JPS5767544A - Improved preparation of 1-2(allylphenyxy)-3-isopropylaminopropan-2-ol - Google Patents
Improved preparation of 1-2(allylphenyxy)-3-isopropylaminopropan-2-olInfo
- Publication number
- JPS5767544A JPS5767544A JP14265480A JP14265480A JPS5767544A JP S5767544 A JPS5767544 A JP S5767544A JP 14265480 A JP14265480 A JP 14265480A JP 14265480 A JP14265480 A JP 14265480A JP S5767544 A JPS5767544 A JP S5767544A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- reacted
- isopropylamino
- propanediol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the titled compound useful as an antiarrhythmic agent easily in high yield at a low cost, by reacting 3-isopropylamino-1,2-propanediol as a starting material with ethyl carbonate, and converting the resultant novel intermediate oxazolidinone derivative into the titled compound.
CONSTITUTION: 3-Isopropylamino-1,2-propanediol of formulaIis reacted with ethyl carbonate to give a 5-hydroxymethyl-3-isopropyl-2-oxazolidinone of formula II, which is then reacted with p-toluenesulfonyl chloride in pyridine at room temperature to afford a compound of formula III. The resultant compound of formula III is reacted with an alkaline metallic salt of 2-allylphenol in DMF at 60W100°C to give a compound of formula IV, which is then refluxed in a mixed solution of 4N- NaOH-ethanol (1:3) to afford the aimed compound of formula V. The optimal concentration of the alkali is such that the final concentration of 1N is reached. The concentration higher than the valve or a temperature of 100°C or above causes the isomerization of the alkyl group.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14265480A JPS5767544A (en) | 1980-10-13 | 1980-10-13 | Improved preparation of 1-2(allylphenyxy)-3-isopropylaminopropan-2-ol |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14265480A JPS5767544A (en) | 1980-10-13 | 1980-10-13 | Improved preparation of 1-2(allylphenyxy)-3-isopropylaminopropan-2-ol |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5767544A true JPS5767544A (en) | 1982-04-24 |
Family
ID=15320383
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14265480A Pending JPS5767544A (en) | 1980-10-13 | 1980-10-13 | Improved preparation of 1-2(allylphenyxy)-3-isopropylaminopropan-2-ol |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5767544A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5034535A (en) * | 1988-04-22 | 1991-07-23 | Astra Pharmaceutical Production Aktiebolag | Process for S-metoprolol via oxazolidin-2-one |
-
1980
- 1980-10-13 JP JP14265480A patent/JPS5767544A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5034535A (en) * | 1988-04-22 | 1991-07-23 | Astra Pharmaceutical Production Aktiebolag | Process for S-metoprolol via oxazolidin-2-one |
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