JPS5799591A - 7alpha-methoxy-3-cephem derivative, its preparation and antibacterial agent comprising it - Google Patents
7alpha-methoxy-3-cephem derivative, its preparation and antibacterial agent comprising itInfo
- Publication number
- JPS5799591A JPS5799591A JP17386580A JP17386580A JPS5799591A JP S5799591 A JPS5799591 A JP S5799591A JP 17386580 A JP17386580 A JP 17386580A JP 17386580 A JP17386580 A JP 17386580A JP S5799591 A JPS5799591 A JP S5799591A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- methoxy
- antibacterial agent
- compound shown
- cephem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 7α-methoxy-3-cephem derivative shown by the formula I(R1 is H, OH; R2 is a group shown by the formula II, etc.) and its nontoxic salt.
EXAMPLE: 7β-[D-2-(6,7-Dihydroxychromone-3-carboxamide)-2-(4-hydroxyphenyl) acetamido]-7α-methoxy-3-[5-carboxymethyl-2-(1,3,4-thiadiazolyl)]thiomethyl-3- cephem-4-carboxylic acid.
USE: An antibacterial agent. Effective against Gram-positive and Gram-negative bacteria, especially against slightly curable bacteria such as Pseudomonas aeruginosa and bacteria capable of producing β-lactamase.
PROCESS: A compound shown by the formula III or its salt is reacted with a compound shown by the formula IV or its reactive derivative (e.g., acid chloride) in an inert solvent in the presence or absence of a basic reagent or a silylating agent, to give the desired compound shown by the formula I.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17386580A JPS5799591A (en) | 1980-12-11 | 1980-12-11 | 7alpha-methoxy-3-cephem derivative, its preparation and antibacterial agent comprising it |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17386580A JPS5799591A (en) | 1980-12-11 | 1980-12-11 | 7alpha-methoxy-3-cephem derivative, its preparation and antibacterial agent comprising it |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5799591A true JPS5799591A (en) | 1982-06-21 |
Family
ID=15968561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP17386580A Pending JPS5799591A (en) | 1980-12-11 | 1980-12-11 | 7alpha-methoxy-3-cephem derivative, its preparation and antibacterial agent comprising it |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5799591A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6222694A (en) * | 1985-07-23 | 1987-01-30 | 三洋電機株式会社 | Washing machine |
-
1980
- 1980-12-11 JP JP17386580A patent/JPS5799591A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6222694A (en) * | 1985-07-23 | 1987-01-30 | 三洋電機株式会社 | Washing machine |
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