JPS59230633A - Preparation of coated particulate substance - Google Patents
Preparation of coated particulate substanceInfo
- Publication number
- JPS59230633A JPS59230633A JP58105313A JP10531383A JPS59230633A JP S59230633 A JPS59230633 A JP S59230633A JP 58105313 A JP58105313 A JP 58105313A JP 10531383 A JP10531383 A JP 10531383A JP S59230633 A JPS59230633 A JP S59230633A
- Authority
- JP
- Japan
- Prior art keywords
- powder
- substance
- coated
- added
- core
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000126 substance Substances 0.000 title claims abstract description 41
- 239000000843 powder Substances 0.000 claims abstract description 68
- 239000003094 microcapsule Substances 0.000 claims abstract description 25
- 238000000034 method Methods 0.000 claims abstract description 21
- 239000007788 liquid Substances 0.000 claims abstract description 9
- 238000003756 stirring Methods 0.000 claims abstract description 7
- 229920001169 thermoplastic Polymers 0.000 claims abstract description 7
- 239000004416 thermosoftening plastic Substances 0.000 claims abstract description 7
- 235000011837 pasties Nutrition 0.000 claims abstract description 4
- 239000000463 material Substances 0.000 claims description 22
- 239000011162 core material Substances 0.000 claims description 18
- 239000008187 granular material Substances 0.000 claims description 16
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000000576 coating method Methods 0.000 abstract description 25
- 239000011248 coating agent Substances 0.000 abstract description 18
- 239000003925 fat Substances 0.000 abstract description 12
- 235000014113 dietary fatty acids Nutrition 0.000 abstract description 9
- 239000000194 fatty acid Substances 0.000 abstract description 9
- 229930195729 fatty acid Natural products 0.000 abstract description 9
- 239000011164 primary particle Substances 0.000 abstract description 7
- 150000004665 fatty acids Chemical class 0.000 abstract description 6
- 229920002472 Starch Polymers 0.000 abstract description 4
- 239000002775 capsule Substances 0.000 abstract description 4
- 239000008107 starch Substances 0.000 abstract description 4
- 235000019698 starch Nutrition 0.000 abstract description 4
- -1 fatty acid ester Chemical class 0.000 abstract description 3
- 150000005846 sugar alcohols Polymers 0.000 abstract description 3
- 239000010775 animal oil Substances 0.000 abstract description 2
- 239000007864 aqueous solution Substances 0.000 abstract description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract description 2
- 235000019871 vegetable fat Nutrition 0.000 abstract description 2
- 239000008158 vegetable oil Substances 0.000 abstract description 2
- 230000016615 flocculation Effects 0.000 abstract 2
- 238000005189 flocculation Methods 0.000 abstract 2
- 150000002191 fatty alcohols Chemical class 0.000 abstract 1
- 235000014593 oils and fats Nutrition 0.000 abstract 1
- 239000002904 solvent Substances 0.000 description 12
- 235000019197 fats Nutrition 0.000 description 10
- 239000002245 particle Substances 0.000 description 10
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 9
- 229930182817 methionine Natural products 0.000 description 9
- 239000003921 oil Substances 0.000 description 8
- 235000019198 oils Nutrition 0.000 description 8
- 229920002678 cellulose Polymers 0.000 description 5
- 235000010980 cellulose Nutrition 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 239000001913 cellulose Substances 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 239000001993 wax Substances 0.000 description 4
- 238000001035 drying Methods 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 238000005096 rolling process Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 229920002261 Corn starch Polymers 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 238000005054 agglomeration Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 239000004203 carnauba wax Substances 0.000 description 2
- 235000013869 carnauba wax Nutrition 0.000 description 2
- 239000005018 casein Substances 0.000 description 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 2
- 235000021240 caseins Nutrition 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 229940099112 cornstarch Drugs 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 235000001727 glucose Nutrition 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 229940100486 rice starch Drugs 0.000 description 2
- 238000010008 shearing Methods 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- 239000003760 tallow Substances 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- 108010076119 Caseins Proteins 0.000 description 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 108010073771 Soybean Proteins Proteins 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- MANKSFVECICGLK-UHFFFAOYSA-K aloxiprin Chemical compound [OH-].[Al+3].CC(=O)OC1=CC=CC=C1C([O-])=O.CC(=O)OC1=CC=CC=C1C([O-])=O MANKSFVECICGLK-UHFFFAOYSA-K 0.000 description 1
- 229940024544 aluminum aspirin Drugs 0.000 description 1
- DNEHKUCSURWDGO-UHFFFAOYSA-N aluminum sodium Chemical compound [Na].[Al] DNEHKUCSURWDGO-UHFFFAOYSA-N 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000001877 deodorizing effect Effects 0.000 description 1
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 229940014259 gelatin Drugs 0.000 description 1
- 150000002314 glycerols Chemical class 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000009775 high-speed stirring Methods 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 235000013923 monosodium glutamate Nutrition 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000004170 rice bran wax Substances 0.000 description 1
- 235000019384 rice bran wax Nutrition 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 229940073490 sodium glutamate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 235000013555 soy sauce Nutrition 0.000 description 1
- 235000019710 soybean protein Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Jellies, Jams, And Syrups (AREA)
- Seasonings (AREA)
- Formation And Processing Of Food Products (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Grain Derivatives (AREA)
- General Preparation And Processing Of Foods (AREA)
Abstract
Description
【発明の詳細な説明】
本発明は被覆された粉粒体物質の製造法に関し、吸湿性
、溶解性などの改良された粉粒体物質を得る方法に関す
る。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for producing a coated granular material, and to a method for obtaining a granular material with improved hygroscopicity, solubility, etc.
一般に、粉末や顆粒などにコーディングを行う方法とし
ては、コーテイング材を水或いは有機溶剤に溶解し、粉
末や顆粒を空気によシ流動化させながら或いは転勤板上
を転動させながらこの溶液を噴霧し、次いで乾燥してコ
ーティングを行う方法、或いは油脂や高級脂肪酸などの
熱可溶性物質を加熱融解して流動或いは転動させている
粉粒体に噴霧し、次いで冷却してコーティングを行う方
法などがある。前者のコーティング法では水分や有機溶
剤が被コーテイング物質内部に浸透し保存性を悪化させ
易く、また水分の乾燥や溶剤の除去に多くの時間と設備
を必要とする。後者のコーティング法では設備は比較的
安価であるが、被コーテイング物質の粒径が細かい場合
には凝集が起9表面に均一にコーティングされにくく良
好なコーテイング品を得る事が難かしい。また、被コー
テイング物質が粉末或いは微小顆粒の場合、従来のコー
ティング法ではコーテイング材がバインダーとhV)凝
集造粒が起シ、被コーテイング物質の1次粒子のままで
のコーティングが困難である。また、凝集造粒が起るた
め、空隙が多くなシ均一で良好なコーティングが難かし
いという欠点を有す。Generally, the method for coating powders and granules is to dissolve the coating material in water or an organic solvent, and then spray the solution while fluidizing the powder or granules with air or rolling them on a transfer plate. There are two methods: first, then drying and coating, or heating and melting a heat-soluble substance such as oil or fat or higher fatty acid, spraying it onto fluidized or rolling powder, and then cooling and coating. be. In the former coating method, moisture and organic solvents tend to penetrate into the coated material, impairing storage stability, and require a lot of time and equipment to dry the moisture and remove the solvent. In the latter coating method, the equipment is relatively inexpensive, but if the particle size of the material to be coated is small, agglomeration occurs and it is difficult to coat the surface uniformly, making it difficult to obtain a good coated product. Furthermore, when the material to be coated is a powder or fine granules, in the conventional coating method, the coating material coagulates with the binder and granules, making it difficult to coat the material as primary particles. In addition, since agglomeration and granulation occur, it has the disadvantage that it is difficult to achieve a uniform and good coating due to the large number of voids.
本発明者らは従来のコーティング法での欠点を除くため
鋭意検討した結果、液又はペースト状物質、熱可溶性物
質、熱可塑性物質の1種又は2種以上を粉末に加え粉床
法によシコーティングして粉体壁マイクロカプセルとし
た後、該粉体壁マイクロカプセルに芯となる粉粒体物質
を加え混合機中で攪拌することによって、芯となる物質
の表面に該粉体壁マイクロカプセル又は該粉体壁マイク
ロカプセルの破壊物を均質に付着又は粘着させる事によ
り被コーテイング物質が凝集を起さず、1次粒子のまま
で良好なコーティングが出来ることを見出し本発明を完
成するに至った。As a result of intensive studies to eliminate the drawbacks of conventional coating methods, the present inventors added one or more types of liquid or pasty substances, heat-soluble substances, and thermoplastic substances to powder and applied a coating method using a powder bed method. After coating to form powder-walled microcapsules, a core powder substance is added to the powder-walled microcapsules and stirred in a mixer to coat the powder-walled microcapsules on the surface of the core substance. Alternatively, the inventors discovered that by uniformly adhering or adhering the broken particles of the powder-walled microcapsules, the substance to be coated does not agglomerate and a good coating can be achieved with the primary particles intact, leading to the completion of the present invention. Ta.
まず、本発明の第1工程として液又はペースト状物質、
熱可溶性物質、熱可塑性物質の1種または2種以上を芯
物質とし、粉末を粉体壁とする粉床法によるマイクロカ
プセルを調整する。本発明で用いる粉体壁用の粉末とし
ては微粉でかつ粉床法によるカプセル化の出来るもので
あれば特に限定されるものではない。例えば、澱粉、デ
キストリン、グルコース等の糖類、結晶セルロース、セ
ルロース誘導体等のセルロース類、ゼラチン、カゼイン
、大豆蛋白等の蛋白類、シリカ、タルク、その他が挙げ
られる。First, as the first step of the present invention, a liquid or paste substance,
Microcapsules are prepared by a powder bed method using one or more of a thermosoluble substance and a thermoplastic substance as a core substance and a powder as a powder wall. The powder for the powder wall used in the present invention is not particularly limited as long as it is fine and can be encapsulated by a powder bed method. Examples include saccharides such as starch, dextrin, and glucose, celluloses such as crystalline cellulose and cellulose derivatives, proteins such as gelatin, casein, and soybean protein, silica, talc, and others.
本発明に使用する熱可塑性物質まだは熱可溶性物質とし
ては30℃以上で溶融もしくは軟化する物質であればよ
く、油脂、脂肪酸、脂肪酸エステル、脂肪族高級アルコ
ール、多価アルコール等のろう状物質等がある。油脂と
してはラード、ヘッド、タローなどの動物脂、・9−ム
油、やし油、綿実油等の水素添加した植物油などがある
。ろう状物質としてはカルナバロウ、木ろう、米ぬかろ
う、蜜ろう等がある。脂肪酸としてはステアリン酸、パ
ルミチン酸等の高級脂肪酸、脂肪酸エステルとしてはグ
リセリンモノステアレート等の高級脂肪酸のグリセリン
エステルがある。高級アルコールとしてはラウリルアル
コール、セチルアルコール等が、多価アルコールとして
はマンニット、ソルビット、マルチトール等があげられ
る。液またはペースト状物質としては低融点の動植物油
脂、各種水溶液を用いる事ができる・
粉末法によるマイクロカプセル化は粉体層の上から液滴
を落とすことによシ、液体法が粉体でぬれることを利用
して行なわれる。The thermoplastic substance used in the present invention may be any thermosoluble substance as long as it melts or softens at 30°C or higher, such as waxy substances such as fats and oils, fatty acids, fatty acid esters, aliphatic higher alcohols, and polyhydric alcohols. There is. Examples of fats and oils include animal fats such as lard, head, and tallow, and hydrogenated vegetable oils such as 9-gum oil, coconut oil, and cottonseed oil. Waxy substances include carnauba wax, wood wax, rice bran wax, and beeswax. Examples of fatty acids include higher fatty acids such as stearic acid and palmitic acid, and examples of fatty acid esters include glycerin esters of higher fatty acids such as glycerin monostearate. Examples of higher alcohols include lauryl alcohol and cetyl alcohol, and examples of polyhydric alcohols include mannitol, sorbitol, maltitol, and the like. As the liquid or paste-like substance, low-melting point animal and vegetable oils and fats and various aqueous solutions can be used. Microencapsulation using the powder method involves dropping droplets from above the powder layer, while the liquid method wets the material with the powder. It is done by taking advantage of this.
粉体法については、日刊工業新聞社の「マイクロカプセ
ルJI:1970年、125〜126頁(近藤朝士著)
〕に下記のように記載されておシ、このような方法を応
用することができる。Regarding the powder method, see "Microcapsule JI: 1970, pp. 125-126 (written by Asashi Kondo)" published by Nikkan Kogyo Shimbun.
] is described as follows, and such a method can be applied.
粉床法でカプセルをつくるときは、つぎのような諸形式
があるが、素材である芯物質、壁膜物質、その溶剤、イ
ナートな粉体の4者のうちどれを粉床にし、どれを溶剤
系にするかによって決まってくる。このうちイナートな
粉体は必ずしも必要としないが、前三者はカプセル化の
素材としては必ず必要なものである。When making capsules using the powder bed method, there are various forms as shown below, but which of the four materials - the core material, the wall material, the solvent, and the inert powder - should be used as the powder bed, and which should be used as the powder bed. It depends on whether it is solvent-based or not. Among these, inert powder is not necessarily required, but the first three are absolutely necessary as materials for encapsulation.
(1)壁材を粉末にし、芯物質を溶剤に溶解または分散
したものを落下滴とする。(1) The wall material is powdered and the core material is dissolved or dispersed in a solvent to form falling drops.
(2) 芯物質と壁材の両者の混合物を粉床とし、溶
剤を滴下する〇
(3)芯物質と壁材とイナート粉体との王者を粉床とし
、溶剤を滴下する。(2) A mixture of both the core material and wall material is used as a powder bed, and a solvent is dripped into it. (3) A mixture of the core material, wall material, and inert powder is used as a powder bed, and a solvent is dripped into it.
(4ン イナート粉体を粉床とし、芯物質を壁材溶液
に分散したものを滴下する。(4 Inert powder is used as a powder bed, and the core substance dispersed in the wall material solution is dropped.
(5)壁材粉末を粉床にし、芯物質を壁材溶液に分散し
たものを滴下する。(5) Make the wall material powder into a powder bed, and drop the core material dispersed in the wall material solution.
(6) イナート粉体を粉床とし、熱溶融した芯物質
を落下する。(6) Using inert powder as a powder bed, the hot molten core material is dropped.
以上のように分けられる。イナート粉体とは溶剤に溶解
しない、主として無機性の粉末で、それだけでは厳密な
膜は形成しないが、壁膜に埋めこまれてフィラーの役目
をし、カプセル膜の強化に役立ち、かつ溶剤を吸収して
、滴下されだ液滴の見かけの乾燥を速くする働きをなす
ものである。It can be divided as above. Inert powder is mainly an inorganic powder that does not dissolve in solvents, and although it does not form a strict membrane by itself, it is embedded in the wall membrane and acts as a filler, helping to strengthen the capsule membrane and removing solvents. It acts to absorb and speed up the apparent drying of the dropped droplets.
壁膜材料としてはセルロースアセテートフタレート、ア
ルミニウムアスピリン、ゼラチン、カゼイン、デキスト
リン、グルコースなどが用いられる。しかしこれ以外に
溶剤性があり、かつ細かい粉末にできるものなら、たい
ていの物が使える。できたカプセルの形を気にするとき
は、球形のものが欲しいとき、壁材粉体の溶剤へのぬれ
と溶解速度、滴下液の粘度などが問題になるから、経験
的にその組合わせを決める必要がある。As the wall membrane material, cellulose acetate phthalate, aluminum aspirin, gelatin, casein, dextrin, glucose, etc. are used. However, most other materials can be used as long as they are solvent-based and can be made into fine powder. When you are concerned about the shape of the resulting capsule, if you want a spherical one, the wetting and dissolution rate of the wall material powder in the solvent, the viscosity of the dripping liquid, etc. are issues, so consider the combination empirically. I need to decide.
イナート粉体としてはシリカ、タルク 、ナトリウムア
ルミニウムシリケート、でん朽″゛などが用いられる。As the inert powder, silica, talc, sodium aluminum silicate, decomposition, etc. are used.
とくにイナート粉床のみを粉末としてカプセル化すると
きは、この粒度、かきまぜなどがカプセル化に影響する
。Particularly when encapsulating only the inert powder bed as a powder, the particle size, stirring, etc. affect the encapsulation.
次に、第2工程として前述の粉体壁マイクロカプセルに
芯となる物質の粉末或いは顆粒を加え、強力なせん断力
のかがる混合機中で良く攪拌し、芯となる粉末或いは顆
粒表面に該粉体壁マイクロカプセル又は該マイクロカプ
セルの破壊物を付着式せる。粉体壁マイクロカプセルは
高速度の攪拌羽根のせん断力にょシ破壊され、熱可溶性
物質或いは熱可塑性物質は摩擦熱にょシ融解し、また液
またはペースト状物質はそのまま溶けて被コーテイング
物質の表面に付着、延展する。この際、粉体壁マイクロ
カプセルの粉体壁膜も同時に付着し、被コーテイング物
質表面に新たな粉体壁膜が形成される。Next, in the second step, the powder or granules of the core substance are added to the powder-walled microcapsules and stirred well in a mixer that applies a strong shearing force, so that the core powder or granules are coated on the surface of the core powder or granules. A powder wall microcapsule or a destroyed product of the microcapsule is attached. Powder-walled microcapsules are destroyed by the shear force of the high-speed stirring blades, thermofusible substances or thermoplastic substances are melted by frictional heat, and liquid or paste-like substances are directly melted onto the surface of the material to be coated. Attach and spread. At this time, the powder wall film of the powder wall microcapsule is also attached at the same time, and a new powder wall film is formed on the surface of the substance to be coated.
このようにして得られたコーティング粉粒体は粉粒体1
ケ1ケの1次粒子上にコーティングされたものである。The coating powder obtained in this way is powder 1.
It is coated on one primary particle.
この1次粒子にコーティングされたものは更に常法に従
って例えば流動層コーティングなどを行えば更に良好な
コーテイング品を得ることができる。If the coated primary particles are further subjected to a conventional method such as fluidized bed coating, an even better coated product can be obtained.
本発明は食品、医薬品、農薬、飼料やその添加物の防湿
、溶解性のコントロール、防臭、固結防止法として、ま
た、嬌臭、嬌味、着色、賦形などの目的に用いる事がで
きる。また、これらの目的に応じて甘味料、着香料、着
色料などを添加することもできる。The present invention can be used as a method for preventing moisture, controlling solubility, deodorizing, and preventing caking of foods, pharmaceuticals, agricultural chemicals, feeds, and their additives, and for purposes such as adding odor, flavor, coloring, and shaping. . In addition, sweeteners, flavoring agents, coloring agents, etc. can also be added depending on these purposes.
本発明の特徴は得られる粉粒体物質が芯となる物質が粉
末であってもコーテイング物質を均質にコーティングす
ることができることにあシ、従来法では芯となる物質が
粉末の状態ではコーティングが非常に困難であシ、凝集
造粒された状態となるのに対し、本発明方法によれば1
00μ程度の粉末であっても1次粒子のままでコーティ
ングでき、優れたものである。また、コーティング装置
は攪拌装置などであって従来のものよシ比較的単純であ
って、かつ短時間に行なわれるので費用が安くすむ方法
であった。また、本発明の方法は溶媒や水を全く使用し
ていないので乾燥工程なども必要としない方法であシ、
設備、時間を必要とせず、溶媒や水に対して不安定な物
質にも用いることができる。The feature of the present invention is that the coating material can be uniformly coated even if the core material of the obtained granular material is powder, whereas in the conventional method, coating is not possible when the core material is powder. However, according to the method of the present invention, 1
Even if the powder is about 00μ, it can be coated as a primary particle, which is excellent. Furthermore, the coating device is a stirring device, etc., which is relatively simple compared to conventional coating devices, and can be carried out in a short period of time, making it a low-cost method. Furthermore, since the method of the present invention does not use any solvent or water, it does not require a drying process.
It does not require any equipment or time, and can be used even for substances that are unstable to solvents and water.
実施例1
平均粒径70μのコーンスターチ30gと食用油脂(硬
化牛脂融点40℃)15gを遠心回転メカノミル(MM
−10型)を用い回転数1100Orpで30分間混合
して油脂の粉体壁マイクロカプセルを得た。混合は回転
する粉体層に液滴を落下させる事によるいわゆる粉床法
によって行われた。Example 1 30g of cornstarch with an average particle size of 70μ and 15g of edible fat (hardened beef tallow melting point 40°C) were mixed in a centrifugal rotating Mechano Mill (MM).
-10 type) for 30 minutes at a rotational speed of 1100 Orp to obtain powder-walled oil and fat microcapsules. Mixing was carried out by the so-called powder bed method by dropping droplets onto a rotating powder bed.
次に、メチオニン結晶100gと上記マイクロカプセル
4511とを上記メカノミル中で回転数50 Orpm
にて約30分間攪拌混合した。この際、羽根によるせん
断力によυマイクロカプセルが破壊され、それにともな
いメチオニン結晶表面に油脂とコーンスターチが均質に
付着した。Next, 100 g of methionine crystals and the above microcapsules 4511 were placed in the above Mechano Mill at a rotation speed of 50 Orpm.
The mixture was stirred and mixed for about 30 minutes. At this time, the υ microcapsules were destroyed by the shearing force of the blades, and oil and fat and corn starch were uniformly adhered to the surface of the methionine crystals.
従来の流動コーティング、転動コーティングの方式では
特に芯物質が粉末状の場合には1次粒子のままでコーテ
ィング処理を完了する事が出来ないが、本実施例で得ら
れたものはメチオニンの1次粒子のままでコーティング
されていた。このコーティングされたメチオニンはメチ
オニン特有の臭いが殆んどなく食品への添加のし易い状
態に改善されていた。In conventional fluid coating and rolling coating methods, it is impossible to complete the coating process with the primary particles remaining, especially when the core material is in the form of powder. The particles were coated as they were. The coated methionine had almost no odor peculiar to methionine and was improved to be easily added to foods.
実施例2
平均粒径10μの米澱粉15.9と味の素(株)製置型
油脂[ハイトーン30J15,9とを実施例1と同様に
遠心回転メカノミルを用い回転数11000rpで30
分間混合し、油脂の粉体壁マイクロカプセルを得た。Example 2 Rice starch 15.9 with an average particle size of 10μ and Ajinomoto Co., Inc. stationary fat [Hightone 30J15,9] were mixed in the same manner as in Example 1 using a centrifugal rotating Mechano Mill at a rotation speed of 11,000 rpm.
Mixed for a minute to obtain powder-walled microcapsules of fat and oil.
次に、流動造粒装置によシ粉末醤油50q6、グルタミ
ン酸ソーダ50チの粒径約1胴φはどの顆粒を調整した
。この顆粒50gと上記粉体壁マイクロカプセル20.
9を遠心回転メカノミル中で回転数60 Orpmで約
30分間攪拌混合した◎その結果、顆粒表面に米澱粉、
油脂の均質なコーティングがなされた。この顆粒は未コ
ーテイング品に比較し吸湿固結性が非常に改善されてお
シ、取扱い性の優れたものであった。Next, in a fluidized granulator, 50 q6 powdered soy sauce and 50 ml of sodium glutamate were prepared into granules having a particle size of about 1 cylinder φ. 50 g of these granules and 20 g of the above powder wall microcapsules.
9 was stirred and mixed in a centrifugal rotating Mechanomill at a rotation speed of 60 Orpm for about 30 minutes. As a result, rice starch,
A homogeneous coating of fat and oil was created. These granules had significantly improved moisture absorption and caking properties compared to uncoated products, and were excellent in handleability.
実施例3
平均粒径約10μの結晶セルロース20gとカルナバロ
ウワックス209を遠心回転メカノミルを用い回転数1
1000rp、30分間混合し、ワックスの粉体壁マイ
クロカプセルを得た口広に粒径100〜150μの馬鈴
薯澱粉80Iとメチオニン粉末20gを上記遠心回転メ
カノミル中で回転数1100Orp、30分間混合攪拌
し、メチオニン粉末を澱粉粒子表面に均一に付着させた
。次いで上記ワックスのマイクロカプセル40gを同じ
遠心回転メカノミル中に入れ、回転数60Orpm、6
0分間混合攪拌行った。その結果メチオニンの付着した
澱粉の周囲にワックスと結晶セルロースのコーティング
がなされた。Example 3 20g of crystalline cellulose with an average particle size of about 10μ and carnauba wax 209 were heated at a rotation speed of 1 using a centrifugal rotating Mechanomill.
Mix at 1000 rpm for 30 minutes to obtain wax powder wall microcapsules. Mix and stir 80 I potato starch with a particle size of 100 to 150 μm and 20 g of methionine powder in the centrifugal rotating Mechanomill for 30 minutes at 1100 rpm. Methionine powder was uniformly adhered to the surface of the starch particles. Next, 40 g of the wax microcapsules were placed in the same centrifugal rotating Mechano Mill, and the rotation speed was 60 Orpm.
Mixing and stirring were performed for 0 minutes. As a result, a coating of wax and crystalline cellulose was formed around the starch to which methionine was attached.
このコーティングされたメチオニン顆粒を38℃の温水
へ溶解したところ1時間で約40チの溶出をする事が認
められ、溶解時間のコントロールされたメチオニン顆粒
が得られた。When the coated methionine granules were dissolved in hot water at 38° C., it was observed that about 40 ions were eluted in one hour, and methionine granules with a controlled dissolution time were obtained.
Claims (1)
の1種または2種以上を粉末に加え粉末法によシコーテ
ィングして粉体壁マイクロカプセルとした後、該粉体壁
マイクロカプセルに芯となる物質を加え混合機中で攪拌
することによって、芯となる物質の表面に該粉体壁マイ
クロカプセル又は該粉体壁マイクロカプセルの破壊物を
均質に付着または粘着させることを特徴とする被覆され
た粉粒体物質の製造法。One or more of liquid or pasty substances, thermoplastic substances, and thermosoluble substances are added to the powder and coated by a powder method to form powder-walled microcapsules, and then the powder-walled microcapsules are coated with a core. The powder-walled microcapsules or the broken material of the powder-walled microcapsules are uniformly adhered or adhered to the surface of the core material by adding a substance and stirring in a mixer. A method for producing powdery and granular materials.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58105313A JPS59230633A (en) | 1983-06-13 | 1983-06-13 | Preparation of coated particulate substance |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58105313A JPS59230633A (en) | 1983-06-13 | 1983-06-13 | Preparation of coated particulate substance |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS59230633A true JPS59230633A (en) | 1984-12-25 |
JPS6258771B2 JPS6258771B2 (en) | 1987-12-08 |
Family
ID=14404212
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP58105313A Granted JPS59230633A (en) | 1983-06-13 | 1983-06-13 | Preparation of coated particulate substance |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS59230633A (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61242634A (en) * | 1985-04-18 | 1986-10-28 | Nippon Sanso Kk | Composition retarded in reactivity and dissolubility with water or acid and alkali aqueous solution and its production |
JPS63164863A (en) * | 1986-12-26 | 1988-07-08 | Nippon Oil & Fats Co Ltd | Production of coated organic acid and organic acid salt preparation |
JPS642554A (en) * | 1987-06-23 | 1989-01-06 | Nippon Oil & Fats Co Ltd | Production of coated amino acids |
JPH0662789A (en) * | 1992-08-21 | 1994-03-08 | Nisshin Flour Milling Co Ltd | Powdered seasoning for hydrous food |
JP2004097146A (en) * | 2002-09-12 | 2004-04-02 | Meiji Seika Kaisha Ltd | Granular food and method for producing the same |
JP2005534316A (en) * | 2002-08-02 | 2005-11-17 | プラク・ビオヘム・ベー・ブイ | Encapsulated crystalline lactic acid |
CN103495370A (en) * | 2013-09-11 | 2014-01-08 | 吴江市冰心文教用品有限公司 | Preparation method of permanent bordeaux 2BP microcapsule |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0432078U (en) * | 1990-07-12 | 1992-03-16 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54135033A (en) * | 1978-04-11 | 1979-10-19 | Pentel Kk | Eraser and making method thereof |
JPH04156734A (en) * | 1990-10-19 | 1992-05-29 | Nec Corp | Signal analyzing device |
-
1983
- 1983-06-13 JP JP58105313A patent/JPS59230633A/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54135033A (en) * | 1978-04-11 | 1979-10-19 | Pentel Kk | Eraser and making method thereof |
JPH04156734A (en) * | 1990-10-19 | 1992-05-29 | Nec Corp | Signal analyzing device |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61242634A (en) * | 1985-04-18 | 1986-10-28 | Nippon Sanso Kk | Composition retarded in reactivity and dissolubility with water or acid and alkali aqueous solution and its production |
JPS63164863A (en) * | 1986-12-26 | 1988-07-08 | Nippon Oil & Fats Co Ltd | Production of coated organic acid and organic acid salt preparation |
JPS642554A (en) * | 1987-06-23 | 1989-01-06 | Nippon Oil & Fats Co Ltd | Production of coated amino acids |
JPH0662789A (en) * | 1992-08-21 | 1994-03-08 | Nisshin Flour Milling Co Ltd | Powdered seasoning for hydrous food |
JP2005534316A (en) * | 2002-08-02 | 2005-11-17 | プラク・ビオヘム・ベー・ブイ | Encapsulated crystalline lactic acid |
JP2004097146A (en) * | 2002-09-12 | 2004-04-02 | Meiji Seika Kaisha Ltd | Granular food and method for producing the same |
CN103495370A (en) * | 2013-09-11 | 2014-01-08 | 吴江市冰心文教用品有限公司 | Preparation method of permanent bordeaux 2BP microcapsule |
CN103495370B (en) * | 2013-09-11 | 2015-07-22 | 苏州宸浩纺织科技有限公司 | Preparation method of permanent bordeaux 2BP microcapsule |
Also Published As
Publication number | Publication date |
---|---|
JPS6258771B2 (en) | 1987-12-08 |
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