JPS5716840A - Phneylacetic acid derivative - Google Patents
Phneylacetic acid derivativeInfo
- Publication number
- JPS5716840A JPS5716840A JP8997280A JP8997280A JPS5716840A JP S5716840 A JPS5716840 A JP S5716840A JP 8997280 A JP8997280 A JP 8997280A JP 8997280 A JP8997280 A JP 8997280A JP S5716840 A JPS5716840 A JP S5716840A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- acid derivative
- sulfonyl
- fluoro
- cyano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A phenylacetic acid derivative shown by the formula I (X is nitro or amino; R1 and R3 are H or lower alkyl; R2 is H, alkoxy-carbonyl, cyano, or sulfonyl).
EXAMPLE: α-Ethoxycarbonyl-α-(3-fluoro-4-nitrophenyl)propionic acid ethyl ester.
USE: A raw material for α-(2-fluoro-4-biphenylyl) acetic acid, etc, having anti- inflammatory and analgesic actions.
PROCESS: A 4-halo-2-fluoronitrobenzene shown by the formula II (Y is F or Cl) is reacted with an acetic acid derivative shown by the formula III (R2' is alkoxycarbonyl, cyano or sulfonyl; R3' is lower alkyl) preferably in a polar solvent in the presence of a base, e.g., K2CO3, etc. at room temperature to the reflux temperature of the solvent, to give a compound shown by the formula I where X is NO2, R2 is R2', and R3 is R3' without using a specific reaction reagent under mild conditions in a short process and in high yield.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8997280A JPS5716840A (en) | 1980-07-03 | 1980-07-03 | Phneylacetic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8997280A JPS5716840A (en) | 1980-07-03 | 1980-07-03 | Phneylacetic acid derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5716840A true JPS5716840A (en) | 1982-01-28 |
Family
ID=13985589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8997280A Pending JPS5716840A (en) | 1980-07-03 | 1980-07-03 | Phneylacetic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5716840A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR970042541A (en) * | 1995-12-11 | 1997-07-24 | 김준웅 | Method for preparing alkyl phenylpropionate derivative-14C |
JP2004531517A (en) * | 2001-04-05 | 2004-10-14 | メルク シャープ エンド ドーム リミテッド | Sulfone regulating the action of γ-secretase |
-
1980
- 1980-07-03 JP JP8997280A patent/JPS5716840A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR970042541A (en) * | 1995-12-11 | 1997-07-24 | 김준웅 | Method for preparing alkyl phenylpropionate derivative-14C |
JP2004531517A (en) * | 2001-04-05 | 2004-10-14 | メルク シャープ エンド ドーム リミテッド | Sulfone regulating the action of γ-secretase |
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