JPS5818617A - Cleaning solution for soft contact lens - Google Patents
Cleaning solution for soft contact lensInfo
- Publication number
- JPS5818617A JPS5818617A JP8027082A JP8027082A JPS5818617A JP S5818617 A JPS5818617 A JP S5818617A JP 8027082 A JP8027082 A JP 8027082A JP 8027082 A JP8027082 A JP 8027082A JP S5818617 A JPS5818617 A JP S5818617A
- Authority
- JP
- Japan
- Prior art keywords
- cleaning
- chlorite
- scl
- soln
- soft contact
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/10—Halogens or compounds thereof
- A61L12/102—Chlorine dioxide (ClO2)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Eyeglasses (AREA)
- Detergent Compositions (AREA)
Abstract
Description
【発明の詳細な説明】
本発明はソフトコンタクトレンズ（以下ＳＣＬという）
用の洗浄液に関する。[Detailed Description of the Invention] The present invention provides soft contact lenses (hereinafter referred to as SCL).
Concerning cleaning liquid for use.
従来よりＳＣＬ表面に付着した油脂あるいはゴミなどを
例えば、界面活性剤を含有する洗浄液を用いて、ＳＣＬ
を洗浄することが知られている。Conventionally, oils, fats, dirt, etc. that have adhered to the SCL surface can be removed using, for example, a cleaning solution containing a surfactant.
It is known to wash.
また界面活性剤等では除去不可能な例えば、蛋白質など
の成分については蛋白質分解酵素などにより分解除去す
ることが知られている。Furthermore, it is known that components such as proteins, which cannot be removed by surfactants or the like, can be decomposed and removed by proteolytic enzymes or the like.
しかしながら、蛋白質分解酵素を用いる除去方法は、蛋
白質については分解除去できるものの該酵素自体が蛋白
質である為にＳＣＬに付着しやすいという問題点がある
。However, the removal method using a protease can decompose and remove proteins, but since the enzyme itself is a protein, there is a problem in that it tends to adhere to SCL.
また、これ以外にたとえば次亜塩素酸塩を用いる洗浄方
法も知られているが１次亜塩素酸塩は作用が強すぎるた
め、ＳＣＬ自身の物性低下を招くおそれがある。In addition, cleaning methods using, for example, hypochlorite are also known, but since primary hypochlorite has too strong an effect, there is a risk that the physical properties of the SCL itself will deteriorate.
このような状況に鑑み本発明者らは鋭意検討した結果、
以下に述べる本実゛明に到達した。In view of this situation, the inventors of the present invention have conducted extensive studies, and as a result,
We have reached the main truth described below.
すなわち本発明は、亜塩素酸塩と分解促進用触媒とを含
有することを特徴とするソフトコンタクトレンズ用洗浄
液に関するものである。That is, the present invention relates to a cleaning liquid for soft contact lenses characterized by containing a chlorite and a catalyst for promoting decomposition.
本発明の洗浄液中に含まれる亜塩素酸塩とは。What is chlorite contained in the cleaning solution of the present invention?
例えば亜塩素酸ナトリウム、亜塩素酸カリウムなどを挙
げることができる。中でも亜塩素酸ナトリウムが特に好
ましい。洗浄液中に含まれる亜塩素酸塩の濃度としては
約０．０００１〜５チ、好ましくは０．０００５〜０．
５チの範囲である。Examples include sodium chlorite and potassium chlorite. Among them, sodium chlorite is particularly preferred. The concentration of chlorite contained in the cleaning solution is about 0.0001-5, preferably 0.0005-0.
The range is 5.
また、ここにいう分解促進用触媒とは１本発明の洗浄液
中に含まれる亜塩素酸塩の分解を促進するようなもので
あり、具体例としては、たとえばクエン酸、ブドウ糖、
塩酸、硫酸、チオ硫酸ナトリウム、亜硫酸水素ナトリウ
ム、ノ葛イドロサルフアイトなどの物質をあげることが
でき、中でもりエン酸とブドウ糖がレンズの物性を低下
させることなく、シかも洗浄効果にもすぐれているので
好ましいものである。これらは単独のみならず２種以上
を併用しても用いることができる。Further, the decomposition promoting catalyst referred to herein is one that promotes the decomposition of chlorite contained in the cleaning solution of the present invention, and specific examples include citric acid, glucose,
Substances such as hydrochloric acid, sulfuric acid, sodium thiosulfate, sodium hydrogen sulfite, and hydrosulfite can be used, and among them, enoic acid and glucose do not deteriorate the physical properties of the lens and have excellent cleaning effects. This is preferable because there are These can be used not only alone but also in combination of two or more.
また洗浄液のｐＨとしては１本発明の目的をそこなわな
い限シ適宜選択できるが１例えば２〜１２゜好ましくは
３〜１０の範囲である。The pH of the cleaning solution can be selected as appropriate as long as it does not impede the object of the present invention, and is, for example, in the range of 2 to 12 degrees, preferably 3 to 10 degrees.
本発明の洗浄液には亜塩素酸および分解促進用触媒のほ
かに、たとえば次のような物質も添加することができる
。In addition to chlorous acid and a catalyst for promoting decomposition, the following substances can also be added to the cleaning solution of the present invention.
エチレンジアミン四酢酸、尿素、ホウ酸、ホウ酸ナトリ
ウム、水酸化ナトリウム、エチレンジアミン四酢酸塩な
どの物質をあげることができ、さらにこれらの他に界面
活性剤なども添加することが可能である。上記の物質は
、酸化あるいは還元作用のための活性補助剤とも呼ぶこ
とができる。Substances such as ethylenediaminetetraacetic acid, urea, boric acid, sodium borate, sodium hydroxide, and ethylenediaminetetraacetate can be mentioned, and in addition to these, surfactants and the like can also be added. The substances mentioned above can also be referred to as active auxiliaries for oxidizing or reducing effects.
本発明の洗浄液は、従来公知のソフトコンタクトレンズ
に適用でき、洗浄処理時間も短く、シかも蛋白質の除去
のみ々らず、脱色などの効果が発現される。The cleaning solution of the present invention can be applied to conventionally known soft contact lenses, requires a short cleaning treatment time, and exhibits effects such as decolorization as well as protein removal.
本発明の洗浄液を用いたＳＣＬの洗浄方法の一例は、た
とえば次のとおシである。An example of a method for cleaning an SCL using the cleaning liquid of the present invention is as follows.
まず亜塩素酸塩および分解促進用触媒（および必要に応
じて活性補助剤など）を含む洗浄液を調整し、この中に
洗浄するＳ′ｃ Ｌを浸漬する。この場合、洗浄液の温
度としては例えば、室温ないし煮沸１２０℃付近の温度
条件が適宜選択できる。しかしながら、温度条件が低い
と処理に長時間を要し、温度が高い場合には短くなる傾
向がみられる。First, a cleaning solution containing chlorite and a catalyst for promoting decomposition (and an activation auxiliary agent, etc., if necessary) is prepared, and S'c L to be cleaned is immersed in this solution. In this case, the temperature of the cleaning liquid can be appropriately selected from, for example, room temperature to boiling temperature of around 120°C. However, when the temperature conditions are low, the treatment takes a long time, and when the temperature is high, it tends to be shortened.
このようにして洗浄処理されたＳＣＬは、好ましくは洗
浄液中で室温まで放置冷却された後、水洗され必要に応
じて残存している亜塩素酸塩をチオ硫酸ナトリウム、亜
硫酸水素ナトリウムなどで分解し１次いで生理食塩水の
溶液に浸漬して、再び使用に供されるのである。The SCL thus cleaned is preferably left to cool to room temperature in a cleaning solution, then washed with water and, if necessary, decomposed the remaining chlorite with sodium thiosulfate, sodium bisulfite, etc. First, it is immersed in a physiological saline solution and used again.
上記のような洗浄処理に適当なＳＣＬとしては。SCL suitable for the above-mentioned cleaning process is:
例えばポリビニルピロリドンを主成分とする高含水ＳＣ
Ｌやポリヒドロキシエチルメタアクリレートを主成分と
する低含水ＳＣＬがあげられる。For example, high water content SC whose main component is polyvinylpyrrolidone
Examples include low water content SCL whose main components are L and polyhydroxyethyl methacrylate.
以下、実施例によシ本発明を更に詳しく説明する。Hereinafter, the present invention will be explained in more detail with reference to Examples.
実施例１
亜塩素酸ナトリウムおよび分解促進用触媒としてクエン
酸を用いて第１表に示すような洗浄液部１〜３を調整し
た。Example 1 Cleaning liquid parts 1 to 3 as shown in Table 1 were prepared using sodium chlorite and citric acid as a catalyst for promoting decomposition.
各々の洗浄液［ＳＣＬ１枚を浸漬し、常圧水浴で３０分
間煮沸した。室温まで放置、冷却後レンズを取り出し２
０ｍ１！の水に５分間浸け、これを３回繰返しレンズの
水洗を行った。次に生理食塩水溶液に３０分間浸漬して
からレンズのＵＶスペクトルを測定し洗浄効果を評価し
た。結果は第１表に示す。One sheet of SCL was immersed in each cleaning solution and boiled in a normal pressure water bath for 30 minutes. Leave it to room temperature and take out the lens after cooling 2
0m1! The lens was soaked in water for 5 minutes, and this process was repeated three times to rinse the lens. Next, the lens was immersed in a physiological saline solution for 30 minutes, and then the UV spectrum of the lens was measured to evaluate the cleaning effect. The results are shown in Table 1.
なお１例中の洗浄効果については、ソフトコンタクトレ
ンズの洗浄処理前と処理後の紫外線スペクトル（第１図
）の吸収変化から９次のごとく格付し記号で示しである
。The cleaning effectiveness in one example is shown in 9-order grades based on absorption changes in the ultraviolet spectrum (Fig. 1) before and after the cleaning treatment of the soft contact lens.
第 １ 表
また亜塩素酸ナトリウムのｐＨ曲線はｐＨ＝ ７付近で
は、わずかな組成やその他の条件変化で急激に変動する
ため、併記した溶液のｐＨは説明を容易にするために示
したもので１条件を決定するものではない。Table 1 Also, the pH curve of sodium chlorite fluctuates rapidly around pH = 7 due to slight changes in composition or other conditions, so the pH of the solutions shown together is shown for ease of explanation. It does not determine one condition.
なお、ここで用いたＳＣＬは高含水レンズである“Ｂｒ
ｅａｔｈ−０″（束し■製）である。The SCL used here is a high water content lens “Br”.
eath-0'' (made by bundled ■).
また、ここでぃうＵＶスペクトルグラフの一例を第１図
に示す。第１図中９点線は人による装着後の汚れレンズ
の紫外線スペクトル、実線は本発明の洗浄液で洗浄処理
した後の紫外線吸収スペクトルを表わすものである。Further, an example of the UV spectrum graph described here is shown in FIG. In FIG. 1, the nine-dot line represents the ultraviolet spectrum of the dirty lens after it has been worn by a person, and the solid line represents the ultraviolet absorption spectrum after cleaning with the cleaning solution of the present invention.
なお９図中の横軸は吸収率、縦軸は波長（ｎｍ）を示す
。In addition, the horizontal axis in FIG. 9 shows the absorption rate, and the vertical axis shows the wavelength (nm).
実施例２
亜塩素酸す）ＩＪウムの水溶液に５種々の分解促進用触
媒を水に溶解した後添加して、第２表に示した組成の洗
浄液ｍ４〜９を調合した。各洗浄液２０ｍＩ！に一定期
間装着したレンズを１枚浸漬し室温で１６時間放置した
。次にレンズを取り出し２０ｍｊの水に５分間浸け、こ
れを３回繰返した。Example 2 Five different catalysts for promoting decomposition were dissolved in water and then added to an aqueous solution of IJium chlorite to prepare cleaning liquids m4 to m9 having the compositions shown in Table 2. 20mI of each cleaning solution! One lens, which had been worn for a certain period of time, was immersed in the solution and left at room temperature for 16 hours. Next, the lens was taken out and immersed in 20 mj of water for 5 minutes, and this was repeated three times.
水洗後生埋置塩液（０９チ食塩水）５ｍ／に３０分間浸
け、レンズのＵＶスペクトルを測定しＵＶスペクトルの
変化から、洗浄効果を評価した。結果を第２表に示す。After washing with water, the lenses were immersed in 5 m/ml of raw burial salt solution (09-chi saline solution) for 30 minutes, the UV spectrum of the lenses was measured, and the cleaning effect was evaluated from the change in the UV spectrum. The results are shown in Table 2.
なおレンズは、高含水８ＣＬである” Ｂｒｅａｔｈ−
〇″ （東し麹製）を用いた。The lens has a high water content of 8CL.
〇″ (manufactured by Higashishikoji) was used.
実施例６
亜塩素酸ナトリウムの水溶液に種々の分解促進用触媒を
単独または組合せて添加し第６表に示す各種組成の洗浄
液部１０〜１３を調合した。洗浄液ｍ１３の洗浄条件は
９８℃、６０分間で処理しその他の条件および洗浄液部
１０〜１２のレンズの洗浄処理条件および方法さらに洗
浄効果等は実施例１と同様に行った。結果を第３表に示
す。Example 6 Various decomposition promoting catalysts were added singly or in combination to an aqueous solution of sodium chlorite to prepare cleaning liquid parts 10 to 13 having various compositions shown in Table 6. The cleaning conditions for the cleaning liquid m13 were 98° C. for 60 minutes, and the other conditions, cleaning treatment conditions and method for the lenses in the cleaning liquid parts 10 to 12, and the cleaning effect were the same as in Example 1. The results are shown in Table 3.
なお、レンズとしては洗浄液ｍ１０〜１２に対しては高
含水ＳＣＬである“Ｂｒｅａｔｈ−０″（束し■製）を
用い、洗浄液部１３はＨＥＭＡ系の＝ ５ｏｆｌｅｎｓ
” （Ｂ ＆ Ｌ社製）を用いた。As for the lenses, "Breath-0" (manufactured by Tsukushishi ■), which is a high water content SCL, is used for the cleaning liquid m10 to m12, and the cleaning liquid part 13 is a HEMA-based = 5oflens.
” (manufactured by B & L) was used.
第 ３ 表
実施例４
第４表に示すような組成からなる洗浄液部１４゜１５を
調合した。この洗浄液を用いて繰返し洗浄して強度劣化
を調べた。洗浄方法は実施例６と同様に行なった。洗浄
条件および結果を第４表に示す。なお用いたＳＣＬは”
Ｂｒｅａｔｈ−０″ （束し■製）である。ブドウ糖を
添加した洗浄液嵩１５は。Table 3 Example 4 A cleaning liquid portion 14-15 having the composition shown in Table 4 was prepared. This cleaning solution was used for repeated cleaning to examine strength deterioration. The cleaning method was the same as in Example 6. The washing conditions and results are shown in Table 4. The SCL used is “
Breath-0'' (manufactured by Tsukushishi ■).The volume of the cleaning liquid to which glucose has been added is 15.
強度は常法により“テンシロン″ （東洋ホールドウィ
ン社製）を用いて測定した。The strength was measured using "Tensilon" (manufactured by Toyo Holdwin Co., Ltd.) in a conventional manner.
第 ４ 表Table 4
第１図はＢＣＬの洗浄前稜の紫外線吸収スペクトルを示
すグラフの一例である。
特許出願人 東 し 株 式 会 社第１図
ｖＬ 収牢FIG. 1 is an example of a graph showing the ultraviolet absorption spectrum of the edge of BCL before cleaning. Patent applicant Toshi Co., Ltd. Figure 1 vL Prison
Claims (1)
特徴とするソフトコンタクトレンズ用洗浄液。(1) A cleaning liquid for soft contact lenses characterized by containing a chlorite and a catalyst for promoting decomposition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8027082A JPS5818617A (en) | 1982-05-14 | 1982-05-14 | Cleaning solution for soft contact lens |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8027082A JPS5818617A (en) | 1982-05-14 | 1982-05-14 | Cleaning solution for soft contact lens |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11639381A Division JPS5818616A (en) | 1981-07-27 | 1981-07-27 | Cleaning solution for soft contact lens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5818617A true JPS5818617A (en) | 1983-02-03 |
| JPH0149922B2 JPH0149922B2 (en) | 1989-10-26 |
Family
ID=13713596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8027082A Granted JPS5818617A (en) | 1982-05-14 | 1982-05-14 | Cleaning solution for soft contact lens |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5818617A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61219928A (en) * | 1985-03-26 | 1986-09-30 | Toray Ind Inc | Cleaner for contact lens and its cleaning method |
| EP0196075A2 (en) * | 1985-03-26 | 1986-10-01 | Toray Industries, Inc. | Cleaning system for contact lenses and process for cleaning the same |
| JPS61260214A (en) * | 1985-05-15 | 1986-11-18 | Toray Ind Inc | Detergent for contact lens and method for washing contact lens |
| US4780152A (en) * | 1986-08-15 | 1988-10-25 | Hoya Corporation | Kit for contact lens cleaning and method for contact lens cleaning |
| US5185161A (en) * | 1984-03-21 | 1993-02-09 | Alcide Corporation | Disinfection method and composition therefor |
| WO2004032979A3 (en) * | 2002-10-07 | 2004-07-01 | Alcide Corp | Acidified chlorite compositions containing nitrogenous stabilizers and systems and methods related thereto |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5714821A (en) * | 1980-07-01 | 1982-01-26 | Senjiyu Seiyaku Kk | Preserving and/or washing liquid for contact lens |
-
1982
- 1982-05-14 JP JP8027082A patent/JPS5818617A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5714821A (en) * | 1980-07-01 | 1982-01-26 | Senjiyu Seiyaku Kk | Preserving and/or washing liquid for contact lens |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5185161A (en) * | 1984-03-21 | 1993-02-09 | Alcide Corporation | Disinfection method and composition therefor |
| JPS61219928A (en) * | 1985-03-26 | 1986-09-30 | Toray Ind Inc | Cleaner for contact lens and its cleaning method |
| EP0196075A2 (en) * | 1985-03-26 | 1986-10-01 | Toray Industries, Inc. | Cleaning system for contact lenses and process for cleaning the same |
| JPH0133805B2 (en) * | 1985-03-26 | 1989-07-14 | Toray Industries | |
| JPS61260214A (en) * | 1985-05-15 | 1986-11-18 | Toray Ind Inc | Detergent for contact lens and method for washing contact lens |
| US4780152A (en) * | 1986-08-15 | 1988-10-25 | Hoya Corporation | Kit for contact lens cleaning and method for contact lens cleaning |
| WO2004032979A3 (en) * | 2002-10-07 | 2004-07-01 | Alcide Corp | Acidified chlorite compositions containing nitrogenous stabilizers and systems and methods related thereto |
| US8388990B2 (en) | 2002-10-07 | 2013-03-05 | Ecolab Usa Inc. | Acidified chlorite compositions containing nitrogenous stabilizers and systems and methods related thereto |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0149922B2 (en) | 1989-10-26 |
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