JPS57106678A - Preparation of dibenzothiepinpropionic acid derivative - Google Patents
Preparation of dibenzothiepinpropionic acid derivativeInfo
- Publication number
- JPS57106678A JPS57106678A JP18124880A JP18124880A JPS57106678A JP S57106678 A JPS57106678 A JP S57106678A JP 18124880 A JP18124880 A JP 18124880A JP 18124880 A JP18124880 A JP 18124880A JP S57106678 A JPS57106678 A JP S57106678A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- acid
- acid derivative
- condensation agent
- dibenzothiepinpropionic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To prepare the titled compound having antiphlogistic and analgesic activities, industrially advantageously in view of the yield, the number of reaction steps, and reaction operation, by cyclizing an easily available dicarboxylic acid derivative in the presence of a condensation agent.
CONSTITUTION: The compound of formula II is prepared by reacting the dicarboxylic acid derivative of formulaIin the presence of a condensation agent such as sulfuric acid, polyphosphoric acid, polyphosphoric acid ester, etc. at room temp. W150°C. The starting compound of formulaIcan be synthesized by hydrolyzing the compound of formula III (R is lower alkyl), e.g. 5-(α-cyano)ethyl-2- phenylthiophenylacetic acid ester, in a mixture of hydrobromic acid and acetic acid. The amount of the condensation agent is 1W30pts.wt. per 1pt. of the compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18124880A JPS57106678A (en) | 1980-12-23 | 1980-12-23 | Preparation of dibenzothiepinpropionic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18124880A JPS57106678A (en) | 1980-12-23 | 1980-12-23 | Preparation of dibenzothiepinpropionic acid derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57106678A true JPS57106678A (en) | 1982-07-02 |
JPH0129793B2 JPH0129793B2 (en) | 1989-06-14 |
Family
ID=16097378
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP18124880A Granted JPS57106678A (en) | 1980-12-23 | 1980-12-23 | Preparation of dibenzothiepinpropionic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57106678A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU590450B2 (en) * | 1987-09-30 | 1989-11-02 | Nippon Chemiphar Co. Ltd. | Process for the preparation of dibenzothiepin derivative |
WO2013161842A1 (en) | 2012-04-24 | 2013-10-31 | 日本ケミファ株式会社 | Method for producing zaltoprofen and derivative thereof |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4603276B2 (en) * | 2004-03-05 | 2010-12-22 | 茂治 前川 | Method for producing dibenzothiepine propionic acid derivative |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5553282A (en) * | 1978-10-17 | 1980-04-18 | Nippon Chemiphar Co Ltd | Dibenzothiepin derivative and its preparation |
JPS55153782A (en) * | 1979-05-17 | 1980-11-29 | Dainippon Pharmaceut Co Ltd | Dibenzo (b,f) thiepin derivative |
JPS55164681A (en) * | 1979-06-01 | 1980-12-22 | Merck & Co Inc | Prostaglandin antagonist |
-
1980
- 1980-12-23 JP JP18124880A patent/JPS57106678A/en active Granted
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5553282A (en) * | 1978-10-17 | 1980-04-18 | Nippon Chemiphar Co Ltd | Dibenzothiepin derivative and its preparation |
JPS55153782A (en) * | 1979-05-17 | 1980-11-29 | Dainippon Pharmaceut Co Ltd | Dibenzo (b,f) thiepin derivative |
JPS55164681A (en) * | 1979-06-01 | 1980-12-22 | Merck & Co Inc | Prostaglandin antagonist |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU590450B2 (en) * | 1987-09-30 | 1989-11-02 | Nippon Chemiphar Co. Ltd. | Process for the preparation of dibenzothiepin derivative |
WO2013161842A1 (en) | 2012-04-24 | 2013-10-31 | 日本ケミファ株式会社 | Method for producing zaltoprofen and derivative thereof |
KR20140132737A (en) | 2012-04-24 | 2014-11-18 | 닛뽕 케미파 가부시키가이샤 | Method for producing zaltoprofen and derivative thereof |
Also Published As
Publication number | Publication date |
---|---|
JPH0129793B2 (en) | 1989-06-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EXPY | Cancellation because of completion of term |