JPS57156500A - Composition containing s-adenosyl-l-methionine and its preparation - Google Patents
Composition containing s-adenosyl-l-methionine and its preparationInfo
- Publication number
- JPS57156500A JPS57156500A JP4304781A JP4304781A JPS57156500A JP S57156500 A JPS57156500 A JP S57156500A JP 4304781 A JP4304781 A JP 4304781A JP 4304781 A JP4304781 A JP 4304781A JP S57156500 A JPS57156500 A JP S57156500A
- Authority
- JP
- Japan
- Prior art keywords
- water
- soluble
- salt
- acid
- sam
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Saccharide Compounds (AREA)
Abstract
PURPOSE: The titled water-soluble composition, containing S-adenosyl-L-methionine (SAM), an acid and a water-soluble Ca salt, and having improved storage stability, safety for a living body and producticity and economic efficiency on an industrial scale.
CONSTITUTION: S-Adenosyl-L-methionine (SAM), an acid and a water-soluble Ca salt are mixed at a molar ratio preferably 1: (0.5W2):(2W6) to give the aimed composition. Preferably, the following components are used. (A) One or more acids, e.g. hydrochloric, acetic, lactic or p-toluenesulfonic acid, which with the third component water-soluble Ca salt will not form a water-insoluble compound in an aqueous solution and with the SAM will form and/or form a water-soluble salt are used as the acid. (B) One or more Ca salts e.g. calcium chloride, calcium acetate or calcium lactate, soluble in water at ordinary temperature in an amount of 1% (W/V) or more are used as the water-soluble Ca salt. (C) SAM is purified by the ion exchange chromatography and converted into the salt type of the acid.
USE: Chemotherapeutic agents for hypometabolic diseases.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4304781A JPS57156500A (en) | 1981-03-23 | 1981-03-23 | Composition containing s-adenosyl-l-methionine and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4304781A JPS57156500A (en) | 1981-03-23 | 1981-03-23 | Composition containing s-adenosyl-l-methionine and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57156500A true JPS57156500A (en) | 1982-09-27 |
Family
ID=12652966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4304781A Pending JPS57156500A (en) | 1981-03-23 | 1981-03-23 | Composition containing s-adenosyl-l-methionine and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57156500A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4558122A (en) * | 1981-09-11 | 1985-12-10 | Bioresearch S.P.A. | Stable s-adenosylmethionine derivatives, the process for their preparation, and therapeutic compositions which contain them as active principle |
WO2007083631A1 (en) * | 2006-01-17 | 2007-07-26 | Mitsubishi Gas Chemical Company, Inc. | Method of stabilizing s-adenosyl-l-methionine and stabilized composition |
WO2007132831A1 (en) | 2006-05-16 | 2007-11-22 | Mitsubishi Gas Chemical Company, Inc. | Method of producing s-adenosyl-l-methionine-containing dry yeast having excellent storage stability, the product thereof and composition for oral intake |
-
1981
- 1981-03-23 JP JP4304781A patent/JPS57156500A/en active Pending
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4558122A (en) * | 1981-09-11 | 1985-12-10 | Bioresearch S.P.A. | Stable s-adenosylmethionine derivatives, the process for their preparation, and therapeutic compositions which contain them as active principle |
WO2007083631A1 (en) * | 2006-01-17 | 2007-07-26 | Mitsubishi Gas Chemical Company, Inc. | Method of stabilizing s-adenosyl-l-methionine and stabilized composition |
EP1982721A4 (en) * | 2006-01-17 | 2010-02-17 | Mitsubishi Gas Chemical Co | Method of stabilizing s-adenosyl-l-methionine and stabilized composition |
US8148348B2 (en) | 2006-01-17 | 2012-04-03 | Mitsubishi Gas Chemical Company, Inc. | Method of stabilizing S-adenosyl-L-methionine and stabilized composition |
JP5071112B2 (en) * | 2006-01-17 | 2012-11-14 | 三菱瓦斯化学株式会社 | Method for stabilizing S-adenosyl-L-methionine and stabilized composition |
KR101330352B1 (en) * | 2006-01-17 | 2013-11-15 | 미츠비시 가스 가가쿠 가부시키가이샤 | Method of stabilizing s-adenosyl-l-methionine and stabilized composition |
WO2007132831A1 (en) | 2006-05-16 | 2007-11-22 | Mitsubishi Gas Chemical Company, Inc. | Method of producing s-adenosyl-l-methionine-containing dry yeast having excellent storage stability, the product thereof and composition for oral intake |
EP2017331A4 (en) * | 2006-05-16 | 2010-06-09 | Mitsubishi Gas Chemical Co | Method of producing s-adenosyl-l-methionine-containing dry yeast having excellent storage stability, the product thereof and composition for oral intake |
JP5136409B2 (en) * | 2006-05-16 | 2013-02-06 | 三菱瓦斯化学株式会社 | Process for producing S-adenosyl-L-methionine-containing dry yeast having excellent storage stability, product thereof and composition for oral consumption |
US9080158B2 (en) | 2006-05-16 | 2015-07-14 | Mitsubishi Gas Chemical Company, Inc. | Method of producing S-adenosyl-L-methionine-containing dry yeast having excellent storage stability, the product thereof and composition for oral intake |
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