JPS57126477A - Preparation of nicotinic acid derivative - Google Patents
Preparation of nicotinic acid derivativeInfo
- Publication number
- JPS57126477A JPS57126477A JP1119481A JP1119481A JPS57126477A JP S57126477 A JPS57126477 A JP S57126477A JP 1119481 A JP1119481 A JP 1119481A JP 1119481 A JP1119481 A JP 1119481A JP S57126477 A JPS57126477 A JP S57126477A
- Authority
- JP
- Japan
- Prior art keywords
- preparation
- pyrrone
- anilinomethylene
- dihydro
- acid derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pyridine Compounds (AREA)
Abstract
PURPOSE: To obtain 4-hydroxy-6-methylnicotinic acid useful as an intermediate for drugs industrially advantageously, by reacting 3-anilinomethylene-6-methyl-4- oxo-3,4-dihydro-2-pyrrone with ammonia.
CONSTITUTION: 1mol Compound shown by the formulaI(R1 is aryl; R2 is H, 1W3C alkyl, cycloalkyl), e.g., 3-anilinomethylene-6-methyl-4-oxo-3,4-dihydro-2- pyrrone is reacted with 2W4mol ammonia in a solvent such as methoxyethanol in a sealed tube or in an autoclave at 80W120°C, to give a compound shown by the formula II useful as an intermediate for drugs such as a cephalosporin derivative, etc. from industrially easily obtainable raw materials by one step without using expensive raw materials such as N,N-dimethylformamide methylacetal, etc.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1119481A JPS57126477A (en) | 1981-01-27 | 1981-01-27 | Preparation of nicotinic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1119481A JPS57126477A (en) | 1981-01-27 | 1981-01-27 | Preparation of nicotinic acid derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57126477A true JPS57126477A (en) | 1982-08-06 |
JPS6261031B2 JPS6261031B2 (en) | 1987-12-18 |
Family
ID=11771239
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1119481A Granted JPS57126477A (en) | 1981-01-27 | 1981-01-27 | Preparation of nicotinic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57126477A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59161359A (en) * | 1983-03-07 | 1984-09-12 | Tokuyama Soda Co Ltd | Preparation of 3-hydroxypyridone compound |
-
1981
- 1981-01-27 JP JP1119481A patent/JPS57126477A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59161359A (en) * | 1983-03-07 | 1984-09-12 | Tokuyama Soda Co Ltd | Preparation of 3-hydroxypyridone compound |
JPH0414106B2 (en) * | 1983-03-07 | 1992-03-11 | Tokuyama Soda Kk |
Also Published As
Publication number | Publication date |
---|---|
JPS6261031B2 (en) | 1987-12-18 |
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