JPS577482A - 1,3-benzoxazine derivative and its preparation - Google Patents

1,3-benzoxazine derivative and its preparation

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Publication number
JPS577482A
JPS577482A JP8202080A JP8202080A JPS577482A JP S577482 A JPS577482 A JP S577482A JP 8202080 A JP8202080 A JP 8202080A JP 8202080 A JP8202080 A JP 8202080A JP S577482 A JPS577482 A JP S577482A
Authority
JP
Japan
Prior art keywords
formula
alkyl
benzoxazine
halogen
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8202080A
Other languages
Japanese (ja)
Inventor
Atsusuke Terada
Kazuyuki Wachi
Hidekazu Mitsusaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP8202080A priority Critical patent/JPS577482A/en
Publication of JPS577482A publication Critical patent/JPS577482A/en
Pending legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formula I (R1 is alkyl or aryl; R2 is alkyl or together with R1 forms an alkylene; R3 is H, alkyl, alkoxyl or halogen).
EXAMPLE: 2,2-Dimethyl-3-(2-pyridylthio)-4-oxo-4H-1,3-benzoxazine.
USE: An anti-inflammatory agent.
PROCESS: An imidoyl halide derivative of a 1,3-benzoxazine expressed by formula II (X is halogen) is reacted with 2-mercaptopyridine N-oxide at a molar ratio of 1:2 or equimolar amounts in the presence of a base, e.g. triethylamine, in a solvent, e.g. methylene chloride, at 30W100°C to give an intermediate product of formula III or IV, which is then heated in the absence or presence of an organic solvent, e.g. methylene chloride, at 30W100°C to afford the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP8202080A 1980-06-17 1980-06-17 1,3-benzoxazine derivative and its preparation Pending JPS577482A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8202080A JPS577482A (en) 1980-06-17 1980-06-17 1,3-benzoxazine derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8202080A JPS577482A (en) 1980-06-17 1980-06-17 1,3-benzoxazine derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS577482A true JPS577482A (en) 1982-01-14

Family

ID=13762832

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8202080A Pending JPS577482A (en) 1980-06-17 1980-06-17 1,3-benzoxazine derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS577482A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0307226A2 (en) * 1987-09-11 1989-03-15 American Cyanamid Company Process for the preparation of a macrolide compound

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0307226A2 (en) * 1987-09-11 1989-03-15 American Cyanamid Company Process for the preparation of a macrolide compound

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