JPS5626848A - Optical resolution of (+-)-1-phenylethylamine - Google Patents

Optical resolution of (+-)-1-phenylethylamine

Info

Publication number
JPS5626848A
JPS5626848A JP10226179A JP10226179A JPS5626848A JP S5626848 A JPS5626848 A JP S5626848A JP 10226179 A JP10226179 A JP 10226179A JP 10226179 A JP10226179 A JP 10226179A JP S5626848 A JPS5626848 A JP S5626848A
Authority
JP
Japan
Prior art keywords
phenylethylamine
acid
optical resolution
mandelic acid
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10226179A
Other languages
Japanese (ja)
Other versions
JPH024581B2 (en
Inventor
Naomi Kamiya
Masahide Yoshikawa
Tadashi Tobiyama
Hiroyuki Nohira
Rieko Fujimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamakawa Yakuhin Kogyo KK
Original Assignee
Yamakawa Yakuhin Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamakawa Yakuhin Kogyo KK filed Critical Yamakawa Yakuhin Kogyo KK
Priority to JP10226179A priority Critical patent/JPS5626848A/en
Publication of JPS5626848A publication Critical patent/JPS5626848A/en
Publication of JPH024581B2 publication Critical patent/JPH024581B2/ja
Granted legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To carry out optical resolution of the titled compound, an optical resolving agent for a racemic acid and an asymmetric sourse for asymmetric synthesis in high, yield by using an optically active mandelic acid as an optical resolving agent.
CONSTITUTION: Optical resolution of (±)-1-phenylethylamine is cariied out by using an optically active mandelic acid, where a soluble (±)-1-phenylethyl-amine salt may be present. Water is preferable as a solvent. The above treatment forms a diastereomeric salt, which is optically resolved by the deference in solubility thereof. The salt thus obtained is treated with a base to give (+)- or (-)-1-phenylethylamine, which is then treated with an acid to recover (-)- or (+)-mandelic acid.
COPYRIGHT: (C)1981,JPO&Japio
JP10226179A 1979-08-13 1979-08-13 Optical resolution of (+-)-1-phenylethylamine Granted JPS5626848A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10226179A JPS5626848A (en) 1979-08-13 1979-08-13 Optical resolution of (+-)-1-phenylethylamine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10226179A JPS5626848A (en) 1979-08-13 1979-08-13 Optical resolution of (+-)-1-phenylethylamine

Publications (2)

Publication Number Publication Date
JPS5626848A true JPS5626848A (en) 1981-03-16
JPH024581B2 JPH024581B2 (en) 1990-01-29

Family

ID=14322644

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10226179A Granted JPS5626848A (en) 1979-08-13 1979-08-13 Optical resolution of (+-)-1-phenylethylamine

Country Status (1)

Country Link
JP (1) JPS5626848A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6354342A (en) * 1986-08-26 1988-03-08 Daicel Chem Ind Ltd Optical resolution of (+-)-alpha-ethylbenzylamine
JP2002316952A (en) * 2001-04-18 2002-10-31 Daito Kagaku Kk Method for optical purification of optically active 2- phenoxypropionic acid
WO2008072773A1 (en) * 2006-12-15 2008-06-19 Sumitomo Chemical Company, Limited Method for producing (1r,2r)-2-amino-1-cyclopentanol
US8399655B2 (en) 2005-03-07 2013-03-19 Shire Canada Inc. Process and methods for the preparation of optically active cis-2-hydroxymethyl-4-(cytosin-1′-yl)-1,3-oxathiolane or pharmaceutically acceptable salts thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4718737U (en) * 1971-04-05 1972-11-01

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4718737U (en) * 1971-04-05 1972-11-01

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6354342A (en) * 1986-08-26 1988-03-08 Daicel Chem Ind Ltd Optical resolution of (+-)-alpha-ethylbenzylamine
JP2002316952A (en) * 2001-04-18 2002-10-31 Daito Kagaku Kk Method for optical purification of optically active 2- phenoxypropionic acid
US8399655B2 (en) 2005-03-07 2013-03-19 Shire Canada Inc. Process and methods for the preparation of optically active cis-2-hydroxymethyl-4-(cytosin-1′-yl)-1,3-oxathiolane or pharmaceutically acceptable salts thereof
WO2008072773A1 (en) * 2006-12-15 2008-06-19 Sumitomo Chemical Company, Limited Method for producing (1r,2r)-2-amino-1-cyclopentanol

Also Published As

Publication number Publication date
JPH024581B2 (en) 1990-01-29

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