JPS57169422A - Novel antiulcer substance horphyosine and its preparation - Google Patents
Novel antiulcer substance horphyosine and its preparationInfo
- Publication number
- JPS57169422A JPS57169422A JP56056178A JP5617881A JPS57169422A JP S57169422 A JPS57169422 A JP S57169422A JP 56056178 A JP56056178 A JP 56056178A JP 5617881 A JP5617881 A JP 5617881A JP S57169422 A JPS57169422 A JP S57169422A
- Authority
- JP
- Japan
- Prior art keywords
- sargassum
- horphyosine
- kjellman
- yamada
- chloroform
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
NEW MATERIAL:Horphyosine having the following physical and chemical properties: appearance, neutral colorless flaky crystal; melting point, 124W125°C; specific rotation,[α]D27=-40.4 (C=1.0, chloroform); molecular formula C27H42O3; molecular weight, 414 (mass spectrometry); solublitity, hardly soluble in water, soluble in methanol, ethanol, etc.; color reaction, changes to brown color with concentrated sulfuric acid, negative to ninhydrin reaction, etc.; etc.
USE: Antiulcer agent.
PROCESS: Seaweeds such as Porphyra tenera Kjellman, Ulva pertusa Kjellman, Ecklonia cava Kjellman, Ulva fasciata Delile, Eisenia bicyclis Setchell, Sargassum ringgoldianum Harvey, Grateloupia turuturu Yamada, Gracilaria textorii Suringar, Sargassum tenuifolium Yamada, Sargassum tortile C.Agardh, Sargassum thunbergii O.Kuntze, Ishige foliacea Okamura, Ishige Okamurai Yendo, etc. are washed with water, and without or after drying, extracted with an organic solvent (e.g. n-hexane, benzene, chloroform, etc.). The extract is concentrated and purified by adsorption chromatography, etc. to obtain pure crystalline horphyosine. Dose: 2W3g/day for oral administration and ≤1,000mg/day for injection.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56056178A JPS6045854B2 (en) | 1981-04-13 | 1981-04-13 | New anti-ulcer substance phorhuiosin and its production method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56056178A JPS6045854B2 (en) | 1981-04-13 | 1981-04-13 | New anti-ulcer substance phorhuiosin and its production method |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57169422A true JPS57169422A (en) | 1982-10-19 |
JPS6045854B2 JPS6045854B2 (en) | 1985-10-12 |
Family
ID=13019849
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56056178A Expired JPS6045854B2 (en) | 1981-04-13 | 1981-04-13 | New anti-ulcer substance phorhuiosin and its production method |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6045854B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7691388B2 (en) * | 2006-03-24 | 2010-04-06 | Ocean Nutrition Canada Limited | Compositions comprising Porphyra and methods of making and using thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54156690A (en) * | 1978-05-31 | 1979-12-10 | Matsushita Electric Ind Co Ltd | Humidity sensing element |
-
1981
- 1981-04-13 JP JP56056178A patent/JPS6045854B2/en not_active Expired
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54156690A (en) * | 1978-05-31 | 1979-12-10 | Matsushita Electric Ind Co Ltd | Humidity sensing element |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7691388B2 (en) * | 2006-03-24 | 2010-04-06 | Ocean Nutrition Canada Limited | Compositions comprising Porphyra and methods of making and using thereof |
Also Published As
Publication number | Publication date |
---|---|
JPS6045854B2 (en) | 1985-10-12 |
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