JPS57126417A - Remedy for circulatory disease - Google Patents
Remedy for circulatory diseaseInfo
- Publication number
- JPS57126417A JPS57126417A JP1020781A JP1020781A JPS57126417A JP S57126417 A JPS57126417 A JP S57126417A JP 1020781 A JP1020781 A JP 1020781A JP 1020781 A JP1020781 A JP 1020781A JP S57126417 A JPS57126417 A JP S57126417A
- Authority
- JP
- Japan
- Prior art keywords
- phenoxy
- converted
- ethoxycarbonyloxy
- remedy
- nitratoethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
NEW MATERIAL:A compound expressed by formulaI(R is straight chain or branched alkyl; R2 is H, halogen, carbamoyl, etc.; Q is direct bond or -O-; A is 1W6C alkylene; m and n are 1 or 2) and a salt thereof.
EXAMPLE: 1-Isopropylamino-3-[3-( 2-nitratoethoxy )phenoxy]-2-propanol expressed by formula II.
USE: A remedy for circulatory diseases having vascular smooth muscle relaxing, heart rate reducing action due to adrenergic β- and α-blocking actions, reducing action on myocardial oxygen consumption, blood flow increasing, hypotensive actions, etc.
PROCESS: 2-[(3-Ethoxycarbonyloxy)phenoxy]ethanol is converted into 2-[(3- ethoxycarbonyloxy)phenoxy]-ethyl nitrate. The 3-ethoxycarbonyloxy group is then converted into an OH group, and the resultant compound is then converted into 1,2-epoxy-3-[3-(2-nitratoethoxy)phenoxy]propane to give the exemplified compound expressed by formula II.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1020781A JPS57126417A (en) | 1981-01-28 | 1981-01-28 | Remedy for circulatory disease |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1020781A JPS57126417A (en) | 1981-01-28 | 1981-01-28 | Remedy for circulatory disease |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57126417A true JPS57126417A (en) | 1982-08-06 |
JPH0143723B2 JPH0143723B2 (en) | 1989-09-22 |
Family
ID=11743818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1020781A Granted JPS57126417A (en) | 1981-01-28 | 1981-01-28 | Remedy for circulatory disease |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57126417A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5328903A (en) * | 1990-04-28 | 1994-07-12 | Taisho Pharmaceutical Co. Ltd. | Composition for solid pharmaceutical preparations containing vitamin D3 derivative |
-
1981
- 1981-01-28 JP JP1020781A patent/JPS57126417A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5328903A (en) * | 1990-04-28 | 1994-07-12 | Taisho Pharmaceutical Co. Ltd. | Composition for solid pharmaceutical preparations containing vitamin D3 derivative |
Also Published As
Publication number | Publication date |
---|---|
JPH0143723B2 (en) | 1989-09-22 |
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