JPS55157566A - Prostaglandin analog and its preparation - Google Patents

Prostaglandin analog and its preparation

Info

Publication number
JPS55157566A
JPS55157566A JP6379679A JP6379679A JPS55157566A JP S55157566 A JPS55157566 A JP S55157566A JP 6379679 A JP6379679 A JP 6379679A JP 6379679 A JP6379679 A JP 6379679A JP S55157566 A JPS55157566 A JP S55157566A
Authority
JP
Japan
Prior art keywords
group
formula
compound
iminomethylene
configuration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6379679A
Other languages
Japanese (ja)
Inventor
Nobuyuki Hamanaka
Toshiji Kosuge
Shuichi Ouchida
Shinsuke Hashimoto
Haruki Niwa
Masaki Hayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to JP6379679A priority Critical patent/JPS55157566A/en
Publication of JPS55157566A publication Critical patent/JPS55157566A/en
Pending legal-status Critical Current

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  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The title compound of formula I [X is ethylene or cis-vinylene group; Y is ehtylene, trans-vinylene group, etc.; R1 and R2 are H, methyl or ethyl groups; R2 is further OH; R3 is single bond or 1W4C alkylene group; R4 is H, 1W8C alkyl, 4W7C cycloalkyl group, etc.; R5 is H or 1W6C alkyl group; the iminomethylene group at the 11- and 9-positions is each α-configuration, or R-, S-configuration or their mixture when the carbon atom at the 15-position is asymmetric), and its nontoxic salt.
EXAMPLE: (5Z, 13E)-(9α, 11α, 15S)-11,9-Iminomethylene-15-hydroxyprosta-5,13- dienoic acid ammonium salt.
USE: A vasopressor, platelet aggregating agent, biosynthesis inhibitor of thromboxane A2 or platelet aggregation inhibitor.
PROCESS: A compound of formula II (R6 is alkylsulfonyl group) is reacted with a compound of the formula R5NH2 to give the compound of formula III.
COPYRIGHT: (C)1980,JPO&Japio
JP6379679A 1979-05-25 1979-05-25 Prostaglandin analog and its preparation Pending JPS55157566A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6379679A JPS55157566A (en) 1979-05-25 1979-05-25 Prostaglandin analog and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6379679A JPS55157566A (en) 1979-05-25 1979-05-25 Prostaglandin analog and its preparation

Publications (1)

Publication Number Publication Date
JPS55157566A true JPS55157566A (en) 1980-12-08

Family

ID=13239691

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6379679A Pending JPS55157566A (en) 1979-05-25 1979-05-25 Prostaglandin analog and its preparation

Country Status (1)

Country Link
JP (1) JPS55157566A (en)

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