JPS57106668A - Preparation of n,n'-bis-(3-(3',4',5'-trimethoxybenzoyloxy)- propyl)homopiperazine - Google Patents

Preparation of n,n'-bis-(3-(3',4',5'-trimethoxybenzoyloxy)- propyl)homopiperazine

Info

Publication number
JPS57106668A
JPS57106668A JP18262380A JP18262380A JPS57106668A JP S57106668 A JPS57106668 A JP S57106668A JP 18262380 A JP18262380 A JP 18262380A JP 18262380 A JP18262380 A JP 18262380A JP S57106668 A JPS57106668 A JP S57106668A
Authority
JP
Japan
Prior art keywords
reacting
homopiperazine
trimethoxybenzoic acid
propyl
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP18262380A
Other languages
Japanese (ja)
Inventor
Kazuo Satoie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TOHO IYAKU KENKYUSHO KK
Original Assignee
TOHO IYAKU KENKYUSHO KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TOHO IYAKU KENKYUSHO KK filed Critical TOHO IYAKU KENKYUSHO KK
Priority to JP18262380A priority Critical patent/JPS57106668A/en
Publication of JPS57106668A publication Critical patent/JPS57106668A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To prepare the titled compound useful as a remedy for ischemic cardiopathy, under mild conditions, in a relatively short time, with simple operation, only by reacting 3,4,5-trimethoxybenzoic acid 3'-tosyloxypropyl ester with homopiperazine.
CONSTITUTION: The objective N,N'-bis[3-(3',4',5'-trimethoxybenzoyloxy)-propyl] homopiperazine of formula II is prepared by reacting 3,4,5-trimethoxybenzoic acid 3'-tosyloxy-propyl ester of formulaI. The starting compound of formulaI can be obtained by reacting 3,4,5,-trimethoxybenzoic acid with 3-chloropropanol, and reacting the resultant 3,4,5-trimethoxybenzoic acid 3'-hydroxypropyl ester with tosyl chloride.
EFFECT: The objective compound can be prepared in high purity and yield.
USE: It has an activity for increasing the oxygen-supplying capacity of erythrocyte as well as the coronary vessel dilating and coronary blood flow increasing activities.
COPYRIGHT: (C)1982,JPO&Japio
JP18262380A 1980-12-23 1980-12-23 Preparation of n,n'-bis-(3-(3',4',5'-trimethoxybenzoyloxy)- propyl)homopiperazine Pending JPS57106668A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP18262380A JPS57106668A (en) 1980-12-23 1980-12-23 Preparation of n,n'-bis-(3-(3',4',5'-trimethoxybenzoyloxy)- propyl)homopiperazine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18262380A JPS57106668A (en) 1980-12-23 1980-12-23 Preparation of n,n'-bis-(3-(3',4',5'-trimethoxybenzoyloxy)- propyl)homopiperazine

Publications (1)

Publication Number Publication Date
JPS57106668A true JPS57106668A (en) 1982-07-02

Family

ID=16121518

Family Applications (1)

Application Number Title Priority Date Filing Date
JP18262380A Pending JPS57106668A (en) 1980-12-23 1980-12-23 Preparation of n,n'-bis-(3-(3',4',5'-trimethoxybenzoyloxy)- propyl)homopiperazine

Country Status (1)

Country Link
JP (1) JPS57106668A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3403778A1 (en) * 1984-02-03 1985-08-08 Degussa Ag, 6000 Frankfurt CYANOMETHYL- (2-CYANO-ETHYL) - (3-HYDROXY-PROPYL) -AMINE HIS USE FOR PRODUCING 1- (3-HYDROXY-PROPYL) -1,4-DIAZEPANE AND 1,4-BIS (3- (3rd , 4,5-TRIMETHOXYBENZOYLOXY) -PROPYL) -DIAZEPAN
JPS61100571A (en) * 1984-10-19 1986-05-19 デグツサ・アクチエンゲゼルシヤフト Purification of dilaepp base

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3403778A1 (en) * 1984-02-03 1985-08-08 Degussa Ag, 6000 Frankfurt CYANOMETHYL- (2-CYANO-ETHYL) - (3-HYDROXY-PROPYL) -AMINE HIS USE FOR PRODUCING 1- (3-HYDROXY-PROPYL) -1,4-DIAZEPANE AND 1,4-BIS (3- (3rd , 4,5-TRIMETHOXYBENZOYLOXY) -PROPYL) -DIAZEPAN
JPS61100571A (en) * 1984-10-19 1986-05-19 デグツサ・アクチエンゲゼルシヤフト Purification of dilaepp base

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