JPS57139092A - New antibiotic istamycin a1, b1, c1 or a2 - Google Patents

New antibiotic istamycin a1, b1, c1 or a2

Info

Publication number
JPS57139092A
JPS57139092A JP56024359A JP2435981A JPS57139092A JP S57139092 A JPS57139092 A JP S57139092A JP 56024359 A JP56024359 A JP 56024359A JP 2435981 A JP2435981 A JP 2435981A JP S57139092 A JPS57139092 A JP S57139092A
Authority
JP
Japan
Prior art keywords
istamycin
gram
amino
expressed
aimed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56024359A
Other languages
Japanese (ja)
Inventor
Hamao Umezawa
Yoshiro Okami
Shinichi Kondo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP56024359A priority Critical patent/JPS57139092A/en
Publication of JPS57139092A publication Critical patent/JPS57139092A/en
Pending legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An antibiotic substance istamycin A1, B1, C1 or A2 expressed by formulaI(R1 is amino and R2 is H; or R1 is H and R2 is amino: R3 is HCO- or NH2CO-, R4 is methyl or ethyl) or an acid addition salt thereof.
EXAMPLE: Istamycin A1 expressed by formula II.
USE: An antimicrobial agent capable of inhibiting the growth of Gram-positive and Gram-negative bacteria with low toxicity.
PROCESS: A microorganism, e.g. Streptomyces tenjimariensis SS-939 strain (FER M-P No.4932), capable of producing istamycin is inoculated into a culture medium containing nutrient sources utilizable by ordinary microorganisms, and cultivated aerobically by the spinner culture method in the liquid usually at 25W30°C for 2W7 days. The aimed substance in the culture fluid is then adsorbed by various adsorbents, eluted, purified and separated by the thin layer chromatography, etc. to give the aimed istamycin A1, B1, C1 or A2.
COPYRIGHT: (C)1982,JPO&Japio
JP56024359A 1981-02-23 1981-02-23 New antibiotic istamycin a1, b1, c1 or a2 Pending JPS57139092A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56024359A JPS57139092A (en) 1981-02-23 1981-02-23 New antibiotic istamycin a1, b1, c1 or a2

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56024359A JPS57139092A (en) 1981-02-23 1981-02-23 New antibiotic istamycin a1, b1, c1 or a2

Publications (1)

Publication Number Publication Date
JPS57139092A true JPS57139092A (en) 1982-08-27

Family

ID=12135994

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56024359A Pending JPS57139092A (en) 1981-02-23 1981-02-23 New antibiotic istamycin a1, b1, c1 or a2

Country Status (1)

Country Link
JP (1) JPS57139092A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59130187A (en) * 1982-11-01 1984-07-26 マイルス・ラボラトリ−ス・インコ−ポレ−テツド Heteromorphous clonin of gene in bacillus microorganism

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59130187A (en) * 1982-11-01 1984-07-26 マイルス・ラボラトリ−ス・インコ−ポレ−テツド Heteromorphous clonin of gene in bacillus microorganism
JPS6254473B2 (en) * 1982-11-01 1987-11-16 Miles Lab

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