JPS56145271A - 2-azetidinone derivative - Google Patents

2-azetidinone derivative

Info

Publication number
JPS56145271A
JPS56145271A JP4755480A JP4755480A JPS56145271A JP S56145271 A JPS56145271 A JP S56145271A JP 4755480 A JP4755480 A JP 4755480A JP 4755480 A JP4755480 A JP 4755480A JP S56145271 A JPS56145271 A JP S56145271A
Authority
JP
Japan
Prior art keywords
compounds
formula
lower alkyl
grignard reagent
novel compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4755480A
Other languages
Japanese (ja)
Other versions
JPS643187B2 (en
Inventor
Harutoshi Kubota
Masayuki Shibuya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP4755480A priority Critical patent/JPS56145271A/en
Publication of JPS56145271A publication Critical patent/JPS56145271A/en
Publication of JPS643187B2 publication Critical patent/JPS643187B2/ja
Granted legal-status Critical Current

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Landscapes

  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PURPOSE: A Grignard reagent is made to act on β-amino esters to produce 2-azetidinone derivatives bearing an olefinic substituent on the 4-position, which include some novel compounds and are used as synthetic intermediates of carbapenem ring compounds.
CONSTITUTION: A β-aminoester of formula I (R1, R2 is H, lower alkyl; R3 is lower alkenyl; R4 is lower alkyl) such as methyl 3-amino-6-heptenoate is dissolved in an appropriate solvent and combined with an ethereal solution of a Grignard reagent such as o-tolylmagnesium bromide in an inert gas atmosphere such as argon under cooling. They are stirred at room temperature for several hrs to several days. After excess reagent is decomposed with an ammonium chloride solution, the reaction mixture is neutralized with an acid such as hydrochloric acid to give 2-azetidinone derivatives bearing an olefinic substituent on the 4 position including novel compounds of formula II (compounds with H as R1 and R2 and 3-butenyl as R3 are excluded.).
COPYRIGHT: (C)1981,JPO&Japio
JP4755480A 1980-04-11 1980-04-11 2-azetidinone derivative Granted JPS56145271A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4755480A JPS56145271A (en) 1980-04-11 1980-04-11 2-azetidinone derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4755480A JPS56145271A (en) 1980-04-11 1980-04-11 2-azetidinone derivative

Publications (2)

Publication Number Publication Date
JPS56145271A true JPS56145271A (en) 1981-11-11
JPS643187B2 JPS643187B2 (en) 1989-01-19

Family

ID=12778386

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4755480A Granted JPS56145271A (en) 1980-04-11 1980-04-11 2-azetidinone derivative

Country Status (1)

Country Link
JP (1) JPS56145271A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6394569B2 (en) 2015-11-06 2018-09-26 信越半導体株式会社 Wafer polishing method and polishing apparatus

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5448786A (en) * 1977-08-06 1979-04-17 Beecham Group Ltd Betaalactam compound*its manufacture and composition
JPS5466697A (en) * 1977-10-19 1979-05-29 Merck & Co Inc 33substitutedd66substitutedd77oxoo11 azabicyclo*3*2*0**heptaa22enee22carboxylic acid

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5448786A (en) * 1977-08-06 1979-04-17 Beecham Group Ltd Betaalactam compound*its manufacture and composition
JPS5466697A (en) * 1977-10-19 1979-05-29 Merck & Co Inc 33substitutedd66substitutedd77oxoo11 azabicyclo*3*2*0**heptaa22enee22carboxylic acid

Also Published As

Publication number Publication date
JPS643187B2 (en) 1989-01-19

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