JPS5716880A - Thiothromboxane analog and its preparation - Google Patents

Thiothromboxane analog and its preparation

Info

Publication number
JPS5716880A
JPS5716880A JP9001180A JP9001180A JPS5716880A JP S5716880 A JPS5716880 A JP S5716880A JP 9001180 A JP9001180 A JP 9001180A JP 9001180 A JP9001180 A JP 9001180A JP S5716880 A JPS5716880 A JP S5716880A
Authority
JP
Japan
Prior art keywords
hydroxyl
formula
alkyl
preparation
vinylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9001180A
Other languages
Japanese (ja)
Inventor
Nobuyuki Hamanaka
Toshiji Kosuge
Masaki Hayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to JP9001180A priority Critical patent/JPS5716880A/en
Publication of JPS5716880A publication Critical patent/JPS5716880A/en
Pending legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Compounds of formula I (X is ethylene, cis-vinylene; Y is ethylene, trans-vinylene; R1 is H, alkyl; R2 is H, hydroxyl, or hydroxyl protected with a group that can be removed in an acidic condition; R3 is single bond, alkylene; R4 is H, alkyl; m is integer of 1W6), when R2 is H, hydroxyl, the crathlate thereof with cyclodextrin and when R1 is H, the nontoxic salt of the free acid.
EXAMPLE: ( 5Z,13E )-( 15αβ )-9,11-Methano-15-( tetrahydropyran-2-yloxy )-11α- thiothromba-5,13-dienoic methyl ester.
USE: An agent for inhibiting the biosynthesis of thromboxane A2.
PREPARATION: A compound of formula II (R6 is R2 other than hydroxyl) and the ylide of formula III (R7 is phenyl, alkyl) are subjected to the Witting reaction and esterified, when necessary, to give the compound of formula IV.
COPYRIGHT: (C)1982,JPO&Japio
JP9001180A 1980-07-03 1980-07-03 Thiothromboxane analog and its preparation Pending JPS5716880A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9001180A JPS5716880A (en) 1980-07-03 1980-07-03 Thiothromboxane analog and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9001180A JPS5716880A (en) 1980-07-03 1980-07-03 Thiothromboxane analog and its preparation

Publications (1)

Publication Number Publication Date
JPS5716880A true JPS5716880A (en) 1982-01-28

Family

ID=13986713

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9001180A Pending JPS5716880A (en) 1980-07-03 1980-07-03 Thiothromboxane analog and its preparation

Country Status (1)

Country Link
JP (1) JPS5716880A (en)

Similar Documents

Publication Publication Date Title
JPS5444639A (en) Prostaglandin analog and its preparation
JPS51149247A (en) Prostaglandin analogues, process for their preparation and drug compos itions containing them as effective ingredients
JPS5716880A (en) Thiothromboxane analog and its preparation
JPS5395958A (en) Prostaglandin analogues and process for their preparation
JPS5419946A (en) Prostaglandin analog compound and their preparation
ES8301912A1 (en) Prostacycline derivatives, their preparation and applications as medicines.
JPS5236646A (en) Process for preparation of prostaglandin derivatives and pharmceutical composition containing the compounds as effectual components
JPS54130543A (en) Prostagladin i2 analog, and its preparation
JPS56152455A (en) Prostaglandin analog, compound, its preparation, and drug composition comprising it
JPS5735542A (en) Novel bicyclooctane derivative, its salt and preparation thereof
JPS545953A (en) Prostaglandin analogous compounds, process for their preparation and pharmaceutical composition containing the same as active constituents
JPS5227750A (en) Prostaglandin analogues,their preparation, and pharmaceutical composit ions containing the same as active ingredient
JPS5495689A (en) Suspension polymerization of vinyl monomer
JPS5569564A (en) Prostaglandin analog compound and its preparation
JPS5424865A (en) Prostaglandin i2 analogues and their preparation
JPS51128942A (en) Prostaglandin analogues, process for preparing there of and pharmaceut ical compositions containing said analogues
JPS52111547A (en) Prostaglandin analogous compounds, their preparation and pharmaceutica l component containing the same
JPS5795937A (en) Leucotriene a analogous compound, its preparation, and leucotriene biosynthetic inhibitor containing said compound as active constituent
JPS5398953A (en) Prostaglandin x analogues and process for their preparation
JPS51125046A (en) Process for preparing prostaglandin analogues
JPS53137952A (en) Prostaglandin 1 l2 analogous compounds and process for their preparation
JPS5543035A (en) Low drifting powdery pesticide
JPS51149245A (en) Prostaglandin analogues, process for their preparation and drug compos itions containing them as effeftive ingredients
JPS5236649A (en) Process for preparation of prostaglandin analogs and pharmceutical com position containing the compounds as effetual components
JPS55157566A (en) Prostaglandin analog and its preparation