JPS5746977A - Novel prostacyclin and its preparation - Google Patents

Novel prostacyclin and its preparation

Info

Publication number
JPS5746977A
JPS5746977A JP12121080A JP12121080A JPS5746977A JP S5746977 A JPS5746977 A JP S5746977A JP 12121080 A JP12121080 A JP 12121080A JP 12121080 A JP12121080 A JP 12121080A JP S5746977 A JPS5746977 A JP S5746977A
Authority
JP
Japan
Prior art keywords
prostacyclin
agent
expressed
formula
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12121080A
Other languages
Japanese (ja)
Other versions
JPH026754B2 (en
Inventor
Seiji Kurozumi
Takeshi Yu
Takeo Oba
Toshio Tanaka
Noriaki Okamura
Kenzo Watanabe
Kiyoshi Sakauchi
Akira Otsu
Tatsuyuki Naritomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP12121080A priority Critical patent/JPS5746977A/en
Publication of JPS5746977A publication Critical patent/JPS5746977A/en
Publication of JPH026754B2 publication Critical patent/JPH026754B2/ja
Granted legal-status Critical Current

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  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A prostacyclin expressed by formula I (R1 is H or 1W10C lower alkyl; R2, R3 and R4 are H, silyl or acyl) or a pharmacologically acceptable salt of the acid when R1 is H.
EXAMPLE: Methyl ester bis-tert-butyldimethylsilylether of 7-acetoxy-PGI2.
USE: A remedy or preventing agent for diseases of thrombosis, antiasthmatic agent, antiulcer agent, hypotensive agent or intermediate for another compound. The compound is stable due to the substituent group introduced into the 7-position of the prostacyclin.
PROCESS: A prostacyclin expressed by formula II (R' is 1W4C lower alkyl) is treated with a carboxylic acid anhydride-pyridine, and if desired hydrolyzed and/or protected.
COPYRIGHT: (C)1982,JPO&Japio
JP12121080A 1980-09-03 1980-09-03 Novel prostacyclin and its preparation Granted JPS5746977A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12121080A JPS5746977A (en) 1980-09-03 1980-09-03 Novel prostacyclin and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12121080A JPS5746977A (en) 1980-09-03 1980-09-03 Novel prostacyclin and its preparation

Publications (2)

Publication Number Publication Date
JPS5746977A true JPS5746977A (en) 1982-03-17
JPH026754B2 JPH026754B2 (en) 1990-02-13

Family

ID=14805595

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12121080A Granted JPS5746977A (en) 1980-09-03 1980-09-03 Novel prostacyclin and its preparation

Country Status (1)

Country Link
JP (1) JPS5746977A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5799580A (en) * 1980-10-27 1982-06-21 Chinoin Gyogyszer Es Vegyeszet 7-substituted pgi2 derivative and manufacture
JPS59185534A (en) * 1983-04-07 1984-10-22 Honda Motor Co Ltd Production of plunger for valve lash adjuster
JPS59185533A (en) * 1983-04-07 1984-10-22 Honda Motor Co Ltd Production of plunger for valve lash adjuster
JPS59209440A (en) * 1983-05-12 1984-11-28 Honda Motor Co Ltd Production of plunger for valve lash adjuster
JPS60106635A (en) * 1983-11-14 1985-06-12 Honda Motor Co Ltd Manufacture of push rod for engine
JP2012503143A (en) * 2008-09-23 2012-02-02 イートン コーポレーション Ball plunger used for hydraulic lash adjuster and method of manufacturing the ball plunger

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5799580A (en) * 1980-10-27 1982-06-21 Chinoin Gyogyszer Es Vegyeszet 7-substituted pgi2 derivative and manufacture
JPH0314030B2 (en) * 1980-10-27 1991-02-25 Kinoin Giogisuzeru Esu Begiesuzechi Terumekeku Giara Ruto
JPS59185534A (en) * 1983-04-07 1984-10-22 Honda Motor Co Ltd Production of plunger for valve lash adjuster
JPS59185533A (en) * 1983-04-07 1984-10-22 Honda Motor Co Ltd Production of plunger for valve lash adjuster
JPH0356813B2 (en) * 1983-04-07 1991-08-29
JPS59209440A (en) * 1983-05-12 1984-11-28 Honda Motor Co Ltd Production of plunger for valve lash adjuster
JPH0356814B2 (en) * 1983-05-12 1991-08-29
JPS60106635A (en) * 1983-11-14 1985-06-12 Honda Motor Co Ltd Manufacture of push rod for engine
JP2012503143A (en) * 2008-09-23 2012-02-02 イートン コーポレーション Ball plunger used for hydraulic lash adjuster and method of manufacturing the ball plunger

Also Published As

Publication number Publication date
JPH026754B2 (en) 1990-02-13

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