JPS57139092A - New antibiotic istamycin a1, b1, c1 or a2 - Google Patents
New antibiotic istamycin a1, b1, c1 or a2Info
- Publication number
- JPS57139092A JPS57139092A JP56024359A JP2435981A JPS57139092A JP S57139092 A JPS57139092 A JP S57139092A JP 56024359 A JP56024359 A JP 56024359A JP 2435981 A JP2435981 A JP 2435981A JP S57139092 A JPS57139092 A JP S57139092A
- Authority
- JP
- Japan
- Prior art keywords
- istamycin
- gram
- amino
- expressed
- aimed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:An antibiotic substance istamycin A1, B1, C1 or A2 expressed by formulaI(R1 is amino and R2 is H; or R1 is H and R2 is amino: R3 is HCO- or NH2CO-, R4 is methyl or ethyl) or an acid addition salt thereof.
EXAMPLE: Istamycin A1 expressed by formula II.
USE: An antimicrobial agent capable of inhibiting the growth of Gram-positive and Gram-negative bacteria with low toxicity.
PROCESS: A microorganism, e.g. Streptomyces tenjimariensis SS-939 strain (FER M-P No.4932), capable of producing istamycin is inoculated into a culture medium containing nutrient sources utilizable by ordinary microorganisms, and cultivated aerobically by the spinner culture method in the liquid usually at 25W30°C for 2W7 days. The aimed substance in the culture fluid is then adsorbed by various adsorbents, eluted, purified and separated by the thin layer chromatography, etc. to give the aimed istamycin A1, B1, C1 or A2.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56024359A JPS57139092A (en) | 1981-02-23 | 1981-02-23 | New antibiotic istamycin a1, b1, c1 or a2 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56024359A JPS57139092A (en) | 1981-02-23 | 1981-02-23 | New antibiotic istamycin a1, b1, c1 or a2 |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57139092A true JPS57139092A (en) | 1982-08-27 |
Family
ID=12135994
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56024359A Pending JPS57139092A (en) | 1981-02-23 | 1981-02-23 | New antibiotic istamycin a1, b1, c1 or a2 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57139092A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59130187A (en) * | 1982-11-01 | 1984-07-26 | マイルス・ラボラトリ−ス・インコ−ポレ−テツド | Heteromorphous clonin of gene in bacillus microorganism |
-
1981
- 1981-02-23 JP JP56024359A patent/JPS57139092A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59130187A (en) * | 1982-11-01 | 1984-07-26 | マイルス・ラボラトリ−ス・インコ−ポレ−テツド | Heteromorphous clonin of gene in bacillus microorganism |
JPS6254473B2 (en) * | 1982-11-01 | 1987-11-16 | Miles Lab |
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