JPS57106678A - Preparation of dibenzothiepinpropionic acid derivative - Google Patents

Preparation of dibenzothiepinpropionic acid derivative

Info

Publication number
JPS57106678A
JPS57106678A JP18124880A JP18124880A JPS57106678A JP S57106678 A JPS57106678 A JP S57106678A JP 18124880 A JP18124880 A JP 18124880A JP 18124880 A JP18124880 A JP 18124880A JP S57106678 A JPS57106678 A JP S57106678A
Authority
JP
Japan
Prior art keywords
compound
acid
acid derivative
condensation agent
dibenzothiepinpropionic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP18124880A
Other languages
Japanese (ja)
Other versions
JPH0129793B2 (en
Inventor
Hideo Iida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Priority to JP18124880A priority Critical patent/JPS57106678A/en
Publication of JPS57106678A publication Critical patent/JPS57106678A/en
Publication of JPH0129793B2 publication Critical patent/JPH0129793B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To prepare the titled compound having antiphlogistic and analgesic activities, industrially advantageously in view of the yield, the number of reaction steps, and reaction operation, by cyclizing an easily available dicarboxylic acid derivative in the presence of a condensation agent.
CONSTITUTION: The compound of formula II is prepared by reacting the dicarboxylic acid derivative of formulaIin the presence of a condensation agent such as sulfuric acid, polyphosphoric acid, polyphosphoric acid ester, etc. at room temp. W150°C. The starting compound of formulaIcan be synthesized by hydrolyzing the compound of formula III (R is lower alkyl), e.g. 5-(α-cyano)ethyl-2- phenylthiophenylacetic acid ester, in a mixture of hydrobromic acid and acetic acid. The amount of the condensation agent is 1W30pts.wt. per 1pt. of the compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP18124880A 1980-12-23 1980-12-23 Preparation of dibenzothiepinpropionic acid derivative Granted JPS57106678A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP18124880A JPS57106678A (en) 1980-12-23 1980-12-23 Preparation of dibenzothiepinpropionic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18124880A JPS57106678A (en) 1980-12-23 1980-12-23 Preparation of dibenzothiepinpropionic acid derivative

Publications (2)

Publication Number Publication Date
JPS57106678A true JPS57106678A (en) 1982-07-02
JPH0129793B2 JPH0129793B2 (en) 1989-06-14

Family

ID=16097378

Family Applications (1)

Application Number Title Priority Date Filing Date
JP18124880A Granted JPS57106678A (en) 1980-12-23 1980-12-23 Preparation of dibenzothiepinpropionic acid derivative

Country Status (1)

Country Link
JP (1) JPS57106678A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU590450B2 (en) * 1987-09-30 1989-11-02 Nippon Chemiphar Co. Ltd. Process for the preparation of dibenzothiepin derivative
WO2013161842A1 (en) 2012-04-24 2013-10-31 日本ケミファ株式会社 Method for producing zaltoprofen and derivative thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4603276B2 (en) * 2004-03-05 2010-12-22 茂治 前川 Method for producing dibenzothiepine propionic acid derivative

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5553282A (en) * 1978-10-17 1980-04-18 Nippon Chemiphar Co Ltd Dibenzothiepin derivative and its preparation
JPS55153782A (en) * 1979-05-17 1980-11-29 Dainippon Pharmaceut Co Ltd Dibenzo (b,f) thiepin derivative
JPS55164681A (en) * 1979-06-01 1980-12-22 Merck & Co Inc Prostaglandin antagonist

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5553282A (en) * 1978-10-17 1980-04-18 Nippon Chemiphar Co Ltd Dibenzothiepin derivative and its preparation
JPS55153782A (en) * 1979-05-17 1980-11-29 Dainippon Pharmaceut Co Ltd Dibenzo (b,f) thiepin derivative
JPS55164681A (en) * 1979-06-01 1980-12-22 Merck & Co Inc Prostaglandin antagonist

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU590450B2 (en) * 1987-09-30 1989-11-02 Nippon Chemiphar Co. Ltd. Process for the preparation of dibenzothiepin derivative
WO2013161842A1 (en) 2012-04-24 2013-10-31 日本ケミファ株式会社 Method for producing zaltoprofen and derivative thereof
KR20140132737A (en) 2012-04-24 2014-11-18 닛뽕 케미파 가부시키가이샤 Method for producing zaltoprofen and derivative thereof

Also Published As

Publication number Publication date
JPH0129793B2 (en) 1989-06-14

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Legal Events

Date Code Title Description
EXPY Cancellation because of completion of term