
å·ã«ã¯äžå°ã®çŽè£œãããªãã¯ã¹ã®è¢«èŠãšããŠæ¥µçŽ°
ãã€ã©ã¡ã³ãã®å ééæ§ã®ç¶²ã®äœ¿çšãææ¡ãããŠ
ãããããªã¢ããç¹ç¶ãä»åœç¹èš±ç¬¬2170397å·ã«
é瀺ãããŠããããããã®ç€ºåã«ããããããã
åŸæ¥ãæ äœãããªãã¯ã¹ãšããŠäž»ãšããŠçšããã
ãŠããææã§ãã€ãŠãæ¬çºæã«ç¹ã«é©ããææ
ã¯ãçŽã®ããšãåžæ°Žæ§ã®çŽã§ãããããããŠæ
äœãããªãã¯ã¹çšã®å¥œé©ãªææãéžæããã«åœã€
ãŠã¯ã倧ããªå·Ÿãããããšã該ãããªãã¯ã¹ã¯å
çš®ã®ç©çç圢ç¶ãåãããããšãç解ã§ãããã
ãããã¹ãŠã®åãæ¬çºæã®ç¯å²ã«å ¥ããã®ã§ã
ãã æ¬çºæã«ãããŠã¯ãçšéå€ãçšããããšã«ãã€
ãŠé¡èã«å¢å€§ããå®å®æ§ãåŸãããããé©ãã¹ã
ããšã«ãçšéå€ãšäžèšããããŠé žãšã¹ãã«ãè©Šéš
çšçµæç©äžã«äœµçšããããšã«ãã€ãŠããã«å€§ããª
å®å®æ§ãšæ床ãåŸãããããšãå€æããã å®å®æ§ããã³æ床ãåäžãããæ¬çºæã®æ¹æ³ã
å®çŸãããæ©æ§ã¯æããã§ã¯ãªãããæ¬çºæã«æŒ
ãŠèšè¿°ããã䞻匵ãããããŠé žãšã¹ãã«ã®ç¹ç°ãª
ååŠçæ§è³ªã¯ããã®æšå®ã«å¯ŸããŠåççãªæ ¹æ ã
äžãããã®ã§ãããéé žåç©ãäžè¬ã«äžå®å®ãªå
åç©ã§ãå°ãªããšãèªç¶çã«ååšãã倧æµã®åå
ç©ãããäžå®å®ã§ããããšã¯ç¥ãããŠããããã
ãã®ã¯ççºæ§ã§ãããææ©ããããã«ãªãã·ã
ïŒäŸãã°ãã¯ã¡ã³ããããã«ãªãã·ãïŒã®ããš
ããä»ã®ãã®ã¯æ¯èŒçå®å®ã§ããããæœè¡æåæ§
è©Šéšå ·ã«éåžžçšãããããããªé žã®ååšäžã«ãã
ãŠã¯å®¹æã«å解ãããšèããããããã®å解åå¿
ãããã«è¿°ã¹ãããšãè¢«é žåæ§æ瀺è¬ã®ååšäžã§
èµ·ããªãã°ãé žåéå åå¿ãèµ·ãããã®æ©ã ãšã
ãåå¿ã¯éé žåæåæ§è©Šè¬ã¹ããªããã®æ床äœäž
ã®åå ãšãªããã®ãšèããããã äžæ¹ãããã«è¿°ã¹ãããšãããŠé žãšã¹ãã«ã«ã
ããŠã¯ãäºç°æ§é ïŒbicylic strutureïŒäžã®çªçŽ
ååããã³ããŠçŽ ååã®é 眮ãç¹ç°ã§ãããåã
ã¯å¥ã ã®æ©é ååãšãªã€ãŠãããçæ¹ã®æ©é ã«ã
ãçªçŽ ååã¯é»åå¯åºŠã倧ã§ãã€ãŠãååã®è»žã
ãå€æ¹ã«çªåºããéå ±æé»å察ãæããŠãããä»
ã®æ©é ååã§ããããŠçŽ ååã¯ååã®è»žã®ä»ç«¯ã«
äœçœ®ããé»åãäžè¶³ããç¶æ ã§ãããé»åå¯åºŠã®
é«ãé°ã€ãªã³ãšé äœçµåãæãã ãããã€ãŠãååã®çªçŽ åå端ããé»åå¯åºŠã
é«ãããã«ãããã³ãšçµåãããããšã¯å åèã
ãããäžæ¹ãé»åãäžè¶³ããŠããæ©é ã®ããŠçŽ å
åã¯é°æ§ã®ãã«ãªãã·ãæ®åºãšé äœçµåãããã
ããããŠãããã«è°è«ããäºç°æ§ååã«ãããã
ã®ç¹ç°ãªé»åã®ååžãããã®ååããã«ãªãã·ã
ã®ãããã³ãšé žçŽ ååã®éã«ååŠçã«æ¿å ¥ããã
é äœçµåããã€ãªã³å¯Ÿã圢æããããšã«ããæ¬çº
æã®è©Šéšçšçµæç©äžã®ææ©éé žåç©ãå®å®åãã
ãŠãããã®ãšèããããã ããããŠãæ¬çºæã®è©Šéšçšçµæç©ã«ãããŠã¯ã
äŸè©Šè©Šæã®æº¶åªååããã«ãªãã·ãâãã¬ãŒãã»
ã³ã³ãã¬ãã¯ã¹ãç Žå£ãããã«ãªãã·ããéé¢ã
ãŠããããéé žå掻æ§ç©è³ªã®ååšäžã§æ瀺è¬ãé ž
åãããŸã§ãææ©ããããã«ãªãã·ããæ瀺è¬ãš
ã€ãªã³çã«åå¿ããããšã劚ããããããã«å®å®
æ§ãèããå¢å€§ãããã®ãšèããããã æ¬çºæãåŠäœã«ãªããã€çšããããããã«æ確
ã«ç€ºãããã«ãããã«ã¯æ¬çºæã®å¥œãŸããå®æœæ
æ§ã説æããããã«ã次ã«å®æœäŸãæ²ããã A.è©Šéšçšçµæç©ããã³è©Šéšå ·ã®èª¿è£œ å®æœäŸ ïŒ è©Šéšçšçµæç© è±ã€ãªã³æ°Ž150mlã«æ¬¡ã®æåã溶解ãããããš
ã«ãããè©Šéšçšçµæç©ã調補ãããåæåã¯ãèš
èŒãããé åºã§æ°Žäžã«æ·»å ããã ã¯ãšã³é žäžãããªãŠã 3.2ïœ ã¯ãšã³é ž 2.2ïœ ãšãã¬ã³ãžã¢ãã³åé ¢é žåãããªãŠã å¡© 0.1ïœ ãžã¡ãã«ã¹ã«ãã³ 10.0ïœ ã©ãŠãªã«ç¡«é žãããªãŠã 1.0ïœ ïŒâã¡ããã·ãããªã³ 0.5ïœ ãžã¡ãã«ã¹ã«ããã·ã 25.0ml ã¢ã»ãã³ 25.0ml ã¯ã¡ã³ããããã«ãªãã·ã 2.0ïœ ããªãšã¿ããŒã«ã¢ãã³ ãã¬ãŒã 10.0ïœ ïŒã¢ã«ããªããã»ã±ãã«ã«ã»ã³ã³ãããŒã»ã€ã³
ã³ãŒãã¬ãŒãããïŒ ïœâãã«ã€ãžã³ 0.4ïœ å®æœäŸ ïŒ è©Šéšå · ã¯ãããã³3MMçŽçãå®æœäŸïŒã®è©Šéšå ·ã«
浞挬ãããç¢æŒ¬ããçŽçãçŽ15åé70âã§ä¹Ÿç¥
ããè©Šéšçšçµæç©ãå«æµžããæ äœãããªãã¯ã¹ã
äœæããã次ã«ä¹Ÿç¥ããæ äœãããªãã¯ã¹ãã
3M瀟ããè³Œå ¥ããäž¡é¢æ¥çããŒããçšããŠãã©
ã¹ããã¯ïŒããªã¹ãã¬ã³ïŒçãããã¯ãã©ã¹ãã
ã¯ã®æãæã«è²Œãä»ãããåŸãããè©Šéšå ·ã¯éé ž
å掻æ§ç©è³ªãå«æããŠãããšæãããå°¿ã®åŠãäŸ
è©Šè©Šæäžã«æµžããæ äœãããªãã¯ã¹ã®åè²ã芳å¯
ããããšã«ãã€ãŠè©²ç©è³ªãå®éããããã«çšãã
ããšãã§ããã B.å皮詊éšçšçµæç©ã®å®å®æ§è©Šéš å®æœäŸ ïŒ çšéå€ã®å¹æ 500mlã®ããŒã«ã«æ¬¡ã®æåãå ããã ã¯ãããã«ã 100ml ã¯ã¡ã³ããããã«ãªãã·ã 4.0ïœ ïœâãã«ã€ãžã³ 0.4ïœ ãžã¡ãã«ã¹ã«ããã·ã 25.0ml åèšã®æŽ»æ§æåãšæ··åãããšæ·¡é»è²ãåããã
åŸãããè©Šéšçšçµæç©ããšã«ã¬ã³ãã€ã€ãŒãã©ã¹
ã³ïŒäžè§ãã©ã¹ã³ïŒã«ç§»ãæ ãããŠå®éšå°äžã«å®€
æž©ïŒçŽ18.3âïŒã§äžæ©æŸçœ®ãããäžæ¥åŸãè©Šéšçš
çµæç©ã¯èª¿è£œæã«æ¯ã¹ãŠãããã«æè²ã«å€åãã
ã ãã§ãã€ãã æ¯èŒäŸ ïŒ å®æœäŸïŒãšã®æ¯èŒ æ¬é¡çºæãšæ¯èŒãè¡ãªãããã«ãå¯Ÿç §ãšãªãè©Š
éšçšçµæç©ãããžã¡ãã«ã¹ã«ããã·ãã®ä»£ãã«ã
ãã«25mlã®ã¯ãããã«ã ãå ãã以å€ãå®æœäŸïŒ
ã®æäœæ³ã«åŸã€ãŠèª¿è£œããããã®ãžã¡ãã«ã¹ã«ã
ãã·ããå«ãŸãªãè©Šéšçšçµæç©ãäžè§ãã©ã¹ã³ã«
å ¥ããŠæ ãããå®æœäŸïŒãšåæ§ïŒããªãã¡18.3â
ã§äžæ¥éïŒã«ããå®éšå°äžã«æŸçœ®ãããå®æœäŸïŒ
ã®çµæç©ãšç°ãªããå¯Ÿç §ã®çµæç©ã¯ã»ãšãã©é»è²
ãšãªã€ãããã®ããšã¯ãçšéå€ã®æ·»å ã«ãã€ãŠè©Š
éšçšçµæç©ã®å®å®æ§ãæ¹è¯ãããŠããããšã瀺ã
ãŠããã C.ããŠé žãšã¹ãã«ã«ããè©Šéšå ·ã®å®å®å æ¯èŒäŸ ïŒ å¯Ÿç §è©Šéš æ¬éé žåé µçŽ ã«å¯ŸããŠæåæ§ãæããè©Šè¬å«æã¹
ããªããã®äœæã®ããã«ã次ã«ç€ºãè©Šéšçšçµæç©
溶液ã調補ããããã®é åäžã«ã¯æ¬çºæã®ããŠé ž
ãšã¹ãã«æåã¯å«ãŸããŠããªãã æ°Ž 150ml ã¯ãšã³é žäžãããªãŠã 3.2ïœ ã¯ãšã³é ž 22ïœ ãšãã¬ã³ãžã¢ãã³åé ¢é žåãããªãŠã å¡© 0.1ïœ ãžã¡ãã«ã¹ã«ãã³ 10.0ïœ ã©ãŠãªã«ç¡«é žãããªãŠã 1.0ïœ ïŒâã¡ããã·ãããªã³ 0.5ïœ ãžã¡ãã«ã¹ã«ããã·ã 25.0ml ã¢ã»ãã³ 25.0ml ã¯ã¡ã³ããããã«ãªãã·ã 2.0ïœ ïœâãã«ã€ãžã³ 0.4ïœ ã¯ãããã³3MMçŽã®ïŒéšåãäžèšã®è©Šéšçš
çµæç©æº¶æ¶²ã«æµžæŒ¬ããåŸã70âã«ä¹Ÿç¥ããã也ç¥
ããçŽãçŽïŒmmè§ã«åæããããããŠããçã
äž¡é¢æ¥çããŒãïŒ3M瀟ããå ¥æå¯èœïŒãçšããŠ
ãã©ã¹ããã¯è£œã®æã¡æã«è²ŒçããŠè©Šéšå ·ãäœæ
ããã å®æœäŸ ïŒ æ¬çºæ ã¯ã¡ã³ããããã«ãªãã·ããæ·»å ããåã«ã10
ïœã®ããªãšã¿ããŒã«ã¢ãã³ ãã¬ãŒããæ·»å ãã
ä»ã¯äžèšã®æ¯èŒäŸïŒãšåæ§ã«ããŠæº¶æ¶²ã調補ã
ãããã®æº¶æ¶²ããæ¯èŒäŸïŒãšåæ§ã«ããŠè©Šéšå ·ã
äœæããã å®æœäŸ ïŒ 1.4âãžã¢ã¶ãã·ã¯ããïŒïŒïŒïŒïŒããªã¯ã¿ã³ ã¯ã¡ã³ããããã«ãªãã·ããæ·»å ããåã«ã10
ïœã®ïŒïŒïŒâãžã¢ã¶ãã·ã¯ããïŒïŒïŒïŒïŒããªã¯
ã¿ã³ãæ·»å ããä»ã¯äžèšã®æ¯èŒäŸ22ãšåæ§ã«ããŠ
溶液ã調補ããããã®æº¶æ¶²ãæ¯èŒäŸïŒãšåæ§ã«ã
ãŠè©Šéšå ·ãäœæããããã«äœ¿çšããã å®æœäŸ ïŒ ãããµã¡ãã¬ã³ããã©ãã³ ã¯ã¡ã³ããããã«ãªãã·ããæ·»å ããåã«ã10
ïœã®ãããµã¡ãã¬ã³ããã©ãã³ãæ·»å ããŠä»ã¯ã
äžèšã®æ¯èŒäŸïŒãšåæ§ã«ããŠæº¶æ¶²ã調補ãããã
ã®æº¶æ¶²ããäžèšã®æ¯èŒäŸïŒãšåæ§ã«ããŠè©Šéšå ·ã
äœæããã å®æœäŸ ïŒ å®å®æ§åã³æ床ã®æ¯èŒ æ¯èŒäŸïŒããã³å®æœäŸïŒãïŒã®è©Šéšå ·ãä¿é²æ¡
件äžã«ãããããçã®çžå¯Ÿçãªå®å®æ§ãšæ床ã枬
å®ãããæ¯èŒäŸïŒããã³å®æœäŸïŒãïŒã®è©Šéšå ·ã¯
çŽ60âã§ïŒæ¥éä¿åãããå®æœäŸïŒã®è©Šéšå ·ã¯çŽ
70âã§ïŒæ¥éæŸçœ®ããããããçã®ä¿é²æ¡ä»¶äžã«
ããããè©Šéšå ·ã¯ã次ã«çŸäžåã®äžïŒïŒppmïŒã®è¡
液ãå«æããå°¿äžã«æµžæŒ¬ããããšã«ãã€ãŠãã®æ
床ã枬å®ããããããªãšã¿ããŒã«ã¢ãã³ ãã¬ãŒ
ããå«ãè©Šéšå ·ïŒå®æœäŸïŒïŒã®ã¿ããã®æœè¡æ¿åºŠ
ïŒããªãã¡ã1dåœã0.015mgïŒã§è²ã®å€åã瀺ã
ããä»ã®è©Šéšå ·ã¯ãã®æœè¡æ¿åºŠã«å¯ŸããŠã¯æåæ§
ã瀺ããªãã€ãã D.çšéå€ã«ããè©Šéšå ·ã®å®å®å å®æœäŸ ïŒ æ¬¡ã«ç€ºãè¡šïŒã«èšèŒãããåçš®ã®éã®ãžã¡ãã«
ã¹ã«ããã·ããå«ãïŒçš®ã®è©Šéšçšçµæç©ããïŒçš®
ã®è©Šéšå ·ãäœæããããïŒçš®ã®è©Šéšçšçµæç©æº¶æ¶²
ã¯ãã¹ãŠæ¬¡ã®é åãçšããŠèª¿è£œãããã æ°Ž 75ml ã¯ãšã³é žäžãããªãŠã 3.2ïœ ã¯ãšã³é ž 4.5ïœ ããªãšã¿ããŒã«ã¢ãã³ ãã¬ãŒã 10.0ïœ ãšãã¬ã³ãžã¢ãã³åé ¢é žåãããªãŠã å¡© 0.1ïœ ãžã¡ãã«ã¹ã«ãã³ 5.0ïœ ã©ãŠãªã«ç¡«é žãããªãŠã 1.0ïœ ïŒâã¡ããã·ãããªã³ 0.5ïœ ã¯ã¡ã³ããããã«ãªãã·ã 2.0ïœ ïœâãã«ã€ãžã³ 0.4ïœ ïŒçš®ã®è©Šéšçšçµæç©æº¶æ¶²ã®åã ã«ããããã次
ã«ç€ºãéã®ãžã¡ãã«ã¹ã«ããã·ããšã¡ã¿ããŒã«ã
æ·»å ããã
ãè¡šã
次ã«ãäžèšã®è©Šéšçšçµæç©æº¶æ¶²ã®åã
ãã¯ãã
ãã³3MMçŽã«å«æµžãããããšã«ãã€ãŠè©Šéšå ·
ã調補ããã溶液ã«æµžæŒ¬ããçŽçãããããã®
溶液ããåŒãäžãã也ç¥ããããã«70âã®ãªãŒã
ã³äžã§18æéä¿é²è©Šéšã«ä»ãããä¿é²è©Šéšã®åŸã
åã ã®è©Šéšçšã¹ããªãããæ°é®®ãªå šè¡ãå°¿ãçšã
ãŠçŸäžåã®äžã«çšéããäŸè©Šæº¶æ¶²äžã§è©Šéšããã
åã¹ããªããã®åè²ã®åŒ·ããæ¯èŒããçµæãè¡šïŒ
ã«ç€ºãã
ãã³3MMçŽã«å«æµžãããããšã«ãã€ãŠè©Šéšå ·
ã調補ããã溶液ã«æµžæŒ¬ããçŽçãããããã®
溶液ããåŒãäžãã也ç¥ããããã«70âã®ãªãŒã
ã³äžã§18æéä¿é²è©Šéšã«ä»ãããä¿é²è©Šéšã®åŸã
åã ã®è©Šéšçšã¹ããªãããæ°é®®ãªå šè¡ãå°¿ãçšã
ãŠçŸäžåã®äžã«çšéããäŸè©Šæº¶æ¶²äžã§è©Šéšããã
åã¹ããªããã®åè²ã®åŒ·ããæ¯èŒããçµæãè¡šïŒ
ã«ç€ºãã
ãè¡šã
ãè¡šã
è¡šïŒäžã®ããŒã¿ããæçœãªãããã«ãæ床ã¯è©Š
éšçšçµæç©äžã«çšããããçšéå€ïŒããã§ã¯ããž
ã¡ãã«ã¹ã«ããã·ãïŒã®éãšå ±ã«å¢å€§ããã E.åçš®ã®çšéå€ã«ãã€ãŠä»äžãããè©Šéšçšçµæ
ç©ïŒããŠé žãšã¹ãã«ãå«ãïŒã®å®å®æ§ã®å¢å€§ å®æœäŸ ïŒ ïŒçš®ã®è©Šéšçšçµæç©ãå®æœäŸïŒãšåæ§ã«èª¿è£œã
ããããã®ãã¡ã®ïŒçš®ã¯ç°ã€ãçšéå€ãå«ã¿ãäž
çš®ïŒå¯Ÿç §ïŒã¯çšéå€ãå«ãã§ããªãã€ãããã®å®
éšã®ç®çã¯ãçµæç©äžã®ããŠé žãšã¹ãã«ã®éãäž
å®ã«ä¿æããå Žåãéé žå掻æ§ç©è³ªã«å¯ŸããŠæå
æ§ãæããè©Šéšçšçµæç©ã®å®å®æ§ã®å¢å€§ã«å¯Ÿãã
åçš®çšéå€ã®å¹æã調ã¹ãããšã§ãã€ãã 次ã«ç€ºãæåãå«ã溶液ã調補ããã æ°Ž 50ml ã¯ãšã³é žäžãããªãŠã 3.2ïœ ã¯ãšã³é ž 2.2ïœ ã©ãŠãªã«ç¡«é žãããªãŠã 1.0ïœ ïŒâã¡ããã·ãããªã³ 1.0ïœ ã¡ã¿ããŒã« 50.0ml ããªãšã¿ããŒã«ã¢ãã³ ãã¬ãŒã 5.0ïœ ã¯ã¡ã³ããããã«ãªãã·ã 2.0ïœ ïœâãã«ã€ãžã³ 0.4ïœ ãã®æº¶æ¶²ã®å°éãïŒæ¬ã®è©Šéšç®¡ã®åã ã«å ã
ãããã®åŸãè¡šïŒã«ç€ºãããçšéå€ã®å°éãåè©Š
éšç®¡ã«å ããè©Šéšç®¡ã«æ ãããå®éšå°äžã«å®€æž©äž
ã§ïŒé±éæŸçœ®ãããïŒé±éåŸãè©Šéšç®¡ãè²èª¿ã®çž
察çãªåŒ·ãïŒæãïŒã«ã€ããŠè©Šéšãããè²èª¿ã匷
ããã°åŒ·ãçšãè©Šéšçšçµæç©ã¯äžå®å®ã§ãããçµ
æããå®å®æ§ãäœäžããé åºïŒããªãã¡è©Šéšçšçµ
æç©ïŒã¯æãå®å®ã§ãããè©Šéšçšçµæç©ïŒã¯æã
äžå®å®ã§ããïŒã§è¡šïŒäžã«ç€ºããã
éšçšçµæç©äžã«çšããããçšéå€ïŒããã§ã¯ããž
ã¡ãã«ã¹ã«ããã·ãïŒã®éãšå ±ã«å¢å€§ããã E.åçš®ã®çšéå€ã«ãã€ãŠä»äžãããè©Šéšçšçµæ
ç©ïŒããŠé žãšã¹ãã«ãå«ãïŒã®å®å®æ§ã®å¢å€§ å®æœäŸ ïŒ ïŒçš®ã®è©Šéšçšçµæç©ãå®æœäŸïŒãšåæ§ã«èª¿è£œã
ããããã®ãã¡ã®ïŒçš®ã¯ç°ã€ãçšéå€ãå«ã¿ãäž
çš®ïŒå¯Ÿç §ïŒã¯çšéå€ãå«ãã§ããªãã€ãããã®å®
éšã®ç®çã¯ãçµæç©äžã®ããŠé žãšã¹ãã«ã®éãäž
å®ã«ä¿æããå Žåãéé žå掻æ§ç©è³ªã«å¯ŸããŠæå
æ§ãæããè©Šéšçšçµæç©ã®å®å®æ§ã®å¢å€§ã«å¯Ÿãã
åçš®çšéå€ã®å¹æã調ã¹ãããšã§ãã€ãã 次ã«ç€ºãæåãå«ã溶液ã調補ããã æ°Ž 50ml ã¯ãšã³é žäžãããªãŠã 3.2ïœ ã¯ãšã³é ž 2.2ïœ ã©ãŠãªã«ç¡«é žãããªãŠã 1.0ïœ ïŒâã¡ããã·ãããªã³ 1.0ïœ ã¡ã¿ããŒã« 50.0ml ããªãšã¿ããŒã«ã¢ãã³ ãã¬ãŒã 5.0ïœ ã¯ã¡ã³ããããã«ãªãã·ã 2.0ïœ ïœâãã«ã€ãžã³ 0.4ïœ ãã®æº¶æ¶²ã®å°éãïŒæ¬ã®è©Šéšç®¡ã®åã ã«å ã
ãããã®åŸãè¡šïŒã«ç€ºãããçšéå€ã®å°éãåè©Š
éšç®¡ã«å ããè©Šéšç®¡ã«æ ãããå®éšå°äžã«å®€æž©äž
ã§ïŒé±éæŸçœ®ãããïŒé±éåŸãè©Šéšç®¡ãè²èª¿ã®çž
察çãªåŒ·ãïŒæãïŒã«ã€ããŠè©Šéšãããè²èª¿ã匷
ããã°åŒ·ãçšãè©Šéšçšçµæç©ã¯äžå®å®ã§ãããçµ
æããå®å®æ§ãäœäžããé åºïŒããªãã¡è©Šéšçšçµ
æç©ïŒã¯æãå®å®ã§ãããè©Šéšçšçµæç©ïŒã¯æã
äžå®å®ã§ããïŒã§è¡šïŒäžã«ç€ºããã
ãè¡šã
ãè¡šã
è¡šïŒäžãè©ŠæïŒããã³ïŒã¯ããããå®å®æ§ã瀺
ããã溶液ïŒã¯ããçšã§ããªããããããªãè¯å¥œ
ãªå®å®æ§ãæããŠããã溶液ïŒãïŒã¯äžçšåºŠã®å®
å®æ§ãæãã溶液ïŒããªãã¡å¯Ÿç §ã¯ã溶液ïŒãïŒ
ã«æ¯ã¹ãŠã¯ããã«äžå®å®ã§ãã€ãã F.奜ãŸããå®æœæ æ§ å®æœäŸ 10 次ã«ç€ºãæåã150c.c.ã®æ°Žäžã§æ··åããã ã¯ãšã³é žäžãããªãŠã 3.2ïœ ã¯ãšã³é ž 2.2ïœ ãšãã¬ã³ãžã¢ãã³åé ¢é žåãããªãŠã å¡© 0.1ïœ ãžã¡ãã«ã¹ã«ãã³ 10.0ïœ ã©ãŠãªã«ç¡«é žãããªãŠã 1.0ïœ ïŒâã¡ããã·ãããªã³ 0.5ïœ ãžã¡ãã«ã¹ã«ããã·ã 25.0ml ã¢ã»ãã³ 25.0ml ããªãšã¿ããŒã«ã¢ãã³ ãã¬ãŒã 10.0ïœ ã¯ã¡ã³ããããã«ãªãã·ã 2.0ïœ ïœâãã«ã€ãžã³ 0.4ïœ ã¯ãããã³3MMçŽã®ã¹ããªãããäžèšã®æº¶
液ã«æµžæŒ¬ãã70âã§ä¹Ÿç¥ããã也ç¥ããæç¹ã§
çŽãïŒçïŒmmã®æ¹åœ¢ã«åæããããããã®æ¹åœ¢
ãã倧ãããçŽïŒã15mmã®ããªã¹ãã¬ã³è£œã®æã¡
æã«äž¡é¢æ¥çããŒãïŒ3M瀟補ïŒãçšããŠè²Œãä»
ããã äžèšã®å®éšäŸã«åŸã€ãŠèª¿è£œãããè©Šéšå ·ãã60
âãïŒæ¥éã®ä¿é²è©Šéšã«ä»ããããããçã¯å°ã
ãšã0.015mgïŒ ã®æ¿åºŠã§å°¿äžã«ååšããæœè¡ã«å¯Ÿ
ãæåæ§ã瀺ãããšãããã€ãã å®æœäŸ 11 ãã®å®æœäŸã¯æ¬æ现æžã«ãããŠé瀺ãããè©Šéš
å ·ã®ç¬¬ïŒã®å¥œãŸããå®æœæ æ§ãå ·äœçã«èª¬æãã
ãã®ã§ãããè©Šéšçšçµæç©ã¯ãããŒã«ãŒäžã§æ¬¡ã«
瀺ãæåãã次ã«ç€ºãé åºã§ãæ¹æäžã§æ··åãã
ããšã«ãã€ãŠèª¿è£œãããã æ°Ž 75ml ã¯ãšã³é žäžãããªãŠã 3.2ïœ ã¯ãšã³é ž 4.15ïœ ããªãšã¿ããŒã«ã¢ãã³ ãã¬ãŒã 10.0ïœ ãšãã¬ã³ãžã¢ãã³åé ¢é ž 0.1ïœ ã©ãŠãªã«ç¡«é žãããªãŠã 1.5ïœ ãžã¡ãã«ã¹ã«ãã³ 10.0ïœ ïŒâã¡ããã·ãããªã³ 0.6ïœ ïŒ®ïŒïŒ®âãžã¡ãã«ã¹ã«ãã«ã ã¢ãã 75 ml ã¯ã¡ã³ããããã«ãªãã·ã 3.0ïœ ïœâãã«ã€ãžã³ 0.8ïœ ã¯ãããã³3MMçŽã®ã¹ããªãããäžèšã®çµ
æç©ã«æµžæŒ¬ããåŸãçŽ90ã92âã§çŽ11åé也ç¥ã
ãã也ç¥ããã¹ããªããã次ã«äž¡é¢æ¥çããŒãã
çšããŠãã©ã¹ããã¯è£œã®æã¡æã«è²Œãä»ãããã
ãã€ãã®ã¹ããªããã70âã§ïŒæ¥éä¿åããããš
ã«ãã€ãŠä¿é²è©Šéšã«ä»ãããä»ã®ãã®ã¯40âã§12
é±éä¿åãããïŒçµã®ã¹ããªããã¯æ°é®®ãªå šè¡ã
å°¿ã§çŸäžåã®ïŒã«çšéãã溶液ã«æ¥è§Šãããæã
éç·è²ãåããã G.è£å å®æœäŸ å®æœäŸ 12 è©Šéšçšçµæç© ãžã¡ãã«ã¹ã«ãã³ã®ä»£ããã«ã¡ãã«ãšãã«ã¹ã«
ãã³ã䜿çšãã以å€ã¯å®æœäŸïŒãšåæ§ã«ããŠè©Šéš
çšçµæç©ã調補ããã å®æœäŸ 13 æ¬çºæ 10ïœã®ããªãšã¿ããŒã«ã¢ãã³ ãã¬ãŒãã®ä»£ã
ãã«10ïœã®ïŒ®ïŒïŒ®âãžâïœâãããããŒã«ââ
ãšã¿ããŒã«ã¢ãã³ ãã¬ãŒããæ·»å ããä»ã¯å®æœ
äŸïŒãšåæ§ã«ããŠæº¶æ¶²ã調補ããããã®æº¶æ¶²ãã
æ¯èŒäŸïŒãšåæ§ã«ããŠè©Šéšå ·ãäœæããããã®ã
ãã«ããŠäœæããè©Šéšå ·ãçŽ60âã§ïŒæ¥éä¿åã
ãã次ãã§ããã®ãããªä¿é²æ¡ä»¶äžã«ãããè©Šéš
å ·ãçŸäžåã®äžïŒïŒppmïŒã®è¡æ¶²ãå«æããå°¿äžã«
浞挬ããããšã«ãã€ãŠãã®æ床ã枬å®ãããïŒ
ïŒâãžâïœâãããããŒã«ââãšã¿ããŒã«ã¢
ãã³ ãã¬ãŒããå«ãæ¬å®æœäŸã®è©Šéšå ·ã¯ãå®æœ
äŸïŒãšåæ§ã«ããã®æœè¡æ¿åºŠïŒããªãã¡ã1dlåœ
ã0.015mgïŒã§è²ã®å€åã瀺ããã å®æœäŸ 14 çšéå€ã«ããè©Šéšå ·ã®å®å®å ããªãšã¿ããŒã«ã¢ãã³ ãã¬ãŒãã®ä»£ããã«
ïŒïŒ®âãžãšã¿ããŒã«ââïœâãããããŒã«ã¢
ãã³ ãã¬ãŒãã䜿çšãã以å€ã¯å®æœäŸïŒãšåæ§
ã«ããŠïŒçš®ã®è©Šéšçšçµæç©æº¶æ¶²ã調補ããããã®
ïŒçš®ã®è©Šéšçšçµæç©æº¶æ¶²ã®åã ã«ãããããå®æœ
äŸïŒã®è¡šïŒã«ç€ºãéã®ãžã¡ãã«ã¹ã«ããã·ããšã¡
ã¿ããŒã«ãæ·»å ããã 次ã«ããããè©Šéšçšçµæç©æº¶æ¶²ã®åã ãã¯ãã
ãã³3MMçŽã«å«æµžãããããšã«ãã€ãŠè©Šéšå ·
ã調補ããã溶液ã«æµžæŒ¬ããçŽçãããããã®
溶液ããåŒãäžãã也ç¥ããããã«70âã®ãªãŒã
ã³äžã§18æéä¿é²è©Šéšã«ä»ãããä¿é²è©Šéšã®åŸã
åã ã®è©Šéšçšã¹ããªãããæ°é®®ãªå šè¡ãå°¿ãçšã
ãŠçŸäžåã®äžã«çšéããäŸè©Šæº¶æ¶²äžã§è©Šéšããã
åã¹ããªããã®åè²ã®åŒ·ããæ¯èŒããçµæãå®æœ
äŸïŒã«ãããè¡šïŒã«ç€ºãçµæãšåæ§ã§ãã€ãã å®æœäŸ 15 åçš®ã®çšéå€ã«ãã€ãŠä»äžãããè©Šéšçšçµæç©
ïŒããŠé žãšã¹ãã«ãå«ãïŒã®å®å®æ§ã®å¢å€§ çšéå€ãšããŠã®ïŒ®ïŒïŒ®âãžã¡ãã«ãã«ã ã¢ãã
ãâã¡ãã«ââãšãã«ãã«ã ã¢ããã«ä»£ãã
以å€ã¯å®æœäŸïŒãšåæ§ã«ããŠïŒ®âã¡ãã«ââãš
ãã«ãã«ã ã¢ããã®çšéå€ãšããŠã®å¹æã調ã¹
ãããã®çµæãâã¡ãã«ââãšãã«ãã«ã ã¢
ãããå®æœäŸïŒã®è¡šïŒã«ãããŠç€ºããïŒïŒ®âãž
ã¡ãã«ãã«ã ã¢ãããšåæ§ã«ããããå®å®æ§ã瀺
ããã èŠçŽããã«ãåè¿°ã®å®æœäŸã¯ãæ¬çºæïŒå®æœäŸ
ïŒïŒïŒããã³12ïŒã®çµæç©ããã³è©Šéšå ·ãããã«
調補ã䜿çšãããã瀺ããåãå®å®æ§åã³æ床ã®
æ¯èŒçµæãå瀺ãïŒå®æœäŸïŒãïŒãæ¯èŒäŸïŒãïŒ
ããã³å®æœäŸ13ã15ïŒãããã«åãæ¬çºæã®å¥œãŸ
ããå®æœæ æ§ãèšè¿°ããŠããïŒå®æœäŸ10ããã³
11ïŒãè©Šéšçšçµæç©ã«ãããçšéå€ã®åç¬äœ¿çšã®
å¹æã¯å®æœäŸïŒããã³æ¯èŒäŸïŒã«ç€ºãããŠãã
ããçšéå€ããã³ããŠé žãšã¹ãã«ã䜵çšããè©Šéš
å ·ã«ãããå¹æã¯æ¯èŒäŸïŒãå®æœäŸïŒãïŒããã³
å®æœäŸ13ã14ã«ç€ºãããŠãããåçš®ã®çšéå€ã®äœ¿
çšã¯å®æœäŸïŒããã³å®æœäŸ15ã«å ·äœçã«ç€ºãããŠ
ããã
ããã溶液ïŒã¯ããçšã§ããªããããããªãè¯å¥œ
ãªå®å®æ§ãæããŠããã溶液ïŒãïŒã¯äžçšåºŠã®å®
å®æ§ãæãã溶液ïŒããªãã¡å¯Ÿç §ã¯ã溶液ïŒãïŒ
ã«æ¯ã¹ãŠã¯ããã«äžå®å®ã§ãã€ãã F.奜ãŸããå®æœæ æ§ å®æœäŸ 10 次ã«ç€ºãæåã150c.c.ã®æ°Žäžã§æ··åããã ã¯ãšã³é žäžãããªãŠã 3.2ïœ ã¯ãšã³é ž 2.2ïœ ãšãã¬ã³ãžã¢ãã³åé ¢é žåãããªãŠã å¡© 0.1ïœ ãžã¡ãã«ã¹ã«ãã³ 10.0ïœ ã©ãŠãªã«ç¡«é žãããªãŠã 1.0ïœ ïŒâã¡ããã·ãããªã³ 0.5ïœ ãžã¡ãã«ã¹ã«ããã·ã 25.0ml ã¢ã»ãã³ 25.0ml ããªãšã¿ããŒã«ã¢ãã³ ãã¬ãŒã 10.0ïœ ã¯ã¡ã³ããããã«ãªãã·ã 2.0ïœ ïœâãã«ã€ãžã³ 0.4ïœ ã¯ãããã³3MMçŽã®ã¹ããªãããäžèšã®æº¶
液ã«æµžæŒ¬ãã70âã§ä¹Ÿç¥ããã也ç¥ããæç¹ã§
çŽãïŒçïŒmmã®æ¹åœ¢ã«åæããããããã®æ¹åœ¢
ãã倧ãããçŽïŒã15mmã®ããªã¹ãã¬ã³è£œã®æã¡
æã«äž¡é¢æ¥çããŒãïŒ3M瀟補ïŒãçšããŠè²Œãä»
ããã äžèšã®å®éšäŸã«åŸã€ãŠèª¿è£œãããè©Šéšå ·ãã60
âãïŒæ¥éã®ä¿é²è©Šéšã«ä»ããããããçã¯å°ã
ãšã0.015mgïŒ ã®æ¿åºŠã§å°¿äžã«ååšããæœè¡ã«å¯Ÿ
ãæåæ§ã瀺ãããšãããã€ãã å®æœäŸ 11 ãã®å®æœäŸã¯æ¬æ现æžã«ãããŠé瀺ãããè©Šéš
å ·ã®ç¬¬ïŒã®å¥œãŸããå®æœæ æ§ãå ·äœçã«èª¬æãã
ãã®ã§ãããè©Šéšçšçµæç©ã¯ãããŒã«ãŒäžã§æ¬¡ã«
瀺ãæåãã次ã«ç€ºãé åºã§ãæ¹æäžã§æ··åãã
ããšã«ãã€ãŠèª¿è£œãããã æ°Ž 75ml ã¯ãšã³é žäžãããªãŠã 3.2ïœ ã¯ãšã³é ž 4.15ïœ ããªãšã¿ããŒã«ã¢ãã³ ãã¬ãŒã 10.0ïœ ãšãã¬ã³ãžã¢ãã³åé ¢é ž 0.1ïœ ã©ãŠãªã«ç¡«é žãããªãŠã 1.5ïœ ãžã¡ãã«ã¹ã«ãã³ 10.0ïœ ïŒâã¡ããã·ãããªã³ 0.6ïœ ïŒ®ïŒïŒ®âãžã¡ãã«ã¹ã«ãã«ã ã¢ãã 75 ml ã¯ã¡ã³ããããã«ãªãã·ã 3.0ïœ ïœâãã«ã€ãžã³ 0.8ïœ ã¯ãããã³3MMçŽã®ã¹ããªãããäžèšã®çµ
æç©ã«æµžæŒ¬ããåŸãçŽ90ã92âã§çŽ11åé也ç¥ã
ãã也ç¥ããã¹ããªããã次ã«äž¡é¢æ¥çããŒãã
çšããŠãã©ã¹ããã¯è£œã®æã¡æã«è²Œãä»ãããã
ãã€ãã®ã¹ããªããã70âã§ïŒæ¥éä¿åããããš
ã«ãã€ãŠä¿é²è©Šéšã«ä»ãããä»ã®ãã®ã¯40âã§12
é±éä¿åãããïŒçµã®ã¹ããªããã¯æ°é®®ãªå šè¡ã
å°¿ã§çŸäžåã®ïŒã«çšéãã溶液ã«æ¥è§Šãããæã
éç·è²ãåããã G.è£å å®æœäŸ å®æœäŸ 12 è©Šéšçšçµæç© ãžã¡ãã«ã¹ã«ãã³ã®ä»£ããã«ã¡ãã«ãšãã«ã¹ã«
ãã³ã䜿çšãã以å€ã¯å®æœäŸïŒãšåæ§ã«ããŠè©Šéš
çšçµæç©ã調補ããã å®æœäŸ 13 æ¬çºæ 10ïœã®ããªãšã¿ããŒã«ã¢ãã³ ãã¬ãŒãã®ä»£ã
ãã«10ïœã®ïŒ®ïŒïŒ®âãžâïœâãããããŒã«ââ
ãšã¿ããŒã«ã¢ãã³ ãã¬ãŒããæ·»å ããä»ã¯å®æœ
äŸïŒãšåæ§ã«ããŠæº¶æ¶²ã調補ããããã®æº¶æ¶²ãã
æ¯èŒäŸïŒãšåæ§ã«ããŠè©Šéšå ·ãäœæããããã®ã
ãã«ããŠäœæããè©Šéšå ·ãçŽ60âã§ïŒæ¥éä¿åã
ãã次ãã§ããã®ãããªä¿é²æ¡ä»¶äžã«ãããè©Šéš
å ·ãçŸäžåã®äžïŒïŒppmïŒã®è¡æ¶²ãå«æããå°¿äžã«
浞挬ããããšã«ãã€ãŠãã®æ床ã枬å®ãããïŒ
ïŒâãžâïœâãããããŒã«ââãšã¿ããŒã«ã¢
ãã³ ãã¬ãŒããå«ãæ¬å®æœäŸã®è©Šéšå ·ã¯ãå®æœ
äŸïŒãšåæ§ã«ããã®æœè¡æ¿åºŠïŒããªãã¡ã1dlåœ
ã0.015mgïŒã§è²ã®å€åã瀺ããã å®æœäŸ 14 çšéå€ã«ããè©Šéšå ·ã®å®å®å ããªãšã¿ããŒã«ã¢ãã³ ãã¬ãŒãã®ä»£ããã«
ïŒïŒ®âãžãšã¿ããŒã«ââïœâãããããŒã«ã¢
ãã³ ãã¬ãŒãã䜿çšãã以å€ã¯å®æœäŸïŒãšåæ§
ã«ããŠïŒçš®ã®è©Šéšçšçµæç©æº¶æ¶²ã調補ããããã®
ïŒçš®ã®è©Šéšçšçµæç©æº¶æ¶²ã®åã ã«ãããããå®æœ
äŸïŒã®è¡šïŒã«ç€ºãéã®ãžã¡ãã«ã¹ã«ããã·ããšã¡
ã¿ããŒã«ãæ·»å ããã 次ã«ããããè©Šéšçšçµæç©æº¶æ¶²ã®åã ãã¯ãã
ãã³3MMçŽã«å«æµžãããããšã«ãã€ãŠè©Šéšå ·
ã調補ããã溶液ã«æµžæŒ¬ããçŽçãããããã®
溶液ããåŒãäžãã也ç¥ããããã«70âã®ãªãŒã
ã³äžã§18æéä¿é²è©Šéšã«ä»ãããä¿é²è©Šéšã®åŸã
åã ã®è©Šéšçšã¹ããªãããæ°é®®ãªå šè¡ãå°¿ãçšã
ãŠçŸäžåã®äžã«çšéããäŸè©Šæº¶æ¶²äžã§è©Šéšããã
åã¹ããªããã®åè²ã®åŒ·ããæ¯èŒããçµæãå®æœ
äŸïŒã«ãããè¡šïŒã«ç€ºãçµæãšåæ§ã§ãã€ãã å®æœäŸ 15 åçš®ã®çšéå€ã«ãã€ãŠä»äžãããè©Šéšçšçµæç©
ïŒããŠé žãšã¹ãã«ãå«ãïŒã®å®å®æ§ã®å¢å€§ çšéå€ãšããŠã®ïŒ®ïŒïŒ®âãžã¡ãã«ãã«ã ã¢ãã
ãâã¡ãã«ââãšãã«ãã«ã ã¢ããã«ä»£ãã
以å€ã¯å®æœäŸïŒãšåæ§ã«ããŠïŒ®âã¡ãã«ââãš
ãã«ãã«ã ã¢ããã®çšéå€ãšããŠã®å¹æã調ã¹
ãããã®çµæãâã¡ãã«ââãšãã«ãã«ã ã¢
ãããå®æœäŸïŒã®è¡šïŒã«ãããŠç€ºããïŒïŒ®âãž
ã¡ãã«ãã«ã ã¢ãããšåæ§ã«ããããå®å®æ§ã瀺
ããã èŠçŽããã«ãåè¿°ã®å®æœäŸã¯ãæ¬çºæïŒå®æœäŸ
ïŒïŒïŒããã³12ïŒã®çµæç©ããã³è©Šéšå ·ãããã«
調補ã䜿çšãããã瀺ããåãå®å®æ§åã³æ床ã®
æ¯èŒçµæãå瀺ãïŒå®æœäŸïŒãïŒãæ¯èŒäŸïŒãïŒ
ããã³å®æœäŸ13ã15ïŒãããã«åãæ¬çºæã®å¥œãŸ
ããå®æœæ æ§ãèšè¿°ããŠããïŒå®æœäŸ10ããã³
11ïŒãè©Šéšçšçµæç©ã«ãããçšéå€ã®åç¬äœ¿çšã®
å¹æã¯å®æœäŸïŒããã³æ¯èŒäŸïŒã«ç€ºãããŠãã
ããçšéå€ããã³ããŠé žãšã¹ãã«ã䜵çšããè©Šéš
å ·ã«ãããå¹æã¯æ¯èŒäŸïŒãå®æœäŸïŒãïŒããã³
å®æœäŸ13ã14ã«ç€ºãããŠãããåçš®ã®çšéå€ã®äœ¿
çšã¯å®æœäŸïŒããã³å®æœäŸ15ã«å ·äœçã«ç€ºãããŠ
ããã
Claims (1)
- ãç¹èš±è«æ±ã®ç¯å²ã ïŒ ææ©ããããã«ãªãã·ãïŒè©²ããããã«ãªã
ã·ãããã³éé žå掻æ§ç©è³ªã®ååšäžã§æ€åºå¯èœãª
å¿çãåºãããšãã§ããæ瀺è¬ïŒãªãã³ã« 次åŒïŒ ãåŒãåã¯ãåŒã ãåŒäžãR1ããã³R2ã¯åäžã§ãç°ãªã€ãŠããŠ
ããããããããæ°ŽçŽ ååãççŽ ååïŒãçŽïŒã®
ã¢ã«ãã«åºãããã¯ã¢ãªãŒã«åºãè¡šããïŒãã
ãããåŒãããã³ãåŒãã«ãã ãŠãR1ããã³R2ãåæã«æ°ŽçŽ ååã§ããå Žåã
é€ããïŒR3ã¯æ°ŽçŽ ååãççŽ ååïŒãçŽïŒã®ã¢ã«
ãã«åºãããã¯ã¢ãªãŒã«åºãè¡šããããã§ç€ºãã
ãæ§é ãæããçšéå€ãããã¯ãããã®æ··åç© ãããªãããšãç¹åŸŽãšããäŸè©Šè©Šæäžã®éé žå掻
æ§ç©è³ªãå®éããããã®è©Šéšçšçµæç©ã ïŒ çšéå€ããžã¡ãã«ã¹ã«ããã·ãããžã¡ãã«ã¹
ã«ãã³ãïŒNâ²âãžã¡ãã«ãã«ã ã¢ããããã³
ãžã«ã¹ã«ããã·ããïŒâã¯ããããšãã«ã¹ã«ã
ã³ãïŒâãã«ãªãâïŒâãããããšãã«ã¹ã«ãã³
åã¯ãããã®æ··åç©ã§ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé
èšèŒã®çµæç©ã ïŒ çšéå€ããžã¡ãã«ã¹ã«ãã³ãšïŒ®ïŒNâ²âãžã¡
ãã«ãã«ã ã¢ããã®æ··åç©ã§ããç¹èš±è«æ±ã®ç¯å²
第ïŒé èšèŒã®çµæç©ã ïŒ ææ©ããããã«ãªãã·ããïœâããã«ããã
ãã«ãªãã·ããã¯ã¡ã³ããããã«ãªãã·ãããžã€
ãœãããã«ãã³ãŒã³ããããã«ã€ãã·ããïŒïŒïŒ
âãžã¡ãã«ãããµã³âïŒïŒïŒâãžããããã«ãªã
ã·ãããã©ã¡ã¿ã³ããããã«ãªãã·ãåã¯ããã
ã®æ··åç©ã§ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®çµæ
ç©ã ïŒ ææ©ããããã«ãªãã·ããã¯ã¡ã³ããããã«
ãªãã·ãã§ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®çµæ
ç©ã ïŒ æ瀺è¬ããã³ãžãžã³ãïŒâãã«ã€ãžã³ãïŒïŒ
3â²ïŒïŒïŒ5â²âããã©ã¡ãã«ãã³ãžãžã³ãïŒïŒïŒâ
ãžã¢ãããã«ãªã¬ã³åã¯ãããã®æ··åç©ã§ããç¹
èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®çµæç©ã ïŒ æ瀺è¬ãïŒâãã«ã€ãžã³ã§ããç¹èš±è«æ±ã®ç¯
å²ç¬¬ïŒé èšèŒã®çµæç©ã ïŒ (a)ã¯ã¡ã³ããããã«ãªãã·ãã(b)ãã³ãžãž
ã³ãïŒâãã«ã€ãžã³ãïŒïŒ3â²ïŒïŒïŒ5â²âããã©ã¡
ãã«ãã³ãžãžã³ãïŒïŒïŒâãžã¢ãããã«ãªã¬ã³å
ã¯ãããã®æ··åç©ããéžæãããæ瀺è¬ã(c)ãžã¡
ãã«ã¹ã«ãã³ãšïŒ®ïŒïŒ®âãžã¡ãã«ãã«ã ã¢ããã®
æ··åç©ãå«æããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®çµ
æç©ã ïŒ ææ©ããããã«ãªãã·ãïŒè©²ããããã«ãªã
ã·ãããã³éé žå掻æ§ç©è³ªã®ååšäžã§æ€åºå¯èœãª
å¿çãåºãããšãã§ããæ瀺è¬ïŒãªãã³ã« (a) 次åŒïŒãåŒãå㯠ãåŒã ãåŒäžãR1ããã³R2ã¯åäžã§ãç°ãªã€ãŠããŠ
ããããããããæ°ŽçŽ ååãççŽ ååïŒãçŽïŒã®
ã¢ã«ãã«åºãããã¯ã¢ãªãŒã«åºãè¡šããïŒãã
ãããåŒãããã³ãåŒãã«ãã ãŠãR1ããã³R2ãåæã«æ°ŽçŽ ååã§ããå Žåã
é€ããïŒãR3ã¯æ°ŽçŽ ååãççŽ ååïŒãçŽïŒã®ã¢
ã«ãã«åºãããã¯ã¢ãªãŒã«åºãè¡šããããã§ç€ºã
ããæ§é ãæããçšéå€ãããã¯ãããã®æ··åç©
ããã³ (b) 次åŒïŒ ïŒåŒäžãïœïŒïœããã³ïœã¯åäžã§ãç°ãªã€ãŠããŠ
ããããããããïŒãçŽïŒã®æŽæ°ãè¡šãããïŒ ã§ç€ºãããæ§é ãæããããŠé žãšã¹ãã«ããæã
ããšãç¹åŸŽãšããäŸè©Šè©Šæäžã®éé žå掻æ§ç©è³ªã
å®éããããã®è©Šéšçšçµæç©ã ïŒïŒ çšéå€ããžã¡ãã«ã¹ã«ããã·ãããžã¡ãã«
ã¹ã«ãã³ãïŒNâ²âãžã¡ãã«ãã«ã ã¢ãããã
ã³ãžã«ã¹ã«ããã·ããïŒâã¯ããããšãã«ã¹ã«ã
ã³ãïŒâãã«ãªãâïŒâãããããšãã«ã¹ã«ãã³
åã¯ãããã®æ··åç©ã§ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé
èšèŒã®çµæç©ã ïŒïŒ çšéå€ããžã¡ãã«ã¹ã«ãã³ãšïŒ®ïŒNâ²âãž
ã¡ãã«ãã«ã ã¢ããã®æ··åç©ã§ããç¹èš±è«æ±ã®ç¯
å²ç¬¬ïŒïŒé èšèŒã®çµæç©ã ïŒïŒ ããŠé žãšã¹ãã«ãããªã¡ã¿ããŒã«ã¢ãã³ã
ãã¬ãŒããããªãšã¿ããŒã«ã¢ãã³ããã¬ãŒããã
ãªïŒïœâãããããŒã«ïŒã¢ãã³ããã¬ãŒãåã¯ã
ããã®æ··åç©ã§ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®
çµæç©ã ïŒïŒ ããŠé žãšã¹ãã«ãããªãšã¿ããŒã«ã¢ãã³ã
ãã¬ãŒãã§ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒïŒé èšèŒã®çµ
æç©ã ïŒïŒ çšéå€ããžã¡ãã«ã¹ã«ããã·ããïŒ
Nâ²âãžã¡ãã«ãã«ã ã¢ããåã¯ãããã®æ··åç©
ã§ãããããŠé žãšã¹ãã«ãããªã¡ã¿ããŒã«ã¢ãã³
ãã¬ãŒããããªãšã¿ããŒã«ã¢ãã³ ãã¬ãŒãã
ããªïŒïœâãããããŒã«ïŒã¢ãã³ããã¬ãŒãåã¯
ãããã®çµæç©ã§ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒ
ã®çµæç©ã ïŒïŒ çšéå€ããžã¡ãã«ã¹ã«ãã³ãšïŒ®ïŒïŒ®âãžã¡
ãã«ãã«ã ã¢ããã®æ··åç©ã§ãããããŠé žãšã¹ã
ã«ãããªãšã¿ããŒã«ã¢ãã³ ãã¬ãŒãã§ããç¹èš±
è«æ±ã®ç¯å²ç¬¬ïŒïŒé èšèŒã®çµæç©ã ïŒïŒ ææ©ããããã«ãªãã·ããïœâããã«ãã
ããã«ãªãã·ããã¯ã¡ã³ããããã«ãªãã·ãããž
ã€ãœãããã«ãã³ãŒã³ããããã«ãªãã·ããïŒïŒ
ïŒâãžã¡ãã«ãããµã³âïŒïŒïŒâãžããããã«ãª
ãã·ãããã©ã¡ã¿ã³ããããã«ãªãã·ãåã¯ãã
ãã®æ··åç©ã§ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®çµ
æç©ã ïŒïŒ ææ©ããããã«ãªãã·ããã¯ã¡ã³ãããã
ã«ãªãã·ãã§ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒïŒé èšèŒã®
çµæç©ã ïŒïŒ æ瀺è¬ããã³ãžãžã³ãïŒâãã«ã€ãžã³ã
ïŒïŒ3â²ïŒïŒïŒ5â²âããã©ã¡ãã«ãã³ãžãžã³ãïŒïŒ
ïŒâãžã¢ãããã«ãªã¬ã³åã¯ãããã®æ··åç©ã§ã
ãç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®çµæç©ã ïŒïŒ æ瀺è¬ãïŒâãã«ã€ãžã³ã§ããç¹èš±è«æ±ã®
ç¯å²ç¬¬ïŒïŒé èšèŒã®çµæç©ã ïŒïŒ (a)ã¯ã¡ã³ããããã«ãªãã·ãã(b)ãã³ãžãž
ã³ãïŒâãã«ã€ãžã³ãïŒïŒ3â²ïŒïŒïŒ5â²âããã©ã¡
ãã«ãã³ãžãžã³ãïŒïŒïŒâãžã¢ãããã«ãªã¬ã³å
ã¯ãããã®æ··åç©ããéžæãããæ瀺è¬ã(c)ãžã¡
ãã«ã¹ã«ãã³ãšïŒ®ïŒïŒ®âãžã¡ãã«ãã«ã ã¢ããã®
æ··åç©ããã³(d)ããªãšã¿ããŒã«ã¢ãã³ ãã¬ãŒã
ãå«æããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®çµæç©ã
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/777,001 US4071321A (en) | 1977-03-14 | 1977-03-14 | Test composition and device for determining peroxidatively active substances |
US05/777,002 US4071317A (en) | 1977-03-14 | 1977-03-14 | Test composition and device for determining peroxidatively active substances and process for preparing same |
US05/777,005 US4071318A (en) | 1977-03-14 | 1977-03-14 | Test composition and device for determining peroxidatively active substances |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS53115288A JPS53115288A (en) | 1978-10-07 |
JPS6122780B2 true JPS6122780B2 (ja) | 1986-06-03 |
Family
ID=27419729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP897778A Granted JPS53115288A (en) | 1977-03-14 | 1978-01-31 | Testing compound* tool* and method for determining active peroxide substance and manufacture of testing tool |
Country Status (12)
Country | Link |
---|---|
JP (1) | JPS53115288A (ja) |
AR (1) | AR220329A1 (ja) |
AU (1) | AU3279478A (ja) |
BR (1) | BR7800603A (ja) |
CA (1) | CA1098808A (ja) |
DE (2) | DE2857298C2 (ja) |
FR (1) | FR2384261A1 (ja) |
GB (1) | GB1552747A (ja) |
HU (1) | HU177004B (ja) |
IN (1) | IN148528B (ja) |
IT (1) | IT1104148B (ja) |
SE (1) | SE430104B (ja) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4290773A (en) * | 1979-11-13 | 1981-09-22 | Miles Laboratories, Inc. | Stabilization of benzidine-type indicators with various enhancers |
US4318984A (en) * | 1979-11-13 | 1982-03-09 | Miles Laboratories, Inc. | Stabilized composition, test device, and method for detecting the presence of a sugar in a test sample |
JPS56147066A (en) * | 1980-04-17 | 1981-11-14 | Terumo Corp | Specimen for detection of latent blood |
DE3048662A1 (de) * | 1980-12-23 | 1982-07-22 | Boehringer Mannheim Gmbh, 6800 Mannheim | Stabilisierte zubereitung von tetrazoliumsalzen |
US4340669A (en) * | 1981-02-12 | 1982-07-20 | Miles Laboratories, Inc. | System for the determination of glucose in fluids |
DE3425118A1 (de) * | 1984-07-07 | 1986-01-16 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue redox-indikatoren |
JP2610460B2 (ja) * | 1987-12-03 | 1997-05-14 | 倧æ¥æ¬å°å·æ ªåŒäŒç€Ÿ | æœè¡æ€åºçšçµæç©ããã³ãããçšããæ€æ»äœ |
JP6580568B2 (ja) * | 2013-08-16 | 2019-09-25 | ããã ã«ã³ããâ | å¡©çŽ åææ€æ»çŽ åããã³å®å®åãããïŒïŒ®âãžãšãã«âïœâãã§ãã¬ã³ãžã¢ãã³æº¶æ¶² |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1943580B2 (de) * | 1969-08-27 | 1971-08-05 | Reagens zur blutzuckerbestimmung | |
DE2235127C2 (de) * | 1972-07-18 | 1974-08-08 | Boehringer Mannheim Gmbh, 6800 Mannheim | Diagnostisches Mittel zum Nachweis von Blut und anderen peroxidatisch wirksamen Substanzen in KörperflÌssigkeiten |
-
1978
- 1978-01-25 CA CA295,641A patent/CA1098808A/en not_active Expired
- 1978-01-27 AU AU32794/78A patent/AU3279478A/en active Pending
- 1978-01-30 DE DE2857298A patent/DE2857298C2/de not_active Expired
- 1978-01-30 HU HU78MI629A patent/HU177004B/hu unknown
- 1978-01-30 DE DE2803955A patent/DE2803955C3/de not_active Expired
- 1978-01-31 JP JP897778A patent/JPS53115288A/ja active Granted
- 1978-01-31 IT IT7847859A patent/IT1104148B/it active
- 1978-01-31 BR BR7800603A patent/BR7800603A/pt unknown
- 1978-01-31 AR AR270911A patent/AR220329A1/es active
- 1978-01-31 FR FR7802592A patent/FR2384261A1/fr active Granted
- 1978-01-31 SE SE7801164A patent/SE430104B/sv not_active IP Right Cessation
- 1978-02-17 GB GB6419/78A patent/GB1552747A/en not_active Expired
- 1978-03-20 IN IN211/DEL/78A patent/IN148528B/en unknown
Also Published As
Publication number | Publication date |
---|---|
SE430104B (sv) | 1983-10-17 |
FR2384261A1 (fr) | 1978-10-13 |
JPS53115288A (en) | 1978-10-07 |
BR7800603A (pt) | 1978-10-03 |
IT1104148B (it) | 1985-10-14 |
IT7847859A0 (it) | 1978-01-31 |
AR220329A1 (es) | 1980-10-31 |
SE7801164L (sv) | 1978-09-15 |
DE2803955B2 (de) | 1980-07-03 |
DE2803955A1 (de) | 1978-09-21 |
CA1098808A (en) | 1981-04-07 |
AU3279478A (en) | 1979-08-02 |
HU177004B (hu) | 1981-06-28 |
IN148528B (ja) | 1981-03-21 |
FR2384261B1 (ja) | 1984-06-29 |
DE2803955C3 (de) | 1981-04-23 |
GB1552747A (en) | 1979-09-19 |
DE2857298C2 (de) | 1984-03-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS6123508B2 (ja) | ||
US4071317A (en) | Test composition and device for determining peroxidatively active substances and process for preparing same | |
JP2922003B2 (ja) | éé žå掻æ§ç©è³ªã®æ€å®ã®ããã®çµæç©ãçšå ·åã³æ¹æ³ã®æ¹è¯ | |
EP0123115B1 (en) | Ascorbate interference-resistant composition, device and method for the determination of peroxidatively active substances | |
US4556640A (en) | Stabilized test composition, device and method for the determination of peroxidatively active substances | |
JP2928649B2 (ja) | éé žå掻æ§ç©è³ªã®æ€å®ã®ããã®çµæç©ãçšå ·åã³æ¹æ³ | |
CA1060906A (en) | 3,3',5,5'-tetraalkylbenzidines and their use as indicators in diagnostic agents | |
FI80072B (fi) | Askorbatresistant, pao brett omraode verkande glukostestkomposition, testapparat och -metod. | |
FI85774B (fi) | Stabil komposition foer bestaemning av peroxidativt aktiva aemnen. | |
JPS6326869B2 (ja) | ||
EP0121192B1 (en) | Analytical test composition, device, method for its preparation and method for the determination of peroxidatively active substance | |
JPS6333670B2 (ja) | ||
CS250653B2 (en) | Means for searched component's presence determination e. g. glucose in tested sample | |
JPS6122780B2 (ja) | ||
JPH0225152B2 (ja) | ||
US6210971B1 (en) | Assay for the detection of creatinine | |
JPH0532040B2 (ja) | ||
US4290771A (en) | Diagnostic agent for the detection of urobilinogen | |
CA1134247A (en) | Bilirubin-resistant determination of uric acid | |
JPH0418630B2 (ja) | ||
JPS59195157A (ja) | éé žåç©æŽ»æ§åç©è³ªæž¬å®çšè©Šéšçµæç©ãè©Šéšå ·äžŠã³ã«ãããã®äœ¿çšæ¹æ³ããã³è£œé æ¹æ³ | |
CS219888B2 (cs) | ZkuÅ¡ebnà prostÅedek pro stanovenà pÅÃtomnosti peroxidaÄnÄ ÃºÄinnÃœch látek | |
JPH0576396A (ja) | å®å®åãããåè²è©Šéšææããã³åè²è©Šéšå · |