JPS572279A - Dibenzoxazepin derivative - Google Patents
Dibenzoxazepin derivativeInfo
- Publication number
- JPS572279A JPS572279A JP7417780A JP7417780A JPS572279A JP S572279 A JPS572279 A JP S572279A JP 7417780 A JP7417780 A JP 7417780A JP 7417780 A JP7417780 A JP 7417780A JP S572279 A JPS572279 A JP S572279A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- dibenzoxazepin
- derivative
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A dibenzoxazepin derivative of formula I (R1 is H, lower alkyl, or lower alkoxy; R2 is lower alkoxycarbonyl; R3 is lower alkyl or phenyl).
EXAMPLE: 10, 11-Dihydro-2, 4-dimethoxy-11-phenyldibenzo[ b,f ][ 1,4 ]oxazepin-8- carboxylic acid ethyl ester.
USE: It has antilipemic activity and blood platelet coagulation inhibiting activity, and is useful as a medicine.
PROCESS: The compound of formula I can be prepared by the catalytic reduction of the compound of formula II in a solvent such as methanol, tetrahydrofuran, etc. in the presence of a catalyst such as 5W10% Raney nickel or palladium-carbon. The compound of formula II is also new, and can be prepared by heating e.g. the compound of formula III in a solvent such as benzene in the presence of a dehydrating agent such as phosphorus oxychloride.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7417780A JPS572279A (en) | 1980-06-04 | 1980-06-04 | Dibenzoxazepin derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7417780A JPS572279A (en) | 1980-06-04 | 1980-06-04 | Dibenzoxazepin derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS572279A true JPS572279A (en) | 1982-01-07 |
JPH0220638B2 JPH0220638B2 (en) | 1990-05-10 |
Family
ID=13539615
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7417780A Granted JPS572279A (en) | 1980-06-04 | 1980-06-04 | Dibenzoxazepin derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS572279A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4886815A (en) * | 1984-06-20 | 1989-12-12 | Schachar Ronald A | Treatment and prevention of retinal edema with dopaminergic antagonists |
US4886795A (en) * | 1984-06-20 | 1989-12-12 | Schachar Ronald A | Treatment and prevention of retinal edema with dopaminergic antagonists |
JPH0452600U (en) * | 1990-09-10 | 1992-05-06 | ||
US11649218B2 (en) * | 2018-03-09 | 2023-05-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | C-Abl tyrosine kinase inhibitory compound embodiments and methods of making and using the same |
-
1980
- 1980-06-04 JP JP7417780A patent/JPS572279A/en active Granted
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4886815A (en) * | 1984-06-20 | 1989-12-12 | Schachar Ronald A | Treatment and prevention of retinal edema with dopaminergic antagonists |
US4886795A (en) * | 1984-06-20 | 1989-12-12 | Schachar Ronald A | Treatment and prevention of retinal edema with dopaminergic antagonists |
JPH0452600U (en) * | 1990-09-10 | 1992-05-06 | ||
US11649218B2 (en) * | 2018-03-09 | 2023-05-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | C-Abl tyrosine kinase inhibitory compound embodiments and methods of making and using the same |
Also Published As
Publication number | Publication date |
---|---|
JPH0220638B2 (en) | 1990-05-10 |
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