JPS5746977A - Novel prostacyclin and its preparation - Google Patents
Novel prostacyclin and its preparationInfo
- Publication number
- JPS5746977A JPS5746977A JP12121080A JP12121080A JPS5746977A JP S5746977 A JPS5746977 A JP S5746977A JP 12121080 A JP12121080 A JP 12121080A JP 12121080 A JP12121080 A JP 12121080A JP S5746977 A JPS5746977 A JP S5746977A
- Authority
- JP
- Japan
- Prior art keywords
- prostacyclin
- agent
- expressed
- formula
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Furan Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A prostacyclin expressed by formula I (R1 is H or 1W10C lower alkyl; R2, R3 and R4 are H, silyl or acyl) or a pharmacologically acceptable salt of the acid when R1 is H.
EXAMPLE: Methyl ester bis-tert-butyldimethylsilylether of 7-acetoxy-PGI2.
USE: A remedy or preventing agent for diseases of thrombosis, antiasthmatic agent, antiulcer agent, hypotensive agent or intermediate for another compound. The compound is stable due to the substituent group introduced into the 7-position of the prostacyclin.
PROCESS: A prostacyclin expressed by formula II (R' is 1W4C lower alkyl) is treated with a carboxylic acid anhydride-pyridine, and if desired hydrolyzed and/or protected.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12121080A JPS5746977A (en) | 1980-09-03 | 1980-09-03 | Novel prostacyclin and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12121080A JPS5746977A (en) | 1980-09-03 | 1980-09-03 | Novel prostacyclin and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5746977A true JPS5746977A (en) | 1982-03-17 |
JPH026754B2 JPH026754B2 (en) | 1990-02-13 |
Family
ID=14805595
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12121080A Granted JPS5746977A (en) | 1980-09-03 | 1980-09-03 | Novel prostacyclin and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5746977A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5799580A (en) * | 1980-10-27 | 1982-06-21 | Chinoin Gyogyszer Es Vegyeszet | 7-substituted pgi2 derivative and manufacture |
JPS59185534A (en) * | 1983-04-07 | 1984-10-22 | Honda Motor Co Ltd | Production of plunger for valve lash adjuster |
JPS59185533A (en) * | 1983-04-07 | 1984-10-22 | Honda Motor Co Ltd | Production of plunger for valve lash adjuster |
JPS59209440A (en) * | 1983-05-12 | 1984-11-28 | Honda Motor Co Ltd | Production of plunger for valve lash adjuster |
JPS60106635A (en) * | 1983-11-14 | 1985-06-12 | Honda Motor Co Ltd | Manufacture of push rod for engine |
JP2012503143A (en) * | 2008-09-23 | 2012-02-02 | イートン コーポレーション | Ball plunger used for hydraulic lash adjuster and method of manufacturing the ball plunger |
-
1980
- 1980-09-03 JP JP12121080A patent/JPS5746977A/en active Granted
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5799580A (en) * | 1980-10-27 | 1982-06-21 | Chinoin Gyogyszer Es Vegyeszet | 7-substituted pgi2 derivative and manufacture |
JPH0314030B2 (en) * | 1980-10-27 | 1991-02-25 | Kinoin Giogisuzeru Esu Begiesuzechi Terumekeku Giara Ruto | |
JPS59185534A (en) * | 1983-04-07 | 1984-10-22 | Honda Motor Co Ltd | Production of plunger for valve lash adjuster |
JPS59185533A (en) * | 1983-04-07 | 1984-10-22 | Honda Motor Co Ltd | Production of plunger for valve lash adjuster |
JPH0356813B2 (en) * | 1983-04-07 | 1991-08-29 | ||
JPS59209440A (en) * | 1983-05-12 | 1984-11-28 | Honda Motor Co Ltd | Production of plunger for valve lash adjuster |
JPH0356814B2 (en) * | 1983-05-12 | 1991-08-29 | ||
JPS60106635A (en) * | 1983-11-14 | 1985-06-12 | Honda Motor Co Ltd | Manufacture of push rod for engine |
JP2012503143A (en) * | 2008-09-23 | 2012-02-02 | イートン コーポレーション | Ball plunger used for hydraulic lash adjuster and method of manufacturing the ball plunger |
Also Published As
Publication number | Publication date |
---|---|
JPH026754B2 (en) | 1990-02-13 |
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