CA1229563A - Method for disinfecting and cleaning contact lenses - Google Patents
Method for disinfecting and cleaning contact lensesInfo
- Publication number
- CA1229563A CA1229563A CA000516571A CA516571A CA1229563A CA 1229563 A CA1229563 A CA 1229563A CA 000516571 A CA000516571 A CA 000516571A CA 516571 A CA516571 A CA 516571A CA 1229563 A CA1229563 A CA 1229563A
- Authority
- CA
- Canada
- Prior art keywords
- solution
- contact lens
- hydrogen peroxide
- contact lenses
- lenses
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Abstract
ABSTRACT
A method for disinfecting and cleaning contact lenses is disclosed wherein the lenses are first treated with a peroxide solution to effect disinfection and then are sub-sequently treated with a catalyst which decomposes the perox-ide in a rapid, turbulent manner so as to facilitate removal of surface contamination. The catalyst is preferably catal-ase, which when used as an aqueous solution is particularly effective in increasing the speed and thorouqhness of perox-ide removal from the lenses. A contact lens treatment solution and a contact lens disinfection system are also disclosed.
A method for disinfecting and cleaning contact lenses is disclosed wherein the lenses are first treated with a peroxide solution to effect disinfection and then are sub-sequently treated with a catalyst which decomposes the perox-ide in a rapid, turbulent manner so as to facilitate removal of surface contamination. The catalyst is preferably catal-ase, which when used as an aqueous solution is particularly effective in increasing the speed and thorouqhness of perox-ide removal from the lenses. A contact lens treatment solution and a contact lens disinfection system are also disclosed.
Description
~Z5~5~3 METHOD FOR DISINFECTING AND CLEANING CONTACT LENSES
FIELD OF THE INVENTION
This invention relates generally to the disinfect-in and cleaning of contact lenses, particularly by first contacting the lenses with an aqueous peroxide disinfection solution, and then with a peroxide decomposition catalyst.
The invention is concerned in particular with a contact lens treatment solution useful for cleaning contact lenses through the rapid decomposition of residual peroxide contained in the lenses after disinfection, and with a contact lens disinfect-ion system.
BACKGROUND OF THE INVENTION
-During the use of contact lenses, the lenses become contaminated and the accumulation of pathogenic germs must not be permitted to exceed a critical limit in order to avoid the danger of an infection of the eye. For this reason, a daily disinfection of contact lenses is necessary. This is particularly true for hydrophilic soft lenses, which are used widely today.
For this purpose, a method is known which utilizes hydrogen peroxide, which has an oxidizing, germ-killing, odor-killing and cleaning effect. In this method, the contact lenses are first exposed to the action of an aqueous peroxide disinfection solution, preferably a 1 to 5 percent solution of hydrogen peroxide, although other peroxides such as sodium Jo ~Z29563 perorate, sodium per carbonate and urea peroxide may be em-plowed. This treatment can, for example take place in a small container in which the contact lenses are arranged in a carrying basket. The time period during which the hydrogen peroxide must act on the contact lenses in order to achieve a sufficient disinfection and cleaning is approximately 20 minutes. The residual hydrogen peroxide which adheres to the contact lenses must subsequently be removed, and in the known method this is done by moving the contact lenses into a second container which contains a neutral liquid and a octal-yet, in the presence of which catalyst the hydrogen peroxide is decomposed into water and oxygen according to the formula:
OWE OWE + 2 The catalyst is a metal-coated solid body.
A disadvantage of the conventional method is that the second method step, namely the decomposition of the hydrogen peroxide, takes a relatively long time. At least four hours are typically needed for this. If, for example, a user of contact lenses forgets in the evening to change the contact lenses from the hydrogen peroxide solution to the solution containing the catalyst, there is usually insuf-fishnet time the next morning to remove the hydrogen peroxide residues from the contact lenses and thereby avoid a burning sensation in the eyes during wearing of the contact lenses.
In a modified version of the above-described known i63 method, the metallic catalyst is already present in the hydrogen peroxide solution during the time when the hydrogen peroxide solution acts on the contact lenses. According to this modified method, the disinfecting and cleaning of the contact lenses and -the decomposition of the hydrogen peroxide by the catalyst start at the same time. This is possible in this known method, since the decomposition which is effected by the catalyst takes place slowly, leaving sufficient qua-lilies of active peroxide to complete the disinfection prior to complete decomposition. This one-step method also has the disadvantage in being very slow, taking several hours to de-compose the peroxide to a tolerable level. Moreover, further rinsing of the lenses with saline solution is generally recommended to remove any remaining residues of hydrogen peroxide.
A basic purpose of the present invention is to imp prove the known disinfection method as described above so that the time span required for the peroxide decomposition step is substantially reduced and at the same time a very high-grade removal of the peroxide is achieved along with a vigorous cleaning of the lenses.
SUMMARY OF THE INVENTION
In one aspect, the invention provides a contact lens treatment solution comprising an aqueous solution con-twining a catalytically effective amount of dissolved octal-aye and about 0.8 to 1.0% sodium chloride.
In another aspect, the invention provides a contact lens disinfection system comprising:
(a) an aqueous hydrogen peroxide disinfection solution sufficient to disinfect a contact lens; and (b) a catalytically effective amount of kettles sufficient to decompose the hydrogen peroxide adhering to said contact lens after disinfect-ion.
DETAILED DESCRIPTION
Kettles is an enzyme which is preferably obtained from beef liver and has a crystalline structure. It can be obtained on the market as a highly concentrated solution disk solved in 30% glycerin and 10% ethanol, as well as other forms, and is used in the grocery industry, in particular in the treatment of milk.
The invention is based on the recognition that the removal of hydrogen peroxide residues from contact lenses in the presence of kettles as catalyst takes place sub-staunchly more quickly and thoroughly than when conventional catalysts are used. In the method according to the invention, the time span for the decomposition step takes only a few minutes (approximately 5 minutes). In the method according to the invention, it is thus not important if a user of contact lenses forgets in the evening to start the decomposition step, since taking care of it the next morning requires only a few minutes. Through -the very turbulent decomposition of the hydrogen peroxide, not only is the necessary treatment ~Z;~S~5~i3 time substantially shortened, but since the catalyst which is added in solution also reaches the hydrogen peroxide which has penetrated the contact lens material, an explosion-like decomposition takes place which breaks off contamination from the surface of the lens. The removal of hydrogen peroxide residues with the inventive method is so thorough that a sub-sequent washing of the lens in a salt solution is not needed.
In using the organic material kettles, there exists a practical problem that it is not very stable and storing it is difficult. The above-mentioned highly concern-treated kettles solution, which can be obtained in commerce, must be stored at 4C and even then can be stored only for several months. According to the invention, the kettles for carrying out the inventive method can be stored in sodium chloride solution, in which it has surprisingly been found to be capable of storage for a very long time with minimal tempt erasure susceptibility. The stability of the kettles in this form makes the method according to the invention extremely well suited for practical use. For this purpose, a volume part of kettles in the above-mentioned commercially avail-able form is added to approximately 100 to 1000 volume parts, preferably 400 to 600 volume parts, of an approximately 0.8 to 1.0~ sodium chloride solution. Of course, even more diluted concentrations of kettles may be employed so long as a catalytically effective amount is present to decompose the peroxide in a reasonable length of time.
The decomposition step can be carried out in So various ways. At the end of the disinfection time, kettles in the form of tablets or a highly concentrated solution can be added directly to the hydrogen peroxide in the treatment container to effect a vigorous decomposition. An alternative approach involves replacing the hydrogen peroxide solution in the container with a neutral liquid, such as, for example, water or a sodium chloride solution, to which is then added a somewhat highly concentrated kettles solution or tablets containing kettles. One can best use, as the liquid which replaces the hydrogen peroxide solution in the container, the above-described liquid composition which consists of a octal-ytically effective amount of kettles dissolved in a sodium chloride solution, preferably a 0.8% to 1.0~ sodium chloride solution. It is also possible to work with two containers, wherein one container contains the hydrogen peroxide solution and the other container contains the neutral liquid with the kettles, in either solid or dissolved form. Particularly during the treatment of contact lenses, an aqueous sodium chloride solution is preferably used as the neutral liquid for the decomposition step, the concentration of which approximately corresponds with the concentration of eye fluid, usually referred to as an isotonic solution.
For practicality in carrying out the inventive method, it is also conceivable to press the kettles in a crystalline form, with a suitable highly water-soluble base material, into tablets. For the base material, commercially available substances can be used. These tablets then replace ~l22S~563 the above-mentioned highly concentrated kettles solution and can be added directly to the peroxide solution to effect decomposition thereof, or can be added to the neutral liquid, or aqueous saline solution, to form a kettles solution, on situ, for action upon contact lenses.
Another way for carving out the inventive method would be to employ kettles in an immobilized or resin-bonded insoluble form wherein it could be used repeatedly in the same manner as the before-described metal catalysts.
The concentration in which the kettles is added, in its commercially available form, to the base liquid, for example -the hydrogen peroxide solution or the sodium chloride solution, can vary in a wide range from approximately 0.1 to 1 percent by volume, or even lesser quantities so long as a catalytically effective amount is present in the final solution to effect a reasonably fast decomposition.
This application is a division of Canadian Patent Application No. 454,358, filed May 15, 1984.
FIELD OF THE INVENTION
This invention relates generally to the disinfect-in and cleaning of contact lenses, particularly by first contacting the lenses with an aqueous peroxide disinfection solution, and then with a peroxide decomposition catalyst.
The invention is concerned in particular with a contact lens treatment solution useful for cleaning contact lenses through the rapid decomposition of residual peroxide contained in the lenses after disinfection, and with a contact lens disinfect-ion system.
BACKGROUND OF THE INVENTION
-During the use of contact lenses, the lenses become contaminated and the accumulation of pathogenic germs must not be permitted to exceed a critical limit in order to avoid the danger of an infection of the eye. For this reason, a daily disinfection of contact lenses is necessary. This is particularly true for hydrophilic soft lenses, which are used widely today.
For this purpose, a method is known which utilizes hydrogen peroxide, which has an oxidizing, germ-killing, odor-killing and cleaning effect. In this method, the contact lenses are first exposed to the action of an aqueous peroxide disinfection solution, preferably a 1 to 5 percent solution of hydrogen peroxide, although other peroxides such as sodium Jo ~Z29563 perorate, sodium per carbonate and urea peroxide may be em-plowed. This treatment can, for example take place in a small container in which the contact lenses are arranged in a carrying basket. The time period during which the hydrogen peroxide must act on the contact lenses in order to achieve a sufficient disinfection and cleaning is approximately 20 minutes. The residual hydrogen peroxide which adheres to the contact lenses must subsequently be removed, and in the known method this is done by moving the contact lenses into a second container which contains a neutral liquid and a octal-yet, in the presence of which catalyst the hydrogen peroxide is decomposed into water and oxygen according to the formula:
OWE OWE + 2 The catalyst is a metal-coated solid body.
A disadvantage of the conventional method is that the second method step, namely the decomposition of the hydrogen peroxide, takes a relatively long time. At least four hours are typically needed for this. If, for example, a user of contact lenses forgets in the evening to change the contact lenses from the hydrogen peroxide solution to the solution containing the catalyst, there is usually insuf-fishnet time the next morning to remove the hydrogen peroxide residues from the contact lenses and thereby avoid a burning sensation in the eyes during wearing of the contact lenses.
In a modified version of the above-described known i63 method, the metallic catalyst is already present in the hydrogen peroxide solution during the time when the hydrogen peroxide solution acts on the contact lenses. According to this modified method, the disinfecting and cleaning of the contact lenses and -the decomposition of the hydrogen peroxide by the catalyst start at the same time. This is possible in this known method, since the decomposition which is effected by the catalyst takes place slowly, leaving sufficient qua-lilies of active peroxide to complete the disinfection prior to complete decomposition. This one-step method also has the disadvantage in being very slow, taking several hours to de-compose the peroxide to a tolerable level. Moreover, further rinsing of the lenses with saline solution is generally recommended to remove any remaining residues of hydrogen peroxide.
A basic purpose of the present invention is to imp prove the known disinfection method as described above so that the time span required for the peroxide decomposition step is substantially reduced and at the same time a very high-grade removal of the peroxide is achieved along with a vigorous cleaning of the lenses.
SUMMARY OF THE INVENTION
In one aspect, the invention provides a contact lens treatment solution comprising an aqueous solution con-twining a catalytically effective amount of dissolved octal-aye and about 0.8 to 1.0% sodium chloride.
In another aspect, the invention provides a contact lens disinfection system comprising:
(a) an aqueous hydrogen peroxide disinfection solution sufficient to disinfect a contact lens; and (b) a catalytically effective amount of kettles sufficient to decompose the hydrogen peroxide adhering to said contact lens after disinfect-ion.
DETAILED DESCRIPTION
Kettles is an enzyme which is preferably obtained from beef liver and has a crystalline structure. It can be obtained on the market as a highly concentrated solution disk solved in 30% glycerin and 10% ethanol, as well as other forms, and is used in the grocery industry, in particular in the treatment of milk.
The invention is based on the recognition that the removal of hydrogen peroxide residues from contact lenses in the presence of kettles as catalyst takes place sub-staunchly more quickly and thoroughly than when conventional catalysts are used. In the method according to the invention, the time span for the decomposition step takes only a few minutes (approximately 5 minutes). In the method according to the invention, it is thus not important if a user of contact lenses forgets in the evening to start the decomposition step, since taking care of it the next morning requires only a few minutes. Through -the very turbulent decomposition of the hydrogen peroxide, not only is the necessary treatment ~Z;~S~5~i3 time substantially shortened, but since the catalyst which is added in solution also reaches the hydrogen peroxide which has penetrated the contact lens material, an explosion-like decomposition takes place which breaks off contamination from the surface of the lens. The removal of hydrogen peroxide residues with the inventive method is so thorough that a sub-sequent washing of the lens in a salt solution is not needed.
In using the organic material kettles, there exists a practical problem that it is not very stable and storing it is difficult. The above-mentioned highly concern-treated kettles solution, which can be obtained in commerce, must be stored at 4C and even then can be stored only for several months. According to the invention, the kettles for carrying out the inventive method can be stored in sodium chloride solution, in which it has surprisingly been found to be capable of storage for a very long time with minimal tempt erasure susceptibility. The stability of the kettles in this form makes the method according to the invention extremely well suited for practical use. For this purpose, a volume part of kettles in the above-mentioned commercially avail-able form is added to approximately 100 to 1000 volume parts, preferably 400 to 600 volume parts, of an approximately 0.8 to 1.0~ sodium chloride solution. Of course, even more diluted concentrations of kettles may be employed so long as a catalytically effective amount is present to decompose the peroxide in a reasonable length of time.
The decomposition step can be carried out in So various ways. At the end of the disinfection time, kettles in the form of tablets or a highly concentrated solution can be added directly to the hydrogen peroxide in the treatment container to effect a vigorous decomposition. An alternative approach involves replacing the hydrogen peroxide solution in the container with a neutral liquid, such as, for example, water or a sodium chloride solution, to which is then added a somewhat highly concentrated kettles solution or tablets containing kettles. One can best use, as the liquid which replaces the hydrogen peroxide solution in the container, the above-described liquid composition which consists of a octal-ytically effective amount of kettles dissolved in a sodium chloride solution, preferably a 0.8% to 1.0~ sodium chloride solution. It is also possible to work with two containers, wherein one container contains the hydrogen peroxide solution and the other container contains the neutral liquid with the kettles, in either solid or dissolved form. Particularly during the treatment of contact lenses, an aqueous sodium chloride solution is preferably used as the neutral liquid for the decomposition step, the concentration of which approximately corresponds with the concentration of eye fluid, usually referred to as an isotonic solution.
For practicality in carrying out the inventive method, it is also conceivable to press the kettles in a crystalline form, with a suitable highly water-soluble base material, into tablets. For the base material, commercially available substances can be used. These tablets then replace ~l22S~563 the above-mentioned highly concentrated kettles solution and can be added directly to the peroxide solution to effect decomposition thereof, or can be added to the neutral liquid, or aqueous saline solution, to form a kettles solution, on situ, for action upon contact lenses.
Another way for carving out the inventive method would be to employ kettles in an immobilized or resin-bonded insoluble form wherein it could be used repeatedly in the same manner as the before-described metal catalysts.
The concentration in which the kettles is added, in its commercially available form, to the base liquid, for example -the hydrogen peroxide solution or the sodium chloride solution, can vary in a wide range from approximately 0.1 to 1 percent by volume, or even lesser quantities so long as a catalytically effective amount is present in the final solution to effect a reasonably fast decomposition.
This application is a division of Canadian Patent Application No. 454,358, filed May 15, 1984.
Claims (4)
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A contact lens treatment solution comprising an aqueous solution containing a catalytically effective amount of dissolved catalase and about 0.8 to 1.0%
sodium chloride.
sodium chloride.
2. A contact lens disinfection system comprising:
(a) an aqueous hydrogen peroxide disinfection solution sufficient to disinfect a contact lens; and (b) a catalytically effective amount of catalase sufficient to decompose the hydrogen peroxide adhering to said contact lens after disinfection.
(a) an aqueous hydrogen peroxide disinfection solution sufficient to disinfect a contact lens; and (b) a catalytically effective amount of catalase sufficient to decompose the hydrogen peroxide adhering to said contact lens after disinfection.
3. A contact lens disinfection system according to claim 2 wherein said aqueous hydrogen peroxide sterilizing solution is of 1 to 5% concentration.
4. A contact lens disinfection system according to claim 3 wherein said catalytically effective amount of catalase is dissolved in a sterile aqueous solution containing about 0.8 to 1.0% sodium chloride.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000516571A CA1229563A (en) | 1984-05-15 | 1986-08-21 | Method for disinfecting and cleaning contact lenses |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000454358A CA1228556A (en) | 1984-05-15 | 1984-05-15 | Method for disinfecting and cleaning contact lenses |
| CA000516571A CA1229563A (en) | 1984-05-15 | 1986-08-21 | Method for disinfecting and cleaning contact lenses |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000454358A Division CA1228556A (en) | 1984-05-15 | 1984-05-15 | Method for disinfecting and cleaning contact lenses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1229563A true CA1229563A (en) | 1987-11-24 |
Family
ID=4127871
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000454358A Expired CA1228556A (en) | 1984-05-15 | 1984-05-15 | Method for disinfecting and cleaning contact lenses |
| CA000516571A Expired CA1229563A (en) | 1984-05-15 | 1986-08-21 | Method for disinfecting and cleaning contact lenses |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000454358A Expired CA1228556A (en) | 1984-05-15 | 1984-05-15 | Method for disinfecting and cleaning contact lenses |
Country Status (1)
| Country | Link |
|---|---|
| CA (2) | CA1228556A (en) |
-
1984
- 1984-05-15 CA CA000454358A patent/CA1228556A/en not_active Expired
-
1986
- 1986-08-21 CA CA000516571A patent/CA1229563A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CA1228556A (en) | 1987-10-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |