JPS5677247A - 2-hydroxyoxanilic acid derivative - Google Patents
2-hydroxyoxanilic acid derivativeInfo
- Publication number
- JPS5677247A JPS5677247A JP15393579A JP15393579A JPS5677247A JP S5677247 A JPS5677247 A JP S5677247A JP 15393579 A JP15393579 A JP 15393579A JP 15393579 A JP15393579 A JP 15393579A JP S5677247 A JPS5677247 A JP S5677247A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- immunity
- halogen
- delayed type
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:Titled derivatives of formula I (A is hydroxyl, amino; R1 is halogen, nitro; R2 is H or the same atom or group as in R1) and their salts.
EXAMPLE: Ethyl 5-chloro-2-hydroxyoxanilate.
USE: Immunoaccelerator, carcinostatic, antirheumatic, remedy for chronic hepatitis: they have activity of immunity acceleration, antitumorigenic effect and of strongly increasing delayed type allergy by delayed type skin reaction. They are effective for prevention and propylactis against viral attack caused by reduction in immunity.
PREPARATION: The reaction of an aminophenol of formula II with oxalyl halide of formula III (X is halogen) is conducted in an appropriate solvent such as benzene in the presence of a base such as pyridine at room temperature or under cooling to produce the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15393579A JPS5677247A (en) | 1979-11-28 | 1979-11-28 | 2-hydroxyoxanilic acid derivative |
CA000365668A CA1181070A (en) | 1979-11-28 | 1980-11-27 | Process of producing 2-hydroxyoxanilic acid derivatives |
ES80497294A ES8201955A1 (en) | 1979-11-28 | 1980-11-28 | 2-Hydroxyoxanilic acid derivatives and salts, their preparation and pharmaceutical compositions containing them. |
AT80304303T ATE7385T1 (en) | 1979-11-28 | 1980-11-28 | DERIVATIVES OF 2-HYDROXYOXALACIDEANILIDE AND THEIR SALTS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
EP80304303A EP0030436B1 (en) | 1979-11-28 | 1980-11-28 | 2-hydroxyoxanilic acid derivatives and salts, their preparation and pharmaceutical compositions containing them |
DE8080304303T DE3067784D1 (en) | 1979-11-28 | 1980-11-28 | 2-hydroxyoxanilic acid derivatives and salts, their preparation and pharmaceutical compositions containing them |
US06/416,317 US4457872A (en) | 1979-11-28 | 1982-09-09 | 2-Hydroxyoxanilic acid derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15393579A JPS5677247A (en) | 1979-11-28 | 1979-11-28 | 2-hydroxyoxanilic acid derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5677247A true JPS5677247A (en) | 1981-06-25 |
JPS6362509B2 JPS6362509B2 (en) | 1988-12-02 |
Family
ID=15573287
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15393579A Granted JPS5677247A (en) | 1979-11-28 | 1979-11-28 | 2-hydroxyoxanilic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5677247A (en) |
-
1979
- 1979-11-28 JP JP15393579A patent/JPS5677247A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6362509B2 (en) | 1988-12-02 |
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