JPS58156835A - Chemical analysis and measurement device - Google Patents
Chemical analysis and measurement deviceInfo
- Publication number
- JPS58156835A JPS58156835A JP3939082A JP3939082A JPS58156835A JP S58156835 A JPS58156835 A JP S58156835A JP 3939082 A JP3939082 A JP 3939082A JP 3939082 A JP3939082 A JP 3939082A JP S58156835 A JPS58156835 A JP S58156835A
- Authority
- JP
- Japan
- Prior art keywords
- analytical element
- rotary table
- analytical
- chemical analysis
- analysis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
Description
【発明の詳細な説明】
本発明は化学分析測定装置、詳しくは反応試薬が含浸さ
れた分析素子により液体試料を化学的に分（２）
析し測定するための装置に関するものである。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a chemical analysis and measurement device, and more particularly to a device for chemically analyzing and measuring a liquid sample using an analytical element impregnated with a reaction reagent.
一般に、人体の体液その他の液体試料について、当該液
体試料における特定の成分の含有の有無或いはその含有
量等を知るべき場合が多く、このために反応試薬による
化学分析が竹なねれる。液体試料の化学分析法としては
、乾式法と湿式法とがあるが、このうち乾式法は、特定
の試薬が含浸された薄板状の多孔質体をマウントに挾み
込んで成る液体試料分析素子を用い、この分析素子に分
析すべき液体試料を滴下して供給し、これを反応用恒温
槽内に置いて液体試料と試薬とを反応せしめ、その反ｌ
１６１の進行状態又は結果を、例えば反応による色の濃
度変化を光学式濃度測定器により測定する手段、その他
の手段により測足検Ｕ１する方法であり、液体試料を実
際上固体として取り扱うことができる点で非常に便利で
ある。In general, it is often necessary to know whether or not a specific component is contained in the liquid sample, or the content thereof, with respect to human body fluids or other liquid samples, and for this reason, chemical analysis using reaction reagents is popular. There are two methods for chemical analysis of liquid samples: the dry method and the wet method. Of these, the dry method uses a liquid sample analysis element consisting of a thin plate-like porous body impregnated with a specific reagent inserted into a mount. The liquid sample to be analyzed is supplied dropwise to this analytical element using a thermostatic chamber, and the liquid sample is placed in a thermostatic chamber for reaction to cause the liquid sample and reagent to react.
This is a method of measuring the progress status or results of 161, for example, by measuring the change in color density due to the reaction using an optical density meter, or by other means, and it is possible to treat a liquid sample as a solid in practice. Very convenient in that respect.
而して斯かる液体試料の分析においては、各液体試料を
多数の項目について分析することが曲常必要とされ、又
多数の液体胆料番こつぃてのそのような分析を高い効率
で行なわれることがψましい。Therefore, in the analysis of such liquid samples, it is often necessary to analyze each liquid sample for a large number of items, and it is necessary to use a large number of liquid bile samples to perform such analyzes with high efficiency. It's a shame to be lost.
（８）
従来における乾式法による分析方法においては、液体試
料を１１０えた分析素子の多数を恒温槽内に１ｅいて液
体試料と試薬との反応を進行せしめ、分析素子の各々に
おいて必要とされる反応時間か経過した分析素子を移送
機構により測定領域に移送して当該測定領域に配設した
測定器によって当該分析素子についての渭１定を行なう
ようにしている。(8) In the conventional dry method analysis method, a large number of analytical elements each containing a liquid sample are placed in a constant temperature bath to allow the reaction between the liquid sample and the reagent to proceed, and the reaction required in each analytical element is carried out. After a certain period of time has elapsed, the analytical element is transferred to a measurement area by a transfer mechanism, and a measuring device placed in the measurement area performs a constant determination of the analytical element.
しかしながらこのような方法においては、多数の分析素
子をいわは無秩序な状態で恒温槽内に置いており、また
成る分析素子をこ必要とされる反応１侍聞は当該分析素
子の試薬の種類Ｇこよって異なる固有の時間であってし
かも筒度の厳密さが必要とされるものであるので、多数
の分析素子の各々が測定を行なうべき時点に到達する順
序等に規則性を有せしめることか困難を極め、特Ｇこ、
反応の進行状伸を測定検出するためには同一の分析素子
について、１回の測定のみでなくその測定から古び所定
時間の間反応せしめた後第２回の測定を行なうことか必
要であるが、このような分析素子による分析をも一緒に
行なうときには、事情は一層し雑となる。However, in such a method, a large number of analytical elements are placed in a constant temperature bath in a so-called disordered state, and the reaction time required for each analytical element is dependent on the type of reagent G of the analytical element. Therefore, it is necessary to have regularity in the order in which each of the large number of analytical elements reaches the point at which it should perform measurements, since these are different specific times and require strict cylindricity. Extremely difficult, special G,
In order to measure and detect the progress of the reaction, it is necessary not only to perform one measurement on the same analytical element, but also to perform a second measurement after allowing it to react for a predetermined period of time since the first measurement. , the situation becomes even more complicated when analysis using such an analytical element is also performed.
以上のような理由から、従来の方法においては、同時に
分析処理を施すことのｇ］能な分析素子の数が少数に制
限され、従って高い効率で分相をｒｒｆｆうことかでき
ず、又移送機構の購成−Ｌの問題から恒温槽を相当に太
きくしなけれはならず、これＧこ伴って更に仲の種々の
弊害が生ずる等の欠点があった。For the reasons mentioned above, in conventional methods, the number of analytical elements capable of simultaneously performing analytical processing is limited to a small number, and therefore it is not possible to perform phase separation with high efficiency. Due to the problem of purchasing the mechanism, the thermostatic chamber had to be made considerably thicker, which also had the disadvantage of causing various other problems.
なお、複数の測定器を用いることは、測定器には固有の
微妙な特性があってそれが測定英和−に異なるため測宇
値の間軸性が失われることとなり、従ってすべての分子
／Ｔ素子について同一の測定ＲＮ ニより測定すること
が必要である。Furthermore, when using multiple measuring instruments, each measuring instrument has its own subtle characteristics that differ between the English and Japanese measurements, which results in the loss of the linearity of the measured values. It is necessary to measure the elements using the same measurement RN.
本発明は以上の如き事情に基いてなされたものであって
、小型にして高い効率で液体試料の化学分析を達成する
ことのできる化学分析測定装置を提供することを目的と
する。The present invention has been made based on the above-mentioned circumstances, and an object of the present invention is to provide a chemical analysis and measurement device that is small in size and can perform chemical analysis of a liquid sample with high efficiency.
本発明の特数とするところは、恒温槽と、この恒温槽内
に設けた、その外周縁に沿って複数の分析素子保持部を
有する回転テーブルと、前記恒温（５）
檜に形成した分析素子挿入口及び分析素子排出口と、前
記＠濡槽内において前記回転テーブルの外周縁に対向す
るよう設けた分析素子用測定器と、前記回転テーブルを
歩進的に回転せしめる駆ｆ！Ｉｊ １ｍ隅とを具えて成
り、前記回転テーブルの歩進的回転における休止時に、
前記分析素子挿入口及び分析素子排出口並びに前記分析
素子用測定器の各々に苅応する位１ｎにそれぞれ前記回
転テーブルの何れかの分析素子保持部が同時に位置され
る点にある０
以下図面によって本発明の一実施例について説明する。The special feature of the present invention is a constant temperature bath, a rotary table provided in the constant temperature bath and having a plurality of analytical element holding parts along the outer periphery thereof, and the above-mentioned constant temperature (5) An element insertion port, an analytical element outlet, an analytical element measuring device provided in the @ wet bath so as to face the outer periphery of the rotary table, and a drive for rotating the rotary table step by step. Ij 1m corner, and at rest in the stepwise rotation of the rotary table,
At a point where any of the analytical element holding parts of the rotary table are located at the same time in a position corresponding to each of the analytical element insertion port, the analytical element outlet, and the analytical element measuring device, respectively. An embodiment of the present invention will be described.
本発明においては、第１図に示すように、反応用恒温槽
１内において、回転テーブル２を水平面内で回転するよ
う垂直な回転軸３により支持せしめ、この回転軸３Ｑこ
は、例えはその恒温槽ｌ外に突出せしめた先端に設けた
ギア機構４を介して、モータ等の回転駆動源（図示せず
）より坤びる駆動軸５を連結せしめる。前記回転テーブ
ル２は第２図にも示すように円形であり、その外周縁に
は、（６）
多数の分析素子保持部６ 、６ 、−−−−− （図示
の例では合計１２（向）を回転テーブルの全周に亘って
等しい角度間隔θ（図示の例ではθ＝ ８０１％）で並
ぶよう形成して成り、各分析素子保持部６−１第８図に
も示すように、回転テーブル２の外周を含む上面部分を
除去した状態の四部７により形成され、この四部７の背
壁面７１及び両側壁向７２゜７３は、第２図に破線で示
す分析素子Ｅの外形に適合した輪郭を描くものであり、
又凹部７の底壁面７４は、回転テーブル２０半径方向内
方に向うに従って下方に傾斜する斜面とし、この底壁面
７↓には凹部７の＋ｔ％壁７５を貫通する貫通孔８を、
当該四部７に保持される分析素子Ｅの中央における試薬
部Ｒに相当する位置に形成する。In the present invention, as shown in FIG. 1, a rotary table 2 is supported in a constant temperature reaction chamber 1 by a vertical rotary shaft 3 so as to rotate in a horizontal plane. A drive shaft 5, which is driven by a rotational drive source (not shown) such as a motor, is connected via a gear mechanism 4 provided at the tip protruding from the thermostatic chamber l. The rotary table 2 has a circular shape as shown in FIG. ) are arranged at equal angular intervals θ (in the illustrated example, θ=801%) around the entire circumference of the rotary table, and as shown in FIG. It is formed by the four parts 7 with the upper surface portion including the outer periphery of the table 2 removed, and the back wall surface 71 and both side wall directions 72° 73 of the four parts 7 conform to the external shape of the analytical element E shown by the broken line in FIG. It outlines the
The bottom wall surface 74 of the recess 7 is a slope that slopes downward as it goes inward in the radial direction of the rotary table 20, and a through hole 8 penetrating the +t% wall 75 of the recess 7 is formed in the bottom wall surface 7↓.
It is formed at a position corresponding to the reagent part R in the center of the analytical element E held in the four parts 7.
又前記回転テーブル２の外周に沿って、分析素子供給口
ＩＯ及び分析素子排出口１１を前記恒温槽１の周壁に形
成すると共に、回転テーブル２の回転方向における分析
素子供給口ｌＯと分析素子リド出口１１との間に、例え
ば反射型色濃度肝より成る測定器１２を固定して設け、
分析素子供給口（７）
ＩＯに対する測定器１２及び分析素子排出口１１の位置
関係を、何れも、前記分析素子保持部６゜６、−ｍ−の
隣接するものの角度間隔θの整数倍となるようにすると
共に、前記回転テーブル２が角度θづつステップ状に歩
進的に回転するよう、即ち、角度θの回転一体止−角度
θの回転一体止が繰り返されるよう、前記駆動１Ｉｉｌ
ＩＩ５に連結された回転部ＩＩｌ源を制御し且つ前記歩
進的回転における回転テーブル２の体止位１ａか、分析
素子保持部６゜６、−ｍ−の一つが前記分析素子供給口
１０と対向した状態となるようＦｌｉＩＩｏＩする側副
機構（図示せず）を設ける。Further, along the outer periphery of the rotary table 2, an analyte inlet IO and an analyte outlet 11 are formed on the peripheral wall of the constant temperature chamber 1, and an analyte inlet IO and an analyte lid in the rotating direction of the rotary table 2 are formed. A measuring device 12 consisting of, for example, a reflective color density liver is fixedly provided between the outlet 11 and the
The positional relationship of the measuring device 12 and the analytical element outlet 11 with respect to the analytical element inlet (7) IO is set to be an integral multiple of the angular interval θ between the adjacent analytical element holding parts 6゜6, -m-. At the same time, the drive 1Iil is set so that the rotary table 2 is rotated in a stepwise manner by the angle θ, that is, the rotation is stopped at the angle θ and the rotation is stopped at the angle θ repeatedly.
The rotation unit IIl source connected to II5 is controlled, and one of the body resting positions 1a of the rotary table 2 during the stepwise rotation or the analytical element holding parts 6゜6, -m- is connected to the analytical element supply port 10. A collateral mechanism (not shown) is provided for FliIIoI to be in an opposed state.
史に前記分析素子供給口１ｏを介して、分析素子を１枚
づつ供給する分析１子供給機構を設ける。First, an analysis element feeding mechanism is provided which feeds analysis elements one by one through the analysis element feeding port 1o.
図示の例の分析素子供給機溝は、前記恒温槽１の上部に
積重するよう設けた上部室１６に、分析素子堆積体Ｓを
収納保持する筒状の分析素子堆積体収納部１７を形成し
、この分析素子堆積体Ｓよりその最下方に位置する１つ
の分析素子を送り出す送り出しｔｌｒ４１ｇを設け、こ
の送り出しＩＭ構１８よりの分析素子をその上昇位置に
おいて受は取って前記分析素子供給口１０と同レベルの
降下位置に降下するエレベータ１９を設け、このエレベ
ータ１９が降下位置にあるときにこれに載置された分析
素子を前記分析素子供給口１０を介してＩＩＪ１転テー
ブル２上に送入する送入機構２ｏを設けてＮ成される。The analytical element feeder groove in the illustrated example forms a cylindrical analytical element stack housing section 17 for storing and holding analytical element stacks S in an upper chamber 16 provided so as to be stacked on top of the thermostatic chamber 1. A delivery tlr 41g is provided to send out one analysis element located at the lowest position from this analysis element stack S, and the receiver takes the analysis element from this delivery IM structure 18 in its raised position and transfers it to the analysis element supply port 10. An elevator 19 that descends to the same level as the descending position is provided, and when this elevator 19 is in the descending position, the analytical element placed thereon is sent onto the IIJ1 transfer table 2 through the analytical element child supply port 10. A feeding mechanism 2o is provided to do this.
そして前記エレベータ１９上に載置された分析素子に液
体試料を滴下供給する試料供給し購２１を設ける。A sample supply outlet 21 is provided for dropping a liquid sample onto the analysis element placed on the elevator 19.
詳細に説明すると、前記送り出し機構１８は、回転駆動
される円板３ｏに連結されたクランクアーム３１により
、レール８２上を往復動する送り出しロッド３３を有゛
シ、この送り出しロッド３３が付勢されて図の左方に＃
細し、分析素子堆積体収納部１７内にその底壁１７Ａに
沿ってロッド挿入口８４より突入し、最下方の分析素子
を押し出してこれを出口８５より、上昇位１ｕに位置さ
れているエレベータ１９の載置面４ｏ上に移動せしめる
ものである。To explain in detail, the sending mechanism 18 has a sending rod 33 that reciprocates on a rail 82 by a crank arm 31 connected to a rotationally driven disc 3o, and this sending rod 33 is biased. # on the left side of the diagram
The rod inserts into the analytical element stack housing 17 along the bottom wall 17A through the rod insertion port 84, pushes out the lowest analytical element, and carries it out through the exit 85 into the elevator located at the ascending level 1u. 19 onto the mounting surface 4o.
試料供給機ｆｆ１２１は、ル「＜シてエレベータ１９（
９）
上に載置された分析素子に液体試料を１滴又は数滴滴下
する。The sample feeder ff121 is moved to the elevator 19 (
9) Drop one or several drops of the liquid sample onto the analytical element placed above.
ｎＩＪ記エレベータ１９は、その載置面の両側において
、上下方向に沖びるガイドロッド４１により上下動自在
に支持され、一群のプーリ４２に懸架された駆動ベルト
４３を介してモータ４４によりその上昇位置に上昇され
、又＠線で示す降下位置に降下される。The elevator 19 is vertically movably supported by guide rods 41 extending vertically on both sides of its mounting surface, and is moved to its raised position by a motor 44 via a drive belt 43 suspended on a group of pulleys 42. It is then raised to the lowering position indicated by the @ line.
前記送入機構２０は、例えは前記送り出し機構１８と同
様の構成を有し、送入ロッド４６が付勢されることによ
り、下降位置にあるエレベータ１９上の分析素子が押さ
れて分析素子供給口ｌｏより恒温槽１内に送入される。The feeding mechanism 20 has the same configuration as the feeding mechanism 18, and when the feeding rod 46 is biased, the analytical element on the elevator 19 in the lowered position is pushed and the analytical element is supplied. It is sent into the thermostatic chamber 1 from the opening LO.
又前記測定器１２は、回転テーブル２の外周縁の上面及
び下面とそれぞれ近接して対向する上方部分５ｏと下方
部分５１とを有し、上方部分５゜内には、対応して位置
されている分析素子保持部６の分析素子を当該保持部６
との間に挾圧する挟圧部材が設けられ、下方部分５１内
には、挾圧された分析素子の試薬部Ｒにおける色の濃度
を測定（１０）
する反射型色Ｑ度＃Ｉの検出部、即ち測定用光を前記分
析素子保持部６の貫通孔８を介して分析素子に投射する
光投射体と、当該分析素子よりの反射光を受光する受光
体とが設けられる。The measuring device 12 also has an upper portion 5o and a lower portion 51 that closely face the upper and lower surfaces of the outer peripheral edge of the rotary table 2, respectively, and are located within the upper portion 5° in a corresponding manner. The analytical element in the analytical element holding unit 6 that is in the analytical element holding unit 6 is
A clamping member is provided for clamping between the two, and in the lower part 51 is a reflection type color Q degree #I detection unit that measures the color density in the reagent portion R of the clamped analytical element (10). That is, a light projector that projects measurement light onto the analytical element through the through hole 8 of the analytical element holding section 6, and a light receiver that receives the reflected light from the analytical element are provided.
Ｍｔ＋記分析素子排出口１１は前記分析素子供給口１０
と同様に形成され、これに関連して、当該分析素子耕出
口１１に対応して位置された分析素子保持部６上の分析
素子を恒温槽１外に排出するための１Ｌ例えば貫通孔８
を介して挿入されて分析素子を分析素子保持部６より外
して排出する（至）械的排出機構が設けられる。The Mt+ analytical element outlet 11 is connected to the analytical element inlet 10.
In connection therewith, a 1L through hole 8 for ejecting the analytical element on the analytical element holding part 6 to the outside of the thermostatic chamber 1 located corresponding to the analytical element cultivating port 11 is provided.
A mechanical ejection mechanism is provided for removing and ejecting the analytical element from the analytical element holding part 6 after being inserted through the analytical element holding part 6.
本発明化学分析測定装置は以上のような構成であるから
、図示の例において分析素子堆積体Ｓより分析素子１枚
を送り出す送り出しｆｉｌｉｓ、エレベータ１９及び送
入機ｍ２ｏｚｗびに液体試料供給ＷＩＮｍｚｌにより、
液体試料が加えられた分析素子が分析素子供給口１ｏを
介して、そのときは休止している回転テーブル２の対応
する分析素子保持部に供給される。この分析素子は歩進
的に同転する回転テーブル２の分析素子保持部により保
（１１）
持されて搬送され、回転テーブル２が定められた回数だ
け歩進的に回転した陵に測定器１２に対応する位置にお
いて休止し、この休止時間内に測定５１２による測定が
なされ、その後更に搬送されて分析素子排出口１１に対
応する位置に休止したときに分析素子排出口１］を介し
て恒温槽ｌより排出される。Since the chemical analysis and measurement apparatus of the present invention has the above-described configuration, in the illustrated example, the delivery filis that sends out one analytical element from the analytical element stack S, the elevator 19, the feeding machine m2ozw, and the liquid sample supply WINmzl,
The analytical element to which the liquid sample has been added is supplied via the analytical element supply port 1o to the corresponding analytical element holding section of the rotary table 2, which is at rest at that time. This analytical element is held and conveyed by the analytical element holding part of the rotary table 2 which rotates step by step. During this pause time, the measurement 512 is performed, and when the device is further transported and paused at the position corresponding to the analytical element outlet 11, it is transferred to the thermostatic chamber via the analytical element outlet 1. It is discharged from l.
而して本発明においては、回転テーブル２の分析素子保
持部６ 、６、−−一の隣接するものの角度間隔θの整
数倍の角度関係をもって、分析素子供給口ＩＯ及び分析
素子排出口１１並びに測定器１２が配役されていると共
に、回転テーブル２は角度θを回転の単位として歩進的
に回転されしかもこの歩進的回転における休止位置は、
分析素子保持１１Ｓ６．６．−−−の何れかのものが必
ず分析素子供給口ＩＯ１分析素子排出口１１及び測定器
１２に対応して位置される位置であるため、回転テープ
σ 飼
ル２の歩進的回転における１回の休止時間において、分
析素子供給口１０より対応する分析素子保持部へ反応せ
しめるべき分析素子を供給すること、測定器１２により
対応する分析素子保持部の分析素子の所要の測定を行な
うこと、及び分析素子排出口１１より対応する分析素子
保持部の測定が完了した分析素子を排出すること、の合
計８種の処理操作を同時に行なうことができ、しかもこ
の同時処理操作を各休止時間毎に行なうことができるの
で、極めて高い効率で所要の化学分析処理を達成するこ
とができる。In the present invention, the analytical element inlet IO, analytical element outlet 11, and The measuring device 12 is installed, and the rotary table 2 is rotated step by step using an angle θ as a unit of rotation, and the rest position in this stepwise rotation is as follows.
Analytical element holding 11S6.6. --- is always located at a position corresponding to the analytical element inlet IO1, the analytical element outlet 11, and the measuring device 12. During the downtime, the analytical element to be reacted is supplied from the analytical element supply port 10 to the corresponding analytical element holding part, the required measurement of the analytical element in the corresponding analytical element holding part is carried out by the measuring instrument 12, and A total of eight types of processing operations can be performed at the same time, including discharging analytical elements that have completed measurement from the corresponding analytical element holding portions from the analytical element discharge port 11, and this simultaneous processing operation is performed at each rest time. Therefore, the required chemical analysis processing can be achieved with extremely high efficiency.
そして反応に必要な時間は、分析素子供給口ｌＯから回
転テーブル２の分析素子保持部６に分析素子が供給され
た時点から当該分析素子が測定器１２の位置に到達する
までの時間に一致すればよいから、分析素子保持部６．
６．−−一の角度間隔θ、分析素子供給口１０に対する
測定器１２の角度関係即ちこれをｎθ（ｎは整数）で表
わしたときのｎの値、詑びに回転テーブル２の歩進的回
転における１回の休止時間の隣さ及び１回の（ロ）転動
作の所要時間を適宜設定することにより、所要の反応時
間を得ることかできる。The time required for the reaction must match the time from when the analytical element is supplied from the analytical element supply port IO to the analytical element holding part 6 of the rotary table 2 until the analytical element reaches the position of the measuring instrument 12. The analytical element holding section 6.
6. --An angular interval θ, the angular relationship of the measuring device 12 to the analyte sample supply port 10, that is, the value of n when this is expressed as nθ (n is an integer), and 1 in the stepwise rotation of the rotary table 2. The required reaction time can be obtained by appropriately setting the adjacency of the rest times and the time required for one rolling motion.
又本発明においては、回転テーブル２をその分（１３）
析素子保持部８ 、６、−−一の角度間隔θを１回の歩
進的回転の角度とせず、θの整数倍の角度を単位として
歩進的回転を行なわせるようにしてもよい。この場合に
は、１回の歩進的回転の角度をｍθ（ｍは整数）とすれ
は、−の分析素子保持部に対しｍ＠目に後続する分析素
子保持部が順次測定器１２等に対応する位置に到達する
こととなり、供給された分析素子は少なくとも１回測定
器１２に対応する位置を通過した後に測定器１２に対応
した位置に到達して測定されるようになる。勿論この場
合においては分析素子保持部の全数との関係において前
記整数ｍの値を選ぶことが必要となるが、反応に比較的
長い時間を必要とする場合に、装置を大型とすることな
く、これを容易に達成することができる。In addition, in the present invention, the rotary table 2 is arranged so that the angular interval θ of one (13) analysis element holding portions 8, 6, -- is not the angle of one stepwise rotation, but an angle that is an integral multiple of θ. Stepwise rotation may be performed as a unit. In this case, if the angle of one stepwise rotation is mθ (m is an integer), then the analytical element holder that follows the m@th analytical element holder is sequentially attached to the measuring instrument 12 etc. with respect to the negative analytical element holder. After passing through the position corresponding to the measuring device 12 at least once, the supplied analytical element reaches the position corresponding to the measuring device 12 and is measured. Of course, in this case, it is necessary to select the value of the integer m in relation to the total number of analytical element holding parts, but when the reaction requires a relatively long time, it is possible to avoid making the apparatus large-sized. This can be easily achieved.
更に、同一の分析素子について、所定の反応時間を挾ん
で２回以上に亘って測定を行なうべき場合においては、
上述したような、固定された単位角度で回転テーブル２
を歩進的に回転せしめる方式において、膜数回訓定器１
２に対応する位置に（１４）
休止せしめるようにすることができ、更に、特定の閤号
によって回転テーブル２の回転駆動源を制御して、特定
の分析素子が供給された分析素子保持部を測定器１２に
対応する位置Ｇこ急行せしめて測定を行ない、測定終了
俊元の梳本的プロセスに戻すようにすることもできる。Furthermore, in cases where the same analytical element should be measured twice or more with a predetermined reaction time in between,
Rotary table 2 at a fixed unit angle as described above.
In the method of rotating stepwise, the membrane training device 1 is rotated several times.
(14) at a position corresponding to 2, and furthermore, the rotational drive source of the rotary table 2 can be controlled by a specific lock number to control the analytical element holder to which a specific analytical element has been supplied. It is also possible to make the measuring device 12 move quickly to the corresponding position G, perform the measurement, and then return to the original Otsumoto-like process when the measurement is completed.
以上のように、回転テーブル２を利用していることから
、本発明においては槙々の要請に十分に応えることがで
きる。回転テーブル２の制御のための具体的手段として
は、公知の制団１方式を利用すればよい。As described above, since the rotary table 2 is used, the present invention can fully meet the various demands. As a specific means for controlling the rotary table 2, the known System 1 method may be used.
本発明においては以上のように、小型であってしかも高
い効率で液体試料の化学分析を達成することができるが
、図示の実施例においては更に次のような利点が得られ
る。即ち、分析素子保持部６の各々を四部７により購成
せしめ、当該四部７の輪郭を分析素子の外形に適合せし
めると共にその底壁面７４を回転テーブル２０半径方向
内方＆ご向うに従って下方に傾斜する斜面としているた
め、回転テーブル２の外周縁の外部から分析素子を送（
１５）
人することが容易に且つ確実に達成され、分析素子が確
実に所定の位置状態で分析素子保持部に落ち着き、更に
用動部分を含む保持機構を妾することなく、回転テーブ
ル２の回転に対して事実上分析素子を回転テーブル２に
固定的に保持された状態とすることができ、その搬送を
位置ズレ等の弊害を伴わずに確実に達成することができ
、大きな酷頼性が得られる。As described above, in the present invention, it is possible to achieve chemical analysis of a liquid sample with high efficiency in a small size, but the illustrated embodiment further provides the following advantages. That is, each of the analytical element holding parts 6 is made up of four parts 7, and the contours of the four parts 7 are adapted to the outer shape of the analytical element, and the bottom wall surface 74 is inclined downwardly inward and toward the rotary table 20 in the radial direction. Because it has a slope that allows the analysis element to be sent from outside the outer periphery of the rotary table 2 (
15) Rotation of the rotary table 2 is easily and reliably achieved, the analytical element is securely settled in the analytical element holding part in a predetermined position, and furthermore, the rotation of the rotary table 2 is achieved without involving the holding mechanism including the movable part. In fact, the analytical element can be held fixedly on the rotary table 2, and its transportation can be achieved reliably without any adverse effects such as misalignment, resulting in great reliability. can get.
以上本発明を一実施例を中心に説明したが、本発明にお
いては種々変更を加えることができる。Although the present invention has been described above focusing on one embodiment, various modifications can be made to the present invention.
例えば、実施例における分析素子供給機溝は具体的な一
例を示すものであって、他の同様な機能を有するもの、
Ｍｌｊち液体試薬が加えられた分析素子を１つづつ分析
素子供給口１０より回転テーブル２上に送入し得るもの
を用いてもよい。又分析素子堆積体収納部１７を膜数設
けてその各々には種類の異なる分析素子を収納し、適当
な選択−溝に１ よって選択された分析素子を供給
するようにすること、更にこの場合において、選択され
た分析素子の種類に応じて回転テーブル２の動作を制■
１することか可能である。更に回転テーブル２の分析素
子保持部についても既述の例に限られる必要はなく、特
に測定器１２が分析素子の上面において測定可能なもの
であれば貫通孔８は不要である。又測定器１２も任意の
もの、例えば触針を有するもの等を利用することができ
る。For example, the analyte feeder groove in the example shows a specific example, and other devices having a similar function,
It is also possible to use a device that can feed analytical elements to which a liquid reagent has been added one by one onto the rotary table 2 from the analytical element supply port 10. In addition, a number of analytical element stack housing sections 17 are provided, each of which stores a different type of analytical element, and the analytical element selected by the appropriate selection groove is supplied. , the operation of the rotary table 2 is controlled according to the type of analysis element selected.
It is possible to do 1. Further, the analytical element holding portion of the rotary table 2 is not limited to the above-mentioned example, and the through hole 8 is not required especially if the measuring device 12 is capable of measuring the upper surface of the analytical element. Further, any measuring device 12 can be used, for example, one having a stylus.
以上のように本発明によれば、小型にして高い効率で液
体試料の化学分析を達成することのできる化学分析測定
装置を提供することができる。As described above, according to the present invention, it is possible to provide a chemical analysis and measurement device that is small in size and can perform chemical analysis of a liquid sample with high efficiency.
第１図は本発明化学分析測定装置の一実施例の説明用断
面図、第２図は回転テーブルの説明用平面図、第３図は
分析素子保持部についての説明用断面図■図である。
■・・・恒温槽 ２・・・回転テーブル６・
・・分析素子保持部 ７・・・四部８・・・貫通孔
ＩＯ・・・分析素子供給口１１・・・分析素
子排出口 １２・・・測定器１６・・・上部室
１１・・・分析素子堆積体収納部
１８・・・送りａｌ Ｌ機構（１７）
１９、・、エレベータ ２ｏ・・・送入機溝２１・
・・液体試料供給機向
Ｅ・・・分析素子 Ｓ・・・分析素子堆積体Ｒ
・・・試薬部
γ１図
第３図Fig. 1 is an explanatory cross-sectional view of one embodiment of the chemical analysis and measurement device of the present invention, Fig. 2 is an explanatory plan view of the rotary table, and Fig. 3 is an explanatory cross-sectional view of the analytical element holding part. . ■... Constant temperature bath 2... Rotary table 6.
...Analysis element holding part 7...Four parts 8...Through hole
IO...Analyzing element inlet 11...Analyzing element outlet 12...Measuring instrument 16...Upper chamber
11... Analytical element stack housing section
18...Feed al L mechanism (17) 19...Elevator 2o...Feeder groove 21.
...Liquid sample supply device E...Analytical element S...Analytical element stack R
...Reagent part γ1 diagram Figure 3
Claims (1)
って膜数の分析素子保持部を有する回転テーブルと、前
記恒温槽に形成した分析素子挿入口及び分析素子排出口
と、前記恒温槽内において前記回転テーブルの外周縁に
対向するよう設けた分析素子用測定器と、前記回転テー
ブルを歩進的に回転せしめる駆動機構とを具えて成り、
前記回転テーブルの歩進的回転における休止時に、前記
分析素子挿入口及び分析素子排出口並びに前記分析素子
用測定器の各々に対応する位置にそれぞれ前記回転テー
ブルの何れかの分相素子保持部が同時に位置されること
を特徴とする化学分析測定装置。1) a constant temperature chamber, a rotary table provided in the constant temperature chamber and having a number of analytical element holding parts along the outer periphery thereof, and an analytical element insertion port and an analytical element outlet formed in the constant temperature chamber; comprising: an analytical element measuring instrument disposed to face the outer periphery of the rotary table in the thermostatic chamber; and a drive mechanism that rotates the rotary table step by step;
When the rotary table is at rest in the stepwise rotation, one of the phase splitting element holding parts of the rotary table is located at a position corresponding to each of the analytical element insertion port, the analytical element outlet, and the analytical element measuring device. A chemical analysis and measurement device characterized in that they are located at the same time.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3939082A JPS58156835A (en) | 1982-03-15 | 1982-03-15 | Chemical analysis and measurement device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3939082A JPS58156835A (en) | 1982-03-15 | 1982-03-15 | Chemical analysis and measurement device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS58156835A true JPS58156835A (en) | 1983-09-17 |
Family
ID=12551672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3939082A Pending JPS58156835A (en) | 1982-03-15 | 1982-03-15 | Chemical analysis and measurement device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58156835A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4795613A (en) * | 1984-07-17 | 1989-01-03 | Konishiroku Photo Industry Co., Ltd. | Biochemical analyzer |
| US5081038A (en) * | 1987-03-12 | 1992-01-14 | Fuji Photo Film Co., Ltd. | Analytical method and apparatus using chemical analytical slides |
| USRE34012E (en) * | 1984-07-17 | 1992-07-28 | Konishiroku Photo Industry Co., Ltd. | Biochemical analyzer |
| EP0679895A1 (en) * | 1994-04-29 | 1995-11-02 | Johnson & Johnson Clinical Diagnostics, Inc. | Analyzer elevator assembly |
| JP2013079928A (en) * | 2011-10-05 | 2013-05-02 | Techno Medica Co Ltd | Qualitative analyzer |
| JP2013079926A (en) * | 2011-10-05 | 2013-05-02 | Techno Medica Co Ltd | Qualitative analyzer |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5381292A (en) * | 1976-12-17 | 1978-07-18 | Eastman Kodak Co | Chemical analyzer |
| JPS5728258A (en) * | 1980-06-16 | 1982-02-15 | Eastman Kodak Co | Apparatus to be used for chemical analyzer |
-
1982
- 1982-03-15 JP JP3939082A patent/JPS58156835A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5381292A (en) * | 1976-12-17 | 1978-07-18 | Eastman Kodak Co | Chemical analyzer |
| JPS5728258A (en) * | 1980-06-16 | 1982-02-15 | Eastman Kodak Co | Apparatus to be used for chemical analyzer |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4795613A (en) * | 1984-07-17 | 1989-01-03 | Konishiroku Photo Industry Co., Ltd. | Biochemical analyzer |
| USRE34012E (en) * | 1984-07-17 | 1992-07-28 | Konishiroku Photo Industry Co., Ltd. | Biochemical analyzer |
| US5081038A (en) * | 1987-03-12 | 1992-01-14 | Fuji Photo Film Co., Ltd. | Analytical method and apparatus using chemical analytical slides |
| EP0679895A1 (en) * | 1994-04-29 | 1995-11-02 | Johnson & Johnson Clinical Diagnostics, Inc. | Analyzer elevator assembly |
| JP2013079928A (en) * | 2011-10-05 | 2013-05-02 | Techno Medica Co Ltd | Qualitative analyzer |
| JP2013079926A (en) * | 2011-10-05 | 2013-05-02 | Techno Medica Co Ltd | Qualitative analyzer |
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