JPS55157566A - Prostaglandin analog and its preparation - Google Patents
Prostaglandin analog and its preparationInfo
- Publication number
- JPS55157566A JPS55157566A JP6379679A JP6379679A JPS55157566A JP S55157566 A JPS55157566 A JP S55157566A JP 6379679 A JP6379679 A JP 6379679A JP 6379679 A JP6379679 A JP 6379679A JP S55157566 A JPS55157566 A JP S55157566A
- Authority
- JP
- Japan
- Prior art keywords
- group
- formula
- compound
- iminomethylene
- configuration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The title compound of formula I [X is ethylene or cis-vinylene group; Y is ehtylene, trans-vinylene group, etc.; R1 and R2 are H, methyl or ethyl groups; R2 is further OH; R3 is single bond or 1W4C alkylene group; R4 is H, 1W8C alkyl, 4W7C cycloalkyl group, etc.; R5 is H or 1W6C alkyl group; the iminomethylene group at the 11- and 9-positions is each α-configuration, or R-, S-configuration or their mixture when the carbon atom at the 15-position is asymmetric), and its nontoxic salt.
EXAMPLE: (5Z, 13E)-(9α, 11α, 15S)-11,9-Iminomethylene-15-hydroxyprosta-5,13- dienoic acid ammonium salt.
USE: A vasopressor, platelet aggregating agent, biosynthesis inhibitor of thromboxane A2 or platelet aggregation inhibitor.
PROCESS: A compound of formula II (R6 is alkylsulfonyl group) is reacted with a compound of the formula R5NH2 to give the compound of formula III.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6379679A JPS55157566A (en) | 1979-05-25 | 1979-05-25 | Prostaglandin analog and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6379679A JPS55157566A (en) | 1979-05-25 | 1979-05-25 | Prostaglandin analog and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55157566A true JPS55157566A (en) | 1980-12-08 |
Family
ID=13239691
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6379679A Pending JPS55157566A (en) | 1979-05-25 | 1979-05-25 | Prostaglandin analog and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55157566A (en) |
-
1979
- 1979-05-25 JP JP6379679A patent/JPS55157566A/en active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US4113778A (en) | 2-Decarboxy-2-hydroxy-methyl-ω-phenoxy-PGE analogs | |
JPS5444639A (en) | Prostaglandin analog and its preparation | |
GB1507211A (en) | Prostaglandin analogues | |
JPS51149247A (en) | Prostaglandin analogues, process for their preparation and drug compos itions containing them as effective ingredients | |
JPS55157566A (en) | Prostaglandin analog and its preparation | |
GB1484591A (en) | Prostaglandin compositions | |
GB1396206A (en) | Prostaglandins and the preparation thereof | |
JPS54125653A (en) | Prostaglandin i2 analog, its preparation, and drug composition comprising it as active constituent | |
JPS5569564A (en) | Prostaglandin analog compound and its preparation | |
US4001286A (en) | Phenyl-substituted prostaglandin-β-type anologs | |
JPS5419946A (en) | Prostaglandin analog compound and their preparation | |
US4138574A (en) | Cis-4,5-didehydro-16-phenoxy-PGA1 compounds | |
JPS54130543A (en) | Prostagladin i2 analog, and its preparation | |
JPS56152455A (en) | Prostaglandin analog, compound, its preparation, and drug composition comprising it | |
JPS5573678A (en) | Simultated compound of thio-prostaglandin i1, its preparation and drug composition containing it as active ingredient | |
US4223157A (en) | 6-Keto-ωaryl-PGE1 compounds | |
JPS53103464A (en) | Prostaglandin x analogues and process for their preparation | |
GB1530154A (en) | Prostaglandin analogues | |
JPS5236646A (en) | Process for preparation of prostaglandin derivatives and pharmceutical composition containing the compounds as effectual components | |
US4251466A (en) | 2-Decarboxy-2-hydroxymethyl-6-keto-PGE1 compounds | |
US4235998A (en) | 2-Decarboxy-2-aminomethyl-9-deoxy-5,9α-epoxy-4,5-didehydro-PGF1 compounds | |
US4005115A (en) | Phenyl-substituted prostaglandin-A type analogs | |
JPS5716880A (en) | Thiothromboxane analog and its preparation | |
US4236019A (en) | Esters of prostacyclin-type compounds | |
CA1040195A (en) | Cyclopentane derivatives |