JPS5625113A - Preparation of hemostatic collagen powder - Google Patents
Preparation of hemostatic collagen powderInfo
- Publication number
- JPS5625113A JPS5625113A JP10040579A JP10040579A JPS5625113A JP S5625113 A JPS5625113 A JP S5625113A JP 10040579 A JP10040579 A JP 10040579A JP 10040579 A JP10040579 A JP 10040579A JP S5625113 A JPS5625113 A JP S5625113A
- Authority
- JP
- Japan
- Prior art keywords
- collagen
- pretreated
- chips
- purification
- solubilizing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
PURPOSE: To solubilize collagen chips without further pulverization, to facilitate the washing and purification, and to improve the purity and yield of collagen, by treating pretreated collagen chips with a protease capable of solubilizing collagen under specific weakly alkaline conditions.
CONSTITUTION: A collagen raw material obtained by removing impurities from crude collagen followed by purification and pelletizing, is pretreated with an aqueous mixture of caustic soda and sodium sulfate. The pretreated collagen is made to react with a protease capable of solubilizing collagen under weakly alkaline conditions of pH7W10 (e.g. "Pronase" , Trade name of Kaken Kagaku KK) for 10W30hr to effect the selective scission of the telo-peptide part without breaking the peptide linkage of the collagen molecule. The solubilized collagen thus obtained is washed with water and with a dilute acid solution, dried, and pulverized to 28W 400mesh powder.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10040579A JPS5625113A (en) | 1979-08-07 | 1979-08-07 | Preparation of hemostatic collagen powder |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10040579A JPS5625113A (en) | 1979-08-07 | 1979-08-07 | Preparation of hemostatic collagen powder |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5625113A true JPS5625113A (en) | 1981-03-10 |
JPS6236496B2 JPS6236496B2 (en) | 1987-08-07 |
Family
ID=14273064
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10040579A Granted JPS5625113A (en) | 1979-08-07 | 1979-08-07 | Preparation of hemostatic collagen powder |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5625113A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58103322A (en) * | 1981-11-30 | 1983-06-20 | ソシエテ・アノニム・ド・デヴロップマン・デ・ユテイリザ−ション・デュ・キュイ−ル | Manufacture of collagen composition |
EP0372966A2 (en) * | 1988-12-08 | 1990-06-13 | JOHNSON & JOHNSON MEDICAL, INC. | Hemostatic collagen paste composition |
JP2010233552A (en) * | 2009-03-31 | 2010-10-21 | Hamamatsu Univ School Of Medicine | Highly sensitive detection method for highly virulent oral cavity bacteria |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS51130519A (en) * | 1975-05-01 | 1976-11-12 | Nippi:Kk | Process for preparating collagen powder for hemostasis |
JPS5365358A (en) * | 1976-11-22 | 1978-06-10 | Nippi Inc | Collagen fiber dispersion |
-
1979
- 1979-08-07 JP JP10040579A patent/JPS5625113A/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS51130519A (en) * | 1975-05-01 | 1976-11-12 | Nippi:Kk | Process for preparating collagen powder for hemostasis |
JPS5365358A (en) * | 1976-11-22 | 1978-06-10 | Nippi Inc | Collagen fiber dispersion |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58103322A (en) * | 1981-11-30 | 1983-06-20 | ソシエテ・アノニム・ド・デヴロップマン・デ・ユテイリザ−ション・デュ・キュイ−ル | Manufacture of collagen composition |
EP0372966A2 (en) * | 1988-12-08 | 1990-06-13 | JOHNSON & JOHNSON MEDICAL, INC. | Hemostatic collagen paste composition |
JP2010233552A (en) * | 2009-03-31 | 2010-10-21 | Hamamatsu Univ School Of Medicine | Highly sensitive detection method for highly virulent oral cavity bacteria |
Also Published As
Publication number | Publication date |
---|---|
JPS6236496B2 (en) | 1987-08-07 |
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