JPS5625188A - 7alpha-methoxycephalosporin - Google Patents

7alpha-methoxycephalosporin

Info

Publication number
JPS5625188A
JPS5625188A JP9991779A JP9991779A JPS5625188A JP S5625188 A JPS5625188 A JP S5625188A JP 9991779 A JP9991779 A JP 9991779A JP 9991779 A JP9991779 A JP 9991779A JP S5625188 A JPS5625188 A JP S5625188A
Authority
JP
Japan
Prior art keywords
formula
compound
protecting group
carboxyl
gram
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9991779A
Other languages
Japanese (ja)
Inventor
Isamu Saikawa
Shuntaro Takano
Hiroyuki Imaizumi
Isamu Takakura
Yuichi Ochiai
Takashi Yasuda
Hideo Taki
Masaru Tai
Hiroshi Kodama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Priority to JP9991779A priority Critical patent/JPS5625188A/en
Priority to GB7933266A priority patent/GB2048241B/en
Priority to IN1014/CAL/79A priority patent/IN151442B/en
Priority to AU51290/79A priority patent/AU533685B2/en
Priority to DE19792939747 priority patent/DE2939747A1/en
Priority to IL58374A priority patent/IL58374A0/en
Priority to MX798417U priority patent/MX6640E/en
Priority to CA000336866A priority patent/CA1136615A/en
Priority to NL7907344A priority patent/NL191416C/en
Priority to AT0649779A priority patent/AT366388B/en
Priority to FR7924739A priority patent/FR2455051A1/en
Priority to PT70282A priority patent/PT70282A/en
Priority to FI793076A priority patent/FI793076A/en
Priority to CH895079A priority patent/CH642664A5/en
Priority to US06/081,835 priority patent/US4263292A/en
Priority to SE7908242A priority patent/SE448996B/en
Priority to IT50455/79A priority patent/IT1164051B/en
Priority to DD79216049A priority patent/DD146603A5/en
Priority to HU79TO1118A priority patent/HU180307B/en
Priority to AR278394A priority patent/AR228425A1/en
Priority to DK418579A priority patent/DK418579A/en
Priority to PH23137A priority patent/PH16244A/en
Priority to ES492444A priority patent/ES8104304A1/en
Priority to AT71781A priority patent/AT368164B/en
Priority to AT71481A priority patent/AT368162B/en
Priority to AT71681A priority patent/AT368163B/en
Publication of JPS5625188A publication Critical patent/JPS5625188A/en
Priority to AR285525A priority patent/AR227922A1/en
Priority to AR285524A priority patent/AR226897A1/en
Priority to AR285526A priority patent/AR231724A1/en
Priority to IN651/CAL/82A priority patent/IN154829B/en
Priority to IN652/CAL/82A priority patent/IN154841B/en
Priority to SE8405101A priority patent/SE8405101L/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Cephalosporin Compounds (AREA)

Abstract

NEW MATERIAL:The titled compound of formula I (R1 and R3 are lower alkyls; R2 is alkyl; R4 is an organic group linked via O or S; R5 is H or carboxyl-protecting group; R6 is OH-protecting group; n is 0, 1 or 2), and a salt thereof.
EXAMPLE: Sodium salt of 7β-[ D-α-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)- β-(S)-methoxybutanamido ]-7α-methoxy-3-[ 5-(1-methyl-1H-tetrazolyl)thiomethyl]-Δ3-cephem-4-carboxylic acid.
USE: An antimicrobial agent active against Gram-positive and Gram-negative bacteria, and an intermediate therefor.
PROCESS: A compound of formula II is reacted with a reactive derivative at the carboxyl group of a compound expressed by formula III, preferably an acid chloride or acid azide, preferably at -40W30°C, to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP9991779A 1978-06-13 1979-08-07 7alpha-methoxycephalosporin Pending JPS5625188A (en)

Priority Applications (32)

Application Number Priority Date Filing Date Title
JP9991779A JPS5625188A (en) 1979-08-07 1979-08-07 7alpha-methoxycephalosporin
GB7933266A GB2048241B (en) 1979-04-23 1979-09-26 7a-methoxycenphalosporins and process for producing the same
IN1014/CAL/79A IN151442B (en) 1979-04-23 1979-09-26
AU51290/79A AU533685B2 (en) 1979-04-23 1979-09-28 72-methoxycephalosporins
DE19792939747 DE2939747A1 (en) 1979-04-23 1979-10-01 NEW 7 ALPHA METHOXYCEPHALOSPORINE AND METHOD FOR THE PRODUCTION THEREOF
IL58374A IL58374A0 (en) 1979-04-23 1979-10-03 Novel 7 -methoxycephalosporins and process for producing the same
MX798417U MX6640E (en) 1979-04-23 1979-10-03 PROCEDURE FOR THE PREPARATION OF 7 ALPHA-METOXYCHEPHALOSPORINS
CA000336866A CA1136615A (en) 1979-04-23 1979-10-03 7.alpha.-METHOXYCEPHALOSPORINS AND PROCESS FOR PRODUCING THE SAME
NL7907344A NL191416C (en) 1979-04-23 1979-10-03 Alpha-methoxycephalosporins and pharmaceutical composition containing them.
SE7908242A SE448996B (en) 1979-04-23 1979-10-04 7ALFA METOXICE PHALOSPORINE DERIVATIVES AND PROCEDURES FOR PREPARING THEREOF
FR7924739A FR2455051A1 (en) 1979-04-23 1979-10-04 NOVEL 7A-METHOXYCEPHALOSPORINS, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
PT70282A PT70282A (en) 1979-04-23 1979-10-04 Process for preparing novel 7alpha-methoxycephalosporine
FI793076A FI793076A (en) 1979-04-23 1979-10-04 NYA 7 ALPHA-METHOXIC FALOSPORINER FOR FARING WITHOUT FRAMSTAELLNING
CH895079A CH642664A5 (en) 1979-04-23 1979-10-04 7ALPHA-METHOXYCEPHALOSPORINE AND METHOD FOR THE PRODUCTION THEREOF.
US06/081,835 US4263292A (en) 1978-06-13 1979-10-04 7α-methoxycephalosporins and pharmaceutical composition comprising the same
AT0649779A AT366388B (en) 1979-04-23 1979-10-04 METHOD FOR PRODUCING NEW 7 ALPHA METHOXYCEPHALOSPORINES
IT50455/79A IT1164051B (en) 1979-04-23 1979-10-04 7 ALPHA METHOXYPHALOSPORINE PROCEDURE FOR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DD79216049A DD146603A5 (en) 1979-04-23 1979-10-05 PROCESS FOR THE PREPARATION OF NEW 7 ALPHA-METHOXYCEPHALOSPORINES
HU79TO1118A HU180307B (en) 1979-04-23 1979-10-05 Process for producing new 7-beta-square bracket bracket-2,3-dioxo-1-piperazine-carboxamido-aracket closed-hydroxy-amido-square bracket closed-7-alpha-metoxy -ceph-3-eme-4-carboxylic acid derivatives
AR278394A AR228425A1 (en) 1979-04-23 1979-10-05 PREPARATION PROCEDURE OF 7ALPHA-METOXICEFALOSPORINA
DK418579A DK418579A (en) 1979-04-23 1979-10-05 PROCEDURE FOR THE PREPARATION OF 7ALPHAMETHOXYCEPHALOSPORINES
PH23137A PH16244A (en) 1979-04-23 1979-10-05 7-alpha-methoxycephalosporins and pharmaceutical composition comprising the same
ES492444A ES8104304A1 (en) 1979-04-23 1980-06-13 A METHOD FOR THE PRODUCTION OF A 7A-METOXICEFALOSPORINA (Machine-translation by Google Translate, not legally binding)
AT71781A AT368164B (en) 1979-04-23 1981-02-16 METHOD FOR PRODUCING NEW 7ALPHAMETHOXYCEPHALOSPORINES
AT71481A AT368162B (en) 1979-04-23 1981-02-16 METHOD FOR PRODUCING NEW 7ALPHAMETHYOXYCEPHALOSPORINES
AT71681A AT368163B (en) 1979-04-23 1981-02-16 METHOD FOR PRODUCING NEW 7ALPHAMETHOXYCEPHALOSPORINES
AR285525A AR227922A1 (en) 1979-04-23 1981-05-29 PREPARATION PROCEDURE OF 7ALPHA-METOXICEFALOSPORINA
AR285524A AR226897A1 (en) 1979-04-23 1981-05-29 PREPARATION PROCEDURE FOR 72 ALPHA-METOXICEFALOSPORINA
AR285526A AR231724A1 (en) 1979-04-23 1981-05-29 PREPARATION PROCEDURE FOR 7A-METOXYCHEPHALOSPORIN
IN651/CAL/82A IN154829B (en) 1979-04-23 1982-06-07
IN652/CAL/82A IN154841B (en) 1979-04-23 1982-06-07
SE8405101A SE8405101L (en) 1979-04-23 1984-10-11 NEW 7ALFA METOXICE PHALOSPORINES AND PROCEDURES FOR PRODUCING THEREOF

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9991779A JPS5625188A (en) 1979-08-07 1979-08-07 7alpha-methoxycephalosporin

Publications (1)

Publication Number Publication Date
JPS5625188A true JPS5625188A (en) 1981-03-10

Family

ID=14260124

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9991779A Pending JPS5625188A (en) 1978-06-13 1979-08-07 7alpha-methoxycephalosporin

Country Status (1)

Country Link
JP (1) JPS5625188A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61180789A (en) * 1985-02-01 1986-08-13 ブリストル―マイアーズ　スクイブ　コムパニー Crystalline triethylamine salt of cephbperazone

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61180789A (en) * 1985-02-01 1986-08-13 ブリストル―マイアーズ　スクイブ　コムパニー Crystalline triethylamine salt of cephbperazone

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