JPS5697287A - Preparation of 2-piperazino-8-ethyl-5,8-dihydro-5-oxopyrido 2, 3-d pyrimidine-6-carboxylic acid - Google Patents
Preparation of 2-piperazino-8-ethyl-5,8-dihydro-5-oxopyrido 2, 3-d pyrimidine-6-carboxylic acidInfo
- Publication number
- JPS5697287A JPS5697287A JP72680A JP72680A JPS5697287A JP S5697287 A JPS5697287 A JP S5697287A JP 72680 A JP72680 A JP 72680A JP 72680 A JP72680 A JP 72680A JP S5697287 A JPS5697287 A JP S5697287A
- Authority
- JP
- Japan
- Prior art keywords
- oxopyrido
- piperazino
- pyrimidine
- dihydro
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- YPOXGDJGKBXRFP-UHFFFAOYSA-N pyrimidine-4-carboxylic acid Chemical compound OC(=O)C1=CC=NC=N1 YPOXGDJGKBXRFP-UHFFFAOYSA-N 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 230000035484 reaction time Effects 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PURPOSE: To obtain the titled compound useful as an antimicrobial agent in high yield and purity, by oxidizing the corresponding 5,6,7,8-tetrahydro compound in the presence of light with air or O2.
CONSTITUTION: Air or O2 is introduced into an inert solvent, e.g. benzene, in which a compound of formula I (R is H or lower alkyl) is present in the presence of light or the solution is simply agitated to give the titled compound of formula II. The reaction time of 0.5W4hr is usually enough.
EFFECT: The reaction can be carried out at room temperature without formation of by-products and the introducing step of a complicated protecting group. Therefore, the method is industrial and advantageous.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP72680A JPS5697287A (en) | 1980-01-07 | 1980-01-07 | Preparation of 2-piperazino-8-ethyl-5,8-dihydro-5-oxopyrido 2, 3-d pyrimidine-6-carboxylic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP72680A JPS5697287A (en) | 1980-01-07 | 1980-01-07 | Preparation of 2-piperazino-8-ethyl-5,8-dihydro-5-oxopyrido 2, 3-d pyrimidine-6-carboxylic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5697287A true JPS5697287A (en) | 1981-08-05 |
Family
ID=11481732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP72680A Pending JPS5697287A (en) | 1980-01-07 | 1980-01-07 | Preparation of 2-piperazino-8-ethyl-5,8-dihydro-5-oxopyrido 2, 3-d pyrimidine-6-carboxylic acid |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5697287A (en) |
-
1980
- 1980-01-07 JP JP72680A patent/JPS5697287A/en active Pending
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