JPS5690089A - Synthesis of 7-methoxycephem compound - Google Patents

Synthesis of 7-methoxycephem compound

Info

Publication number
JPS5690089A
JPS5690089A JP16767179A JP16767179A JPS5690089A JP S5690089 A JPS5690089 A JP S5690089A JP 16767179 A JP16767179 A JP 16767179A JP 16767179 A JP16767179 A JP 16767179A JP S5690089 A JPS5690089 A JP S5690089A
Authority
JP
Japan
Prior art keywords
compound
formula
compound shown
lower alkyl
methanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP16767179A
Other languages
Japanese (ja)
Other versions
JPS6219432B2 (en
Inventor
Yasuo Hoshiide
Yoshio Hashimoto
Kenichi Suzuki
Takeji Seki
Nariyuki Tasaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NIKKEN KAGAKU KK
Nikken Chemicals Co Ltd
Original Assignee
NIKKEN KAGAKU KK
Nikken Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NIKKEN KAGAKU KK, Nikken Chemicals Co Ltd filed Critical NIKKEN KAGAKU KK
Priority to JP16767179A priority Critical patent/JPS5690089A/en
Publication of JPS5690089A publication Critical patent/JPS5690089A/en
Publication of JPS6219432B2 publication Critical patent/JPS6219432B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as a synthetic intermediate for a compound having a strong resistance to β-lactamase extremely readily by one step, by reacting a cephem compound with methanol in the presence of a compound, e.g., chloramine T and boric acid.
CONSTITUTION: A cephem compound shown by the formula I (R1 is lower alkyl; R2 and R3 are carboxylic acid-protecting group; Y is halogen or lower alkyl; Z is organic or inorganic group residue) is reacted with methanol in the presence of a compound shown by the formula II (R4 is lower alkyl; n is 0-3; M is alkali metal; X is halogen) and boric acid, to give a compound shown by the formula III. The reaction is carried out in an inert solvent, e.g., dichloromethane, etc. at 0W40°C. The compound shown by the formula I as a starting material is obtained by reacting a compound shown by the formula IV and a compound shown by the formula V.
COPYRIGHT: (C)1981,JPO&Japio
JP16767179A 1979-12-25 1979-12-25 Synthesis of 7-methoxycephem compound Granted JPS5690089A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16767179A JPS5690089A (en) 1979-12-25 1979-12-25 Synthesis of 7-methoxycephem compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16767179A JPS5690089A (en) 1979-12-25 1979-12-25 Synthesis of 7-methoxycephem compound

Publications (2)

Publication Number Publication Date
JPS5690089A true JPS5690089A (en) 1981-07-21
JPS6219432B2 JPS6219432B2 (en) 1987-04-28

Family

ID=15854053

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16767179A Granted JPS5690089A (en) 1979-12-25 1979-12-25 Synthesis of 7-methoxycephem compound

Country Status (1)

Country Link
JP (1) JPS5690089A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0742219A1 (en) * 1995-05-10 1996-11-13 Bristol-Myers Squibb Company Preparation and use of 7-((2-carbo-alkoxy-1-methylethenyl) amino)-3-hydroxymethyl-3-cephem-4-carboxylic acids

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0742219A1 (en) * 1995-05-10 1996-11-13 Bristol-Myers Squibb Company Preparation and use of 7-((2-carbo-alkoxy-1-methylethenyl) amino)-3-hydroxymethyl-3-cephem-4-carboxylic acids

Also Published As

Publication number Publication date
JPS6219432B2 (en) 1987-04-28

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