JPS56145271A - 2-azetidinone derivative - Google Patents
2-azetidinone derivativeInfo
- Publication number
- JPS56145271A JPS56145271A JP4755480A JP4755480A JPS56145271A JP S56145271 A JPS56145271 A JP S56145271A JP 4755480 A JP4755480 A JP 4755480A JP 4755480 A JP4755480 A JP 4755480A JP S56145271 A JPS56145271 A JP S56145271A
- Authority
- JP
- Japan
- Prior art keywords
- compounds
- formula
- lower alkyl
- grignard reagent
- novel compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
PURPOSE: A Grignard reagent is made to act on β-amino esters to produce 2-azetidinone derivatives bearing an olefinic substituent on the 4-position, which include some novel compounds and are used as synthetic intermediates of carbapenem ring compounds.
CONSTITUTION: A β-aminoester of formula I (R1, R2 is H, lower alkyl; R3 is lower alkenyl; R4 is lower alkyl) such as methyl 3-amino-6-heptenoate is dissolved in an appropriate solvent and combined with an ethereal solution of a Grignard reagent such as o-tolylmagnesium bromide in an inert gas atmosphere such as argon under cooling. They are stirred at room temperature for several hrs to several days. After excess reagent is decomposed with an ammonium chloride solution, the reaction mixture is neutralized with an acid such as hydrochloric acid to give 2-azetidinone derivatives bearing an olefinic substituent on the 4 position including novel compounds of formula II (compounds with H as R1 and R2 and 3-butenyl as R3 are excluded.).
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4755480A JPS56145271A (en) | 1980-04-11 | 1980-04-11 | 2-azetidinone derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4755480A JPS56145271A (en) | 1980-04-11 | 1980-04-11 | 2-azetidinone derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56145271A true JPS56145271A (en) | 1981-11-11 |
JPS643187B2 JPS643187B2 (en) | 1989-01-19 |
Family
ID=12778386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4755480A Granted JPS56145271A (en) | 1980-04-11 | 1980-04-11 | 2-azetidinone derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56145271A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6394569B2 (en) | 2015-11-06 | 2018-09-26 | 信越半導体株式会社 | Wafer polishing method and polishing apparatus |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5448786A (en) * | 1977-08-06 | 1979-04-17 | Beecham Group Ltd | Betaalactam compound*its manufacture and composition |
JPS5466697A (en) * | 1977-10-19 | 1979-05-29 | Merck & Co Inc | 33substitutedd66substitutedd77oxoo11 azabicyclo*3*2*0**heptaa22enee22carboxylic acid |
-
1980
- 1980-04-11 JP JP4755480A patent/JPS56145271A/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5448786A (en) * | 1977-08-06 | 1979-04-17 | Beecham Group Ltd | Betaalactam compound*its manufacture and composition |
JPS5466697A (en) * | 1977-10-19 | 1979-05-29 | Merck & Co Inc | 33substitutedd66substitutedd77oxoo11 azabicyclo*3*2*0**heptaa22enee22carboxylic acid |
Also Published As
Publication number | Publication date |
---|---|
JPS643187B2 (en) | 1989-01-19 |
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