JPS57106668A - Preparation of n,n'-bis-(3-(3',4',5'-trimethoxybenzoyloxy)- propyl)homopiperazine - Google Patents
Preparation of n,n'-bis-(3-(3',4',5'-trimethoxybenzoyloxy)- propyl)homopiperazineInfo
- Publication number
- JPS57106668A JPS57106668A JP18262380A JP18262380A JPS57106668A JP S57106668 A JPS57106668 A JP S57106668A JP 18262380 A JP18262380 A JP 18262380A JP 18262380 A JP18262380 A JP 18262380A JP S57106668 A JPS57106668 A JP S57106668A
- Authority
- JP
- Japan
- Prior art keywords
- reacting
- homopiperazine
- trimethoxybenzoic acid
- propyl
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare the titled compound useful as a remedy for ischemic cardiopathy, under mild conditions, in a relatively short time, with simple operation, only by reacting 3,4,5-trimethoxybenzoic acid 3'-tosyloxypropyl ester with homopiperazine.
CONSTITUTION: The objective N,N'-bis[3-(3',4',5'-trimethoxybenzoyloxy)-propyl] homopiperazine of formula II is prepared by reacting 3,4,5-trimethoxybenzoic acid 3'-tosyloxy-propyl ester of formulaI. The starting compound of formulaI can be obtained by reacting 3,4,5,-trimethoxybenzoic acid with 3-chloropropanol, and reacting the resultant 3,4,5-trimethoxybenzoic acid 3'-hydroxypropyl ester with tosyl chloride.
EFFECT: The objective compound can be prepared in high purity and yield.
USE: It has an activity for increasing the oxygen-supplying capacity of erythrocyte as well as the coronary vessel dilating and coronary blood flow increasing activities.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18262380A JPS57106668A (en) | 1980-12-23 | 1980-12-23 | Preparation of n,n'-bis-(3-(3',4',5'-trimethoxybenzoyloxy)- propyl)homopiperazine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18262380A JPS57106668A (en) | 1980-12-23 | 1980-12-23 | Preparation of n,n'-bis-(3-(3',4',5'-trimethoxybenzoyloxy)- propyl)homopiperazine |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57106668A true JPS57106668A (en) | 1982-07-02 |
Family
ID=16121518
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP18262380A Pending JPS57106668A (en) | 1980-12-23 | 1980-12-23 | Preparation of n,n'-bis-(3-(3',4',5'-trimethoxybenzoyloxy)- propyl)homopiperazine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57106668A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3403778A1 (en) * | 1984-02-03 | 1985-08-08 | Degussa Ag, 6000 Frankfurt | CYANOMETHYL- (2-CYANO-ETHYL) - (3-HYDROXY-PROPYL) -AMINE HIS USE FOR PRODUCING 1- (3-HYDROXY-PROPYL) -1,4-DIAZEPANE AND 1,4-BIS (3- (3rd , 4,5-TRIMETHOXYBENZOYLOXY) -PROPYL) -DIAZEPAN |
JPS61100571A (en) * | 1984-10-19 | 1986-05-19 | デグツサ・アクチエンゲゼルシヤフト | Purification of dilaepp base |
-
1980
- 1980-12-23 JP JP18262380A patent/JPS57106668A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3403778A1 (en) * | 1984-02-03 | 1985-08-08 | Degussa Ag, 6000 Frankfurt | CYANOMETHYL- (2-CYANO-ETHYL) - (3-HYDROXY-PROPYL) -AMINE HIS USE FOR PRODUCING 1- (3-HYDROXY-PROPYL) -1,4-DIAZEPANE AND 1,4-BIS (3- (3rd , 4,5-TRIMETHOXYBENZOYLOXY) -PROPYL) -DIAZEPAN |
JPS61100571A (en) * | 1984-10-19 | 1986-05-19 | デグツサ・アクチエンゲゼルシヤフト | Purification of dilaepp base |
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