JPS5799591A - 7alpha-methoxy-3-cephem derivative, its preparation and antibacterial agent comprising it - Google Patents

7alpha-methoxy-3-cephem derivative, its preparation and antibacterial agent comprising it

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Publication number
JPS5799591A
JPS5799591A JP17386580A JP17386580A JPS5799591A JP S5799591 A JPS5799591 A JP S5799591A JP 17386580 A JP17386580 A JP 17386580A JP 17386580 A JP17386580 A JP 17386580A JP S5799591 A JPS5799591 A JP S5799591A
Authority
JP
Japan
Prior art keywords
formula
methoxy
antibacterial agent
compound shown
cephem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP17386580A
Other languages
Japanese (ja)
Inventor
Yoshimasa Machida
Isao Saito
Seiichiro Nomoto
Shigeto Negi
Hironori Ikuta
Kyosuke Kito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Priority to JP17386580A priority Critical patent/JPS5799591A/en
Publication of JPS5799591A publication Critical patent/JPS5799591A/en
Pending legal-status Critical Current

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  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 7α-methoxy-3-cephem derivative shown by the formula I(R1 is H, OH; R2 is a group shown by the formula II, etc.) and its nontoxic salt.
EXAMPLE: 7β-[D-2-(6,7-Dihydroxychromone-3-carboxamide)-2-(4-hydroxyphenyl) acetamido]-7α-methoxy-3-[5-carboxymethyl-2-(1,3,4-thiadiazolyl)]thiomethyl-3- cephem-4-carboxylic acid.
USE: An antibacterial agent. Effective against Gram-positive and Gram-negative bacteria, especially against slightly curable bacteria such as Pseudomonas aeruginosa and bacteria capable of producing β-lactamase.
PROCESS: A compound shown by the formula III or its salt is reacted with a compound shown by the formula IV or its reactive derivative (e.g., acid chloride) in an inert solvent in the presence or absence of a basic reagent or a silylating agent, to give the desired compound shown by the formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP17386580A 1980-12-11 1980-12-11 7alpha-methoxy-3-cephem derivative, its preparation and antibacterial agent comprising it Pending JPS5799591A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP17386580A JPS5799591A (en) 1980-12-11 1980-12-11 7alpha-methoxy-3-cephem derivative, its preparation and antibacterial agent comprising it

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17386580A JPS5799591A (en) 1980-12-11 1980-12-11 7alpha-methoxy-3-cephem derivative, its preparation and antibacterial agent comprising it

Publications (1)

Publication Number Publication Date
JPS5799591A true JPS5799591A (en) 1982-06-21

Family

ID=15968561

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17386580A Pending JPS5799591A (en) 1980-12-11 1980-12-11 7alpha-methoxy-3-cephem derivative, its preparation and antibacterial agent comprising it

Country Status (1)

Country Link
JP (1) JPS5799591A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6222694A (en) * 1985-07-23 1987-01-30 三洋電機株式会社 Washing machine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6222694A (en) * 1985-07-23 1987-01-30 三洋電機株式会社 Washing machine

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