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Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
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Publication date
Application filed by Ono Pharmaceutical Co LtdfiledCriticalOno Pharmaceutical Co Ltd
Priority to JP9001180ApriorityCriticalpatent/JPS5716880A/en
Publication of JPS5716880ApublicationCriticalpatent/JPS5716880A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
NEW MATERIAL:Compounds of formula I (X is ethylene, cis-vinylene; Y is ethylene, trans-vinylene; R1 is H, alkyl; R2 is H, hydroxyl, or hydroxyl protected with a group that can be removed in an acidic condition; R3 is single bond, alkylene; R4 is H, alkyl; m is integer of 1W6), when R2 is H, hydroxyl, the crathlate thereof with cyclodextrin and when R1 is H, the nontoxic salt of the free acid.
USE: An agent for inhibiting the biosynthesis of thromboxane A2.
PREPARATION: A compound of formula II (R6 is R2 other than hydroxyl) and the ylide of formula III (R7 is phenyl, alkyl) are subjected to the Witting reaction and esterified, when necessary, to give the compound of formula IV.
COPYRIGHT: (C)1982,JPO&Japio
JP9001180A1980-07-031980-07-03Thiothromboxane analog and its preparation
PendingJPS5716880A
(en)