JPS5767544A - Improved preparation of 1-2(allylphenyxy)-3-isopropylaminopropan-2-ol - Google Patents

Improved preparation of 1-2(allylphenyxy)-3-isopropylaminopropan-2-ol

Info

Publication number
JPS5767544A
JPS5767544A JP14265480A JP14265480A JPS5767544A JP S5767544 A JPS5767544 A JP S5767544A JP 14265480 A JP14265480 A JP 14265480A JP 14265480 A JP14265480 A JP 14265480A JP S5767544 A JPS5767544 A JP S5767544A
Authority
JP
Japan
Prior art keywords
compound
formula
reacted
isopropylamino
propanediol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14265480A
Other languages
Japanese (ja)
Inventor
Sachio Ono
Seishi Mizukoshi
Osamu Komatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Maruko Pharmaceutical Co Ltd
Original Assignee
Maruko Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maruko Pharmaceutical Co Ltd filed Critical Maruko Pharmaceutical Co Ltd
Priority to JP14265480A priority Critical patent/JPS5767544A/en
Publication of JPS5767544A publication Critical patent/JPS5767544A/en
Pending legal-status Critical Current

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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as an antiarrhythmic agent easily in high yield at a low cost, by reacting 3-isopropylamino-1,2-propanediol as a starting material with ethyl carbonate, and converting the resultant novel intermediate oxazolidinone derivative into the titled compound.
CONSTITUTION: 3-Isopropylamino-1,2-propanediol of formulaIis reacted with ethyl carbonate to give a 5-hydroxymethyl-3-isopropyl-2-oxazolidinone of formula II, which is then reacted with p-toluenesulfonyl chloride in pyridine at room temperature to afford a compound of formula III. The resultant compound of formula III is reacted with an alkaline metallic salt of 2-allylphenol in DMF at 60W100°C to give a compound of formula IV, which is then refluxed in a mixed solution of 4N- NaOH-ethanol (1:3) to afford the aimed compound of formula V. The optimal concentration of the alkali is such that the final concentration of 1N is reached. The concentration higher than the valve or a temperature of 100°C or above causes the isomerization of the alkyl group.
COPYRIGHT: (C)1982,JPO&Japio
JP14265480A 1980-10-13 1980-10-13 Improved preparation of 1-2(allylphenyxy)-3-isopropylaminopropan-2-ol Pending JPS5767544A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14265480A JPS5767544A (en) 1980-10-13 1980-10-13 Improved preparation of 1-2(allylphenyxy)-3-isopropylaminopropan-2-ol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14265480A JPS5767544A (en) 1980-10-13 1980-10-13 Improved preparation of 1-2(allylphenyxy)-3-isopropylaminopropan-2-ol

Publications (1)

Publication Number Publication Date
JPS5767544A true JPS5767544A (en) 1982-04-24

Family

ID=15320383

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14265480A Pending JPS5767544A (en) 1980-10-13 1980-10-13 Improved preparation of 1-2(allylphenyxy)-3-isopropylaminopropan-2-ol

Country Status (1)

Country Link
JP (1) JPS5767544A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5034535A (en) * 1988-04-22 1991-07-23 Astra Pharmaceutical Production Aktiebolag Process for S-metoprolol via oxazolidin-2-one

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5034535A (en) * 1988-04-22 1991-07-23 Astra Pharmaceutical Production Aktiebolag Process for S-metoprolol via oxazolidin-2-one

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