JPS5677247A - 2-hydroxyoxanilic acid derivative - Google Patents

2-hydroxyoxanilic acid derivative

Info

Publication number
JPS5677247A
JPS5677247A JP15393579A JP15393579A JPS5677247A JP S5677247 A JPS5677247 A JP S5677247A JP 15393579 A JP15393579 A JP 15393579A JP 15393579 A JP15393579 A JP 15393579A JP S5677247 A JPS5677247 A JP S5677247A
Authority
JP
Japan
Prior art keywords
formula
immunity
halogen
delayed type
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15393579A
Other languages
Japanese (ja)
Other versions
JPS6362509B2 (en
Inventor
Kiyoshi Murase
Toshiyasu Mase
Kenichi Tomioka
Yozo Numazaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Priority to JP15393579A priority Critical patent/JPS5677247A/en
Priority to CA000365668A priority patent/CA1181070A/en
Priority to ES80497294A priority patent/ES8201955A1/en
Priority to AT80304303T priority patent/ATE7385T1/en
Priority to EP80304303A priority patent/EP0030436B1/en
Priority to DE8080304303T priority patent/DE3067784D1/en
Publication of JPS5677247A publication Critical patent/JPS5677247A/en
Priority to US06/416,317 priority patent/US4457872A/en
Publication of JPS6362509B2 publication Critical patent/JPS6362509B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:Titled derivatives of formula I (A is hydroxyl, amino; R1 is halogen, nitro; R2 is H or the same atom or group as in R1) and their salts.
EXAMPLE: Ethyl 5-chloro-2-hydroxyoxanilate.
USE: Immunoaccelerator, carcinostatic, antirheumatic, remedy for chronic hepatitis: they have activity of immunity acceleration, antitumorigenic effect and of strongly increasing delayed type allergy by delayed type skin reaction. They are effective for prevention and propylactis against viral attack caused by reduction in immunity.
PREPARATION: The reaction of an aminophenol of formula II with oxalyl halide of formula III (X is halogen) is conducted in an appropriate solvent such as benzene in the presence of a base such as pyridine at room temperature or under cooling to produce the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP15393579A 1979-11-28 1979-11-28 2-hydroxyoxanilic acid derivative Granted JPS5677247A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP15393579A JPS5677247A (en) 1979-11-28 1979-11-28 2-hydroxyoxanilic acid derivative
CA000365668A CA1181070A (en) 1979-11-28 1980-11-27 Process of producing 2-hydroxyoxanilic acid derivatives
ES80497294A ES8201955A1 (en) 1979-11-28 1980-11-28 2-Hydroxyoxanilic acid derivatives and salts, their preparation and pharmaceutical compositions containing them.
AT80304303T ATE7385T1 (en) 1979-11-28 1980-11-28 DERIVATIVES OF 2-HYDROXYOXALACIDEANILIDE AND THEIR SALTS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
EP80304303A EP0030436B1 (en) 1979-11-28 1980-11-28 2-hydroxyoxanilic acid derivatives and salts, their preparation and pharmaceutical compositions containing them
DE8080304303T DE3067784D1 (en) 1979-11-28 1980-11-28 2-hydroxyoxanilic acid derivatives and salts, their preparation and pharmaceutical compositions containing them
US06/416,317 US4457872A (en) 1979-11-28 1982-09-09 2-Hydroxyoxanilic acid derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15393579A JPS5677247A (en) 1979-11-28 1979-11-28 2-hydroxyoxanilic acid derivative

Publications (2)

Publication Number Publication Date
JPS5677247A true JPS5677247A (en) 1981-06-25
JPS6362509B2 JPS6362509B2 (en) 1988-12-02

Family

ID=15573287

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15393579A Granted JPS5677247A (en) 1979-11-28 1979-11-28 2-hydroxyoxanilic acid derivative

Country Status (1)

Country Link
JP (1) JPS5677247A (en)

Also Published As

Publication number Publication date
JPS6362509B2 (en) 1988-12-02

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